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SciCrunch Registry is a curated repository of scientific resources, with a focus on biomedical resources, including tools, databases, and core facilities - visit SciCrunch to register your resource.

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Resource Name Proper Citation Abbreviations Resource Type Description Keywords Resource Relationships Related Condition Funding Defining Citation Availability Website Status Alternate IDs Alternate URLs Old URLs Parent Organization Resource ID Synonyms Record Last Update Mentions Count
Biomolecular Object Network Databank
 
Resource Report
Resource Website
10+ mentions
Biomolecular Object Network Databank (RRID:SCR_007433) data or information resource, database THIS RESOURCE IS NO LONGER IN SERVICE, documented May 10, 2017. A pilot effort that has developed a centralized, web-based biospecimen locator that presents biospecimens collected and stored at participating Arizona hospitals and biospecimen banks, which are available for acquisition and use by researchers. Researchers may use this site to browse, search and request biospecimens to use in qualified studies. The development of the ABL was guided by the Arizona Biospecimen Consortium (ABC), a consortium of hospitals and medical centers in the Phoenix area, and is now being piloted by this Consortium under the direction of ABRC. You may browse by type (cells, fluid, molecular, tissue) or disease. Common data elements decided by the ABC Standards Committee, based on data elements on the National Cancer Institute''s (NCI''s) Common Biorepository Model (CBM), are displayed. These describe the minimum set of data elements that the NCI determined were most important for a researcher to see about a biospecimen. The ABL currently does not display information on whether or not clinical data is available to accompany the biospecimens. However, a requester has the ability to solicit clinical data in the request. Once a request is approved, the biospecimen provider will contact the requester to discuss the request (and the requester''s questions) before finalizing the invoice and shipment. The ABL is available to the public to browse. In order to request biospecimens from the ABL, the researcher will be required to submit the requested required information. Upon submission of the information, shipment of the requested biospecimen(s) will be dependent on the scientific and institutional review approval. Account required. Registration is open to everyone.. Documented on August 19,2019.BOND, which requires registration of a free account, is a resource used to perform cross-database searches of available sequence, interaction, complex and pathway information. BOND integrates a range of component databases including GenBank and BIND, the Biomolecular Interaction Network Database. BOND contains 70+ million biological sequences, 33,000 structures, 38,000 GO terms, and over 200,000 human curated interactions contained in BIND, and is open access. BOND serves the interests of the developing global interactome effort encompassing the genomic, proteomic and metabolomic research communities. BOND is the first open access search resource to integrate sequence and interaction information. BOND integrates BLAST functionality, and contains a well-documented API. BOND also stores annotation links for sequences, including links to Genome Ontology descriptions, MedLine abstracts, taxon identifiers, associated structures, redundant sequences, sequence neighbors, conserved domains, data base cross-references, Online Mendalian Inheritance in Man identifiers, LocusLink identifiers and complete genomes. BIND on BOND The Biomolecular Interaction Network Database (BIND), a component database of BOND, is a collection of records documenting molecular interactions. The contents of BIND include high-throughput data submissions and hand-curated information gathered from the scientific literature. BIND is an interaction database with three classifications for molecular associations: molecules that associate with each other to form interactions, molecular complexes that are formed from one or more interaction(s) and pathways that are defined by a specific sequence of two or more interactions.Interactions A BIND record represents an interaction between two or more objects that is believed to occur in a living organism. A biological object can be a protein, DNA, RNA, ligand, molecular complex, gene, photon or an unclassified biological entity. BIND records are created for interactions which have been shown experimentally and published in at least one peer-reviewed journal. A record also references any papers with experimental evidence that support or dispute the associated interaction. Interactions are the basic units of BIND and can be linked together to form molecular complexes or pathways. The BIND interaction viewer is a tool to visualize and analyze molecular interactions, complexes and pathways. The BIND interaction viewer uses Ontoglyphs to display information about a protein via attributes such as molecular function, biological process and sub-cellular localization. Ontoglyphs allow to graphically and interactively explore interaction networks, by visualizing interactions in the context of 34 functional, 25 binding specificity and 24 sub-cellular localization Ontoglyphs categories. We will continue to provide an open access version of BOND, providing its subscribers with free, unlimited access to a core content set. But we are confident you will soon want to upgrade to BONDplus. gene, genes, genome, annotation, binding specificity, biological process, complex, dna, genomes, genomic, human, interaction, interactome, ligand, metabolomic, molecular, molecular complex, molecular function, molecular interaction, mouse, ontoglyphs, ontology terms, pathway, photon, protein, protein-protein interactions, proteomic, rna, sequence, structure, sub-cellular localization, taxonomy, unclassified biological entity THIS RESOURCE IS NO LONGER IN SERVICE nif-0000-00571 SCR_007433 BOND 2026-02-11 10:57:33 17
Arvados
 
Resource Report
Resource Website
1+ mentions
Arvados (RRID:SCR_002223) arvados storage service resource, service resource, data repository Bioinformatics platform for storing, organizing, processing, and sharing genomic and other biomedical big data. Designed to make it easier for bioinformaticians to develop analyses, developers to create genomic web applications and IT administers to manage large-scale compute and storage genomic resources. Designed to run on top of cloud operating systems such as Amazon Web Services and OpenStack. Currently, there are implementations that work on AWS and Xen+Debian/Ubuntu. Functionally, Arvados has two major sets of capabilities: (a) data management and (b) compute management. mapreduce/hadoop, genomic, biomedical, data sharing, compute, data management, cloud is listed by: Debian Free, Freely available OMICS_01835 https://sources.debian.org/src/arvados/ SCR_002223 2026-02-11 10:56:25 3
ApiDB ToxoDB
 
Resource Report
Resource Website
100+ mentions
ApiDB ToxoDB (RRID:SCR_013453) ApiDB ToxoDB data or information resource, database A genome and functional genomic database for the protozoan parasite Toxoplasma gondii. It incorporates the sequence and annotation of the T. gondii ME49 strain, as well as genome sequences for the GT1, VEG and RH (Chr Ia, Chr Ib) strains. Sequence information is integrated with various other genomic-scale data, including community annotation, ESTs, gene expression and proteomics data. Organisms * Toxoplasma gondii (ME49, RH, GT1, Veg strains) * Neospora caninum * environmental isolate sequences from numerous species Tools * BLAST: Identify Sequence Similarities * Sequence Retrieval: Retrieve Specific Sequences using IDs and coordinates * PubMed and Entrez: View the Latest Toxoplasma, Neospora Pubmed and Entrez Results * Genome Browser: View Sequences and Features in the genome browser * Ancillary Genome Browse: Access Additional info like Probeset data and Toxoplasma Array info end-sequencing, bac clone, data mining tool, microarray, proteomic sequencing, toxoplasma gondii, bac clone, 8x random shotgun, genomic sequencing project, snp, qtl, sequencing, genomic, non-vertebrate, unicellular, eukaryote, genome, pathogen, toxoplasmosis, bio.tools, FASEB list is listed by: bio.tools
is listed by: Debian
has parent organization: Eukaryotic Pathogen Database Resources
NIAID contract HHSN266200400037C PMID:18003657
PMID:12519989
nif-0000-03572, biotools:toxodb https://bio.tools/toxodb http://ToxoDB.org SCR_013453 Toxoplasma Genomics Resource, ToxoDB 2026-02-11 10:58:52 137
Genes, Genome Features and Maps
 
