Curator Dashboard

Consortium establishing data standards, tools and methods for conducting research in therapeutic areas important to public health including Alzheimer's disease, Parkinson's disease, multiple sclerosis, polycystic kidney disease, and tuberculosis.CDISC and C-Path have agreed to discontinue using separate CFAST brand, but they both remain committed to this mission and continue to partner to develop and publish therapeutic area data standards.

• Organization
• Consortia-pedia, a FasterCures Project
• 12 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on July 31,2025. A software tool for predicting granzyme B and caspase cleavage sites.

• Resource
• SciCrunch
• 13 years ago - by Anonymous

An online collaborative editor for academics that use citations and/or formulas. The editor focuses on the content rather than the layout, so that with the same text, it can be published in multiple ways: On a website, as a printed book, or as an ebook.

• Resource
• SciCrunch
• 13 years ago - by Anonymous

NOTE: The T1D-RAID program is not currently accepting applications. Cooperative program that makes available, on a competitive basis, NCI resources for the pre-clinical development of drugs, natural products, and biologics to facilitate translation to the clinic of novel, scientifically meritorious therapeutic interventions for type 1 diabetes and its complications. A partial listing of those services includes: high-throughput screening, studies in animal models, formulation, pharmacology and toxicology studies, and bulk substances acquisition. Requests to T1D-RAID are brief (20 pages or less), and should clearly outline the resources required to ready the proposed therapeutic agent for clinical trials. T1D-RAID should enable entry into the clinic of promising molecules that are not otherwise likely to receive an adequate and timely clinical test. T1D-RAID is designed to accomplish the tasks that are rate-limiting in bringing discoveries from the laboratory to the clinic. Once a project has been approved, NIDDKstaff interact directly with the Principal Investigator (PI). NCI contractors perform the T1D-RAID-approved tasks under the direction of NIDDKand NCI staff. The required tasks will vary from project to project. In some cases T1D-RAID will support only one or two key missing steps necessary to bring a compound to the clinic; in other cases it may be necessary to supply the entire portfolio of development requirements needed to file an IND. Examples of tasks that can be supported by T1D-RAID include, but are not limited to: * Definition or optimization of dose and schedule for in vivo activity * Development of pharmacology assays * Conduct of pharmacology studies with a pre-determined assay * Acquisition of bulk substance (GMP and non-GMP) * Scale-up production from lab-scale to clinical-trials lot scale * Development of suitable formulations * Development of analytical methods for bulk substances * Production of dosage forms * Stability assurance of dosage forms * Range-finding initial toxicology * IND-directed toxicology, with correlative pharmacology and histopathology * Planning of clinical trials * Regulatory affairs, so that FDA requirements are likely to be satisfied by participating investigators seeking to test new molecular entities in the clinic * IND filing advice The output of T1D-RAID activities will be both products and information that will be made fully available to the originating investigator for support of an IND application and clinical trials. T1D-RAID does not sponsor clinical trials.

• Resource
• dkNET
• 13 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on July 31,2025. A software package for the prediction of calpain cleavage sites.

• Resource
• SciCrunch
• 13 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on July 31,2025. A standard next-generation paper (NGP) digital format for reading and digitally archiving scientific research papers to offer better imaging, data sharing and an improved reading experience. The NGP format is designed to retain traditional elements (i.e. Abstract, Introduction, etc.). Papers are viewed using any web browser running on any computing platform, including mobile devices. A button menu system provides navigation between pages. The format provides a more streamlined reading experience by providing as much information to the reader inline as possible, without requiring the user to skip between pages. To accomplish this, pop-up figure and reference details provide additional information without disrupting the flow of the paper. Clicking on standard figure data reveals full-resolution images, and live web links can be optionally followed from pop-up citations or inline links for additional information. Multimedia, such as hi-definition video or audio clips, is easily embedded within the new NGP format. The reader may also customize their reading experience by selecting alternative text and background color themes. The NGP format was created using non-proprietary open-source software including HTML and Javascript, and can be packaged to run offline independent of a live Internet connection. Data are fully captured and communicated utilizing the latest technologies available. The SCORE Imaging (Petzold et al.) paper was submitted to the publisher using this format to take advantage of its superior technical capabilities (http://zfishbook.org/NGP/).

• Resource
• SciCrunch
• 14 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on July 31,2025. A database of resources on cancer processes such as cell death. It is a subset of a larger database on cancer proteomics that focuses on anti-cancer drugs and cancer types in addition to cancer processes. It utilizes scientific articles from PubMed, UniProt and other resources along with information such as author information, sample types and useful hyperlinks.

• Resource
• SciCrunch
• 13 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on August 30, 2022. Software package that implements 12 major meta-analysis methods for differential expression analysis.Package was removed from the CRAN repository.Formerly available versions can be obtained from the archive.Archived on 2018-01-23 as check problems were not corrected in time.

• Resource
• SciCrunch
• 12 years ago - by Anonymous

A note taking software that synchronizes information such as notes, web clips, audio files, photos and video collected across multiple devices. It allows for easy sharing and collaboration on projects.

• Resource
• SciCrunch
• 14 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on July 31,2025. A novel tool developed using Java program for the high-throughput in silico identification of substrate cleavage sites for various caspases from the amino acid sequences of the substrates.

• Resource
• SciCrunch
• 13 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on July 31,2025. A software program that screens large libraries of compounds including ligands, and their docking.

• Resource
• SciCrunch
• 13 years ago - by Anonymous

Forum for collaborative projects in the field of brain science. Everyone is invited to submit projects, either existing ones that you want to see featured or new ones that you want launch and work on in a collaborative, open way.

• Resource
• SciCrunch
• 14 years ago - by Anonymous

Software package that fits heterogeneous error models for analysis of microarray data

• Resource
• SciCrunch
• 12 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on July 31,2025. An optimization algorithm based on particle swarm optimization (PSO) for solving flexible protein-ligand docking problems.

• Resource
• SciCrunch
• 13 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on July 31,2025. A software platform for low dose electron tomography (ET) for all processing steps: acquisition, alignment, reconstruction, and analysis. Requires: Matlab R2008a and Image Processing Toolbox (V6.1)

• Resource
• SciCrunch
• 15 years ago - by Anonymous

A complete drug designing software suite with an accessible web-server for targeted directed lead molecule discovery.

• Resource
• SciCrunch
• 13 years ago - by Anonymous

An integrated platform for predicting protein-ligand interactions, the visualization of new ideas and analyzing protein targets.

• Resource
• SciCrunch
• 13 years ago - by Anonymous

Google Tech Talks is a grass-roots program at Google for sharing information of interest to the technical community. At its best, it's part of an ongoing discussion about our world featuring top experts in diverse fields. Presentations range from the broadest of perspective overviews to the most technical of deep dives, on topics well-established to wildly speculative.

• Resource
• SciCrunch
• 14 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on July 31,2025. A software for virtual screening and identifying the binding mode of active molecules. It is comprehensively validated, widely used, and allows for high database enrichments. The software utilizes a novel methodology which avoids computationally expensive sequential docking of ligands into multiple protein structures.

• Resource
• SciCrunch
• 13 years ago - by Anonymous

Software package which approximates a complete search of the conformational, orientational, and positional space of the ligand in a given receptor. Used in drug development for predicting protein ligand binding modes and ranking ligands via high throughput virtual screening.

• Resource
• SciCrunch
• 13 years ago - by Anonymous