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https://www.med.upenn.edu/pmi/facilities/muscle-physiology-assessment-core

Core provides investigators with customizable tools and methodolgies to assess in vivo exercise performance, metabolism and respiratory function, as well as in vivo and ex vivo muscle contractility. Provides guidance and training to investigators who want to learn how to collect and process muscle samples for specific uses.

Proper citation: University of Pennsylvania Perelman School of Medicine Muscle Physiology Assessment Core Facility (RRID:SCR_022422) Copy   

•   Source: SciCrunch Registry

http://www.confocal.uct.ac.za/

Light and fluorescence microscopy core facility with focus on applications in infectious disease, pathogen and human health research.

Proper citation: University of Cape Town Institute of Infectious Disease and Molecular Medicine Confocal and Light Microscope Imaging Core Facility (RRID:SCR_022309) Copy   

•   Source: SciCrunch Registry

https://www.dental.upenn.edu/research/core-facilities/live-cell-imaging-core/

Offers wide array of live cell imaging applications.Provides Nikon A1R Laser Scanning Confocal Microscopy system equipped with 4 laser lines to provide 6 different excitation/emission configurations; multiple photomultiplier tubes (PMTs), 32-channel spectral detector, full complement of microscope objectives, high speed image scanner, fully motorized stage and completely controllable environmental chamber. Users have access to NIS Elements AR software and 2D/3D deconvolution module offering sophisticated image analysis and processing features.

Proper citation: University of Pennsylvania Penn Dental Medicine Live Cell Imaging Core Facility (RRID:SCR_022442) Copy   

•   Source: SciCrunch Registry

https://lsbi.chem.tamu.edu/

Facility housed in Department of Chemistry.Designed to be multi user laboratory supporting major research initiatives. Instruments are currently available on fee for use basis, and others may be made available on case by case considerations.

Proper citation: Texas A and M University Laboratory for Synthetic Biologic Interactions Core Facility (RRID:SCR_022287) Copy   

•   Source: SciCrunch Registry

https://www.vet.upenn.edu/research/core-resources-facilities/transgenic-mouse-core

Offers embryological manipulation services, focused on, but not limited to, murine model systems. These services primarily enable generation of genetically modified murine models, as well as experimental research in germ cell function and early embryonic development.

Proper citation: University of Pennsylvania Penn Vet Transgenic Mouse Core Facility (RRID:SCR_022441) Copy   

•   Source: SciCrunch Registry

https://histology.forsyth.org/

Core offers consulting and support services for both soft tissue and precise hard tissue analysis. Services include: tissue processing, embedding, sectioning, staining, and guidance on protocols. Can embed samples in standard molds or custom molds in paraffin, resin, or as frozen tissue for routine histology. Provides special stains and immunohistological studies.

Proper citation: Forsyth Institute Histology Core Facility (RRID:SCR_022165) Copy   

•   Source: SciCrunch Registry

https://ldi.upenn.edu/fellows/fellows-resources/data-and-analytics-support/

Provides secure environment for investigators analyzing protected health information. �It coordinates acquisition, storage, and analysis of data from private and government sources (e.g., Medicare, Medicaid, and others) and facilitates their use by researchers who seek to answer important questions regarding health policy and health care.�

Proper citation: University of Pennsylvania Leonard Davis Institute of Health Economics Health Services Research Data Center Core Facility (RRID:SCR_022439) Copy   

•   Source: SciCrunch Registry

https://www.vet.upenn.edu/research/core-resources-facilities/comparative-pathology-core

Provides support to investigators utilizing animal models to study disease. Comparative Pathology Core, Abramson Cancer Center shared resource, provides expert pathological characterization and validation of mouse and other animal models used in biomedical research by offering expertise of board certified veterinary pathologists and access to histology, immunohistochemistry, and digital pathology services.

Proper citation: University of Pennsylvania Penn Vet Comparative Pathology Core Facility (RRID:SCR_022438) Copy   

•   Source: SciCrunch Registry

https://ldi.upenn.edu/fellows/fellows-resources/data-and-analytics-support/

Provides LDI affiliated investigators access to high quality, skilled data analysts. HEDAP recruits, trains, and manages group of masters level and PhD level statistical analysts. These analysts work with multi disciplinary investigators across funded projects using statistical software packages such as SAS, Stata, and R to manipulate and analyze health care data under guidance of investigators and other collaborators.

