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https://www.ohsu.edu/octri/clinical-and-translational-research-center
Provides nursing, bionutrition, study coordination, and laboratory services and support. Laboratory is designed and equipped to perform both basic and specialized research assays and sample processing in support of translational research studies and trials. Laboratory staff have extensive experience in performance of wide variety of analytical and genetic based assays and procedures.
Proper citation: OHSU Oregon Clinical and Translational Research Center Core Facility (RRID:SCR_009996) Copy
https://www.ohsu.edu/proteomics-shared-resource
Core facility that provides the following services: Protein identification and partial sequencing, Determination of whole protein mass, Targeted SRM analysis of known proteins, Protein quantitation assay, Gel electrophoresis. The OHSU Protemics Shared Resource facility was established to make state-of-the-art mass spectrometry based protein analysis analytical capabilities available to the biomedical research community at OHSU.
Proper citation: OHSU Proteomics Shared Resource Core Facility (RRID:SCR_009991) Copy
http://eagle-i.itmat.upenn.edu/i/00000139-bc23-a113-9dbb-bb2180000000
Core facility that provides the following services: 2D-DIGE equipment access, Trypsin digestion, Metabolite profiling by mass spectrometry, Biomarker quantification by mass spectrometry, Proteomics analysis service. The Proteomics Core Facility in the Penn Genomics Institute is a service and collaborative research resource that balances applied proteomics research with the development of new and improved methods for protein identification, characterization, and quantification. The facility encourages collaborations that apply the tools of proteomics to cutting edge biomedical research. The Proteomics Core Facility is a center not only for services but also for basic and collaborative research and development of two-dimensional gel electrophoretic - and mass spectrometric-based techniques. Prospective users are encouraged to make their inquiries either by e-mail (ian@spirit.gcrc.upenn.edu), or stop by our facility on the eighth floor of BRB II/III.
Proper citation: Penn Proteomics and Systems Biology Core (RRID:SCR_010027) Copy
http://ohsu.eagle-i.net/i/0000012b-00c9-007b-79a3-373680000000
THIS RESOURCE IS NO LONGER IN SERVICE. Documented on December 6,2022. Core facility that provides the following services: G-banded karyotyping, Sister chromatid exchange service, Fluorescent in situ hybridization, Chromosome breakage and radial formation analysis, Ploidy/Aneuploidy Assessment, Mitotic index service. A fee-for-service cytogentics laboratory available to genetics researchers to assist in development and execution of cytogenetics experiments for research purposes. Through rigorous standardization of protocols and customized experiment development, the OHSU Research Cytogenetics Core Laboratory provides high quality metaphase and interphase cytogenetic data to the OHSU research community. Services are also available to non-profit and commercial investigators located in Oregon and elsewhere.
Proper citation: OHSU Research Cytogenetics Core Laboratory (RRID:SCR_009992) Copy
http://www.med.upenn.edu/idom/drc/cores/ria.html
Core which offers high quality immunoassay services to basic, translational, and clinical investigators performing diabetes and related metabolic disease research. The core also provides consultation and training and education services.
Proper citation: Penn Diabetes Research Center Radioimmunoassay and Biomarkers Core Facility (RRID:SCR_010028) Copy
http://eagle-i.itmat.upenn.edu/i/0000013f-52ff-7e24-a468-831a80000000
The MR Sub-Core of the SAIF provides the instrumentation and expertise necessary to perform a broad spectrum of magnetic resonance imaging and spectroscopy studies on a wide range of biological samples including small animals (cats, rabbits, rats, mice), tissue specimens, cultured cells and tissue extracts. This facility includes a conveniently located, well equipped surgery room used for preparing the animals for MR exams and a wide assortment of supporting equipment, i.e. anesthesia machines, MR compatible vital signs monitors (SA Instruments), infusion pumps (Harvard), heating pads, etc. A variety of perishable supplies used in animal preparation are provided by the facility.
Proper citation: Penn Small Animal Imaging Facility: MRI/MRS Sub-Core (RRID:SCR_010032) Copy
http://eagle-i.itmat.upenn.edu/i/0000013f-5317-8a44-a468-831a80000000
Core facility that provides the following services: Optical/bioluminescence in vivo imaging, Small animal bioluminescence/fluorescence imaging support services. The Optical/Bioluminescence Sub-Core of the SAIF provides the capability to perform cellular and molecular non-invasive in-vivo bioluminescence, fluorescence or near-infrared imaging. The instrumentation allows sensitive, non-invasive molecular imaging for a variety of applications including detection and quantification of various bioluminescent or fluorescent reporter-expressing cells or tissues (in culture or in small animals). The facility currently houses a Perkin Elmer IVIS Lumina II, two LI-COR Pearl Impulse Imagers and a Perkin Elmer IVIS Spectrum. The Facility offers assistance with experimental design, regulatory approval, troubleshooting, data management, analysis and display.