Resource Report
Resource Website
1+ mentions
Genes, Genome Features and Maps (RRID:SCR_017524) data or information resource, database Searchable database of mouse genes, DNA segments, cytogenetic markers and QTLs. MGI provides access to integrated data on mouse genes and genome features, from sequences and genomic maps to gene expression and disease models. Data, mouse, gene, DNA, segment, cytogenetic, marker, MGI, genome, feature, sequenced, genomic, map, expression, disease, model Free, Freely available SCR_017524 2026-02-11 10:59:42 5
Comparative Biomedical Sciences Graduate Program
 
Resource Report
Resource Website
1+ mentions
Comparative Biomedical Sciences Graduate Program (RRID:SCR_008304) training resource, postdoctoral program resource The Comparative Biomedical Sciences Graduate Degree program provides exceptional graduate research training in core areas of animal and human health including genomics, immunology, molecular and cellular biology, physiology, infectious disease, neuroscience, pharmacology and toxicology, and oncology. Seventy-five faculty members in a diverse number of UW departments including Bacteriology, Biochemistry, Medical Microbiology and Immunology, Medicine, Oncology, Pathology, Radiology in addition to the 4 departments of the School of Veterinary Medicine are trainers in the program. These internationally recognized professors, as well as the integrative nature of our program, provide outstanding and unique research opportunities for our students. Because the University of Wisconsin is consistently ranked as one of the best 10 graduate institutions in the nation, the strength of our program is not only due to the superb research and teaching of our faculty but also due to the University as a whole. Approximately 55 students, most of whom are Ph.D. candidates, are currently enrolled in the program. Research strategies and academic curricula are tailored to the specific needs of each individual student. Graduates from our program are highly successful in the biotechnology industry and at top-ranked research institutions in the U.S. and abroad. The Comparative Biomedical Sciences Graduate Program offers a diverse number of research opportunities in multiple fields of study. A brief description of some of the major areas of research being performed by faculty affiliated with the Comparative Biomedical Sciences Graduate Program is provided below. Use the pull down menu above or click on the heading to find faculty members doing research in these areas. Sponsors: CBMS is supported by the University of Wisconsin animal, biology, biomedical, cellular, comparative, disease, genomic, health, human, immunology, infectious, medicine, microbiology, molecular, neuroscience, oncology, pharmacology, physiology, radiology, science, toxicology has parent organization: University of Wisconsin-Madison; Wisconsin; USA nif-0000-24383 http://www.vetmed.wisc.edu/pbs/gradprogram/index.shtml SCR_008304 CBMS 2026-02-11 10:57:59 2
Bioconductor
 
