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https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=12880037

Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Notes: This mutant strain was generated by injecting TALEN targeting exon23 of rat Dmd into Crl:SD embryo. The resulting mutant is a 11 bp-deletion in exon 23 leading to a +1 grame shift and premature stop codon 81 bp after the mutation.

Proper citation: RRID:RGD_12880037 Copy   

•   Source: Integrated Animals

https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=12904679

Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown
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Notes: ZFN system was used to introduce a 25-bp deletion mutation in the exon 4 of Cyp2j4 gene of WKY/NCrl rat embryos. This deletion results in premature stop of protein translation.

Proper citation: RRID:RGD_12904679 Copy   

•   Source: Integrated Animals

https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=13800556

Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown
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Notes: The ZFN system targeting exon 2 of Hsd11b2 gene was injected into the F344/IcoCrl embryos to induce a 123-bp deletion removing the 3' end of exon 2 and the first 16-bp of intron B and create a premature stop coden TAG.

Proper citation: RRID:RGD_13800556 Copy   

•   Source: Integrated Animals

https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=12910505

Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown
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Synonyms:
Notes: TALEN mediated 607 bp deletion that includes exon 2 of the Mmp12 gene, resulting in a frameshift and premature stop codon

Proper citation: RRID:RGD_12910505 Copy   

•   Source: Integrated Animals

https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=13800557

Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Notes: This is the wild-type litter mates of the Hsd11b2 F344 mutants created by ZFN system targeting exon 2 of Hsd11b2 gene was injected into the F344/IcoCrl embryos to induce a 123-bp deletion removing the 3' end of exon 2 and the first 16-bp of intron B and create a premature stop coden TAG.

Proper citation: RRID:RGD_13800557 Copy   

•   Source: Integrated Animals

https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=13451132

Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown
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Notes: This Brown Norway from Janvier rat strain spontaneously develops progressive focal retinal layer disorganization, loss of photoreceptors, cystic cavitation, and RMG abnormalities associated with early retinal vascular telangiectasia and late stage subretinal neovascularization. This phenotype bears reminiscent of human Macular telangiectasia 2. A deletion insertion mutation in exon 6 of the rat crb1 was identified to be responsible for this retinal phenotype.

Proper citation: RRID:RGD_13451132 Copy   

•   Source: Integrated Animals

https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=13792705

Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown
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Notes: These ZFN mutant rats were produced by injecting zinc finger nuclease targeting exon 13 of rat Trpv1 into Sprague Dawley embryos. A 2-bp (CA) frameshift deletion in exon 13 was created ( SD-Trpv1em1Sage-/-). This wild type mutant is the wild type offspring from the cross of heterozygous mutants.

Proper citation: RRID:RGD_13792705 Copy   

•   Source: Integrated Animals

https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=13703119

Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown
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Notes: This strain was produced by injecting TALEN targeting exon 2 of rat Lamp2 into SD embryos. The resulting mutation is a 2-bp deletion and results in knockout of Lamp2 protein in Lamp2 y/- male.

Proper citation: RRID:RGD_13703119 Copy   

•   Source: Integrated Animals

https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=13793372

Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown
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Notes: CRISPR/Cas9 system was used to introduce a mutation in the Tlr4 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 1-bp deletion in exon 2. Contact MCW rat distribution at mcwcustomrats@mcw.edu

Proper citation: RRID:RGD_13793372 Copy   

•   Source: Integrated Animals

https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=13800871

Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown
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Notes: CRISPR/Cas9 system was used to introduce a mutation in the P2ry2 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 115-bp deletion in exon 3 in the P2ry2 gene. Contact MCW rat distribution at mcwcustomrats@mcw.edu

Proper citation: RRID:RGD_13800871 Copy   

•   Source: Integrated Animals

https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=13800875

Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown
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Notes: CRISPR/Cas9 and plasmid donor containing floxed human prolactin cDNA were used to insert the human cDNA into the start coden of rat prolactin gene Contact MCW rat distribution at mcwcustomrats@mcw.edu

Proper citation: RRID:RGD_13800875 Copy   

•   Source: Integrated Animals

https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=13800869

Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Notes: CRISPR/Cas9 system was used to introduce a mutation in the P2ry2 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 132-bp deletion in exon 3 in the P2ry2 gene. Contact MCW rat distribution at mcwcustomrats@mcw.edu

Proper citation: RRID:RGD_13800869 Copy   

•   Source: Integrated Animals

https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=13792795

Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown
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Notes: A pair of TALENs targeting exon 1 of the Fh gene was injected into SD embryos to create Fh knock out mutants. The resulting mutation was an 11-bp deletion (acacctttggt) on exon 1 that caused premature stop of FH protein. Breeding of Fh +/- rats was done to generate wildtype (Fh+/+)and Fh (+/-). No homozygous mutant were observed.