Proper citation: Penn Small Animal Imaging Facility: Optical/Bioluminescence Sub-Core (RRID:SCR_010033) Copy
http://ohsu.eagle-i.net/i/0000012b-00ce-7b4f-79a3-373680000000
THIS RESOURCE IS NO LONGER IN SERVICE. Documented on December 6,2022. The Neuropathology Core of the Layton Center for Aging and Alzheimer?s Disease Center is dedicated to studying, through autopsy, the brains of individuals who have been followed longitudinally in the Oregon Alzheimer?s Disease Center Clinical Core. Requests for tissue from the Oregon Brain Bank should be directed to Dr. Randall Woltjer. Dr. Woltjer will be glad to communicate with investigators regarding their tissue needs and to assist them in identifying suitable materials for their studies. Material Transfer Agreements between the requesting and sending institutions are needed before shipment.
Proper citation: OHSU Neuropathology Core (RRID:SCR_009988) Copy
https://www.ohsu.edu/medicinal-chemistry-core/nmr
Core facility that provides the following services: NMR instrument training. A facility that uses a state-of-the-art NMR spectrometer to verify or determine the structure of organic molecules. Housed in the Department of Physiology and Pharmacology, it is designed to exploit the power of designed small molecules as probes of protein and cellular function and to provide the foundation for the development of prototypic therapeutic agents.
Proper citation: OHSU Nuclear Magnetic Resonance Core Facility (RRID:SCR_009989) Copy
http://ohsu.eagle-i.net/i/0000013b-95a6-bd56-c825-3bd680000000
THIS RESOURCE IS NO LONGER IN SERVICE. Documented on December 6,2022. Core facility that provides the following services: Automated DNA sequencing, Realtime PCR analysis and SNP analysis, Automated DNA and RNA preps using robotics, Lentiviral vector preparation for cDNA and shRNA transduction and infection, Semi-automated large-scale genomic DNA preparations., Freezing, thawing, and amplification of cell lines, Preparation of both routine and exotic cell culture medium. The Molecular and Cellular Biology Core provides services, reagents and training for all aspects of molecular biology and cell culture. Services include DNA sequencing, real-time PCR, genotyping, robotic RNA and DNA purification, monkey-specific cDNAs, and customized media and buffers for cell culture. The core also produces lentiviral vectors for cDNA and shRNA delivery. Core personnel assist researchers in maintaining and storing cell lines. The core makes available state-of-the-art equipment, including a 969capillary DNA sequencer, realtime qRT-PCR platforms, and fluorometers for cell-based kinetic analyses..
Proper citation: OHSU Molecular and Cellular Biology Core Laboratory (RRID:SCR_009986) Copy
http://ohsu.eagle-i.net/i/0000012a-24fd-6e5c-d994-629180000000
THIS RESOURCE IS NO LONGER IN SERVICE. Documented on December 6,2022. Core facility that provides the following services: Monoclonal antibody generation, Scaleup production and purification of antibody from existing cell lines. The VGTI Monoclonal Core offers two basic services: the generation of new monoclonal antibodies and the scaleup production and purification of antibody from existing cell lines (a stand -alone phase IV).
Proper citation: OHSU Monoclonal Antibody Core Laboratory (RRID:SCR_009987) Copy
http://www.med.upenn.edu/gtp/vectorcore/
THIS RESOURCE IS NO LONGER IN SERVICE. Documented on October 30,2023. Core whose main aim is to provide vector technology for preclinical studies and other basic research applications. Its services include rovision of AAV, adenoviral and lentiviral based vectors, consultation and advice in the design of custom vectors and in vector serotype/pseudotype selection, and design, cloning and production of plasmid DNA for the production of custom vectors.