Resource Report
Resource Website
10000+ mentions
Bioconductor (RRID:SCR_006442) software repository, software resource, software toolkit Software repository for R packages related to analysis and comprehension of high throughput genomic data. Uses separate set of commands for installation of packages. Software project based on R programming language that provides tools for analysis and comprehension of high throughput genomic data. catalog, analysis, genomic, metadata, comprehension, statistical, data lists: MSstats
lists: MetaCyto
lists: MetaNeighbor
lists: tximport
lists: clusterProfiler
lists: ropls
lists: FlowSOM
lists: scran
lists: Rsubread
lists: riboSeqR
lists: Biostrings
lists: ConsensusClusterPlus
lists: DESeq2
lists: GenomicFeatures
lists: affy
lists: affydata
lists: Genomic Ranges
lists: Goseq
lists: GAGE
lists: CATALYST
lists: Scmap
lists: Scfind
lists: GenomicRanges
lists: org.Rn.eg.db
lists: Extending Guilt by Association by Degree
lists: ggtree
lists: StructuralVariantAnnotation
lists: scTHI
lists: EnhancedVolcano
lists: DEGreport
lists: variancePartition
lists: biomaRt
lists: MSnbase
lists: ReactomePA
lists: SynergyFinder
lists: CiteFuse
lists: fgsea
lists: GSVA
lists: SimFFPE
lists: FilterFFPE
lists: PhenStat
lists: ChIPseeker
lists: AUCell
lists: svaNUMT
lists: KEGGgraph
lists: epialleleR
lists: microbiome
lists: Orthology.eg.db
lists: org.Hs.eg.db
lists: ExperimentHub
lists: combi
is listed by: OMICtools
is listed by: Gene Ontology Tools
is listed by: SoftCite
is affiliated with: RnaSeqGeneEdgeRQL
is related to: asSeq
is related to: Gene Ontology
is related to: CRCView
is related to: R Project for Statistical Computing
is related to: GEO2R
is related to: LIMMA
is related to: VisR
is related to: edgeR
is related to: IMEx - The International Molecular Exchange Consortium
is related to: CATALYSTLite
is related to: ascend
is related to: minet
has parent organization: Fred Hutchinson Cancer Center
is parent organization of: ncdfFlow
is parent organization of: GenomicRanges
is parent organization of: ReadqPCR
is parent organization of: flowCL
is parent organization of: flowBin
is parent organization of: CorMut
is parent organization of: metaSeq
is parent organization of: VariantAnnotation
is parent organization of: ReQON
is parent organization of: timecourse
is parent organization of: RmiR.Hs.miRNA
is parent organization of: AffyRNADegradation
is parent organization of: ArrayExpress (R)
is parent organization of: GEOquery
is parent organization of: MIMOSA
is parent organization of: HEM
is parent organization of: CNTools
is parent organization of: cn.FARMS
is parent organization of: Clonality
is parent organization of: TransView
is parent organization of: pvac
is parent organization of: QUALIFIER
is parent organization of: flowStats
is parent organization of: rTANDEM
is parent organization of: flowFlowJo
is parent organization of: iASeq
is parent organization of: OLINgui
is parent organization of: SigFuge
is parent organization of: Rdisop
is parent organization of: GeneExpressionSignature
is parent organization of: iBMQ
is parent organization of: TDARACNE
is parent organization of: flowQ
is parent organization of: FlipFlop
is parent organization of: RmiR
is parent organization of: bsseq
is parent organization of: ExomePeak
is parent organization of: flowWorkspace
is parent organization of: massiR
is parent organization of: rbsurv
is parent organization of: GeneMeta
is parent organization of: MergeMaid
is parent organization of: categoryCompare
is parent organization of: metahdep
is parent organization of: snpStats: SnpMatrix and XSnpMatrix classes and methods
is parent organization of: CNVtools
is parent organization of: CGEN
is parent organization of: RCASPAR
is parent organization of: iterativeBMAsurv
is parent organization of: multtest
is parent organization of: globaltest
is parent organization of: MinimumDistance
is parent organization of: VegaMC
is parent organization of: VanillaICE
is parent organization of: SNPchip
is parent organization of: SMAP
is parent organization of: quantsmooth
is parent organization of: mBPCR
is parent organization of: ITALICS
is parent organization of: GenoSet
is parent organization of: exomeCopy
is parent organization of: CGHregions
is parent organization of: CGHbase
is parent organization of: beadarraySNP
is parent organization of: GLAD
is parent organization of: methylMnM
is parent organization of: methyAnalysis
is parent organization of: ARRmNormalization
is parent organization of: ChIPsim
is parent organization of: yaqcaffy
is parent organization of: wateRmelon
is parent organization of: sRAP
is parent organization of: spotSegmentation
is parent organization of: SNM
is parent organization of: SNAGEE
is parent organization of: Simpleaffy
is parent organization of: qcmetrics
is parent organization of: MANOR
is parent organization of: limmaGUI
is parent organization of: ffpe
is parent organization of: dyebias
is parent organization of: DEXUS
is parent organization of: BeadDataPackR
is parent organization of: aroma.light
is parent organization of: ArrayTools
is parent organization of: beadarray
is parent organization of: arrayQuality
is parent organization of: arrayMvout
is parent organization of: affyQCReport
is parent organization of: affyPLM
is parent organization of: AffyExpress
is parent organization of: waveTiling
is parent organization of: gprege
is parent organization of: oneChannelGUI
is parent organization of: LMGene
is parent organization of: factDesign
is parent organization of: pickgene
is parent organization of: betr
is parent organization of: SCAN.UPC
is parent organization of: arrayQualityMetrics
is parent organization of: CALIB
is parent organization of: DEDS
is parent organization of: Harshlight
is parent organization of: MiChip
is parent organization of: OCplus
is parent organization of: bridge
is parent organization of: fRMA
is parent organization of: genArise
is parent organization of: lapmix
is parent organization of: maCorrPlot
is parent organization of: maSigPro
is parent organization of: MACAT
is parent organization of: maigesPack
is parent organization of: MDQC
is parent organization of: metaArray
is parent organization of: nnNorm
is parent organization of: plgem
is parent organization of: PVCA
is parent organization of: RAMA
is parent organization of: stepNorm
is parent organization of: virtualArray
is parent organization of: LPE
is parent organization of: vsn
is parent organization of: ACME
is parent organization of: CoGAPS
is parent organization of: flowFP
is parent organization of: rMAT
is parent organization of: SLqPCR
is parent organization of: nondetects
is parent organization of: unifiedWMWqPCR
is parent organization of: sSeq
is parent organization of: CNVrd2
is parent organization of: plateCore
is parent organization of: RSVSim
is parent organization of: TCC
is parent organization of: CQN
is parent organization of: COMPASS
is parent organization of: flowClust
is parent organization of: SPADE
is parent organization of: OrderedList
is parent organization of: SamSPECTRAL
is parent organization of: flowUtils
is parent organization of: RchyOptimyx
is parent organization of: TEQC
is parent organization of: flowType
is parent organization of: ADaCGH2
is parent organization of: flowViz
is parent organization of: flowTrans
is parent organization of: flowQB
is parent organization of: shinyTANDEM
is parent organization of: flowPlots
is parent organization of: flowPhyto
is parent organization of: flowCore
is parent organization of: flowMerge
is parent organization of: flowMap
is parent organization of: flowMeans
is parent organization of: spliceR
is parent organization of: flowMatch
is parent organization of: flowFit
is parent organization of: flowCyBar
is parent organization of: BEAT
is parent organization of: flowBeads
is parent organization of: CAMERA - Collection of annotation related methods for mass spectrometry data
is parent organization of: MBASED
is parent organization of: MethylAid
is parent organization of: sapFinder
is parent organization of: Pathview
is parent organization of: DSS
is parent organization of: RMassBank
is parent organization of: iontree
is parent organization of: Basic4Cseq
is parent organization of: BiGGR
is parent organization of: mzR
is parent organization of: PAPi
is parent organization of: CGHnormaliter
is parent organization of: Chimera
is parent organization of: BRAIN
is parent organization of: tweeDEseq
is parent organization of: SurvComp
is parent organization of: Triplex
is parent organization of: OmicCircos
is parent organization of: ggbio
is parent organization of: HTqPCR
is parent organization of: NormqPCR
is parent organization of: ddCt
is parent organization of: EasyqpcR
is parent organization of: SWAN
is parent organization of: PING
is parent organization of: DMRforPairs
is parent organization of: SeqGSEA
is parent organization of: h5vc
is parent organization of: deepSNV
is parent organization of: RUVSeq
is parent organization of: BHC
is parent organization of: epigenomix
is parent organization of: IRanges
is parent organization of: GeneNetworkBuilder
is parent organization of: MethylSeekR
is parent organization of: SRAdb
is parent organization of: casper
is parent organization of: htSeqTools
is parent organization of: ChIPXpress
is parent organization of: methVisual
is parent organization of: DeconRNASeq
is parent organization of: EDASeq
is parent organization of: RIPSeeker
is parent organization of: ShortRead
is parent organization of: seqbias
is parent organization of: DEGseq
is parent organization of: arrayMagic
is parent organization of: easyRNASeq
is parent organization of: DNAcopy
is parent organization of: CRLMM
is parent organization of: motifRG
is parent organization of: MMDiff
is parent organization of: MiRaGE
is parent organization of: LVSmiRNA
is parent organization of: ExiMiR
is parent organization of: RPA
is parent organization of: CexoR
is parent organization of: lumi
is parent organization of: baySeq
is parent organization of: tRanslatome
is parent organization of: DNaseR
is parent organization of: DEXSeq
is parent organization of: ChIPpeakAnno
is parent organization of: inSilicoMerging
is parent organization of: minfi
is parent organization of: Methylumi
is parent organization of: miRNApath
is parent organization of: sva package
is parent organization of: dmrFinder
is parent organization of: rqubic
is parent organization of: BicARE
is parent organization of: iBBiG
is parent organization of: eisa
is parent organization of: ChAMP
is parent organization of: cghMCR
is parent organization of: Bioconductor mailing list
is parent organization of: DiffBind
is parent organization of: NarrowPeaks
is parent organization of: CSAR
is parent organization of: CSSP
is parent organization of: TargetScore
is parent organization of: snapCGH
is parent organization of: iChip
is parent organization of: TurboNorm
is parent organization of: Ringo
is parent organization of: RLMM
is parent organization of: charm
is parent organization of: BiSeq
is parent organization of: MEDME
is parent organization of: MEDIPS
is parent organization of: BayesPeak
is parent organization of: ChIPseqR
is parent organization of: Rolexa
is parent organization of: cn.mops
is parent organization of: RankProd
is parent organization of: phyloseq
is parent organization of: HiTC
is parent organization of: CancerMutationAnalysis
is parent organization of: aCGH
is parent organization of: Repitools
is parent organization of: flowPeaks
is parent organization of: Mfuzz
is parent organization of: les
is parent organization of: OLIN
is parent organization of: affylmGUI
is parent organization of: CYCLE
is parent organization of: r3Cseq
is parent organization of: Piano
is parent organization of: RamiGO
hosts: DESeq
hosts: rGADEM
hosts: PICS
hosts: Jmosaics
hosts: R453Plus1Toolbox
hosts: BAC
hosts: targetscan.Hs.eg.db
hosts: Starr
hosts: Qvalue
hosts: topGO
hosts: MmPalateMiRNA
hosts: CGHcall
hosts: EGSEA
hosts: NOISeq
Catt Family Foundation ;
Dana Farber Cancer Institute ;
NHGRI R33 HG002708
PMID:15461798 Free, Freely available OMICS_01759, nif-0000-10445 SCR_006442 2026-02-11 10:57:24 22974
Transterm
 
