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http://harvard.eagle-i.net/i/0000012c-9d60-89cb-b977-103480000000

Core facility that provides the following services: Scientific computing for data analysis and scientific graphics, Advice and consultation regarding grant applications and management of clinical trials data, Training in study design, data collection, computerization, and statistical methods.

The Biostatistics Core facility is a shared resource supporting consultation on biostatistics and epidemiology throughout the Dana-Farber/Harvard Cancer Center (DF/HCC). The mission of the core is to ensure that experimental designs, study monitoring and data analyses take advantage of robust, efficient methods that reflect ''best practices'' in biostatistics and epidemiology; to support NIH-funded peer reviewed grants that do not contain salary support for statisticians; and to enable pilot and small scale studies to become part of successful applications for peer-reviewed funding. These services are available to Dana-Farber / Harvard Cancer Center members only. The Biostatistics Core is located across several of the member institutions of the DF/HCC. To contact the Core, please email or call the statistician associated with your disease site.

Proper citation: DF/HCC Biostatistics Core Facility (RRID:SCR_009730) Copy   

•   Source: SciCrunch Registry

http://cau.eagle-i.net/i/00000135-ab9d-72b3-ecf8-187780000000

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on October 27,2023. Core provides next generation sequencing service. Collaborative effort between the CCRTD and the Ovarian Cancer Institute at Georgia Tech University (OCIGT). CCRTD provides laboratory to prepare libraries and to operate the instrument, while OCIGT contributes bioinformatics support for processing the data and additional services to complement genomics data including hardware, software, and personnel. OCIGT contributes patients sample procurement and complementary technologies including Affymetrix microarray technology and mass spectroscopy analysis.

Proper citation: Clark Atlanta University Collaborative Center for Cancer Genomics and Bioinformatics Core Facility (RRID:SCR_009695) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-6e00-af62-55da-381e80000000

Core facility that provides the following services: DNA analysis - Affymetrix GeneChip arrays service, DNA analysis - Illumina infinium whole genome genotyping service, DNA analysis - custom content genotyping service, RNA Analysis - Affymetrix gene expression service, RNA Analysis - Illumina Gene Expression service, RNA Analysis - Illumina whole-genome DASL service. The Genetic Analysis Platform collaborates with scientists at the Broad and across the world to identify and characterize patterns of genetic variation and gene expression. These patterns can yield a deeper understanding of how genetic factors influence disease risk and treatment outcomes in a wide range of human diseases, including type 2 diabetes, Crohn''s disease, schizophrenia, and cancer, among many others. Over the past several years, the platform has been a leading contributor to major projects such as the International Haplotype Map Project, The Cancer Genome Atlas, the 1,000 Genomes Project, the Genes and Environment Initiative, and served as a national genotyping center under a NIH/NCRR program. Genetic Analysis Platform (GAP) scientists are experts in a wide range of genomic technologies and technology platforms, including genotyping, gene expression and directed resequencing, and routinely apply these technologies to studies of both human and non-human samples. In addition, teams of platform researchers work to test out emerging genetic technologies, develop informatics tools and infrastructure to enhance scientific research, and coordinate large-scale projects involving collaborators both within and beyond the Broad.

Proper citation: Broad Genetic Analysis Platform (RRID:SCR_009690) Copy   

•   Source: SciCrunch Registry

http://cau.eagle-i.net/i/00000135-abea-80e6-ecf8-187780000000

In CCRTD, we provide excellent support for Cell Biology research and advanced cell visualization applications. We have complete facilities for cell growth, handling, and storage. Cell Culture Facility maintains Cell Storage Cryo Tanks with uninterruptable liquid nitrogen supply and two separate Cell Culture rooms fully equipped with eight temperature and CO2-controlled Cell Growth Incubators, two Biological Safety Cabinets, Fluorescence-Activated Cell Sorter (FACS), two late model Inverted Digitized Microscope (Zeiss), one of which is fluorescence-enabled and possesses Z-stacking and live cell imaging capabilities, automated Cell Counter (Nexcelom Bioscience), and refrigerated storage for media and cell culture reagents.

