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THIS RESOURCE IS NO LONGER IN SERVICE. Documented on May 4th,2023. The Tissue Bank began collecting tissue from neurosurgical operations in 1978 and has established an organized repository of characterized tissues that have been collected and maintained in a manner useful for a wide range of studies. Copies of each patient''s consent to donate their tissue for research are maintained in a secure area of the Tissue Bank. Clinical data from each case are logged into a secured computer data base. Tissue received into the Tissue Bank is catalogued and referenced by a consecutive numbering system in order to maintain patients'' confidentiality. We have established a complete histology service including tissue processing, embedding, sectioning and H&E staining for fixed tissues, in addition to creating and staining frozen sections. This facility enables the Tissue Bank to support research needs for fixed samples from animal model experiments, to fulfill requests for paraffin sections from diagnostic samples and to provide frozen sections for histologic review.

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• SciCrunch
• 15 years ago - by Anonymous

Web service with well defined methods to enable programmatic access to molecular interactions. Standard for computational access to molecular interaction data resources.

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• SciCrunch
• 13 years ago - by Anonymous

Provides standardized vocabulary of phenotypic abnormalities encountered in human disease. Structured and controlled vocabulary for phenotypic features encountered in human hereditary and other disease. HPO is being developed in collaboration with members of OBO Foundry (Open Biological and Biomedical Ontologies), and logical definitions for HPO terms are being developed using PATO and a number of other ontologies including FMA, GO, ChEBI, and MPATH.

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• SciCrunch
• 14 years ago - by Anonymous

A tool for automatically scheduling events for rapid-presentation event-related (RPER) fMRI experiments (the schedule is the order and timing of events). Events in RPER are presented closely enough in time that their hemodynamic responses will overlap. This requires that the onset times of the events be jittered in order to remove the overlap from the estimate of the hemodynamic response. RPER is highly resistant to habituation, expectation, and set because the subject does not know when the next stimulus will appear or which stimulus type it will be. RPER is also more efficient than fixed-interval event related (FIER) because more stimuli can be presented within a given scanning interval at the cost of assuming that the overlap in the hemodynamic responses will be linear. In SPM parlance, RPER is referred to as ''stochastic design''. This is a subproject of the Center for Functional Neuroimaging Techniques (http://www.nitrc.org/projects/cfnt/)

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• SciCrunch
• 14 years ago - by Anonymous

Commercial marketer, distributor and importer of industrial, medical, pharmaceutical and biological research and health innovation products.

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• SciCrunch
• 13 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE, documented August 23, 2016. Despite considerable research, fundamental questions about chronic fatigue syndrome (CFS) remain at best partially answered. These questions include its definition, validity, the degree to which it results from genetic versus environmental factors, the nature of the substantial comorbidity observed with other conditions, and the basis of the female preponderance. The overarching aim of this project is to shed light on a number of basic questions about CFS via a large, population-based classical twin study. First, we collected data on ~32,000 adults aged 42-65 years (13,000 complete twin pairs) who are members of the Swedish Twin Registry for persistent fatigue, several overlapping conditions (fibromyalgia, irritable bowel syndrome, tension headache, allergy/eczema, generalized anxiety disorder, and major depression), and a detailed medical history. Second, the medical records of all twins who appeared to have CFS-like illness and a subset of those with CFS-explained were requested reviewed by experts. We have addressed a set of critical questions regarding CFS. First, we estimated the prevalence of CFS and its common comorbidities (fibromyalgia, irritable bowel syndrome, tension headache, allergy/eczema, generalized anxiety disorder, and major depression) in one of the largest samples yet studied. Second, we used a variety of multivariate techniques to derive an empirical typology of prolonged fatigue and to assess how this typology compares to the CFS definition. Third, we quantified the genetic and environmental sources of variation for CFS and its comorbid conditions. Fourth, we examined the influence of gender on these sources of variation. Finally, we analyzed the patterns of comorbidity between CFS and fibromyalgia, irritable bowel syndrome, tension headache, allergy/eczema, generalized anxiety disorder, and major depression using multivariate twin analyses and thereby estimated the extent of overlap between the shared and unique genetic and environmental sources of variation. In a follow-up study of 50 MZ twin pairs stringently discordant for CFS, we are now looking at intrapair differences in gene expression.

