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Integrated Animals is a virtual database currently indexing available animal strains and mutants from: AGSC (Ambystoma), BCBC (mice), BDSC (flies), European Xenopus Resource Center (frog), The National Xenopus Resource (frog), Xenopus Express (frog), CWRU Cystic Fibrosis Mouse Models (mice), DGGR (flies), FlyBase (flies), IMSR (mice), MGI (mice), MMRRC (mice), NSRRC (pig), RGD (rats), Sperm Stem Cell Libraries for Biological Research (rats), Tetrahymena Stock Center (Tetrahymena), WormBase (worms), XGSC (Xiphophorus), ZFIN (zebrafish), and ZIRC (zebrafish). Note, the IMSR data is linked, but users may need to re-execute the search if the top mouse is not returned properly.
Note: BCBC is no longer in service, so the links may not be functional.
http://www.wormbase.org/db/get?name=WBStrain00000266
Source Database: WormBase (WB)
Genetic Background:
Affected Genes: WBGene00000912(daf-16)|WBGene00001482(fog-2)
Genomic Alteration: WBGene00000912(daf-16), WBGene00001482(fog-2)
Availability: available
References:
Synonyms: daf-16(mgDf47) I; fog-2(q71) V.
Notes: Temperature sensitive. Maintain by mating males & females at 15C. fog-2(q71) is male-female.
Proper citation: RRID:WB-STRAIN:WBStrain00000266 Copy
http://www.wormbase.org/db/get?name=WBStrain00000267
Source Database: WormBase (WB)
Genetic Background:
Affected Genes: WBGene00000254(bli-4)|WBGene00001746(gsk-3)
Genomic Alteration: WBGene00000254(bli-4), WBGene00001746(gsk-3)
Availability: available
References:
Synonyms: gsk-3(tm2223) I/hT2[bli-4(e937) let-?(q782) qIs48] (I;III).
Notes: Homozygous sterile mutation balanced by bli-4- and GFP-marked translocation. Heterozygotes are WT with pharyngeal GFP signal, and segregate WT GFP, arrested hT2 aneuploids, and non-GFP sterile tm2223 homozygotes. Homozygous hT2[bli-4 let-? qIs48] inviable. Pick WT GFP and check for correct segregation of progeny to maintain. Reference: Furuta T, et al. Development. 2018 May 14;145(10). pii: dev161042. doi: 10.1242/dev.161042.
Proper citation: RRID:WB-STRAIN:WBStrain00000267 Copy
http://www.wormbase.org/db/get?name=WBStrain00000268
Source Database: WormBase (WB)
Genetic Background:
Affected Genes: WBGene00000898(daf-2)|WBGene00006843(unc-119)
Genomic Alteration: WBGene00000898(daf-2), WBGene00006843(unc-119)
Availability: available
References:
Synonyms: daf-2(e1370) unc-119(ed3) III; vizIs23.
Notes: Made_by: Jessica (Jie) Chen|"vizIs23 [pie-1p::GFP::daf-2(WT)::pie-1 3'UTR + unc-119(+)]. Maintain at 15C; pick superficially wild-type animals to avoid silencing of the transgene. pie-1 driven DAF-2 coding region with GFP transgene rescues the germline defects of daf-2(e1370). Slow growing. The transgene is sometimes silenced in the germline resulting in dauerunc animals at 25C. Reference: Lopez AL 3rd, et al. Dev Cell. 2013 Oct 28;27(2):227-40."
Proper citation: RRID:WB-STRAIN:WBStrain00000268 Copy
http://www.wormbase.org/db/get?name=WBStrain00000263
Source Database: WormBase (WB)
Genetic Background:
Affected Genes: WBGene00002136(inx-14)
Genomic Alteration: WBGene00002136(inx-14)
Availability: available
References:
Synonyms: inx-14(ag17) I.
Notes: Enhanced pathogen resistance.
Proper citation: RRID:WB-STRAIN:WBStrain00000263 Copy
http://www.wormbase.org/db/get?name=WBStrain00000264
Source Database: WormBase (WB)
Genetic Background:
Affected Genes:
Genomic Alteration:
Availability: available
References:
Synonyms: agls17[Pmyo-2::mCherry + Pirg-1::gfp]
Notes: agIs17 [myo-2p::mCherry + irg-1p::GFP] IV. GFP in pharynx and intestine that turns on upon infection with pathogenic Pseudomonas aeruginosa strain PA14. Reference: Dunbar TL, et al. Cell Host Microbe. 2012 Apr 19;11(4):375-86.|"WBStrain mapped, WBPaper00049531 added based on AFP_Strain data."|"WBStrain provided so WBPaper00059545 paper added based on AFP_Strain data."|"WBStrain provided so WBPaper00061956 paper added based on AFP_Strain data."