Proper citation: University of Pennsylvania Leonard Davis Institute of Health Economics Data Analyst Pool Core Facility (RRID:SCR_022437) Copy   

•   Source: SciCrunch Registry

https://www.vet.upenn.edu/research/core-resources-facilities/imaging-core

Provides access to optical imaging capabilities for researchers at the University of Pennsylvania, Perelman School of Medicine, Children's Hospital of Philadelphia, and Wistar Institute. Provides instruments and expertise to perform widefield, confocal, multiphoton/intravital imaging, fluorescence lifetime imaging, high content live cell screening, long term single cell imaging, second harmonic imaging, structured illumination super resolution, and total internal reflection fluorescence microscopy, as well as software tools for image analysis. Core has adjacent (in and out) ULAR approved facility to house animals for long term live animal studies.

Proper citation: University of Pennsylvania Penn Vet Imaging Core Facility (RRID:SCR_022436) Copy   

•   Source: SciCrunch Registry

https://www.vet.upenn.edu/research/core-resources-facilities/animal-model-core-corl

Supports discovery to invention to innovation in medical translation.Provides animal model development to enhance scientific rigor during in vivo studies in experimental or naturally occurring disease models. Studies can start on small scale leading towards pivotal non-clinical IND/IDE-enabling trials in support of FDA or OUS-FDA submissions. Core hosts PIs, trainees and sponsors during clinical procedures to support and enrich their experience in cross functional team setting.

Proper citation: University of Pennsylvania Animal Model Core Facility (RRID:SCR_022435) Copy   

•   Source: SciCrunch Registry

https://calm.mcmaster.ca/

Provides access to light microscopy, photo-patterning, and light-assisted 3D printing techniques to help researchers in science, engineering and life sciences as well as our industrial partners achieve their scientific goals.

Proper citation: McMaster University Centre for Advanced Light Microscopy Core Facility (RRID:SCR_022312) Copy   

•   Source: SciCrunch Registry

https://med-upenn.corefacilities.org/service_center/5129/?tab=about

Offers Illumina sequencing and bioinformatic expertise to assist researchers�with gene therapy trial evaluations, viral integration profiling,�CRISPR off-target�analyses. Assists with bioinformatic analyses including RNAseq transcription profiling�and 16S taxonomic assignments.�

Proper citation: University of Pennsylvania Perelman School of Medicine Viral Molecular High Density Sequencing Core Facility (RRID:SCR_022433) Copy   

•   Source: SciCrunch Registry

https://www.med.upenn.edu/carc/

Core provides services to users for performing precision, image guided radiotherapy with both Photons and Protons (including FLASH proton radiotherapy) on cells, rodents and larger animals. Physicists will provide expert dosimetry and treatment planning capabilities. Instrumentation consists of two image guided SARRP 200 Small Animal Radiation Research Platforms (Xstrahl) capable of irradiating rodent tissues from 1 mm-20 mm in diameter; research proton beamline (IBA, Roberts Proton Center); one X-RAD 320ix cabinet x-ray irradiator (Precision X-Ray); and two Cs gamma-ray irradiators (Shepherd Mark I), suitable for whole body radiation of rodents.

Proper citation: University of Pennsylvania Perelman School of Medicine Cell and Animal Radiation Core Facility (RRID:SCR_022377) Copy   

•   Source: SciCrunch Registry

https://www.jurado-lab.com/absl3

Facility offers procedural and animal housing to perform in vivo research with biosafety level 3 pathogens, such as SARS-CoV-2. Services include consultation, specialized training, and basic/advanced technical services. Provides equipment to longitudinally monitor mice over course of infection. Animal housing space includes three ABSL-3 separate housing cubicles with Allentown BCU-2 animal cages. Animals will be housed under pathogen free conditions at AAALAC accredited University Laboratory Animal Resources facilities within Vernon and Shirley Hill Pavilion using animal protocols approved by Institutional Animal Care and Use Committee.

