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http://eagle-i.itmat.upenn.edu/i/0000013f-5341-6a43-a468-831a80000000

Core facility that provides the following services: Contrast enhanced sonography, Quantitative analysis of images, Small animal ultrasound imaging, Blood flow velocity measurement, Tissue motion measurement. The Ultrasound Sub-Core of the SAIF offers an array of research services for pre-clinical research including quantitative image analysis and consultation. Our state-of-the-art ultrasound scanners are available as a resource for conducting your research studies. This rich resource for ultrasound imaging is available at nominal hourly fees for various categories of study. Ultrasound Research Services provides services to a host of groups working on diverse projects such as the measurement of angiogenesis, vascularity, tissue elasticity, the effects of various pharmaceuticals on these measures and more. Such research encompasses a variety of clinical areas including radiology, oncology, cardiology, gynecology, and hematology, among others.

Proper citation: Penn Small Animal Imaging Facility: Ultrasound Sub-Core (RRID:SCR_010034) Copy   

•   Source: SciCrunch Registry

http://www.med.upenn.edu/idom/drc/cores/transmouse.html

Mouse core which generates transgenic and gene-targeted mouse lines for diabetes research.

Proper citation: Penn Diabetes Research Center Transgenic and Chimeric Mouse Core Facility (RRID:SCR_010036) Copy   

•   Source: SciCrunch Registry

http://hawaii.eagle-i.net/i/0000012a-2512-fb79-c99c-aef680000000

Core facility that provides the following services: Brain MRI service. Researchers in the Neuroscience and Magnetic Resonance Research Program are using a research dedicated 3-Tesla scanner to study the human brain and brain diseases. Facilities: The Magnetic Resonance (MR) Processing Core serves the needs of researchers in the MR Research Facility at Queen''s Hospital. Specifically, the MR Image Processing Core provides image processing support, infrastructure development, methodological development and training; expertise is available.

Proper citation: UH Manoa RCMI Magnetic Resonance Image Processing Core (RRID:SCR_010037) Copy   

•   Source: SciCrunch Registry

http://eagle-i.itmat.upenn.edu/i/0000013a-74d2-3dad-d69a-d90d80000000

Core facility that provides the following services: Outpatient study facility access, iDXA scan service, Research specimen processing, Research specimen storage, NIH/Industry clinical trial support, Pharmacy laboratory access, Adipose biopsy, Patient assessment and monitoring, Metabolic testing service, Phlebotomy, Support for bone marrow biopsies. The Clinical and Translational Research Center (CTRC) has two main locations as well as satellite locations. The protocols cover a wide variety of research areas including: HIV, sleep disorders, cholesterol, obesity, diabetes, various cancers, arthritis, hypertension, renal disease, short bowel syndrome, and neonatal and surgical studies as well as new treatments for various diseases. The CTRCs service over 1200 inpatients and over 6000 outpatients a year. Research subjects range from premature infants to the elderly, with the majority of adults being seen at HUP. HUP Unit - Dulles Building: * 8 bed inpatient * 8 chair and 2 bed outpatient unit * metabolic kitchen * Scatterbed nursing services throughout hospital units including the ICUs, ED and operating rooms UPPMC Unit ? 1st Fl Mutch Building: * 18 outpatient treatment beds * metabolic kitchen CHOP Units: * 4 bed inpatient unit - 5 West Main * outpatient unit with 2 treatment rooms, 4 treatment chairs and a consultation room - Main 7 * Scatterbed nursing services in Newborn Nursery - Ravdin Building The nurse manager should be contacted prior to submitting a new protocol submission to the CTRC and discussions should continue throughout the start-up process.

Proper citation: Penn/CHOP CTRC Research Nurse Core (RRID:SCR_010040) Copy   

•   Source: SciCrunch Registry

http://hawaii.eagle-i.net/i/0000012a-2512-4e7e-c99c-aef680000000

Core facility that provides the following services: Gene expression analysis service, SNP analysis service, Genotyping service. We conduct microarray-related experiments, including developing chips for pathogen discovery, evaluating RNA quality and test chips, processing RNA specimens, hybridizing microarray chips, scanning microarray chips and providing raw data for analysis.

