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http://harvard.eagle-i.net/i/0000012c-e198-9f3f-2162-17a280000000

High quality statistical support is important in the preparation of grant applications or study protocols for clinical trials. Such support typically is not readily available to investigators who are new to clinical trials. To address this weakness, the NeuroDiscovery Center provides consulting and collaborative services to its members who are engaged in clinical research applicable to neurodegenerative disease.

Proper citation: Harvard NeuroDiscovery Center - Biostatistics Consultation (RRID:SCR_009850) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012b-00c4-8067-db6e-7a3f80000000

Core facility that provides the following services: Transgene microinjection service, Embryonic stem cell gene targeting service, Blastocyst injection service, Cryopreservation of embryos and sperm, Genotyping service, Mouse consulting service. The Genome Modification Facility (GMF) provides transgenic, gene targeting, and other services to investigators of Harvard University and its affiliated institutions, as well as to investigators within the US and abroad. The GMF performs microinjections of DNA into fertilized embryos to generate transgenic mice, DNA transfection into ES cells for the creation of recombinant ES cell clones, injection of gene-targeted ES cells into host blastocysts to generate gene knock-out or knock-in mice, teratoma formation studies, and other related ES cell-based services. Other services include cryopreservation of mouse sperm and embryos, in vitro fertilization (IVF), recovery of cryopreserved mouse sperm and embryos, rederivation of pathogen free mouse lines, and derivation ES cell lines from wild type and mutant mice with a variety of genetic backgrounds. Our staff provides general consultations on experimental designs and vectors for gene modification-related projects, DNA preparation, recombinant ES clones, mouse genotyping, colony breeding and husbandry. We can also customize services as requested to support development of animal models of human diseases.

Proper citation: Harvard Genome Modification Facility Harvard University (RRID:SCR_009849) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-021d-e404-b2b9-4d8780000000

Core facility that provides the following services: ABI Prism Taqman Allelic Discrimination Assay, OpenArray SNP genotyping, Illumina genotyping, Custom Illumina GoldenGate genotyping, Illumina Infinium genotyping analysis, Illumina methylation analysis. The Partners Genotyping Facility, part of the Partners HealthCare Center for Personalized Genetic Medicine (PCPGM), provides flexible, high quality, high-throughput SNP genotyping to the Harvard-Partners research community, including Harvard Medical School, hospitals in the Partners HealthCare network, investigators in the Dana-Farber-/ Harvard Cancer Center, and the Harvard School of Public Health. The portfolio of Genotyping methods at PCPGM now includes Illumina, TaqMan and TaqMan OpenArrays. Note: DF/HCC members will receive the DF/HCC discount on both genotyping and sequencing services from our facility

Proper citation: Harvard PCPGM Genotyping Facility (RRID:SCR_009846) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012b-00bf-9941-db6e-7a3f80000000

Core facility that provides the following services: Macromolecular X-ray diffraction service, Charge density analysis, Single-Crystal service, Crystal mounting service, Cambridge structural database access, Inorganic crystal structure database access. The X-ray diffraction facility in Harvard University offers single crystal X-ray data collection, structure solution and refinement of small molecule structures.

Proper citation: Harvard FAS Center for Crystallographic Studies (RRID:SCR_009843) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012f-e9e7-e67c-de5a-673e80000000

Core facility that provides the following services: Access to fabrication lab. Technological advances hold a key to greater understanding of the structure and function of complex neural circuits. Neuroengineering is a core facility that provides customized engineering solutions to neuroscience problems faced by our members. Assistance with experimental design, electronics, machining, and software development, are all services provided.

Proper citation: Harvard FAS Center for Brain Science - Neuroengineering Core Facility (RRID:SCR_009841) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012f-0d5e-aceb-cb22-be8c80000000

Implements and maintains specialized computer facilities required by the DERC investigators. A major emphasis of JoslinResearch.org is to provide dynamic web applications that serve essential informational needs of the research community at the Joslin Diabetes Center. These applications provide such functions as automating media provisioning services to DERC laboratories, distributing DERC event schedule information, providing access to troubleshooting information, fully-searchable call schedules with contact information, text messaging services, and access to information about Section, Investigator and Fellow projects and affiliations. All applications adhere to the JoslinResearch.org paradigm of distributed administration without requiring knowledge of web design or web programming. For DERC use only.

Proper citation: JDC Computer Resource (RRID:SCR_009877) Copy   

•   Source: SciCrunch Registry

http://hunter-cuny.eagle-i.net/i/00000136-7e06-6aac-949b-425080000000

The Flow-Cytometry (FACS) facility is located on the ninth floor of the Hunter North building. This facility provides analyses of up to 7 parameters in eukaryotic cell populations and sorts cells under sterile conditions. These analyses can be used to identify and isolate rare cell populations, determine chromosome ploidy in individual cells, study apoptosis, and study cell-signaling among other applications.