Proper citation: University of Pennsylvania Perelman School of Medicine Animal Biosafety Level 3 Core Facility (RRID:SCR_022372) Copy   

•   Source: SciCrunch Registry

https://pathology.med.upenn.edu/research/centers-and-institutes/cooperative-human-tissue-network

Human tissue procurement service within Department of Pathology at HUP, that assists investigators with collection, processing and preservation of research samples. Our staff will personalize sample acquisition and processing to meet project requirements. Samples (malignant, normal, diseased, etc.) and biofluids can be preserved in a range of methods (fresh, frozen, fixed, etc.).

Proper citation: University of Pennsylvania Perelman School of Medicine Cooperative Human Tissue Network Core Facility (RRID:SCR_022407) Copy   

•   Source: SciCrunch Registry

https://www.med.upenn.edu/cbica/cubic.html

Linux based High Performance Computing resource available to faculty conducting research related to medical imaging and informatics. There are over 150 compute nodes with more than 5000 Intel Xeon CPUs and 58TB of RAM, over 100 GPUs, and 600TB of storage in the cluster. Facility management structure is designed to encourage data sharing and use of common software on this powerful resource, particularly in development of new software and application of imaging to new domains.

Proper citation: University of Pennsylvania Perelman School of Medicine CUBIC (HPC Cluster) (RRID:SCR_022406) Copy   

•   Source: SciCrunch Registry

https://www.med.upenn.edu/idom/drc/cores/ria.html

Core offers immunoassay, metabolite, and HPLC services to basic, translational, and clinical investigators performing diabetes and related metabolic disease research.RIA /Biomarkers Core is located on the 12th floor of Smilow Center for Translational Research.Approximately 100 different diabetes, obesity and metabolism-related biomarkers from multiple species including human can be assayed using radioimmunoassay (RIA), enzyme-linked immunosorbent assay (ELISA, both absorbance and fluorometric), multiplex ELISA on the Luminex platform, and enzymatic and HPLC methods for an expanding variety of diabetes and metabolism related metabolites, hormones, catecholamines and cytokines derived from blood, urine, and tissue samples.

Proper citation: University of Pennsylvania Perelman School of Medicine Radioimmunoassay and Biomarkers Core Facility (RRID:SCR_022405) Copy   

•   Source: SciCrunch Registry

https://www.itmat.upenn.edu/bmic/

Supports next generation infrastructure for clinical data storage and management, next generation analytics, next generation infrastructure for support of clinical research including new clinical trials management system and software, next generation infrastructure for centralizing and integrating external sources of data such as genomics data. Enables future clinical and translational research through biomedical informatics education and training targeted at graduate students, postdoctoral students, residents, fellows, as well as faculty across the biomedical research spectrum.

Proper citation: University of Pennsylvania Perelman School of Medicine Center for BioMedical Informatics Core Facility (RRID:SCR_022401) Copy   

•   Source: SciCrunch Registry

https://www.med.upenn.edu/cpob/biostatistical-consulting.html

Service supports consultation and collaboration in areas of biostatistics and epidemiology to Penn vision scientists. Biostatisticians and data management experts provide advice on study design, and offer services in sample size determinations, data management, data analysis, data interpretation, and data presentation. They are active participants in the development and writing of grant applications and manuscripts.Consulting personnel are CPOB members. In addition to their methodological and technical expertise, consultants are knowledgeable about ocular conditions under study in Penn vision community, about commonly used measures that are unique to vision research (visual acuity, refractive error, visual field indices, etc) and specialized statistical analysis techniques required for many experimental designs used in vision research (correlated data techniques to handle appropriately data from two eyes of same subject). Majority of projects are patient oriented researchers,however, CPOB Consulting Service also works on data analysis with bench laboratory scientists.

Proper citation: University of Pennsylvania Perelman School of Medicine Center for Preventive Ophthalmology and Biostatistics Biostatistical Consulting Core Facility (RRID:SCR_022400) Copy   

•   Source: SciCrunch Registry