Proper citation: RRID:RGD_13792795 Copy   

•   Source: Integrated Animals

https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=13792794

Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
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Notes: A pair of TALENs targeting exon 1 of the Fh gene was injected into SD embryos to create Fh knock out mutants. The resulting mutation was an 11-bp deletion (acacctttggt) on exon 1 that caused premature stop of FH protein. No homozygous -/- mutant was revealed in litters.

Proper citation: RRID:RGD_13792794 Copy   

•   Source: Integrated Animals

https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=14390069

Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown
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Notes: The Slc6a4 knockout rat was generated by target-selected ENU-induced mutagenesis. An ENU-induced premature stop codon in exon 3 of the Slc6a4 gene in a female rat (Wistar from Crl) was identified.The heterozygoous mutant rats were used to generate homozygous Slc6a4 knock out rats.

Proper citation: RRID:RGD_14390069 Copy   

•   Source: Integrated Animals

https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=127345097

Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown
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Notes: The Muc1 knock out Sprague Dawley rats were produced by targeted gene mutation at rat Muc1 gene. The deletion was made by microinjection of TALENs and located in the exon 1 of rat Muc1 gene (Gen Bank: NM_012602.1). Genotyping was performed by PCR of tail DNA using primers specific for the rat MUC1 gene with forward primer 5′-CTAGCAAGCCTAAAAGGTGAGAGGT-3′ and reverse primer 5′-ACGAAGAGCATTTGCCTACTC-3′, followed by DNA sequencing analysis. Cyagen Biosciences Inc., Guangzhou, China

Proper citation: RRID:RGD_127345097 Copy   

•   Source: Integrated Animals

https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=150519901

Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown
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Notes: CRISPR/Cas9 system containing guide RNAs targeting exon 2 and intron 2 were introduced into the F344/Stm embryos using a super electroporator NEPA 2. This mutant strain F344-Prkar1b^em2Tua carried a 13-bp frameshift deletion in exon2 creating a premature stop codon in the Prkar1b transcripts. Expression levels of Prkar1b transcripts and protein are significantly decreased in the mutants.

Proper citation: RRID:RGD_150519901 Copy   

•   Source: Integrated Animals

https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=150429825

Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown
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Notes: Exon 25 of the rat Scn9a gene was replaced with the human SCN9A exon counterpart (exon 26) using ZFN technology. The mRNAs of the active ZFN pair targets middle region of the exon (CACCATCATGGTTCTTATAtgcctcAACATGGTAA CCATGATG, ZFN binding sites in uppercase). Charles River Laboratories

Proper citation: RRID:RGD_150429825 Copy   

•   Source: Integrated Animals

https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=13792570

Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
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Notes: The original mutants were created by target-selected ENU-induced mutagenesis in a Brown Norway background. The animals were outcrossed for two generations on a Brown Norway background. they were subsequently backcrossed on a Wistar (Crl:WI) background for four generations. Backcrossings were performed to eliminate possible additional mutations induced by ENU-mutagenesis. Heterozygous oprl1+/- rats were crossed to generate the experimental animals. A C to G transversion at position 3657 in the oprl1 gene (ENSRNOG00000016768), resulting into a premature stop codon (TAC>TAG) in the third exon.

Proper citation: RRID:RGD_13792570 Copy   

•   Source: Integrated Animals

https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=13782146

Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown
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Notes: Bace1 (-/-) rats were generated by SAGE Labs using zinc-finger nuclease (ZFN) technology to create a 137-base pair deletion spanning the translation initiation start site in exon 1 of the rat Bace1 gene, corresponding to chr8:48,766,315-48,766,452 (RGSC 5.0/rn5 assembly)

Proper citation: RRID:RGD_13782146 Copy   

•   Source: Integrated Animals