Proper citation: CAU CCRTD-Cell Biology (RRID:SCR_009691) Copy   

•   Source: SciCrunch Registry

http://eagle-i.itmat.upenn.edu/i/00000139-4506-110d-eb5b-b63c80000000

Core facility that provides the following services: Stem cell differentiation, Stem cell line propagation. The human embryonic stem cell/induced pluripotent Stem Cell (hESC/iPSC) Core generates control and patient-specific iPSC lines by cellular reprogramming using current technologies. The core has a training course in cell maintenance and growth, specialized differentiation protocols for disease modeling and drug screening, and quality-control reagents for the Children?s Hospital and University of Pennsylvania academic communities. The facility maintains five NIH-approved human ESC lines and has generated more than 60 disease-specific iPSC lines.

Proper citation: CHOP Human Embryonic stem cell/induced pluripotent stem cell Core (RRID:SCR_009727) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012c-60a7-d769-c437-ff0b80000000

The BWH-BRI Antibody Core Facility provides high quality, purified monoclonal antibodies to the BWH research community. Because the antibodies are made in-house and require no shipping, they are available at a cost substantially lower than that of commercial vendors. Antibodies are of standardized quality and are available in two convenient aliquots: 500ugs and 10mgs. The Core maintains an inventory of commonly used antibodies, which allows orders to be filled quickly.

Proper citation: BWH-BRI Antibody Core Facility (RRID:SCR_009689) Copy   

•   Source: SciCrunch Registry

http://eagle-i.itmat.upenn.edu/i/00000138-7cbe-8ce9-fbab-3b8480000000

Core facility that provides the following services: Vascular laboratory services, Vascular laboratory service, Carotid intima medial thickness measurment (IMT), Vascular laboratory service, Brachial Artery Reactivity (BART), Echocardiographic laboratory services, Exercise physiology laboratory services, Vascular laboratory service, Continuous arterial spin-labeling perfusion magnetic resonance imaging. The Cardiovascular Core provides cardiac testing services for children. The Core provides the technical services and expertise to conduct the highest quality research, provides research tests in a cost-effective manner, and provides unparalleled training opportunities in clinical research for investigators, fellows, students and technicians.

Proper citation: CHOP CTRC Cardiovascular Imaging Core (RRID:SCR_009722) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012a-2511-e97c-5617-794280000000

Core facility that provides the following services: ES cell transfection (electroporation), Thawing/expansion of targeted ES cells, Microinjection of ES cells into blastocysts, Microinjection of DNA constructs into egg pronuclei for generating transgenic mice, Microinjection of BAC DNAs, DNA injection and microdissection, Lentiviral transgenics service, Injection of induced pluripotent stem cells for testing totipotency, Tail biopsy service, Breeding services, Mouse manipulation consultation. The Brigham & Women''s Hospital Transgenic Core Facility provides services for generating transgenic and knockout mice. Established in 1992, the BWH Core Facility has been providing gene targeting and microinjection services using state-of-the-art facilities and equipment. Dr. Lina Du, formerly a plastic surgeon in Beijing and an expert in microvascular surgery, performs both blastocyst and pronuclear injections. She has over 15 years of experience in embryo manipulation and the generation transgenic mice. The Core Facility has all of the equipment necessary for generation of transgenic mice including a Nikon Diaphot microscope equipped with Nomarski Optics and Narishige micromanipulators for microinjections, Nikon surgical microscopes for egg isolation ad transfer, a sutter needle puller and a de Fonbrune microforge. The facility maintains mice necessary for egg donors, egg recipients, and vasectomized males. This is a non-profit facility and charges are based upon anticipated mouse costs, maintenance of mice and equipment, and purchase of necessary surgical supplies and chemicals. The ES cell culture service has been offered for 6 years. Our staff carries out electroporation of targeting vectors into ES cells and provides investigators with DNA to identify ES cells carrying the desired recombination events. Then they expand the appropriate ES Cells for microinjection into blastocysts by the BWH Transgenic Core.

Proper citation: BWH Transgenic Core Facility (RRID:SCR_009688) Copy   

•   Source: SciCrunch Registry

http://eagle-i.itmat.upenn.edu/i/00000139-4fa9-b5b5-eb5b-b63c80000000

Core facility that provides the following services: Development of assessment methods for pediatric psychological, neuropsychological, and psychiatric research, Intervention development and implementation. The Behavioral Neurosciences Core provides consultation and assistance to investigators regarding psychological, neuropsychological, and psychiatric components of research studies involving pediatric subjects. Together, the services provided by the Behavioral Neurosciences Core offer research infrastructure support across the entire process of research, from pre-design consultation to development and analysis of behavioral data, and across multiple domains of functioning and outcomes.