Proper citation: RRID:WB-STRAIN:WBStrain00000264 Copy
http://www.wormbase.org/db/get?name=WBStrain00000280
Source Database: WormBase (WB)
Genetic Background:
Affected Genes: WBGene00001066(dpy-4)|WBGene00004962(spe-8)
Genomic Alteration: WBGene00001066(dpy-4), WBGene00004962(spe-8)
Availability: available
References:
Synonyms: spe-8(hc40) I; dpy-4(e1166) IV.
Notes: Can be maintained by chunking or setting up male/hermaphrodite crosses. Dpy.
Proper citation: RRID:WB-STRAIN:WBStrain00000280 Copy
http://www.wormbase.org/db/get?name=WBStrain00000281
Source Database: WormBase (WB)
Genetic Background:
Affected Genes: WBGene00000499(chk-2)|WBGene00004399(rol-9)|WBGene00006786(unc-51)
Genomic Alteration: WBGene00000499(chk-2), WBGene00004399(rol-9), WBGene00006786(unc-51)
Availability: available
References:
Synonyms: chk-2(me64) rol-9(sc148)/unc-51(e369) rol-9(sc148) V.
Notes: Heterozygotes are fertile Rollers and segregate fertile non-Rollers (heterozygote), Unc Rollers (unc-51 homozygotes), and non-Unc Rollers that give 96-97% dead eggs (a high % of the survivors are males).
Proper citation: RRID:WB-STRAIN:WBStrain00000281 Copy
http://www.wormbase.org/db/get?name=WBStrain00000282
Source Database: WormBase (WB)
Genetic Background:
Affected Genes: WBGene00004985(spo-11)
Genomic Alteration: WBGene00004985(spo-11)
Availability: available
References:
Synonyms: spo-11(me44)/nT1 [unc-?(n754) let-? qIs50] (IV;V).
Notes: Balanced heterozygotes are GFP+ Unc and segregate GFP+ Unc (heterozygotes), non-GFP non-Unc spo-11(me44) homozygotes, and dead eggs (nT1 homozygotes). spo-11(me44) homozygotes are viable and produce more than 90% dead eggs (a large fraction of the survivors are males strong Him phenotype); cytologically they lack chiasmata in diakinesis-stage oocytes and lack RAD-51 foci. Maintain by picking Unc.|"Supplementary_genotype spo-11(me44)/nT1"|"WBStrain mapped, WBPaper00060717 added based on AFP_Strain data."|"WBStrain mapped, WBPaper00061204 added based on AFP_Strain data."
Proper citation: RRID:WB-STRAIN:WBStrain00000282 Copy
http://www.wormbase.org/db/get?name=WBStrain00000283
Source Database: WormBase (WB)
Genetic Background:
Affected Genes: WBGene00004296(rad-50)
Genomic Alteration: WBGene00004296(rad-50)
Availability: unknown
References:
Synonyms: rad-50(ok197)/nT1[unc-?(n754) let-? qIs50] (IV;V).
Notes: Balanced heterozygotes are GFP+ Unc and segregate GFP+ Unc (heterozygotes), non-GFP non-Unc rad-50(ok197) homozygotes, and dead eggs (nT1 homozygotes). rad-50(ok197) homozygotes are viable and produce more than 98.8% dead eggs (a large fraction of the survivors are males strong Him phenotype); cytologically they lack chiasmata in diakinesis-stage oocytes, but pairing and synapsis appear normal. Maintain by picking Unc.|"No longer available from the CGC"
Proper citation: RRID:WB-STRAIN:WBStrain00000283 Copy
http://www.wormbase.org/db/get?name=WBStrain00000277
Source Database: WormBase (WB)
Genetic Background:
Affected Genes: WBGene00004985(spo-11)
Genomic Alteration: WBGene00004985(spo-11)
Availability: available
References:
Synonyms: spo-11(ok79) IV/nT1 [unc-?(n754) let-?] (IV;V).