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• SciCrunch
• 14 years ago - by Anonymous

A suite of software that allow users to capture, manage, and analyze effectively data from DNA microarray experiments. The suite of tools consist of four major applications, Microarray Data Manager (MADAM), TIGR_Spotfinder, Microarray Data Analysis System (MIDAS), and Multiexperiment Viewer (MeV), as well as a Minimal Information About a Microarray Experiment (MIAME)-compliant MySQL database, all of which are freely available to the scientific research community.

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• SciCrunch
• 13 years ago - by Anonymous

Software that provides a simple way to do some quality control checks on raw sequence data coming from high throughput sequencing pipelines.

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• SciCrunch
• 13 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on May 2nd,2023. TMAD stores raw and processed data from Tissue Microarray experiments along with their corresponding stained tissue images. In addition, TMAD provides methods for data retrieval, grouping of data, analysis and visualization as well as export to standard formats. Researchers at the Stanford University School of Medicine and their collaborators worldwide have constructed many tissue microarrays for use in basic research.

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• SciCrunch
• 16 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on May 2nd, 2023. Sequence composition based classifier for metagenomic sequences. It works by capturing signatures of each sequence based on the sequence composition. Each sequence is modeled as a walk in a de Bruijn graph with underlying Markov chain properties. ClaMS captures stationary parameters of the underlying Markov chain as well as structural parameters of the underlying de Bruijn graph to form this signature. In practice, for each sequence to binned, such a signature is computed and matched to similar signatures computed for the training sets. The best match that also qualifies the normalized distance cut-off wins. In the case that the best match does not qualify this cut-off, the sequence remains un-binned.

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• SciCrunch
• 14 years ago - by Anonymous

A study that aims to find out the most effective medication treatments for Alzheimer's disease symptoms, and to improve the quality of life of people with Alzheimer's disease. The outcomes of these trials will depend not only on randomized treatment assignment but the interactions of the clinical sites with the patients and caregivers. This study's main goals are to generate hypotheses about effectiveness and other issues with antipsychotic use that might undergo future testing.

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• SciCrunch
• 14 years ago - by Anonymous

Collect, bank, and distribute human tissue and fluid specimens by uniting tissue-based research resources within the OSU Department of Pathology and promoting collaborative research within the OSU Medical Center and related national human research projects. The HTRN is comprised of the Pathology Core Facility (PCF), Tissue Archive Service (TAS), Tissue Procurement Service (TPS), AIDS and Cancer Specimen Resource (ACSR), the Cancer and Leukemia Group B Pathology Coordinating Office (CALGB - PCO), and an Adenoma Polyp Tissue Bank (APTB).

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• SciCrunch
• 15 years ago - by Anonymous

The Parkinson''s UK Brain Bank is the UK''s largest brain bank dedicated to Parkinson''s. We collect the brain, spinal cord and a sample of cerebrospinal fluid from people with and without Parkinson''s after death. We supply tissue to researchers investigating Parkinson''s in the UK and around the world who are working towards a cure for Parkinson''s. Vital research relies upon the generosity of donors and their families who make the vital gift of brain donation after death. Become a brain donor and help us to find a cure and improve life for everyone affected by Parkinson''s. Just one donated brain can be used in up to 50 different research studies. The Parkinson''s UK Brain Bank is currently supporting more than 100 research projects. And we have more than 6,000 registered potential donors. Our tissue is: * free - unlike other banks, we don''t charge researchers for tissue * high quality - we collect most tissue within 24 hours of death * fast - we aim to supply tissue within 4 weeks * neuropathologically diagnosed - according to the latest criteria And we can: * issue ethical approval for projects that fit our research criteria - saving you time * provide tissue suitable for all modern research techniques - including snap frozen and fixed samples * offer expertise and training to researchers working with human tissue We don''t just supply brain tissue. We also know a lot about our donors, which means we can provide tissue to match your project. Donated tissue come with clinical notes from the healthcare team. And every donor provides details of their symptoms, medical history, lifestyle and medications. This makes our offer of tissue and information unique.

