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URL: http://scicrunch.org

Proper Citation: NGVB Toxicology Database (RRID:SCR_004763)

Description: THIS RESOURCE IS NO LONGER IN SERVICE, documented May 10, 2017. A pilot effort that has developed a centralized, web-based biospecimen locator that presents biospecimens collected and stored at participating Arizona hospitals and biospecimen banks, which are available for acquisition and use by researchers. Researchers may use this site to browse, search and request biospecimens to use in qualified studies. The development of the ABL was guided by the Arizona Biospecimen Consortium (ABC), a consortium of hospitals and medical centers in the Phoenix area, and is now being piloted by this Consortium under the direction of ABRC. You may browse by type (cells, fluid, molecular, tissue) or disease. Common data elements decided by the ABC Standards Committee, based on data elements on the National Cancer Institute''s (NCI''s) Common Biorepository Model (CBM), are displayed. These describe the minimum set of data elements that the NCI determined were most important for a researcher to see about a biospecimen. The ABL currently does not display information on whether or not clinical data is available to accompany the biospecimens. However, a requester has the ability to solicit clinical data in the request. Once a request is approved, the biospecimen provider will contact the requester to discuss the request (and the requester''s questions) before finalizing the invoice and shipment. The ABL is available to the public to browse. In order to request biospecimens from the ABL, the researcher will be required to submit the requested required information. Upon submission of the information, shipment of the requested biospecimen(s) will be dependent on the scientific and institutional review approval. Account required. Registration is open to everyone.. Documented on August 26, 2019,

The National Gene Vector Biorepository offers an informational toxicology database as a resource to gene therapy investigators. The database contains information on animal studies that have been conducted to study the biodistribution of vector to different target organs and to evaluate potential toxic effects associated with the use of various vector systems. Studies within the database have been submitted to the US FDA in support of gene therapy clinical trials. The purpose of the database is to inform gene therapy investigators about the conclusions of prior toxicology studies and to facilitate the cross-referencing of relevant studies in support of new Investigational New Drug Applications (INDs) applications. The studies are generally small, randomized single dose or dose escalation studies consisting of various animal models from mouse to non-human primate. The study parameters capture the test system, vector information, dose procedures, clinical observations, macroscopic/microscopic pathology, histopathology, tissue collection for PCR analysis, clinical pathology: hematology/chemistry analysis and a summary of the relevant findings. Investigators have agreed to allow submission of their data into this database. The database is also accessible to any investigator in the gene therapy field who would like to share their data. The database is being expanded to include non-GLP studies submitted to the FDA in support of an IND. These studies are conducted under careful compliance parameters and can be critical to platform studies in the development of novel vectors.

Resource Type: data repository, data or information resource, database, service resource, storage service resource