Notes: Heterozygotes are Unc and segregate Uncs (heterozygotes), non-Unc spo-11 homozygotes, and dead eggs (nT1 homozygotes). spo-11 homozygotes produce an average of ~200 fertilized eggs but only about 0.1 progeny survive to adulthood. When mated to N2 males, spo-11 homozygotes will produce at least 5-10 cross progeny.|"Mutagen: diepoxybutane"|"Supplementary_genotype spo-11(ok79) IV/nT1 [unc-? (n754) let-?] (IV;V)"|"Supplementary_genotype spo-11(ok79)/nT1"
Proper citation: RRID:WB-STRAIN:WBStrain00000277 Copy
http://www.wormbase.org/db/get?name=WBStrain00000278
Source Database: WormBase (WB)
Genetic Background:
Affected Genes: WBGene00003405(mre-11)
Genomic Alteration: WBGene00003405(mre-11)
Availability: available
References:
Synonyms: mre-11(ok179) IV/nT1 [unc-?(n754) let-?] (IV;V).
Notes: Heterozygotes are Unc and segregate Uncs (heterozygotes), non-Unc mre-11 homozygotes, and dead eggs (nT1 homozygotes). mre-11 homozygotes produce about 200 fertilized eggs but only about 2-3% of these eggs survive to adulthood (this mutation cannot be maintained in a homozygous condition). Occasionally non-Unc progeny that do not demonstrate the mre-11(ok179) mutant phenotype arise when grown in large liquid cultures. mre-11 is the predicted gene ZC302.1|"Made_by: Deletion Consortium"
Proper citation: RRID:WB-STRAIN:WBStrain00000278 Copy
http://www.wormbase.org/db/get?name=WBStrain00000273
Source Database: WormBase (WB)
Genetic Background:
Affected Genes:
Genomic Alteration:
Availability: available
References:
Synonyms: mnDp66 (X;I); meDf3 X.
Notes: Mutagen:Gamma Rays|"Produces 32% XO male self progeny; nondisjunction is correlated with a high frequency of achiasmate X chromosomes in oocyte nuclei, and a reduced frequency of X chromosome crossovers. meDf3 disrupts the function of the cis-acting X chromosome meiotic pairing center. meDf3/+ heterozygotes produce 4-6% XO progeny, so the presence of meDf3 can be followed in heterozygotes by this weak Him phenotype."
Proper citation: RRID:WB-STRAIN:WBStrain00000273 Copy
http://www.wormbase.org/db/get?name=WBStrain00000275
Source Database: WormBase (WB)
Genetic Background:
Affected Genes:
Genomic Alteration:
Availability: available
References:
Synonyms: mnDp66 (X;I); meDf5 X.
Notes: Mutagen:Gamma Rays|"Produces 32% XO male self-progeny; nondisjunction is correlated with a high frequency of achiasmate X chromosomes in oocyte nuclei, and a reduced frequency of X chromosome crossovers. meDf5 disrupts the function of the cis-acting X chromosome meiotic pairing center. meDf5/+ heterozygotes produce 4-6% XO progeny, so the presence of meDf5 can be followed in heterozygotes by this weak Him phenotype."
Proper citation: RRID:WB-STRAIN:WBStrain00000275 Copy
http://www.wormbase.org/db/get?name=WBStrain00000276
Source Database: WormBase (WB)
Genetic Background:
Affected Genes:
Genomic Alteration:
Availability: available
References:
Synonyms: me8 X.
Notes: Homozygotes produce 10-15% XO male self progeny; nondisjuction is correlated with an increased frequency of achiasmate X chromosomes in oocyte nuclei, and an unaltered distribution of X chromosome crossovers. Heterozygotes produce 1-2% male self-progeny. Homozygotes (and XO hemizygotes) are slower growing than WT; reduced male mating efficiency. me8 disrupts the function of the cis-acting X chromosome meiotic pairing center. Molecular studies show that the me8 chromosome carries a terminal deletion that removes >70 kb from the left end of the X chromosome, including the endogenous telomere; further, a segment of chromosome V has been translocated to the left end of X, and a new telomere has been added de novo to the end of the translocated segment.
