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https://www.crr.columbia.edu/raraf

RARAF is dedicated to providing user-friendly radiation sources and bio-labs for research in biology, radiation biology, and radiation physics.

Proper citation: Columbia University Radiological Research Accelerator Core Facility (RRID:SCR_012639) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/transgenic-mouse-shared-resource-columbia

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on April 22, 2024. Core facility that specializes in the generation and analysis of genetically modified mice, including transgenic and knockout animals, is an essential technology for biomedical research. Our services include: Production of transgenic mice by pronuclear DNA microinjection and embryo transfer. Production of chimeric mice by blastocyst injection of genetically modified ES cells and embryo transfer, which is part of the procedure of producing knockout or knockin mice. Gene targeting, which involves the electroporation of a targeting vector into pluripotent mouse embryonic stem (ES) cells and the selection of gene-targeted clones. Education of investigators and advice on vector and experimental design for experiments using transgenic and knockout mice. Bioimaging: The Animal Imaging Service provides investigators the opportunity for non-invasive detection, localization, and longitudinal monitoring of primary and metastatic cancer cells in vivo, in allograft, zenograft, transgenic and knock-out mouse models. The IVIS Spectrum (Caliper Life Sciences, Hopkinton MA) uses optical imaging technology to detect bioluminescent and fluorescent reporters across the blue to near infrared wavelength region. DNA samples and ES cell lines are injected in the order in which the signed service request forms are received. Currently, the average time from receipt of the service request to injection is approximately 2 weeks. For ES Cell electroporation and expansion, success in gene targeting cannot be guaranteed due to inherent variability in the frequency of targeting different loci, and the possibility of mistakes or mutations in the targeting vector.

Proper citation: Columbia Transgenic Mouse Shared Resource (RRID:SCR_012640) Copy   

•   Source: SciCrunch Registry

http://genepool.bio.ed.ac.uk/

The GenePool is a next-generation genomics and bioinformatics facility based within the School of Biological Sciences, The University of Edinburgh. Which offers collaborative access to DNA sequencing, genotyping and bioinformatics capabilities, using ABI 3730 Sanger, Illumina and Roche 454 technology platforms.

Proper citation: University of Edinburgh GenePool Next Generation Sequencing and Bioinformatics (RRID:SCR_012485) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/electron-microscopy-core-laboratory-upenn

The Electron Microscopy Resource Laboratory (EMRL ) at Penn is a research facility dedicated to ultrastructure analysis of biological samples by electron microscopy (EM). We offer high quality EM imaging services at low cost. With a team of experienced professional staff and state-of-the-art sample preparation and imaging equipment, the EMRL offers users a full spectrum of both transmission EM and scanning EM services.

Proper citation: Penn Electron Microscopy Core Laboratory (RRID:SCR_012642) Copy   

•   Source: SciCrunch Registry

https://pcrlab.vetmed.ucdavis.edu/

Real-time PCR Research and Diagnostics Core Facility accepts research projects from both academic and private sector. The Core Facility can accommodate projects involving laser microdissection, RNA and DNA extractions through semi-automated nucleic acid extractions systems, cDNA synthesis and complete Real-time PCR analysis using a laser 7900 HTA FAST platform.

Proper citation: University of California at Davis Real Time PCR Research and Diagnostics Core Facility (RRID:SCR_012641) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/protein-structure-core-facility

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on April 25,2024. Protein Structure Core Facility operates in the department of Biochemistry and Molecular Biology, on the UNMC campus. The facility performs protein sequencing, amino acid analysis and peptide mapping on a fee-for-service basis. It is located on the first floor of the Durham Research Center

Proper citation: UNMC Protein Structure Core Facility (RRID:SCR_012609) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/babraham-commercialisation-services-ltd

Babraham Institute Enterprise Limited (BIE) is the wholly-owned trading arm of the Babraham Institute. The Babraham Institute undertakes innovative life-sciences research to discover the molecular mechanisms that underlie normal cellular processes and functions, with the aim of improving lifelong wellbeing and healthy ageing.

Proper citation: Babraham Institute Enterprise Limited (RRID:SCR_012566) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/clinical-pharmacology-analytical-services-cpas

The Clinical Pharmacology Analytical Services laboratory (CPAS) resides in the Department of Experimental and Clinical Pharmacology (ECP) in the University of Minnesota College of Pharmacy. CPAS offers quantification services of drug concentrations in biological samples. The CLIA-certified lab and its team of researchers and clinicians the resources to measure drug concentrations in blood and tissue samples of human and animal origin, including animals as patients and animals serving as research models. The lab which opened in October 2003 uses state-of-the-art equipment to facilitate analysis of drugs, xenobiotics, endogenous compounds and biological samples. Capabilities of the core lab include LC-MS/MS, LC-MS, GC-MS, HPLC-UV and HPLC-FLD. Additional, UV and fluorescent plate readers and liquid scintillation counters are available for conducting ELISA, RIA and other assays in a 96-well plate format. Because of its flexible structure, customers can purchase only the services they need, including assay consultation, assay development and validation, conduct of assays and application. Lab services are made available to researchers from within and outside the University of Minnesota community.