Proper citation: UH Manoa RCMI Microarray Core Facility (RRID:SCR_010042) Copy   

•   Source: SciCrunch Registry

http://eagle-i.itmat.upenn.edu/i/0000013a-41e9-a318-01af-beb880000000

Core facility that provides the following services: Data management assistance, Biostatistical analysis assistance. The Study Design and Biostatistics (SDAB) Core works closely with existing resources to provide targeted study design and biostatistics support to ITMAT/CTSA investigators. The Core serves as a direct provider of services, including protocol review, study design, proposal development, and performance of simple to potentially substantial complex analyses. SDAB integrates the support available with the HUP and CHOP Clinical and Translational Research Centers (CTRCs), the expertise and resources of faculty in the Center for Clinical Epidemiology and Biostatistics / Department of Biostatistics and Epidemiology (CCEB/DBE), the Biostatistics Analysis Center (BAC), and the Biostatistics and Data Management Core (BDMC) at CHOP.

Proper citation: Penn/CHOP CTRC Study Design and Biostatistics Core (RRID:SCR_010043) Copy   

•   Source: SciCrunch Registry

http://eagle-i.itmat.upenn.edu/i/00000139-a0f2-42bc-4778-6c3080000000

Core facility that provides the following services: Cell culture and tissue services, DNA isolation service, Cell culture and tissue services, Epstein Barr Virus (EBV) lymphocyte transformation service, Cell culture and tissue services, Fibroblast culture and cryopreservation service, Cell culture and tissue services, Specialized cell isolation service, Molecular biology services, microsatellite haplotyping service, Molecular biology services, mutation analysis service, Molecular biology services, Restriction fragment analysis service, Molecular biology services, RNA services, Molecular biology services, SNP genotyping service, Specimen Collection, Processing, and Point-of-Care services, Bedside tests by Bayer Rapid Point 400, Specimen Collection, Processing, and Point-of-Care services; Collection, processing and storage of specimens, Specimen Collection, Processing, and Point-of-Care services, Packaging and shipping of samples. The Translational Core Laboratory consists of the Specimen Collection, Processing and Point of Care, Biochemistry, Cell Culture/DNA Isolation, and Molecular Biology core laboratories. Laboratory testing is integrated across Penn and CHOP, and TCL services are provided at multiple physical locations at both Penn and CHOP. Penn location: first floor Smilow Center for Translational Research CHOP location: 804 Abramson Research Center (ARC)

Proper citation: Penn/CHOP CTRC Translational Core Laboratories (RRID:SCR_010044) Copy   

•   Source: SciCrunch Registry

http://eagle-i.itmat.upenn.edu/i/0000013a-4211-18b7-01af-beb880000000

Core facility that provides the following services: Clinical study support services. The Office of Human Subject Recruitment and Protection (OHSRP) provides consultation and guidance to the Penn research community on all issues related to adult and pediatric human subjects being seen through the CTRC facilities, including recruitment and protection. The role of the OHSRP is to champion the mission of the feasible, safe and ethical conduct of human subject research within the CTRC. The original Research Subject Advocate (RSA) was a position mandated by the National Center for Research Resources under the NIH and was defined in order to ensure that research was being conducted in ways that did not increase the risk associated with conducting studies. In April 2008, the CTSA Consortium Steering Committee approved and endorsed best practices, which serve to define the mission, scope, and model for research advocacy within the CTSA consortium. The OHSRP has advanced the role of the Research Subject Advocate (RSA) by adopting the 2008 best practices defined by the CTSA Consortium. The OHSRP operations are complementary to and integrative with existing entities at the institution to promote and facilitate safe and ethical conduct of human research. The OHSRA complements the University of Pennsylvania Office of Human Research (OHR) and Institutional Review Board (IRB) in support of ensuring the safety of individuals participating in health research. The OHSRP serves as a resource to the research community and to participants; has a voice in policy regarding research ethics, participants? rights, and research safety; and plays a role in the protection of human subjects and responsible conduct of research educational programs of the institution. The OHSRP has direct access to, an authority that can temporarily suspend a research activity based on ethical and safety concerns so that problems can be explored or resolved through proper procedures. This capacity enables preliminary intervention into problems that might not necessarily invoke an institutional review board (IRB) suspension. The OHSRP has a reporting pathway to institutional officials of appropriate authority and is free of conflict of interest.