Proper citation: RRID:WB-STRAIN:WBStrain00000276 Copy
http://www.wormbase.org/db/get?name=WBStrain00000291
Source Database: WormBase (WB)
Genetic Background:
Affected Genes: WBGene00001072(dpy-10)|WBGene00001872(him-14)|WBGene00006787(unc-52)
Genomic Alteration: WBGene00001072(dpy-10), WBGene00001872(him-14), WBGene00006787(unc-52)
Availability: available
References:
Synonyms: him-14(it21)/mnC1 [dpy-10(e128) unc-52(e444)] II.
Notes: Heterozygotes are wild-type and segregate wild-type heterozygotes, DpyUncs (mnC1 homozygotes), and him-14 homozygotes that produce >95% dead embryos and 45% males. Among these surviving progeny, cytologically they have 12 univalents in diakinesis-stage oocytes owing to a failure to form crossovers during meiosis.
Proper citation: RRID:WB-STRAIN:WBStrain00000291 Copy
http://www.wormbase.org/db/get?name=WBStrain00000293
Source Database: WormBase (WB)
Genetic Background:
Affected Genes: WBGene00001864(him-5)|WBGene00023417(swm-1)
Genomic Alteration: WBGene00001864(him-5), WBGene00023417(swm-1)
Availability: available
References:
Synonyms: swm-1(me87) him-5(e1490) V.
Notes: Sperm activation in virgin males. Very poor sperm transfer.
Proper citation: RRID:WB-STRAIN:WBStrain00000293 Copy
http://www.wormbase.org/db/get?name=WBStrain00000290
Source Database: WormBase (WB)
Genetic Background:
Affected Genes: WBGene00006375(syp-1)
Genomic Alteration: WBGene00006375(syp-1)
Availability: available
References:
Synonyms: syp-1(me17) V/nT1 [unc-?(n754) let-? qIs50] (IV;V).
Notes: Balanced heterozygotes are GFP+ Unc and segregate GFP+ Unc (heterozygotes), non-GFP non-Unc syp-1(me17) homozygotes, and dead eggs (nT1 homozygotes). syp-1(me17) homozygotes produce 95% dead embryos and 38% males. Cytologically they lack chiasmata in diakinesis-stage oocytes, exhibit persistent polarized nuclear organization during earlier meiotic prophase, lack synaptonemal complexes, and exhibit unstable pairing of homologous chromosomes. qIs50 is an insertion of ccEx9747 with markers: myo-2::GFP expressed brightly in the pharynx throughout development, pes-10::GFP expressed in embryos, and a gut promoter (F22B7.9) driving GFP in the intestine.|"Supplementary_genotype syp-1(me17)/nT1g"
Proper citation: RRID:WB-STRAIN:WBStrain00000290 Copy
http://www.wormbase.org/db/get?name=WBStrain00000204
Source Database: WormBase (WB)
Genetic Background:
Affected Genes: WBGene00004932(sod-3)|WBGene00006789(unc-54)
Genomic Alteration: WBGene00004932(sod-3), WBGene00006789(unc-54)
Availability: unknown
References:
Synonyms: dvIs14[unc-54/A1-42(pCL12)+mtl-2::GFP(pCL26);sod-3(gk235)X,
Notes: EMPTY
Proper citation: RRID:WB-STRAIN:WBStrain00000204 Copy
http://www.wormbase.org/db/get?name=WBStrain00000207
Source Database: WormBase (WB)
Genetic Background:
Affected Genes: WBGene00303081(bus-8A)
Genomic Alteration: WBGene00303081(bus-8A)
Availability: available
References:
Synonyms: bus-8A(lj22) X.
Notes: Made_by: A W Tearle|"Skiddy, bleach-sensitive, drug-sensitive, Bus, resistant to Leucobacter Verde2, hypersensitive to Leucobacter Verde1. lj22 is a missense mutation (R32C) in bus-8A and might also affect bus-8B (out-of-frame 5'exon U1). Reference: Partridge et al. (2008) PMID: 18395708."
Proper citation: RRID:WB-STRAIN:WBStrain00000207 Copy
http://www.wormbase.org/db/get?name=WBStrain00000201
Source Database: WormBase (WB)
Genetic Background:
Affected Genes: WBGene00004397(rol-6)
Genomic Alteration: WBGene00004397(rol-6)
Availability: unknown
References:
Synonyms: EMPTY
Notes: (rol-6(su1006)II;Pmyo3::ACR-16::GFP)
Proper citation: RRID:WB-STRAIN:WBStrain00000201 Copy
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