Proper citation: University of Pennsylvania Center for Molecular Therapy for Cystic Fibrosis Vector Core Facility (RRID:SCR_010038) Copy
http://ohsu.eagle-i.net/i/0000012a-24ff-c95f-d994-629180000000
THIS RESOURCE IS NO LONGER IN SERVICE. Documented on December 6,2022. Core facility that provides the following services: Flow cytometry training service, Cell sorting service, Specialized flow cytometric assays. The mission of the Immunology Support Core (ISC) is to develop and provide a wide range of state-of-the-art services, assays, and training in support of NIH-sponsored immunology research involving nonhuman primates (NHP).
Proper citation: OHSU Immunology Support Core Flow Cytometry Unit (RRID:SCR_009981) Copy
http://eagle-i.itmat.upenn.edu/i/00000142-345f-30d3-91c7-0c6080000000
The CTRC Sleep Core provides services in support of clinical sleep research. It is based at two sites: the CHOP Sleep Laboratory, convenient to the CTRC Outpatient Facility on the 7th Floor of Main Hospital and the University of Pennsylvania?s Sleep Laboratory, located on the 11th Floor of the Gates Building which is part of the medical complex of the Hospital of the University of Pennsylvania. The Sleep Core contains a total of six designated research beds, dedicated staff, and state-of-the-art equipment that provides support for a variety of sleep-related research initiatives. Studies performed in the Sleep Core include overnight polysomnography, multiple sleep latency testing, neurobehavioral testing and actigraphy. The Sleep Core��s goals include providing highest-quality sleep studies, extending sleep research to disciplines not traditionally involved in this area, further developing extant multidisciplinary programs, and offering training opportunities for medical students, residents, fellows, and junior faculty in clinical sleep research. The Sleep Core is associated with CHOP?s and UPHS? American Academy of Sleep Medicine-accredited Sleep Center Laboratories. Services for pediatric and adult subjects: * Study Design * Overnight Polysomnography ** Polysomnography Interpretation * Multiple Sleep Latency Testing * Actigraphy * Neurobehavioral testing * Sleep Core Library
Proper citation: Penn/CHOP CTRC Sleep Core (RRID:SCR_010041) Copy
http://upr.eagle-i.net/i/0000012b-00c0-7187-9e37-5ded80000000
Patient Coordinator Services is responsible for scheduling the subjects for the research-related appointments; her goal is to facilitate the participation of the subjects in the clinical studies in collaboration with the research staff and the investigators.
Proper citation: Puerto Rico Clinical and Translational Research Consortium Patients Coordinator Services (RRID:SCR_010045) Copy
http://eagle-i.itmat.upenn.edu/i/00000138-7c65-0571-fbab-3b8480000000
Core facility that provides the following services: Microscope access service, Imaging experimental design consultation service, Confocal microscopy service, Microscopy training service, Scanning electron microscopy sample preparation service, Sputter coating access service, Scanning electron microscope access service. The Cell & Developmental Biology (CDB) Microscopy Core is a full-service facility serving the entire University of Pennsylvania community. Our aim is to provide personalized assistance on all aspects of imaging, from tips on sample preparation to training on one of our microscopes to processing and analysis of image data. Our facility currently houses five confocal and three widefield light microscopes, a scanning electron microscope, and several computers dedicated to image processing and analysis.
Proper citation: Penn Cell and Developmental Biology Microscopy Core (RRID:SCR_010004) Copy
http://eagle-i.itmat.upenn.edu/i/00000138-9a9a-cba0-9cd7-d7e280000000
Core facility that provides the following services: NMR spectrometer access, NMR spectrometer training, NMR spectroscopy service, Consultation service for NMR experimental design. Penn Chemistry NMR Facility provides researchers in the Chemistry and Materials Science and Engineering department access to state-of-the-art instrumentation for high resolution NMR spectroscopy. The Facility provides users extensive training to use spectrometers without supervision and expert advice/consultation on advanced applications of NMR spectroscopy to solve research problems. At present, the Facility operates ten high resolution NMR spectrometers (300-600 MHz) of varying capabilities located in the Chemistry building at the corner of 34th and Spruce street, Philadelphia, PA. Penn Chemistry NMR Facility provides limited solution NMR services (data acquisition and spectrum/structure analysis) to other departments/centers of University of Pennsylvania based on hourly charges. However, these services will be limited to the availability of instrument time and personnel. NMR Facility accepts service samples from outside academic and industrial customers based on per hour charges.