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• SciCrunch
• 15 years ago - by Anonymous

A university in Germany.

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• SciCrunch
• 16 years ago - submitted by Stephen Larson

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on April 28,2023. Platform for Neuroscientists to describe neurons and neural circuitry. Registered users may edit. The ultimate goal is advance the field of Neuromics by creating an encyclopedia of neurons and neural circuitry. NOTE: The database is no longer being maintained due to lack of funding.

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• SciCrunch
• 16 years ago - by Anonymous

Atlas of developing human brain for studying transcriptional mechanisms involved in human brain development. One of the BrainSpan datasets, Exon microarray summarized to genes, is presented. It is a downloadable archive of files containing normalized RNA-Seq expression values for analysis.

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• SciCrunch
• 15 years ago - by Anonymous

Atlas of developing human brain for studying transcriptional mechanisms involved in human brain development. One of the BrainSpan datasets, Exon microarray summarized to genes, is presented. It is a downloadable archive of files containing normalized RNA-Seq expression values for analysis.

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• SciCrunch
• 15 years ago - by Anonymous

UniProt Archive (UniParc) is part of UniProt project. It is a non-redundant archive of protein sequences extracted from public databases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, PIR-PSD, EMBL, EMBL WGS, Ensembl, IPI, PDB, PIR-PSD, RefSeq, FlyBase, WormBase, H-Invitational Database, TROME database, European Patent Office proteins, United States Patent and Trademark Office proteins (USPTO) and Japan Patent Office proteins. UniParc contains only protein sequences. All other information about the protein must be retrieved from the source databases using the database cross-references. Each unique sequence is stored only once with a stable identifier. The format of the identifier is UPI followed by ten hexadecimal numbers, e.g. UPI000000000A. UniParc proteins are linked to their source databases by database cross-references. Each cross-reference links one protein in UniParc to an accession number in a source database. The database cross-reference is active as long as the sequence identified by the source accession number remains unchanged. When the sequence is modified or removed in the source database, the cross-reference from UniParc becomes inactive. Active cross-reference can be used to directly access the source databases but inactive cross-references can only be used to access sequences archives, such as the Sequence Version Archive. UniParc is available for text- and sequence-based searches. Sequences, which are no longer part of any source database, are excluded from sequence-based searches, but they are available for text-based SRS searches. Performing a similarity search against UniParc is equivalent to performing the same search against all databases cross-referenced in UniParc, as UniParc contains all proteins from its source databases. Sequence similarity searches can be done using FASTA, BLAST or Mpsrch.

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• SciCrunch
• 15 years ago - by Anonymous

Portal providing access to all JGI genomic databases and analytical tools, sequencing projects and their status, search for and download assemblies and annotations of sequenced genomes, and interactively explore those genomes and compare them with other sequenced microbes, fungi, plants or metagenomes using specialized systems tailored to each particular class of organisms. The Department of Energy (DOE) Joint Genome Institute (JGI) is a national user facility with massive-scale DNA sequencing and analysis capabilities dedicated to advancing genomics for bioenergy and environmental applications. Beyond generating tens of trillions of DNA bases annually, the Institute develops and maintains data management systems and specialized analytical capabilities to manage and interpret complex genomic data sets, and to enable an expanding community of users around the world to analyze these data in different contexts over the web.

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• SciCrunch
• 15 years ago - by Anonymous

National and international arabidopsis germplasm resource.Stores over million genotypes in physical stocks servicing worldwide Arabidopsis community in more than 50 countries. Stocks are provided under identical cost recovery conditions to academic and commercial researchers. Non-transgenic stocks are sent gratis to K-17 institutions and in special cases. Provides seed and information resources to International Arabidopsis Genome Programme and research community. Maintains accessions of Arabidopsis thaliana (and small number of other related species), including Characterized lines, Mapping populations, and Insertion lines. You may browse or search catalog.

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• SciCrunch
• 15 years ago - by Anonymous