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Integrated Animals is a virtual database currently indexing available animal strains and mutants from: AGSC (Ambystoma), BCBC (mice), BDSC (flies), European Xenopus Resource Center (frog), The National Xenopus Resource (frog), Xenopus Express (frog), CWRU Cystic Fibrosis Mouse Models (mice), DGGR (flies), FlyBase (flies), IMSR (mice), MGI (mice), MMRRC (mice), NSRRC (pig), RGD (rats), Sperm Stem Cell Libraries for Biological Research (rats), Tetrahymena Stock Center (Tetrahymena), WormBase (worms), XGSC (Xiphophorus), ZFIN (zebrafish), and ZIRC (zebrafish). Note, the IMSR data is linked, but users may need to re-execute the search if the top mouse is not returned properly.
Note: BCBC is no longer in service, so the links may not be functional.
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=155641251
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Affected Genes:
Genomic Alteration:
Availability: Live Animals (as of 2022-11-04)
References:
Synonyms:
Notes: The human ACE2 gene was placed under control of the synthetic CAG promoter which allows ubiquitous expression of the gene. Based on droplet digital PCR analysis, the strain carries only 1 copy of the transgene. The integration site is unknown. These rats express the human ACE2 gene. The encoded protein is a functional receptor for the spike glycoprotein of several human coronaviruses including SARS-CoV-2, the causative agent of coronavirus disease-2019 (COVID-19). Rat Resource and Research Center
Proper citation: RRID:RRRC_00946 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=2292532
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Embryo; Cryopreserved Sperm
References:
Synonyms:
Notes: F344 embryos were microinjected with human beta-C-terminal fragment of the amyloid protein Rat Resource and Research Center
Proper citation: RRID:RRRC_00277 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=6480868
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: consomic
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Embryo; Cryopreserved Sperm
References:
Synonyms:
Notes: Chr 2 from LH/Mav was introgressed onto the genetic background of BN/NHsdMcwi and then genotyped Rat Resource & Research Center
Proper citation: RRID:RRRC_00396 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=6480866
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: consomic
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Embryo; Cryopreserved Sperm
References:
Synonyms:
Notes: Chr 13 from LH/Mav was introgressed onto the genetic background of BN/NHsdMcwi and then genotyped Rat Resource & Research Center
Proper citation: RRID:RRRC_00395 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=150523775
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Sperm; Cryorecovery (as of 2022-03-10)
References:
Synonyms:
Notes: This strain was made by pronuclear injection into LEW/Crl embryos. The embryos were co-injected with DNA fragments containing the HLA-B*2705 human gene and the human beta-2-microglobulin gene. The strain carries 20 copies of HLA-B*2705 and 15 copies of the human beta-2-microglobulin gene. Rat Resource and Research Center
Proper citation: RRID:RRRC_00916 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=150523778
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Sperm; Cryorecovery (as of 2022-03-10)
References:
Synonyms:
Notes: This strain carries 35 copies of genomic human B2-microglobulin gene. When crossed with the 21-3 line (RRRC:00 916), the F1 males develop a spontaneous disease mimicking human spondyloarthritis. Rat Resource and Research Center
Proper citation: RRID:RRRC_00917 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=150523780
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Embryo; Cryopreserved Sperm; Cryorecovery (as of 2021-11-19)
References:
Synonyms:
Notes: The ZFN mRNA targeting exon 2 of Erap1 was microinjected into both the pronuclei and the cytoplasm of fertilized LEW eggs. This strain was heterozygous for a 2-bp deletion within the targeted AGGAGA sequence of Erap1. Rat Resource and Research Center
Proper citation: RRID:RRRC_00918 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=2292453
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Sperm
References:
Synonyms:
Notes: this Sleeping Beauty mutants were derived by crossing F344-Tg(T2/Bart3)2Ceb and F344-Tg(PGK2-SB11)Ceb Rat Resource & Research Center
Proper citation: RRID:RRRC_00345 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=1578695
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: inbred
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Embryo; Cryopreserved Sperm
References:
Synonyms:
Notes: Selective breeding of Long-Evans in active two-way shuttle box for high avoidance resulted in these SHA rats. Rat Resource and Research Center
Proper citation: RRID:RRRC_00068 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=6480863
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: inbred
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Embryo; Cryopreserved Sperm
References:
Synonyms:
Notes: BBDR/Rhw from R. H. William Laboratory, University of Washington, Seattle, Washington to Rat Resource & Research Center Rat Resource & Research Center
Proper citation: RRID:RRRC_00463 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=9588570
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Notes: The transgene contains reporter rat expressing eGFP in cFos expressing cells Optogenetics and Transgenic Technology Core, Rat Resource and Research Center
Proper citation: RRID:RRRC_00766 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=155641248
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Notes: The CRISPR/Case9 knock-in rats have cre recombinase-dependent expression of nanoluciferase under the control of HIV LTR promoter inserted to the rat ROSA26 locus. ROSA26 is a synonym for rat Thumpd3-as1 (RGD:6491660) and is used as an official symbol for rat strain nomenclature. Rat Resource and Research Center
Proper citation: RRID:RRRC_00925 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=155641247
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Notes: The mutated ROSA26 locus of LE-(ROSA)26 em1(LTR-nLuc)Ottc (RGD:13208223) was crossed onto Fischer344 background by backcrossing the hybrid to Fischer344 and select for the presence of mutated locus. The LE donor is CRISPR/Case9 knock-in strain that has cre recombinase-dependent expression of nanoluciferase under the control of HIV LTR promoter inserted to the rat ROSA26 locus. ROSA26 is a synonym for rat Thumpd3-as1 (RGD:6491660) and is used as an official symbol for rat strain nomenclature. now deposited at Rat Resource and Research Center
Proper citation: RRID:RRRC_00926 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=155641241
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: congenic
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Sperm (as of 2022-11-03)
References:
Synonyms:
Notes: Congenic strain which was generated using the speed congenic strategy by backcrossing SS/JrHsd and SR/JrHsd parental strains. Rat Resource and Research Center.
Proper citation: RRID:RRRC_00616 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=2305976
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Embryo
References:
Synonyms:
Notes: This is the strain expresses human Amyloidogenic transthyretin (ATTR) V30M driven by the mouse albumin enhancer/promoter, established at Jichi Medical School. National BioResource Project for the Rat in Japan, Rat Resource & Research Center
Proper citation: RRID:RRRC_00339 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=2306541
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: congenic
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Notes: BBDR.BBDP-(D4Mit6-D4Mit7)/Rhw were intercrossed with F344 giving a recombination proximal to Gimap1 fragment. Whole-genome scan, STS and SSLP analyses were done to determine the region introgressed Rat Resource and Research Center
Proper citation: RRID:RRRC_00457 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=155260364
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Sperm (as of 2022-10-06)
References:
Synonyms:
Notes: rat strain in which the rat Cyp3a1 gene (Cyp3a23-3a1, RGD:628626) was inactivated by insertion of a human CYP3A4 minigene (Cyp3A4*) and the linked rat Cyp3a2 locus was simultaneously mutated by CRISPR-mediated indel introduction. Strain contains Indel 8 at the Rat 3A2 locus (55 kb away), The CYP3A4 minigene included a CRISPR/Cas9 gene drive element to enable super-Mendelian inheritance. Strain contains and Active Genetic cassette which encodes a gRNA targeting the Rat 3A1 and 3A2 translation initiation site. ROBUST AND EFFICIENT ACTIVE GENETICS GENE CONVERSION IN THE RAT AND MOUSE Chenyen Lai, Oscar Alvarez, Kristen Read, Don van Fossan,Christopher M Conner, Shannon Xaing-Ru Xu, Dale O. Cowley, Valentino Gantz, David R. Webb, Kurt Jarnagin URL: Doi:10.1101/2022.08.30.505951 URL: Doi:10.1101/2022.08.30.505951
URL: URL: Doi:10.1101/2022.08.30.505951 Rat Resource and Research Center
Proper citation: RRID:RRRC_00970 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=9588572
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Notes: The transgene contains BAC transgenic using rat DAT promoter to express Cre recombinase in dopaminergic neurons Optogenetics and Transgenic Technology Core, Rat Resource and Research Center
Proper citation: RRID:RRRC_00730 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=155641245
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Affected Genes:
Genomic Alteration:
Availability: Live Animals; Cryopreserved Embryo; Cryopreserved Sperm (as of 2023-12-13)
References:
Synonyms:
Notes: Targeted knock-in adding a T2A-iCre to the Oprm1 (mu opioid receptor) in this cre recombinase reporter SD rat Rat Resource and Research Center
Proper citation: RRID:RRRC_00975 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=9588585
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Notes: The transgene contains Cre recombinase expressed from cFos promoter and controllable by Tet activator/repressor Optogenetics and Transgenic Technology Core, Rat Resource and Research Center
Proper citation: RRID:RRRC_00736 Copy
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