Resource Report
Resource Website
10+ mentions
Transterm (RRID:SCR_008244) data or information resource, database Database that provides access to mRNA sequences and associated regulatory elements that were processed from Genbank. These mRNA sequences include complete genomes, which are divided into 5-prime UTRs, 3-prime UTRs, initiation sequences, termination regions and full CDS sequences. This data can be searched for a range of properties including specific mRNA sequences, mRNA motifs, codon usage, RSCU values, information content, etc. element, gene, 3' utr, 5' utr, codon, genome, genomic, initiation, motif, mrna, nucleotide sequences, transcriptional regulator sites, transcription factors databases, region, regulatory, rna sequence, species, termination is listed by: Debian
is listed by: OMICtools
has parent organization: University of Otago; Dunedin; New Zealand
DOI:10.1186/gb-2007-8-2-r22 Public nif-0000-21399, OMICS_06165 https://sources.debian.org/src/transtermhp/ http://uther.otago.ac.nz/Transterm.html SCR_008244 2026-02-11 10:57:58 17
PrimerStudio
 
Resource Report
Resource Website
1+ mentions
PrimerStudio (RRID:SCR_008232) data or information resource, database PrimerParadise is an online PCR primer database for genomics studies. The database contains predesigned PCR primers for amplification of exons, genes and SNPs of almost all sequenced genomes. Primers can be used for genome-wide projects (resequencing, mutation analysis, SNP detection etc). The primers for eukaryotic genomes have been tested with e-PCR to make sure that no alternative products will be generated. Also, all eukaryotic primers have been filtered to exclude primers that bind excessively throughout the genome. Genes are amplified as amplicons. Amplicons are defined as only one genes exons containing maximaly 3000 bp long dna segments. If gene is longer than 3000 bp then it is split into the segments at length 3000 bp. So for example gene at length 5000 bp is split into two segment and for both segments there were designed a separate primerpair. If genes exons length is over 3000 bp then it is split into amplicons as well. Every SNP has one primerpair. In addition of considering repetitive sequences and mono-dinucleotide repeats, we avoid designing primers to genome regions which contain other SNPs. -There are two ways to search for primers: you can use features IDs ( for SNP primers Reference ID, for gene/exon primers different IDs (Ensembl gene IDs, HUGO IDs for human genes, LocusLink IDs, RefSeq IDs, MIM IDs, NCBI gene names, SWISSPROT IDs for bacterial genes, VEGA gene IDs for human and mouse, Sanger S.pombe systematic gene names and common gene names, S.cerevisiae GeneBanks Locus, AccNo, GI IDs and common gene names) -you can use genome regions (chromosome coordinates, chromosome bands if exists) -Currently we provide 3 primers collections: proPCR for prokaryotic organisms genes primers -euPCR for eukaryotic organisms genes/exons primers -snpPCR for eukaryotic organisms SNP primers Sponsors: PrimerStudio is funded by the University of Tartu. eukaryotic, exon, gene, amplicon, amplifcation, analysis, dinucleotide, dna, genome, genomic, molecular probe and primer databases, mononucleotide, mutation, organism, pcr, primer, prokaryotic, region, repetitive, segment, sequence, snp, snp detection nif-0000-21334 SCR_008232 PrimerStudio 2026-02-11 10:57:48 1
Alizadehlab: MeeboChip and HeeboChip Open Source Project
 
Resource Report
Resource Website
1+ mentions
Alizadehlab: MeeboChip and HeeboChip Open Source Project (RRID:SCR_008384) data or information resource, database This is an open-source Mouse Exonic Evidence-Based Oligonucleotide Chip (MEEBOChip), and are in the process of building the human counterpart, HEEBOChip. The set of 70mers for MEEBOChip is already available from Illumina, Inc., with synthesis of HEEBOChip 70mers in progress. Both arrays are based on a novel selection of exonic long-oligonucleotides (70-mers) from a genomic annotation of the corresponding complete genome sequences, using a transcriptome-based annotation of exon structure for each genomic locus. Using a combination of existing and custom-tailored tools and datasets (including millions of mRNA and EST sequences), we built and performed a systematic examination of transcript-supported exon structure for each genomic locus at the base-pair level (i.e., exonic evidence). This strategy allowed them to select both constitutive and in many cases alternative exons for nearly every gene in the corresponding genome (e.g., protocadherin locus), allowing an unprecedented exploration of human and mouse biology. Furthermore, they used experimentally derived data to hone the selection of these 70mers, helping maximize their performance under typical fluorescent labeling and hybridization conditions. Specifically, they applied and refined the ArrayOligoSelector algorithm from Joe DeRisis laboratory to select 70mers, considering not only their uniqueness (i.e., hybridization specificity) within the content of the entire genome, but also to overcome the known biases of labeling and hybridization methods (e.g., 3-biased reverse transcription and in vitro transcription reactions). mouse, exonic, evidence, oligonucleotide, chip, human, array, genomic, annoation, sequence, transcriptome, annotation, dataset, mrna, est, systematic, transcript, exon, locus, biology has parent organization: Stanford University; Stanford; California Stanford University ;
UCSF ;
Stowers-Institute ;
Rockefeller University ;
Basel University
nif-0000-30030 SCR_008384 MeeboChip and HeeboChip 2026-02-11 10:57:49 7
Plasmid Genome Database
 