Proper citation: University of Minnesota Clinical Pharmacology Analytical Services (RRID:SCR_012603) Copy   

•   Source: SciCrunch Registry

https://www.montclair.edu/mmrl/

Interdisciplinary research, teaching and service facility equipped with scanning and transmission electron microscopes, an atomic force microscope, and the ancillary instruments. Provides microscopic imaging, X-ray analysis, and specimen preparation services for biological, pharmaceutical, and materials scientific research. The MMRL consist of four individual microscope rooms, the Histology laboratory, and sample preparation and chemical storage areas.Graduate- and upper-undergraduate-level training is offered in the operation of electron microscopes, sample preparation, and thick/thin sectioning. Currently, MMRL houses transmission electron, scanning electron microscopes, and atomic force microscope. The microscopes available for use include: - Hitachi H-7500 transmission electron microscope - Hitachi S-3400N variable pressure scanning electron microscope with x-ray analysis and digital imaging - Hitachi S-2460N scanning electron microscope with x-ray analysis In addition, the following items are also available for MMRL users: - Three Leica 2030 rotary paraffin microtome - Two LKB ultramicrotomes - A LKB 7800 glass knife maker - Leica Reichert Ultratrim - Denton critical point dryer - Denton sputter coaters (Desk II and Desk IV) - Denton Vacuum evaporators (DV-502A) - Liquid nitrogen dewars (various sizes) - A Leica stereo dissecting microscope - A Tissue-TeK VIP Tissue Processor - A Tissue-TeK II Embedding Center

Proper citation: Montclair University Microscopy and Microanalysis Research Laboratory Core Facility (RRID:SCR_012453) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/immunodetection-and-imaging

Delivering high quality immunohistochemical and immunofluorescent staining on cells and tissue sections, specialising in multi immunoflourescent colocalisation staining technologies. Equipped with three Vision Biosystems Bond staining robots Mike offers high throughput or custom antibody optimisation services. Time consuming multi colocalisation including same species primaries, are automated saving time and money. A large range of imaging platforms including three confocals, widefield, stereology, image analysis, digital photograpy and PALM laser capture microscopy are available. A full range of secondary antibodies and detection systems are available for purchase in ul quantities. There are currently 1900 antibodies recorded on our database.

Proper citation: University of Edinburgh Immunodetection and Imaging (RRID:SCR_012573) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/biomolecular-interaction-centre

The Biomolecular Interaction Centre (BIC) is a multi-disciplinary centre dedicated to the study of molecular interactions critical to biological function. Understanding biomolecular interactions is central to a range of fundamental sciences, new treatments for disease, and a wide range of highly functional products. The Institute includes University of Canterbury researchers from the Colleges of Science and Engineering, as well as Education and Arts and partners with several New Zealand CRIs and Universities. The Centre was founded in 2007 after being awarded funding from the Innovation and Development Fund from the Tertiary Education Commission (TEC). The primary investment of $1.85 million was used to purchase of a suite of state-of-the-art equipment that was supplied by Bio-Rad Laboratories. BIC has recently received a multi-million dollar investment from the University of Canterbury to become one of two new premier research institutes on campus. BIC researchers seek to understand the molecular interactions vital to biology and harness them in a wide range of applications. BIC has a number of Principal, Partner, Associate and Affliated Investigators, together with Post Doctoral Fellows, Postgraduate students and technicians from the University of Canterbury, as well as, other national and international institutions. Many these investigators directly support the research themes of the Centre while others have related research projects that benefit from BIC support.

Proper citation: University of Canterbury Biomolecular Interaction Centre (RRID:SCR_012618) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/pathology-core-facility

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on May 2,2024. Core Pathology is a self funding, CPA accredited department and therefore is a fee-for-service facility providing Histopathology services to members of Queen Mary University and other academic institutes, as well as providing a diagnostic service to the private sector. Our remit is to advise, support or carry out work for research groups.

Proper citation: QMUL BICM Pathology Core Facility (RRID:SCR_012587) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/small-animal-imaging-core-umass

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on April 23,2024. UMMS Small Animal Imaging Core was established in early 2008 to serve the UMMS and extramural research community by providing state-of-the-art small animal imaging.

Proper citation: UMass Medical School Small Animal Imaging Core (RRID:SCR_012620) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/laboratory-of-medical-zoology

We offer expanded tick testing services for a variety of tick-borne pathogens, including Babesia, Anaplasma, Rickettsia, Bartonella, and others.