Proper citation: Penn Chemistry NMR Facility (RRID:SCR_010005) Copy
http://eagle-i.itmat.upenn.edu/i/00000138-7ce8-c10b-fbab-3b8480000000
THIS RESOURCE IS NO LONGER IN SERVICE. Documented on June 1,2023. Core facility that provides the following services: Flow cytometry analysis service, Cell sorting and analysis service, Flow cytometer analyzer access, Introductory flow cytometry training, Advanced and customized flow cytometry training, Flow cytometry consultation service, FACSAria training, Flow cytometry data analysis, BSL2+ biohazardous human cell sorting, BSL2+ murine biohazardous cell sorting, BSL2+ murine cell sorting access, Non-infectious cell sorting access. The Flow Cytometry and Cell Sorting Resource Laboratory is currently recognized as one of the largest and most comprehensive flow cytometry laboratories in the US. In 2010 it was designated a laboratory of exceptional merit by the National Cancer Institute. Using state-of-the-art technology, the resource provides a broad array of, instrumentation, support, education and consultation to the research community at the University of Pennsylvania. A wide variety of cell sorting applications are supported, from high-speed multicolor (up to 14 colors) cell sorting to low-speed, large nozzle, improved viability sorting. Additionally, a wide variety of cell analysis services (up to 20 parameters) are offered, from traditional analog, easier to use tabletop analyzers to many-laser, many-color, high-speed, fully-digital modern instrumentation. Currently the facility offers 6 cell sorters and 19 analytical instruments. A very active training and consultation program is in place to support these activities. The Scientific Director, Dr. Jonni Moore, and the Technical Director, each have over 25 years experience in the field of cytomics. Researchers at the University of Pennsylvania are increasingly engaged in research projects that require 8-plus-parameter cell sorting of infectious cells and primary human tissues. Investigators using the Flow Cytometry and Cell Sorting Shared Resource have access to virtually any type of cytometric services required for a vast array of applications.
Proper citation: Penn Flow Cytometry and Cell Sorting Resource Laboratory (RRID:SCR_010011) Copy
http://eagle-i.itmat.upenn.edu/i/00000138-9b39-142c-9cd7-d7e280000000
Core facility that provides the following services: Investigational drug services, Clinical trial support services. The IDS is charged with safe and responsible handling of investigational drugs. The purpose of the IDS is to maintain control and accountability of investigational drug use in the Medical Center to promote maximum benefit and safety for patients enrolled in studies. Investigational drugs are procured, stored, inventoried, dispensed and used through the IDS in compliance with regulations or guidelines of the FDA, JCAHO, ASHP, Code of Federal Regulations, Pennsylvania State Board of Pharmacy, other applicable organizations and in accordance with Hospital, Medical Center and University policies and guidelines.
Proper citation: Penn Investigational Drug Service (RRID:SCR_010012) Copy
http://eagle-i.itmat.upenn.edu/i/00000138-ba32-e90b-9cd7-d7e280000000
Core facility that provides the following services: Illumina sequencing service, 5500xl sequencing service. The recent boon in high-throughput sequencing technologies has offered enormous potential to applications in genome sequencing, transcriptome profiling, epigenetics, metagenomics, discovery of non-coding RNAs and protein binding sites. A primary mission of PGFI is to lead the development of new genomics technologies at the University of Pennsylvania. In response to the ever growing demand for high-throughput sequencing at Penn, PGFI?s HTS facility was established. In this facility, investigators have access to different types of HTS technology: Illumina?s HiSeq and Applied Biosystem?s SOLiD4 and 5500xl. With two HiSeqs, the facility can provide the latest innovation from Illumina featuring up to 3 billion paired-end reads (up to 100x100 bp reads) per flow cell, 8 lanes per flow cell and 2 flow cells per machine. With the SOLiD4, the facility can provide up to 1.4 billion reads per slide, 50 x 25 bp paired-end reads, up to 8 sectors per slide and 2 flow cells per machine. With the 5500xl, the facility can provide up to 180 Gb or more than 2.8 B reads per run. The 5500xl offers 75 bp fragment runs, 75x35 bp paired-end runs and up to 60 bp x 60 bp mate paired runs with the added bonus of pay-as-you-go sequencing. All platforms offer multiplexing capability. Currently Illumina offers 48 barcodes and Life Technologies offers 96 barcodes. The SOLiD 4 system provides greater than 99.94% accuracy due to 2-base encoding. The 5500xl offers up to 99.99% accuracy utilizing 2-base encoding and Exact Call Chemistry.
Proper citation: Penn High-Throughput Sequencing Facility (RRID:SCR_010015) Copy
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