Proper citation: Penn/CHOP Office of Human Subject Recruitment and Protection (RRID:SCR_010046) Copy   

•   Source: SciCrunch Registry

http://upr.eagle-i.net/i/0000012b-00c0-e8b5-9e37-5ded80000000

Core facility that provides the following services: Training in STEM, Consulting service, Training in TEM, TEM and SEM service, Assistance with immunogold labeling, Maintenance of SEM, Training in SEM. This lab maintains and operates electron microscope facilities for the faculty, investigators and students of the Medical Sciences Campus for research, training and diagnosis. Service charges apply. Contact lab for details.

Proper citation: UPR Central Electron Microscopy Unit (RRID:SCR_010124) Copy   

•   Source: SciCrunch Registry

http://upr.eagle-i.net/i/0000012a-250b-de21-43fb-601a80000000

Core facility that provides the following services: Training in the use of FACSort instrumentation, Flow cytometry consulting service. The specific objectives of this unit are to provide access to flow cytometry technology resources to investigators, students, and technical personnel; to train users in the utilization of flow cytometry; instrumentation and in its multiple applications in biological research; to provide basic technical support in flow cytometry methodology to interested users of the facility, and to encourage the development of new methodology and applications in the area of flow cytometry. Provides specialized seminars in flow cytometry basic and clinical applications.

Proper citation: UPR Flow Cytometry Unit (RRID:SCR_010126) Copy   

•   Source: SciCrunch Registry

http://upr.eagle-i.net/i/0000012f-9804-0f16-f2e2-7b7e80000000

An Core facility

Proper citation: UPR Infectious and Global Diseases Program (RRID:SCR_010127) Copy   

•   Source: SciCrunch Registry

http://hawaii.eagle-i.net/i/0000012b-36a1-af33-2f73-b43980000000

Core facility that provides the following services: DNA and RNA quantification service, DNA quality analysis service, RNA quality analysis service, Genotyping service, Gene expression analysis and DNA copy number analysis service, Pyrosequencing service. The purpose of the Genomics Shared Resource (GSR) laboratory is to provide expertise in the fast developing area of genomic analysis. In response to a growing need for genotyping services by a number of UH Cancer Center investigators, this laboratory was converted into a UH Cancer Center Shared Resource in 1999. Its current mission is to provide nucleic acid extraction, genotyping and expression profiling services in support of the peer-reviewed and IRB-approved research conducted by UH Cancer Center members.

Proper citation: UH Manoa Genomics Shared Resource Core Facility (RRID:SCR_010096) Copy   

•   Source: SciCrunch Registry

http://hawaii.eagle-i.net/i/0000012b-36bb-0138-2f73-b43980000000

Core facility that provides the following services: Aortic banding service, Echocardiogram service, Blood pressure measurement service, Osmotic pump implantation service, LAD ligation service, Mini pump insertion service, Isolated perfused heart assay service, Cryoablation service, Cardiac output measurement service, Small animal surgery service, Transverse aortic constriction service, Invasive hemodynamic measurement service, Tail vein injection service, Training and advice for general mouse surgery techniques. The Center for Cardiovascular Research provides a Mouse Phenotyping Core for the use of investigators at the University, and by special arrangement, for investigators anywhere in Hawaii. We can provide murine echocardiography, blood pressure determinations, surgical procedures and phlebotomy, as well as assistance with mouse husbandry and genotyping.(http://www2.jabsom.hawaii.edu/mousecore/)