Proper citation: UMass Amherst Laboratory of Medical Zoology (RRID:SCR_012586) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/microscopy-core

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on May 22, 2024. Core facility

Proper citation: MGH Microscopy Core (RRID:SCR_012426) Copy   

•   Source: SciCrunch Registry

https://cancer.psu.edu/research/cores/organic-synthesis

Core to advance scientific impact of Penn State Cancer Institute investigators by synthesizing and providing chemical agents that are either not commercially available or cost-prohibitive, to facilitate ongoing cancer research. Assists in efforts towards discovering novel agents for treatment and prevention of cancer. Supports activities of development and synthesis of anticancer agents, chemical carcinogens, their detoxification products, reactive species of metabolic activation and DNA adducts formed with such species. Services also include identification and synthesis of biomarkers of uptake and activation of environmental carcinogens that require deuterated, tritiated, and 14C-labeled isotopes.

Proper citation: Penn State Cancer Institute Organic Synthesis Core Facility (RRID:SCR_012425) Copy   

•   Source: SciCrunch Registry

https://www.utsouthwestern.edu/research/core-facilities/genomics/

Core provides access to next generation sequencing (NGS) to investigators at UT Southwestern, at other institutions in the UT System, and at additional cost to investigators outside of the UT system. Core can receive flow cell ready samples (sequencing libraries that are prepared by the user) or perform sequencing library production for genomic libraries, RNA-SEQ applications, and small RNA (microRNA) applications. Data output routinely will provide de-multiplexing and alignment to the genome of choice using a variety of assembly and analysis programs, including CLC-Biosystems workbench, a BWA-GATK-Genotyper pipeline, a BowTie-Top Hat analysis pathway, and the Illumina ELAND DNA sequence aligner. Limited access to post sequence data analysis software is also available through the core, including both CLC-Biosystems (2 floating licenses available for on campus users) and the Genome Studio software packages.

Proper citation: University of Texas Southwestern Genomics and Microarray Core (RRID:SCR_012431) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/comprehensive-phytopathogen-genomics-resource-cpgr-msu

The Comprehensive Phytopathogen Genomics Resource (CPGR) aims to provide a comprehensive plant pathogen genomics and annotation resource. A major part of the CPGR is the development of diagnostic molecular markers and robust diagnostic protocols for plant pathogens

Proper citation: MSU Comprehensive Phytopathogen Genomics Resource (RRID:SCR_012554) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/histology-core-facility-at-lake-nona

The Histology Core at Lake Nona is a full-service shared resource facility that provides histological services to Sanford-Burnham researchers and investigators throughout the scientific community. The Core offers technical support, consultative, and interpretive pathology to all investigators. Tissue samples are processed with the highest industry quality standards, using state-of-the-art instrumentation. The Core also assists with experiment design as well as the development and interpretation of tests and their results. Sanford-Burnham''''s Histology Core at Lake Nona is committed to collaborating with investigators and advancing research by carrying out critical tissue specimen validation and evaluation. Equipment and Resources: - Thermo Excelsior ES Tissue Processor - Thermo Histocentre_������������������������ 3 Embedding Unit - Thermo Cytospin 4 - Thermo Microm HM355S Microtome - Thermo Printmate 450 Cassette Printer - Thermo Microm HM550 Cryostat - Thermo Microm HM650 V Vibratome with cooling unit - Thermo Microm HM450 Sliding Microtome with freezing unit - Leica IP S Slide Printer - Leica RM2235 Microtome - Leica 1900UV Cryostat - Nikon Eclipse 80i Microscope with AR Elements imaging software - Ventana Discovery XT - Tissue-Tek?? Prisma Automated Slide Stainer and Glas_������������������������ g2 Coverslipper - Aperio ScanScope XT-Brightfield - Aperio ScanScope FL-Fluorescence

Proper citation: Sanford-Burnham Histology Core Facility at Lake Nona (RRID:SCR_012438) Copy   

•   Source: SciCrunch Registry

https://cancer.osu.edu/about/publications-and-reports/magazines-and-publications/frontiers/2013/winter/nucleic-acid-shared-resource-adds-new-technologies-and-applications

The Nucleic Acid Shared Resource (NASR) provides genomic and epigenomic support for cancer research at OSUCCC-James including: Sanger-based DNA Sequencing, Next-Generation Sequencing, Genotyping, DNA Methylation analysis and Gene Expression Analysis. Additionally, the NASR provides consultation and assistance in experimental design, troubleshooting, training, development of novel methodologies and applications, and publication preparation.

Proper citation: OSU Nucleic Acid Shared Resource (RRID:SCR_012643) Copy   

•   Source: SciCrunch Registry