Proper citation: Hunter Flow Cytometry Facility (RRID:SCR_009870) Copy   

•   Source: SciCrunch Registry

http://hunter-cuny.eagle-i.net/i/00000136-8336-80a6-949b-425080000000

Core facility that provides the following services: Bio-imaging instrumentation training, Bio-Imaging data analysis service. The Bio-Imaging facility currently provides optical and video microscopy services.The facility is equiped with two confocal microscopes, a Leica TCS SP2, and a Perkin Elmer UltraVIEW ERS Spinning Disc confocal . In addtion to confocal microscopy the facility is also equipped for bright field, phase contrast, modulation contrast and epi fluorescence microscopy. The facility has two separate wide field image analysis stations. A Nikon Optiphot microscope equipped with a color video system and Compix imaging software, and a Nikon Eclipse TE200 inverted scope. This inverted scope in specially configured to perform calcium ratio imaging is equipped with Molecular Devices Meta Fluor software The facility has recently expanded with the aquisition of a JEOL JEM-100C/CX Transmission Electron Microscope. The facility also is equiped with Typhoon 9410 scanner for the quantitation and localization of sub cellular fluorescent and radioactive molecules. In addition a Densitometer allows for the analysis of 1 and 2 D gels, Southern, northern and western blots and RFPL gels. The facility is also equipped with color and B&W laser printers for the production of publication quality graphics and presentation materials.

Proper citation: Hunter Bio-Imaging Facility (RRID:SCR_009869) Copy   

•   Source: SciCrunch Registry

http://howard.eagle-i.net/i/00000134-a517-1426-bf4c-ca4080000000

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on October 27,2023. Core for bioinformatics consultation and software access. Laboratory of Molecular Computations and Bioinformatics (LMCB) is a resource facility dedicated to the support of computational biomedical research at Howard University. Provides molecular modeling, molecular dynamics, bioinformatics, and computational quantum chemistry capabilities and support to a variety of research projects at Howard University.

Proper citation: Howard University Center for Computational Biology and Bioinformatics Core Facility (RRID:SCR_009864) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/00000139-4a28-1319-4d8e-943b80000000

The Partners Research Computing Core was created by Enterprise Research Infrastructure & Services (ERIS) to offer dedicated services, consultation, and support within the teaching hospitals. Please check the service catalog as new services are added, or contact us if you need a consultation. Initial discussion is at no charge.

Proper citation: Harvard Partners Research Computing Core (RRID:SCR_009861) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000013e-8557-6524-8a53-38db80000000

There is a growing need for animal models to carry out in vivo developmental and regenerative medicine studies of human cells, tissues and organs. The Humanized Neonatal Mouse Center (HNMC) was created to accelerate research in the stem cell field by providing humanized mouse models to study human stem cell engraftment and differentiation in regenerative medicine. We have over 4 years of experience in constructing different types of humanized mouse models, including neonatal heart, lung and kidney injury models. We have extensive experience in hematopoietic stem cell reconstruction. It is our goal at HNMC to facilitate collaborative research in human stem cell biology, where physiologically relevant microenvironments (niches) may be created in vivo to study human stem cell fate and function under experimental settings where disease, damage or degenerative conditions can be controlled. We can provide customized humanized mouse models to the HSCI research community, to collaborate on research studies of common interest, and to advance the general use of these models for a broad range of translational and preclinical studies.

Proper citation: HSCI Humanized Neonatal Mouse Center (RRID:SCR_009815) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/00000141-ec2a-514f-89f9-43eb80000000

Core facility that provides the following services: Project Consultation, CADD Design, and Fabrication. We have many years of experience designing and manufacturing custom tools for medical research. This has allowed us to compile a large collection of different solutions to a wide range of problems. We work on a daily basis with researchers working in these areas of medical science: * Cell Biology * Genetics * Anesthesiology Research * Surgical Research * Pathology Research * Respiratory Biology * Environmental Sciences

Proper citation: HMS Systems Biology Quad Machine Shop (RRID:SCR_009812) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012b-00c3-414f-db6e-7a3f80000000

Core facility that provides the following services: Protein identification from SDS-PAGE gel bands/spots (Coomassie stained level of protein), Protein phosphorylation service, TCA samples service. The Taplin Biological Mass Spectrometry Facility opened in February 2001 as a core facility for the analysis of proteins and peptides by mass spectrometry. The facility is focused on serving the needs of investigators at Harvard Medical School (HMS) and all the Harvard affiliated Institutions.

Proper citation: HMS Taplin Mass Spectrometry Core Facility (RRID:SCR_009813) Copy   

•   Source: SciCrunch Registry

https://nic.med.harvard.edu/

Core facility that provides the following services: User-based microscopy service, Live Specimen Imaging, Widefield Fluorescence, Spinning Disk Confocal Microscopy, Laser Scanning Confocal, Color Imaging, Image Analysis, Microinjection, Phase Contrast and Differential Interference Contrast (DIC), Photo-bleaching, Photo-activation, & Laser Ablation, Microfluidic Perfusion, Imaging and microscopy training. The mission of the NIC@HMS is to: enhance basic research by providing access to state-of-the-art microscopy and imaging equipment, provide training courses on basic and advanced light microscopy techniques for the benefit of HMS and the greater Boston research community, introduce the latest innovations in light microscopy and imaging to the HMS community, serve as a learning center for our corporate partners and contributions, and provide a dedicated NIC@HMS director for ongoing technical consultation and support.