Proper citation: CHOP CTRC Behavioral Neurosciences Core (RRID:SCR_009721) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012a-438e-1d98-3e3e-48fb80000000

Core facility that provides the following services: Sorting or analysis with operator service, Calcium flux measurements service, DNA analysis service, Cell sorting service.

This lab''s mission is to provide high standard cell sorting and analysis services to the research community at the Brigham and Women?s Hospital and the Longwood Medical area.

Proper citation: BWH Flow Cytometry Core Laboratory (RRID:SCR_009683) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012c-654b-2967-c437-ff0b80000000

Core facility that provides the following services: Fluorescence in situ hybridization.

The CytoGenomics Core provides an invaluable technical resource to the investigators of the BWH, MGH, and affiliated institutions. Services are also available to external academic and commercial laboratories; these should contact us via our website for sample submission and pricing. Cytogenetic studies can provide insight into regions of the genome that are pathogenetic in various neoplasms leading to an understanding of the molecular pathways participating in the biology of cancer. It is appropriate to consider cytogenetics as a fundamental adjunct to a variety of investigations underway, including basic and clinical research. For example, a rather simple cytogenetic analysis of mouse ES cells to determine ploidy prior to injections into blastulas leads to a greater success rate in establishing founders for knock-out and knock-in experiments. The primary chromosomal assignment of a gene by a FISH experiment may lead to correlation of a disease with that gene. Other cytogenetic studies may be important in establishing a diagnosis for correlation with clinical outcome. The advent of molecular probes for FISH analysis has facilitated cytogenetic studies in the mouse, and other model organisms and this Core aggressively implements such technologies. In addition to state-of-the-art analyses for human samples, the BWH CytoGenomics Core also performs routine mouse karyotyping and a variety of other molecular cytogenetic analyses, services not easily obtainable elsewhere.

Proper citation: BWH CytoGenomics (RRID:SCR_009681) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012c-64ed-0030-c437-ff0b80000000

Biostatistics support is available to investigators in the Brigham and Women''s and Harvard Medical research community for statistical consulting on issues such as study design and data analysis for manuscripts and grant applications. Resources are limited, so planning ahead is essential. The Biostatistics Consulting Service is part of the Biostatistics Core of the BWH Center for Clinical Investigation (CCI).

Proper citation: BWH Biostatistics Center (RRID:SCR_009680) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012d-b966-5568-4882-b08d80000000

In recognition of the value of small animal imaging to the research community, Children''s Hospital Boston has committed to developing a state-of-the-art Small Animal Imaging Laboratory. The SAIL facility is located within the Department of Radiology''s Kresge Laboratory.

Proper citation: CHB Small Animal Imaging Core Laboratory (RRID:SCR_009719) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012d-c2f2-d124-4882-b08d80000000

The radiopharmaceutical chemistry research program occupies two research laboratories in the Enders research building at Children''s: a radiopharmaceutical chemistry laboratory and a hot laboratory. A separate cell-culture laboratory is also available. The radiopharmaceutical chemistry laboratory contains four fume hoods, approximately 50 linear feet of bench space, and is set up to accommodate three postdoctoral researchers.

Proper citation: CHB Radiopharmaceutical Chemistry Laboratory (RRID:SCR_009718) Copy   

•   Source: SciCrunch Registry

http://dartmouth.eagle-i.net/i/0000012a-24fd-4370-d8a1-249280000000

Core facility that provides the following services: Animal in vivo MRI and MRS Service.

The Biomedical NMR Research Center belongs to the Research Division of the Department of Diagnostic Radiology. Dr. Barjor Gimi is currently Director of the MR center. The Center houses a 7T horizontal bore Varian MR scanner in Vail and a 9.4T horizontal bore Varian MR scanner in Borwell. Research at the Biomedical NMR Research Center aims to advance applications of NMR techniques for tissue characterization in health and disease. We are developing non-invasive MR techniques to reveal unexplored details of anatomy, physiology and biochemistry in vivo. We use multinuclear MR technique both in imaging and spectroscopy modes and work with several animal models to achieve the goals above. Biomedical NMR Research Center provides a wide range of in vivo MR protocols for Dartmouth College and Dartmouth-Hitchcock Medical Center scientists. These include high resolution anatomical and functional MRI scanning procedures from rodents. Localized ��������H and ����������������P NMR spectroscopy can be acquired from several target organs to map, for instance metabolite concentrations, energy state, intracellular pH or tissue temperature.