Proper citation: UH Manoa COBRE Mouse Phenotyping Core (RRID:SCR_010092) Copy   

•   Source: SciCrunch Registry

http://hawaii.eagle-i.net/i/0000012a-2510-aae4-c99c-aef680000000

Core facility that provides the following services: Transgenic mouse generation, In vitro fertilization (IVF) service, Embryo culture service, Embryo freezing service. The Transgenic and Embryonic Stem Cell Gene Targeting Core is a state-of-the-art facility with the expertise in the production of genetically altered subjects. Transgenic subjects carrying new or novel genes are created by microinjection of DNA into the pronuclei of fertilized eggs. Knock-out lacking specific genes of interest are created by homologous recombination in embryonic stem cells followed by injection into blastocysts to create chimeric subjects. Highly experienced personnel produce transgenic and knock-out subjects for UH investigators at very reasonable cost and with very short lead times. (http://www.ibr.hawaii.edu/tc.html)

Proper citation: UH Manoa COBRE Transgenic Core (RRID:SCR_010093) Copy   

•   Source: SciCrunch Registry

http://eagle-i.itmat.upenn.edu/i/00000139-b6a6-e595-9dbb-bb2180000000

Core facility that provides the following services: NBIC instrumentation training, Scanning probe measurement service. The NBIC serves as an incubator for new probes of nanostructure behavior and associated instrumentation development. It is equipped with a suite of scanning probes, opto-electronic/transport tools, and optical probes that are so recently developed as not to be available on commercial instruments. The environment facilitates the development and refinement of new probe-based techniques.

Proper citation: Penn NBIC Probe Facility (RRID:SCR_010023) Copy   

•   Source: SciCrunch Registry

http://eagle-i.itmat.upenn.edu/i/00000138-baad-3af2-9cd7-d7e280000000

Core facility that provides the following services: Behavioral testing training, Behavioral testing consultation service, Neurobehavior Testing Core access, Evaluation of anxiety behavior, Evaluation of circadian activity and rest/activity patterns, Measurement of sleep/wake patterns, Video image analysis of behavioral assays, Tissue harvest and histology prep service, Customized behavior batteries. The Neurobehavior Testing Core provides core facilities and services to test mice in state of the art assays of simple and complex behaviors, including the assessment of circadian rhythms and sleep, learning and memory, motor and sensory function, as well as behavioral assays relevant to translational studies of neurological, neurodevelopmental and psychiatric disorders. The core offers comprehensive behavior phenotyping of your mice or can train your lab personnel to perform the tests in the facility. In addition, we provide consultation on study design including appropriate tests, mouse line/strain, numbers of animals, control groups and breeding strategies. The core will also provide consultation regarding ULAR, IACUC and other regulatory issues. Assistance with data analysis is also available. The behavior apparatus available in the core includes: running wheels and beam splitters to measure circadian activity and rest/activity patterns as well as EEG/EMG recording chambers to measure sleep/wake states. Motor function is assessed using open field activity monitors and Rotarod. Apparatus to measure anxiety-like behavior including zero maze, light/dark chamber, passive/active avoidance chambers and hole poke arenas are also available. Extensive assessment of cognition, learning and memory is conducted with Morris water maze, radial arm maze, 5 choice serial reaction time test and object recognition tests. Tests of behaviors associated with depression (forced swim), schizophrenia (startle/PPI), social interaction (choice and social memory), and drug addiction (conditioned place preference) are also available. Tests of general health and responsiveness are also performed, as these are critical for the evaluation of complex behavior. Support for the core is provided by the Comprehensive Neuroscience Center, the Institute for Translational Medicine and Therapeutics, the Center for Sleep and Circadian Neurobiology and the Perelman School of Medicine.