Resource Report
Resource Website
10+ mentions
Plasmid Genome Database (RRID:SCR_008228) data or information resource, database The Plasmid Genome Database aims to collate biological and genomic data for all bacterial plasmids in the hopes of enabling rapid, interrogation of both meta- and genomic data. Data maintained includes access to all plasmid genomes and information on core genomic features obtained from parsing the original EMBL/DDBJ/NCBI submission. In addition a suite of third party analyses has been performed for each genome to supplement the original annotation. This site also links to Genome Atlases provided by the Centre for Biological Sequence Analysis (CBS). The motivation behind the construction of this site derived from observations from genome sequencing projects: the abundance and inferred importance of the horizontal gene pool (HGP) in bacterial adaptation and evolution. In so far as plasmids are autonomously replicating, extrachromosomal elements they are a readily identifiable and accessible component of the HGP. Also plasmids have been identified in almost all bacterial divisions, ranging in size from less than 2 kbp to > 1.5 Mbp and as such represent a defined, yet diverse and complex sample of genes in the HGP. element, evolution, extrachromosomal, gene, adaptation, atlas, autonomous, bacterial, biological, division, genome, genomic, hgp, plasmid, pool, prokaryote databases, replicate nif-0000-21323 http://www.genomics.ceh.ac.uk/plasmiddb/ SCR_008228 PGD 2026-02-11 10:57:58 21
MIPS Ustilago maydis Database
 
Resource Report
Resource Website
1+ mentions
MIPS Ustilago maydis Database (RRID:SCR_007563) data or information resource, database The MIPS Ustilago maydis Genome Database aims to present information on the molecular structure and functional network of the entirely sequenced, filamentous fungus Ustilago maydis. The underlying sequence is the initial release of the high quality draft sequence of the Broad Institute. The goal of the MIPS database is to provide a comprehensive genome database in the Genome Research Environment in parallel with other fungal genomes to enable in depth fungal comparative analysis. The specific aims are to: 1. Generate and assemble Whole Genome Shotgun sequence reads yielding 10X coverage of the U. maydis genome 2. Integrate the genomic sequence assembly with physical maps generated by Bayer CropScience 3. Perform automated annotation of the sequence assembly 4. Align the strain 521 assembly with the FB1 assembly provided by Exelixis 5. Release the sequence assembly and results of our annotation and analysis to public Ustilago maydis is a basidiomycete fungal pathogen of maize and teosinte. The genome size is approximately 20 Mb. The fungus induces tumors on host plants and forms masses of diploid teliospores. These spores germinate and form haploid meiotic products that can be propagated in culture as yeast-like cells. Haploid strains of opposite mating type fuse and form a filamentous, dikaryotic cell type that invades plant tissue to reinitiate infection. Ustilago maydis is an important model system for studying pathogen-host interactions and has been studied for more than 100 years by plant pathologists. Molecular genetic research with U. maydis focuses on recombination, the role of mating in pathogenesis, and signaling pathways that influence virulence. Recently, the fungus has emerged as an excellent experimental model for the molecular genetic analysis of phytopathogenesis, particularly in the characterization of infection-specific morphogenesis in response to signals from host plants. Ustilago maydis also serves as an important model for other basidiomycete plant pathogens that are more difficult to work with in the laboratory, such as the rust and bunt fungi. Genomic sequence of U. maydis will also be valuable for comparative analysis of other fungal genomes, especially with respect to understanding the host range of fungal phytopathogens. The analysis of U. maydis would provide a framework for studying the hundreds of other Ustilago species that attack important crops, such as barley, wheat, sorghum, and sugarcane. Comparisons would also be possible with other basidiomycete fungi, such as the important human pathogen C. neoformans. Commercially, U. maydis is an excellent model for the discovery of antifungal drugs. In addition, maize tumors caused by U. maydis are prized in Hispanic cuisine and there is interest in improving commercial production. The complete putative gene set of the Broad Institute''s second release is loaded into the database and in addition all deviating putative genes from a putative gene set produced by MIPS with different gene prediction parameters are also loaded. The complete dataset will then be analysed, gene predictions will be manually corrected due to combined information derived from different gene prediction algorithms and, more important, protein and EST comparisons. Gene prediction will be restricted to ORFs larger than 50 codons; smaller ORFs will be included only if similarities to other proteins or EST matches confirm their existence or if a coding region was postulated by all prediction programs used. The resulting proteins will be annotated. They will be classified according to the MIPS classification catalogue receiving appropriate descriptions. All proteins with a known, characterized homolog will be automatically assigned to functional categories using the MIPS functional catalog. All extracted proteins are in addition automatically analysed and annotated by the PEDANT suite. drug, environment, filamentous, functional, fungal, fungal genome databases, fungus, gene, genetic, basidiomycete, cell, codon, culture, dikaryotic, diploid, genome, genomic, germinate, haploid, host, human, infection, maize, mating, meiotic, model, molecular, morphogenesis, network, orf, pathogen, pathologist, phytopathogen, phytopathogenesis, plant, protein, recombination, sequence, signal, spore, strain, structure, teliospore, teosinte, tissue, tumor, ustilago maydis, virulence, yeast nif-0000-21276 SCR_007563 MUMDB 2026-02-11 10:57:37 9
Microbial Genomics Program
 
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1+ mentions
Microbial Genomics Program (RRID:SCR_008140) data or information resource, database Through its Microbial Genome Program (MGP) and its Genomics:GTL (GTL) program, DOEs Office of Biological and Environmental Research (BER) has sequenced more than 485 microbial genomes and 30 microbial communities having specialized biological capabilities. Identifying these genes will help investigators discern how gene activities in whole living systems are orchestrated to solve myriad life challenges. The MGP was begun in 1994 as a spinoff from the Human Genome Program. The goal of the program was to sequence the genomes of a number of nonpathogenic microbes that would be useful in solving DOE''s mission challenges in environmental-waste cleanup, energy production, carbon cycling, and biotechnology. Past projects include microbial genome program, microbial cell project, and the Laboratory Science Program at the DOE Joint Genome Institute. The two ongoing projects are Genomics: GTL program and Community Sequencing Program at the DOE Joint Genome Institute. Sponsors: Site sponsored by the U.S. Department of Energy Office of Science, Office of Biological and Environmental Research, THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025. energy, environmental, gene, biological, biotechnology, carbon, community, cylcling, genome, genomic, living, microbes, microbial, nonpathogenic, system has parent organization: United States Department of Energy THIS RESOURCE IS NO LONGER IN SERVICE nif-0000-20962 SCR_008140 MGP 2026-02-11 10:57:56 2
AnoBase: An Anopheles database
 