Proper citation: Dartmouth Biomedical NMR Research Center (RRID:SCR_009759) Copy   

•   Source: SciCrunch Registry

https://cancer.dartmouth.edu/researchers/bioinformatics-resource.html

THIS RESOURCE IS NO LONGER IN SERVICE.Documented on July 29,2022. Core to support the implementation of bioinformatics resources for cancer research at Dartmouth. Provides consultation and collaboration for research projects of NCCC members, regular workshops, seminars, services including applied bioinformatics and data mining, computer programming and software engineering, database development and programming and high performance computing and systems administration.

Proper citation: Dartmouth-Hitchcock Bioinformatics Shared Resource (RRID:SCR_009758) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-9679-113e-55da-381e80000000

Core facility that provides the following services: Gene expression profiling service, Single nucleotide polymorphism analysis service, Tiling arrays service.

The Microarray Core provides services for genome-wide analysis of gene expression, nucleotide variation, copy number variation, and chromatin protein binding sites. The core platforms include microarrays and next generation sequencing. Consultation on experimental design, and assistance with data analysis are also available. The Microarray Core carries out gene expression profiling on 3'' arrays and on Exon arrays; genotyping and comparative genomic hybridization both on single nucleotide polymorphism (SNP) arrays, and Chromatin ImmunoPrecipitation localization (ChIP-on-Chip). All services use oligonucleotide microarrays. Biostatistical support to assist in analyzing the data is available. The services of the Core are accessible to DFCI investigators and to investigators outside of DFCI.

Proper citation: DFCI Microarray Core Facility (RRID:SCR_009753) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-59aa-00d7-55da-381e80000000

Core facility that provides the following services: Mass spectrometry service.

The Blais Proteomics Center develops and applies state-of-the-art proteomics, informatics, and related technologies for direct interrogation of protein expression, modification, and function in response to biological perturbation in cell-based models of human cancer and primary tissues. The Blais Proteomics Center serves as a valuable resource to support individual research labs at the Dana-Farber and throughout the surrounding research community. As a key component of Dana-Farber?s Strategic Plan for Research, Blais Proteomics actively participates with other Dana-Farber Strategic Research Centers in large-scale studies, designed to leverage disparate capabilities in pursuit of novel, in-depth, and otherwise unattainable insights into human biology and disease. Consistent with our role as a world-class, center of excellence in proteomics science, members of the Blais Proteomics center contribute to the teaching mission at Harvard Medical School and participate in outreach activities designed to introduce and train young scientists and others who may not otherwise have access to these advanced technologies.

Proper citation: DFCI Blais Proteomics Center (RRID:SCR_009748) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-599e-1dc8-55da-381e80000000

Core facility that provides the following services: Separation of plasma and serum from blood samples, Mononuclear cell counting and isolation, DNA isolation, 24 hour urine volume and aliquoting, Research specimen processing, Bone marrow aspiration and blood fixation, Research specimen storage.

The Clinical Research Laboratory (CRL) utilizes protocol-driven standard operating procedures for the processing of pharmacokinetics, pharmacodynamic, and biomarker samples. This includes the processing, storage, and tracking of all research specimens to ensure the successful completion of clinical trials associated with patient treatment. The CRL is dedicated to the highest standards of specimen handling to maintain the integrity of data procurement and analysis for clinical trials.

Proper citation: DFCI Clinical Research Laboratory (RRID:SCR_009749) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-a5f8-a043-55da-381e80000000

The Biocontainment Core Facility supports researchers whose experiments require a Biosafety Level 2 enhanced (BL2+) containment level. The Biocontainment Core adheres to Biosafety Level 3 (BL3) practices. Protective apparel, equipment, and other materials are provided by the core. Two core facilities are available: one is located at the Jimmy Fund building at Dana Farber; the second at The Center for Life Science. Authorized core users may have access to both facilities. Use of the facility is limited to researchers who receive training in BL3 procedures and comply with authorized user requirements. Training is provided by the Biosafety Officer, Core Manager, and authorized users.

Proper citation: DFCI Biohazard Containment Core Facility (RRID:SCR_009746) Copy   

•   Source: SciCrunch Registry