Proper citation: Penn Neurobehavior Testing Core (RRID:SCR_010024) Copy   

•   Source: SciCrunch Registry

http://hawaii.eagle-i.net/i/0000012d-4d11-7063-27fd-1f1480000000

The Harold L. Lyon Arboretum is a leader in the fields of conservation biology, Hawaiian ethnobotany and horticulture. On its 194 acres, Lyon Arboretum maintains a world renowned collection of more than 5,000 tropical plant species; supports Hawaii''s horticultural and agriculture industries; and works to preserve and restore Hawaii''s tropical forests. It is an active research facility and academic resource offering a wide range of programs to local and international communities including an innovative and ground-breaking tissue culture program for propagation of endangered native Hawaiian plants. With an abundant average rainfall of 165 inches, this tropical rainforest setting is an ideal location for growing an enormous diversity of plants. The plant collection features heliconias, gingers, aroids, bromeliads, native Hawaiian plants, and one of the largest palm collections found in a botanical garden.

Proper citation: UH Manoa Lyon Arboretum (RRID:SCR_010102) Copy   

•   Source: SciCrunch Registry

http://hawaii.eagle-i.net/i/0000012b-7f26-419c-2f73-b43980000000

Core facility that provides the following services: Tissue embedding service, Tissue sectioning service, Immunohistochemistry service, In situ hybridization service, DNA extraction service, Tissue microarray slides service, Tissue microarrays service, Genotyping service. The Pathology Shared resource capitalizes on the existing infrastructure of the Center''s tissue repository. The Repository currently consists of fixed, paraffin-embedded tissue specimens from hospitals and laboratories statewide. The purpose of the repository is to provide tissue specimens to Center members and other investigators for research purposes. A priority is placed on the provision of specimens for population-based research and peer-reviewed, extramurally funded projects. The repository is a part of the Residual Tissue Repository Program of the NCI SEER program (http://seer.cancer.gov/biospecimen/).

Proper citation: UH Manoa Pathology Shared Resources (RRID:SCR_010106) Copy   

•   Source: SciCrunch Registry

http://hawaii.eagle-i.net/i/0000012a-2510-e7b9-c99c-aef680000000

The Biostatistics and Data Management Facility (BDMF) was established with a primary mission to provide a range of customized statistical and database management services for RCMI researchers. Realizing a need for a consolidated and integrated statistical resources for biomedical researchers and clinicians at the John A. Burns School of Medicine, the BDMF has rapidly extended services to other programs and groups, including the Asia-Pacific Institute of Tropical Medicine and Infectious Diseases (APITMID), Pacific Biosciences Research Center (PBRC), Excellence in Partnerships for Community Outreach, Research on Health Disparities, and Training (EXPORT), Specialized Neuroscience Research Program (SNRP-I/II), Center of Biomedical Research Excellence (COBRE), Centers of Clinical Research Excellence (CCRE), Clinical Research Education and Career Development (CRECD), RCMI clinical Research Infrastructure Initiative (RCRII), and IDeA Networks of Biomedical Research Excellence (INBRE). The overall mission of the BDMF is to provide quantitative resources essential for investigators to conduct methodologically rigorous medical research in a timely, cost-effective manner. (http://www5.pbrc.hawaii.edu/bdmf/index.html)

Proper citation: UH Manoa RCMI Biostatistics and Data Management Facility (RRID:SCR_010107) Copy   

•   Source: SciCrunch Registry

http://hawaii.eagle-i.net/i/0000012a-2512-5807-c99c-aef680000000

Core facility provides the following services: DNA sequencing service, DNA fragment sizing and genotyping service, Real-time PCR analysis, DNA microarray analysis service, Protein sequencing service. The Greenwood Molecular Biology Facility is a primary research infrastructure operated by the Biotechnology Program of the Pacific Biosciences Research Center. Core serves the biomedical and molecular biology research and educational programs of the University and its associated institutions.

Proper citation: University of Hawaii at Manoa Greenwood Molecular Biology Facility (RRID:SCR_010108) Copy   

•   Source: SciCrunch Registry