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Resource Website
1+ mentions
AnoBase: An Anopheles database (RRID:SCR_008166) data or information resource, database THIS RESOURCE IS NO LONGER IN SERVICE. Documented on November 22, 2023. A database containing genomic/biological information on anopheline mosquitoes, with an emphasis on Anopheles gambiae, the world''''s most important malaria vector. AnoBase is an integrated, relational database of basic biological and genetic data on anopheline species, with a particular emphasis on Anopheles gambiae. It has been designed as an information source and research support tool for the broad vector biology community. Although AnoBase is not a primary genomic database that develops and provides tools to access the genome of the malaria mosquito, it nevertheless contains several sections that offer data of genomic interest such as in situ hybridization images, an integrated gene tool and direct online access to AnoXcel, the proteomic database of An. gambiae. Moreover, AnoBase also contains information on non-gambiae mosquito species and a novel section on studies related to insecticide resistance. gene, genetic, anopheles gambiae, anopheline, biological, biology, community, genomic, in-situ hybridization, insecticide, invertebrate databases, malaria, mosquito, proteomic, specie, vector, image is related to: VectorBase
has parent organization: Foundation for Research and Technology-Hellas; Heraklion; Greece
is parent organization of: Malaria Ontology
NIAID THIS RESOURCE IS NO LONGER IN SERVICE nif-0000-21031 http://www.anobase.org/ SCR_008166 AnoBase 2026-02-11 10:57:46 2
Migratory Locust EST Database
 
Resource Report
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1+ mentions
Migratory Locust EST Database (RRID:SCR_008201) data or information resource, database The migratory locust (Locusta migratoria) is an orthopteran pest and a representative member of hemimetabolous insects. Its transcriptomic data provide invaluable information for molecular entomology study of the insect and pave a way for comparative studies of other medically, agronomically, and ecologically relevant insects. This first transcriptomic database of the locust (LocustDB) has been developed, building necessary infrastructures to integrate, organize, and retrieve data that are either currently available or to be acquired in the future. It currently hosts 45,474 high quality EST sequences from the locust, which were assembled into 12,161 unigenes. This database contains original sequence data, including homologous/orthologous sequences, functional annotations, pathway analysis, and codon usage, based on conserved orthologous groups (COG), gene ontology (GO), protein domain (InterPro), and functional pathways (KEGG). It also provides information from comparative analysis based on data from the migratory locust and five other invertebrate species, such as the silkworm, the honeybee, the fruitfly, the mosquito and the nematode. LocustDB also provides information from comparative analysis based on data from the migratory locust and five other invertebrate species, such as the silkworm, the honeybee, the fruitfly, the mosquito and the nematode. It starts with the first transcriptome information for an orthopteran and hemimetabolous insect and will be extended to provide a framework for incorporation of in-coming genomic data of relevant insect groups and a workbench for cross-species comparative studies. ecologically, entomology, est, fruitfly, functional, gene, agronomically, analysis, annotation, codon, comparative, data, domain, genomic, hemimetabolous, homologous, honeybee, insect, invertebrate, invertebrate databases, locust, locusta migratoria, medically, migratory, molecular, mosquito, nematode, orthologous, orthopteran, pathway, pest, protein, sequence, silkworm, specie, transcriptome, transcriptomic, unigene, ontology has parent organization: BGI; Shenzhen; China nif-0000-21244 SCR_008201 LocustDB 2026-02-11 10:57:46 7
Influenza Research Database (IRD)
 
Resource Report
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10+ mentions
Influenza Research Database (IRD) (RRID:SCR_006641) IRD analysis service resource, data repository, service resource, production service resource, storage service resource, database, data analysis service, data or information resource The Influenza Research Database (IRD) serves as a public repository and analysis platform for flu sequence, experiment, surveillance and related data. avian, clinical, genomic, host, influenza, isolate, mammalian, nonhuman, phenotypic, preventive, proteomic, repository, strain, epitope, surveillance, treatment, virus, protein sequence, immune, 3d protein structure, align, blast, short peptide, flu protein, sequence variation, snp, phylogenetic tree, human, 3d spacial image, image, clinical data, clinical, genomic, proteomic, phenotype is recommended by: NIDDK Information Network (dkNET)
is listed by: DataCite
is listed by: re3data.org
is listed by: FAIRsharing
is related to: Los Alamos National Laboratory
is related to: University of California at Davis; California; USA
is related to: Sage Analytica
is related to: J. Craig Venter Institute
has parent organization: University of Texas Southwestern Medical Center; Texas; USA
has parent organization: Los Alamos National Laboratory
has parent organization: Sage Analytica
Influenza virus, Influenza NIAID PMID:17965094 Acknowledgement requested, The community can contribute to this resource DOI:10.25504/FAIRsharing.ws7cgw, nif-0000-21222, DOI:10.35094, DOI:10.17616/R3S634, r3d100011558 https://www.fludb.org/
https://doi.org/10.17616/R3S634
https://doi.org/10.17616/r3s634
https://doi.org/10.35094/
https://dx.doi.org/10.35094/
https://fairsharing.org/10.25504/FAIRsharing.ws7cgw
https://doi.org/10.17616/R3S634
http://www.fludb.org/brc/home.do?decorator=influenza SCR_006641 , Influenza Research Database, IRD 2026-02-12 09:44:23 28
Descriptions of Plant Viruses
 
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Descriptions of Plant Viruses (RRID:SCR_006656) data or information resource, portal, database, topical portal DPVweb provides a central source of information about viruses, viroids and satellites of plants, fungi and protozoa. Comprehensive taxonomic information, including brief descriptions of each family and genus, and classified lists of virus sequences are provided. The database also holds detailed, curated, information for all sequences of viruses, viroids and satellites of plants, fungi and protozoa that are complete or that contain at least one complete gene. For comparative purposes, it also contains a single representative sequence of all other fully sequenced virus species with an RNA or single-stranded DNA genome. The start and end positions of each feature (gene, non-translated region and the like) have been recorded and checked for accuracy. As far as possible, nomenclature for genes and proteins are standardized within genera and families. Sequences of features (either as DNA or amino acid sequences) can be directly downloaded from the website in FASTA format. The sequence information can also be accessed via client software for PC computers (freely downloadable from the website) that enable users to make an easy selection of sequences and features of a chosen virus for further analyses. The public sequence databases contain vast amounts of data on virus genomes but accessing and comparing the data, except for relatively small sets of related viruses can be very time consuming. The procedure is made difficult because some of the sequences on these databases are incorrectly named, poorly annotated or redundant. The NCBI Reference Sequence project (1) provides a comprehensive, integrated, non-redundant set of sequences, including genomic DNA, transcript (RNA) and protein products, for major research organisms. This now includes curated information for a single sequence of each fully sequenced virus species. While this is a welcome development, it can only deal with complete sequences. An important feature of DPV is the opportunity to access genes (and other features) of multiple sequences quickly and accurately. Thus, for example, it is easy to obtain the nucleotide or amino acid sequences of all the available accessions of the coat protein gene of a given virus species or for a group of viruses. To increase its usefulness further, DPVweb also contains a single representative sequence of all other fully sequenced virus species with an RNA or single-stranded DNA (ssDNA) genome. Sponsors: This site is supported by the Association of Applied Biologists and the Zhejiang Academy of Agricultural Sciences, Hangzhou, People''s Republic of China. family, fungi, gene, amino acid, comparative, development, dna, genome, genomic, genus, nomenclature, non-translated, nucleotide, organism, plant, product, protein, protozoa, region, rna, satellite, sequence, single, specie, taxonomic, transcript, viral databases, viroid, virus, bio.tools is listed by: bio.tools
is listed by: Debian
nif-0000-21127, biotools:dpvweb https://bio.tools/dpvweb SCR_006656 DPV 2026-02-12 09:44:26 11
InParanoid: Eukaryotic Ortholog Groups
 