Proper citation: HMS Nikon Imaging Center (RRID:SCR_009810) Copy   

•   Source: SciCrunch Registry

http://dartmouth.eagle-i.net/i/0000013f-cf91-dd1f-0b49-0d2b80000000

The Ethics Consultation Core (ECC) leverages current ethics activities across Dartmouth, and thus provides the capacity for real-time collaborative ethics advice for investigators throughout the translational research community.

Proper citation: Dartmouth SYNERGY: Ethics Consultation Core (RRID:SCR_009775) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/00000130-08de-721d-de5a-673e80000000

Core facility that provides the following services: Confocal microscopy.

Confocal microscopy offers multiple benefits compared to conventional microscopy, particularly the ability to collect serial, high-resolution optical sections from thick specimens. Multicolor, three-dimensional images can be obtained, providing high-content information from single images. To assist NERCE investigators from throughout the region, NERCE has established a Confocal Microscope Facility at the University of Massachusetts Medical School. Funding through the NERCE has procured a state-of-the-art LEICA SP2 AOBS laser scanning confocal microscope, which combines spectrophotometric detection with confocal microscopy. The instrument is located at the BL2+ facility at the Lazare Research Building, at the University of Massachusetts Medical School, Worcester, MA. The use of live cell imaging combined with green fluorescent protein (GFP) technology is an exciting methodology with which to study the interactions between infectious agents and living cells. A variety of applications are amenable to confocal microscopy techniques and include: monitoring the localization of proteins in living or fixed cells, monitoring changes in the cellular distribution of proteins, and monitoring changes in the activation status and morphological changes in cells exposed to infectious agents.

Proper citation: HMS NERCE Confocal Microscope Resource (RRID:SCR_009805) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012c-c7b2-aa59-a061-4a6580000000

Core facility that provides the following services: Imaging system training, Live cell imaging.

Live-cell imaging is a powerful method that enables investigators to observe cellular trafficking events with a high degree of spatial and temporal resolution, including visualization of individual bacteria or viral particles engaged in the process of infecting eukaryotic cells. A quantitative description of bacterial and viral invasion mechanisms can be obtained through such approaches. NERCE has provided funding to support the use of live-cell imaging for any New England investigator studying NIAID priority pathogens and agents of emerging infectious disease. Investigators interested in working with the Live-Cell Imaging core laboratory should complete the Imaging Core Request Form and send it to Gerald Beltz. There are no fees for use of the live-cell imaging core for research related to NIAID priority pathogens and agents of emerging infectious disease. Please note that since the NERCE program will end in February 2014, our ability to support new requests for services is limited.

Proper citation: HMS NERCE Live-cell Imaging Core (RRID:SCR_009806) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-01e7-f2ed-b2b9-4d8780000000

The molecular electron microscopy facility at Harvard Medical School is predominantly used for our own research and can therefore not be considered a service facility. We are, however, committed to make our technology available to as many research groups in the community as possible. If you are interested to use molecular electron microscopy, please contact us by phone or email.

Proper citation: HMS Molecular Electron Microscopy Facility (RRID:SCR_009802) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/00000142-0084-cc9f-89f9-43eb80000000

Core facility that provides the following services: Instrument operation and data analysis.

Instrumentation for this facility includes an Agilent 6520 Accurate-Mass quadrupole time-of-flight (Q-TOF) LC/MS system with great mass accuracy, mass resolution, and sensitivity for small molecule mass identification/quantitation and metabolomics experiments. It is equipped with an Agilent 1200 series HPLC with DAD UV/V is detection for normal flow LC/MS and nitrogen CID for MS/MS. The Q-TOF LC/MS is located in laboratory of Dr. Suzanne Walker in the Department of Microbiology and Immunobiology.

Proper citation: HMS Microbiology and Immunobiology Biological Chemistry Mass Spec Facility (RRID:SCR_009800) Copy   

•   Source: SciCrunch Registry

http://jsu.eagle-i.net/i/0000012a-2505-e99e-b307-36d480000000

Core facility that provides the following services: Spectrofluorometry service, FTIR service, Atomic absorption spectrometry service, Raman spectrometry service, Gas chromatography service, GC/MS service, HPLC service, LC/MS/MS service, Capillary electrophoresis/mass spectrometry service, FPLC service. The Analytical Core Laboratory objectives are to: 1) provide spectroscopic and chromatographic equipment to investigators of pilot projects in the RCMI Program as well as investigators in other programs in the College of Science, Engineering and Technology for their research needs, 2) to acquire new analytical instruments as well as computers and printers to satisfy the needs of the user community, 3) to respond to the needs for obtaining analytical information in a timely manner, 4) To offer workshops for using major equipment including LC/MS/MS, CE/MS/MS, LC-ICP/MS, Raman microscope system, and FT-IR as well as other conventional instruments at least once each semester for each instrument.

Proper citation: JSU Analytical Core Laboratory (RRID:SCR_009885) Copy   

•   Source: SciCrunch Registry