We support boolean queries, use +,-,<,>,~,* to alter the weighting of terms
Core provides access to imaging instrumentation and expertise that is necessary to integrate advanced imaging technologies into basic and translational biomedical research. Services include Assistance in experimental design; Developing specialty equipment and innovative procedures for imaging; Preparing animals for studies, inducing and maintaining appropriate anesthesia and immobilization of animals during imaging;Processing and interpreting data for publication or grant preparation.
Three-dimensional brain reference atlas based on the RIKEN25v1 MRI-derived template, based on an average of 25 C. jacchus brains resampled to 70 um3 voxel resolution. Includes selected published subcortical parcellations to aid in comparing across parcellation schemes.
Three-dimensional brain reference atlas for macaque basal ganglia created based on annotation of BG structures on Mac25Rhesus template, an averaged MRI template from 25 M. Includes selected published subcortical parcellations to aid in comparing across parcellation schemes. Enables mapping of samples and integration of multimodal data within and across species.
IFGW glass workshop, equipped with specialized staff, provides expertise in glass forming, welding, and cutting of Quartz and Borosilicate, as well as in design and technical drawing.
Core produces and supplies liquid helium and nitrogen to the entire IFGW academic community. Laboratory is equipped with helium liquefier from Linde and nitrogen liquefier from Stirling Cryogenics. In addition, it maintains complex support infrastructure essential for production and distribution of cryogenic liquids.
IFGW hosts a mechanical workshop that produces precision components for advanced research projects.
Software tool for reconstruction of cell spatial organization from single-cell RNA sequencing data based on ligand-receptor mediated self-assembly. Infers cellular spatial organization from scRNA-seq by modeling ligand–receptor-mediated self-assembly. It constructs 3D pseudo-space and quantifies cell–cell interactions for downstream visualization and hypothesis testing.
Software package for flexible spatial reconstruction of single-cell gene expression with optimal transport. Framework for de novo spatial reconstruction of single-cell gene expression. Assigns cells to tissue locations using probabilistic/optimal-transport models, with or without prior marker information, and returns spatial maps and assignment probabilities.
Software tool for assigning single cells from scRNA-seq to spatial transcriptomics coordinates via optimization framework. Supports high-resolution cell/spot alignment, capacity-constrained/domain-aware placement, and outputs per-cell/per-spot assignments and probabilities for downstream visualization and analysis. Used for optimal mapping of scRNA-seq data to spatial transcriptomics data.
Automated sliding microtome with additional capability for cutting large and hard specimens. Offers Choice of manual or mechanized operation, Coaxial specimen orientation and memory function for rapid re-orientation of pre-cut blocks, User-friendly control panel for easy operation, Optional retraction to protect specimen.
Three-dimensional (3D) common coordinate framework (CCF) and reference atlas that defines the spatial organization of the basal ganglia of the adult human brain.
Software repository contains files needed to build the standard and its supplementary documentation. Changes are automatically pushed and built. Information about the SWC file specification.
Software workflow is an open-source, cloud-optimized pipeline developed in collaboration with the BRAIN Initiative Cell Census Network (BICCN) and the BRAIN Initiative Cell Atlas Network (BICAN).
Compartmentalized schema for storing all required aspects of taxonomy. Fields in AIT schema are associated to broad category term which form piece of whole AIT file format.
Harmonized cross-species taxonomy of brain and spinal cord structures. Derived from the Allen Developing Human Brain Atlas (DHBA) ontology, the HOMBA is hierarchical, allowing users to aggregate structures from fine grain parcellations to broad regions. Terminology is harmonized across human, primate, and rodent structures with synonymous terms and includes transient developmental structures. HOMBA is designed for neuroanatomical applications including brain sampling and dissection, tissue block mapping, atlas building, cell-type and pathology localization, and linking cross-species and developmental datasets.
Core provides multiphoton characterization of Genetically-Encoded Probes for the BRAIN Initiative researchers and broader neuroscience community. Services include Measuring of 2-photon absorption spectra in absolute, cross section values; Measuring 3-photon absorption spectra and cross sections; Characterizing multiphoton photobleaching parameters, i.e. quantum yields, nonlinear absorption cross sections:Measuring one-photon absorption, emission, and excitation spectra;Measuring fluorescence quantum yields and lifetimes;Evolving brighter two-photon probes.
Software R package for statistical analyses and comparison of two circadian rhythms. Used to estimate and statistically support differences in mesor, amplitude and phase, between circadian rhythms.
Medical hospital-based research institute in Montreal, Quebec, Canada.
Core provides expertise in confocal, live cell, and fluorescent microscopy. Provides services in experimental design, instrumentation, training, technical assistance, and scientific guidance from sample preparation to data analysis and publication.
Software tool for predicting long-term relapse of tumor spheroids from early post-treatment brightfield image data. We deploy a dataset consisting of time-series radiomics features for predicting the treatment response of tumor spheroids.