Resource Report
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100+ mentions
InParanoid: Eukaryotic Ortholog Groups (RRID:SCR_006801) InParanoid analysis service resource, service resource, production service resource, database, data analysis service, data or information resource Collection of pairwise comparisons between 100 whole genomes generated by a fully automatic method for finding orthologs and in-paralogs between TWO species. Ortholog clusters in the InParanoid are seeded with a two-way best pairwise match, after which an algorithm for adding in-paralogs is applied. The method bypasses multiple alignments and phylogenetic trees, which can be slow and error-prone steps in classical ortholog detection. Still, it robustly detects complex orthologous relationships and assigns confidence values for in-paralogs. The original data sets can be downloaded. protein, ortholog, genome, drosophila pseudoobscura, duplication, entamoeba histolytica, escherichia colik12, eukaryotic, gasterosteus aculeatus, gene, aedes aegypti, apis mellifera, bos taurus, caenorhabditis remanei, candida glabrata, canis familiaris, ciona intestinalis, cryptococcus neoformans, debaromyces hansenii, dictyostelium discoideum, genomic, homolog, inparalog, kluyveromyces lactis, macaca mulatta, monodelphis domestica, orthology, oryza sativa, outparalog, proteome, tetraodon nigroviridis, xenopus tropicalis, blast, proteome, ortholog cluster, cluster, in-paralog, paralog, automatic clustering, genome comparison, FASEB list has parent organization: Stockholm University; Stockholm; Sweden Swedish Research Council ;
Karolinska Institutet; Stockholm; Sweden ;
Pfizer Corporation
PMID:19892828
PMID:18055500
PMID:15608241
PMID:11743721
Acknowledgement requested nif-0000-03024 http://www.cgb.ki.se/inparanoid/ SCR_006801 Inparanoid eukaryotic ortholog database 2026-02-12 09:44:24 186
Mouse Genome Databases
 
Resource Report
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1+ mentions
Mouse Genome Databases (RRID:SCR_007147) MGD topical portal, database, organism-related portal, data or information resource, portal, data set A mouse-related portal of genomic databases and tables of mouse brain data. Most files are intended for you to download and use on your own personal computer. Most files are available in generic text format or as FileMaker Pro databases. The server provides data extracted and compiled from: The 2000-2001 Mouse Chromosome Committee Reports, Release 15 of the MIT microsatellite map (Oct 1997), The recombinant inbred strain database of R.W. Elliott (1997) and R. W. Williams (2001), and the Map Manager and text format chromosome maps (Apr 2001). * LXS genotype (Excel file): Updated, revised positions for 330 markers genotyped using a panel of 77 LXS strain. * MIT SNP DATABASE ONLINE: Search and sort the MIT Single Nucleotide Polymorphism (SNP) database ONLINE. These data from the MIT-Whitehead SNP release of December 1999. * INTEGRATED MIT-ROCHE SNP DATABASE in EXCEL and TEXT FORMATS (1-3 MB): Original MIT SNPs merged with the new Roche SNPs. The Excel file has been formatted to illustrate SNP haplotypes and genetic contrasts. Both files are intended for statistical analyses of SNPs and can be used to test a method outlined in a paper by Andrew Grupe, Gary Peltz, and colleagues (Science 291: 1915-1918, 2001). The Excel file includes many useful equations and formatting that will help in navigating through this large database and in testing the in silico mapping method. * Use of inbred strains for the study of individual differences in pain related phenotypes in the mouse: Elissa J. Chesler''s 2002 dissertation, discussing issues relevant to the integration of genomic and phenomic data from standard inbred strains including genetic interactions with laboratory environmental conditions and the use of various in silico inbred strain haplotype based mapping algorithms for QTL analysis. * SNP QTL MAPPER in EXCEL format (572 KB, updated January 2002 by Elissa Chesler): This Excel workbook implements the Grupe et al. mapping method and outputs correlation plots. The main spreadsheet allows you to enter your own strain data and compares them to haplotypes. Be very cautious and skeptical when using this spreadsheet and the technique. Read all of the caveates. This excel version of the method was developed by Elissa Chesler. This updated version (Jan 2002) handles missing data. * MIT SNP Database (tab-delimited text format): This file is suitable for manipulation in statistics and spreadsheet programs (752 KB, Updated June 27, 2001). Data have been formatted in a way that allows rapid acquisition of the new data from the Roche Bioscience SNP database. * MIT SNP Database (FileMaker 5 Version): This is a reformatted version of the MIT Single Nucleotide Polymorphism (SNP) database in FileMaker 5 format. You will need a copy of this application to open the file (Mac and Windows; 992 KB. Updated July 13, 2001 by RW). * Gene Mapping and Map Manager Data Sets: Genetic maps of mouse chromosomes. Now includes a 10th generation advanced intercross consisting of 500 animals genetoyped at 340 markers. Lots of older files on recombinant inbred strains. * The Portable Dictionary of the Mouse Genome, 21,039 loci, 17,912,832 bytes. Includes all 1997-98 Chromosome Committee Reports and MIT Release 15. * FullDict.FMP.sit: The Portable Dictionary of the Mouse Genome. This large FileMaker Pro 3.0/4.0 database has been compressed with StuffIt. The Dictionary of the Mouse Genome contains data from the 1997-98 chromosome committee reports and MIT Whitehead SSLP databases (Release 15). The Dictionary contains information for 21,039 loci. File size = 4846 KB. Updated March 19, 1998. * MIT Microsatellite Database ONLINE: A database of MIT microsatellite loci in the mouse. Use this FileMaker Pro database with OurPrimersDB. MITDB is a subset of the Portable Dictionary of the Mouse Genome. ONLINE. Updated July 12, 2001. * MIT Microsatellite Database: A database of MIT microsatellite loci in the mouse. Use this FileMaker Pro database with OurPrimersDB. MITDB is a subset of the Portable Dictionary of the Mouse Genome. File size = 3.0 MB. Updated March 19, 1998. * OurPrimersDB: A small database of primers. Download this database if you are using numerous MIT primers to map genes in mice. This database should be used in combination with the MITDB as one part of a relational database. File size = 149 KB. Updated March 19, 1998. * Empty copy (clone) of the Portable Dictionary in FileMaker Pro 3.0 format. Download this file and import individual chromosome text files from the table into the database. File size = 231 KB. Updated March 19, 1998. * Chromosome Text Files from the Dictionary: The table lists data on gene loci for individual chromosomes. gene, genetic, chromosome, genotype, inbred mouse strain, pain, phenotype, polygenic, recombinant, trait, genome, genomic, single nucleotide polymorphism, primer, brain, recombinant inbred mouse strain has parent organization: University of Tennessee Health Science Center; Tennessee; USA nif-0000-20982 SCR_007147 2026-02-12 09:44:31 2
Tetraodon Genome Browser
 
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1+ mentions
Tetraodon Genome Browser (RRID:SCR_007079) data or information resource, portal, database, topical portal The initial objective of Genoscope was to compare the genomic sequences of this fish to that of humans to help in the annotation of human genes and to estimate their number. This strategy is based on the common genetic heritage of the vertebrates: from one species of vertebrate to another, even for those as far apart as a fish and a mammal, the same genes are present for the most part. In the case of the compact genome of Tetraodon, this common complement of genes is contained in a genome eight times smaller than that of humans. Although the length of the exons is similar in these two species, the size of the introns and the intergenic sequences is greatly reduced in this fish. Furthermore, these regions, in contrast to the exons, have diverged completely since the separation of the lineages leading to humans and Tetraodon. The Exofish method, developed at Genoscope, exploits this contrast such that the conserved regions which can be identified by comparing genomic sequences of the two species, correspond only to coding regions. Using preliminary sequencing results of the genome of Tetraodon in the year 2000, Genoscope evaluated the number of human genes at about 30,000, whereas much higher estimations were current. The progress of the annotation of the human genome has since supported the Genoscope hypothesis, with values as low as 22,000 genes and a consensus of around 25,000 genes. The sequencing of the Tetraodon genome at a depth of about 8X, carried out as a collaboration between Genoscope and the Whitehead Institute Center for Genome Research (now the Broad Institute), was finished in 2002, with the production of an assembly covering 90 of the euchromatic region of the genome of the fish. This has permitted the application of Exofish at a larger scale in comparisons with the genome of humans, but also with those of the two other vertebrates sequenced at the time (Takifugu, a fish closely related to Tetraodon, and the mouse). The conserved regions detected in this way have been integrated into the annotation procedure, along with other resources (cDNA sequences from Tetraodon and ab initio predictions). Of the 28,000 genes annotated, some families were examined in detail: selenoproteins, and Type 1 cytokines and their receptors. The comparison of the proteome of Tetraodon with those of mammals has revealed some interesting differences, such as a major diversification of some hormone systems and of the collagen molecules in the fish. A search for transposable elements in the genomic sequences of Tetraodon has also revealed a high diversity (75 types), which contrasts with their scarcity; the small size of the Tetraodon genome is due to the low abundance of these elements, of which some appear to still be active. Another factor in the compactness of the Tetraodon genome, which has been confirmed by annotation, is the reduction in intron size, which approaches a lower limit of 50-60 bp, and which preferentially affects certain genes. The availability of the sequences from the genomes of humans and mice on one hand, and Takifugu and Tetraodon on the other, provide new opportunities for the study of vertebrate evolution. We have shown that the level of neutral evolution is higher in fish than in mammals. The protein sequences of fish also diverge more quickly than those of mammals. A key mechanism in evolution is gene duplication, which we have studied by taking advantage of the anchoring of the majority of the sequences from the assembly on the chromosomes. The result of this study speaks strongly in favor of a whole genome duplication event, very early in the line of ray-finned fish (Actinopterygians). An even stronger evidence came from synteny studies between the genomes of humans and Tetraodon. Using a high-resolution synteny map, we have reconstituted the genome of the vertebrate which predates this duplication - that is, the last common ancestor to all bony vertebrates (most of the vertebrates apart from cartilaginous fish and agnaths like lamprey). This ancestral karyotype contains 12 chromosomes, and the 21 Tetraodon chromosomes derive from it by the whole genome duplication and a surprisingly small number of interchromosomal rearrangements. On the contrary, exchanges between chromosomes have been much more frequent in the lineage that leads to humans. Sponsors: The project was supported by the Consortium National de Recherche en Genomique and the National Human Genome Research Institute. duplication, element, euchromatic, evolution, exon, fish, gene, genetic, actinopterygians, aganth, ancestor, cartilaginous, cdna, chromosome, coding, collagen, cytokine, diversity, genome, genomic, heritage, hormone, human, interchromossomal, intergenic, intron, karyotype, lineage, mammal, molecule, mouse, nigroviridis, protein, proteome, pufferfish, receptor, region, selenoprotein, sequence, size, specie, synteny, system, takifugu, tetraodon, transposable, vertebrate nif-0000-20997 SCR_007079 TGB 2026-02-12 09:44:22 8
aneurIST
 
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Resource Website
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aneurIST (RRID:SCR_007427) aneurIST data or information resource, portal, disease-related portal, topical portal Project focused on cerebral aneurysms and provides integrated decision support system to assess risk of aneurysm rupture in patients and to optimize their treatments. IT infrastructure has been developeded for management and processing of vast amount of heterogeneous data acquired during diagnosis. gene, genetic, adult, cerebral aneurysm, cerebral brain hemorrhage, cerebral hemorrhage, cerebral parenchymal hemorrhage, cerebral hemorrhage, clinical, genomic, human, intracerebral hemorrhage, intracranial aneurysm, subarachnoid hemorrhage, risk, aneurysm rupture, patient, treatment, infrastructure, platform, genomics, disease, personalized risk assessment, bioinformatics, clinical, data management, data integration, data processing, software tool, cerebrum has parent organization: Pompeu Fabra University; Barcelona; Spain Cerebral aneurysm, Subarachnoid hemorrhage, Aging European Union ;
Sixth FPPriority 2 of the Information Society Technologies IST
nif-0000-00538 http://www.cilab.upf.edu/aneurist1/ SCR_007427 aneurIST - Integrated Biomedical Informatics for the Management of Cerebral Aneurysms, (at)neurIST, (at)neurIST - Integrated Biomedical Informatics for the Management of Cerebral Aneurysms 2026-02-12 09:44:27 3

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