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Integrated Animals is a virtual database currently indexing available animal strains and mutants from: AGSC (Ambystoma), BCBC (mice), BDSC (flies), European Xenopus Resource Center (frog), The National Xenopus Resource (frog), Xenopus Express (frog), CWRU Cystic Fibrosis Mouse Models (mice), DGGR (flies), FlyBase (flies), IMSR (mice), MGI (mice), MMRRC (mice), NSRRC (pig), RGD (rats), Sperm Stem Cell Libraries for Biological Research (rats), Tetrahymena Stock Center (Tetrahymena), WormBase (worms), XGSC (Xiphophorus), ZFIN (zebrafish), and ZIRC (zebrafish). Note, the IMSR data is linked, but users may need to re-execute the search if the top mouse is not returned properly.
Note: BCBC is no longer in service, so the links may not be functional.
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=13462045
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Affected Genes:
Genomic Alteration:
Availability: Live Animals (as of 2024-01-17)
References:
Synonyms:
Notes: Pronuclear injection was used to introduce an expression cassette containing the Thy-1 enhancer and GCaMP6f protein coding sequence. GCaMP6f is a genetically encoded calcium indicator. It is a synthetic fusion of green fluorescent protein, calmodulin, and M13, a peptide sequence from myosin light-chain kinase. Rat Resource & Research Center
Proper citation: RRID:RRRC_00830 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=12743645
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: congenic
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Sperm (as of 2017-02-14)
References:
Synonyms:
Notes: The Tcs2 QTL in DA.KHW-(RT1-Db1-RT1-DMb)(DA.1HR10) contains a ~0.2 from DA.1H [DA.KHW-RT1h]. The insert spans 12 genes in the MHC-II region, including RT1-B and RT1-D. All genes in the insert have been sequenced and sequences are available at GenBank. Rat Resource and Research Center
Proper citation: RRID:RRRC_00712 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=12743650
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: congenic
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Sperm (as of 2017-02-14)
References:
Synonyms:
Notes: DA.F-(Tesb-RT1-DMb) (DA.1FR61) contains a ~0.4 Mb (min- max 0.25 - 0.53 Mb) insert from DA.1F (RGD:2307301). The insert spans 12-19 genes in the MHC-II/MHC-III regions, including RT1-B and RT1-D. The 12 genes in the MHC-II region have been sequenced and sequences are available from GenBank. Rat Resource and Research Center
Proper citation: RRID:RRRC_00714 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=12743652
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: congenic
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Sperm (as of 2017-02-14)
References:
Synonyms:
Notes: The Tcs1 QTL in DA.KHW-(RT1-DMa-Mln)(DA.1HR83) contains a ~~0.85 Mb (min - max: 0.61 - 1.08 Mb) insert from DA.1H [DA.KHW-RT1h]. The inserted fragment spans the MHC-I region but excludes most of the MHC-II region, including the RT1-B and RT1-D genes. Rat Resource and Research Center
Proper citation: RRID:RRRC_00716 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=12743655
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: congenic
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Sperm (as of 2017-02-14)
References:
Synonyms:
Notes: The Tcs1 QTL in DA.E3-(RT1-DMa-Mln)(DA.1UR83) contains a ~0.85 Mb (min - max: 0.61 - 1.08 Mb) insert from DA.1U (RGD:10002745). The inserted fragment spans the MHC-I region but excludes most of the MHC-II region, including the RT1-B and RT1-D genes. Rat Resource and Research Center
Proper citation: RRID:RRRC_00717 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=12738452
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Sperm (as of 2017-02-06)
References:
Synonyms:
Notes: This strain develops twice the number of colonic tumors as the F344-ApcPircUwm rats (RGD:1641862). Stop codon mutation at amino acid 1137 of the Apc gene. Nucleotide chr18:26,785,272 (Baylor 3.4/rn4) A to T transversion. Rat Resource and Research Center
Proper citation: RRID:RRRC_00718 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=11667077
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Sperm (as of 2017-01-26)
References:
Synonyms:
Notes: Zinc finger nuclease targeting of exon 3 of the rat estrogen receptor-2 gene resulting in the deletion of exon 3. Rat Resource and Research Center
Proper citation: RRID:RRRC_00719 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=7245482
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Embryo; Cryopreserved Sperm (as of 2019-02-05)
References:
Synonyms:
Notes: Strain carries a 1.8kb transgene consisting of the mouse ROSA26 regulatory sequences driving EGFP. FISH was used to localize the transgene insertion to Chromosome 11q11-q12, proximal to Grik1 and near Ncam2. The transgene is expressed exclusively in male and female germ cells throughtout development. Rat Resource and Research Center
Proper citation: RRID:RRRC_00541 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=7245481
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Embryo; Cryopreserved Sperm (as of 2019-02-05)
References:
Synonyms:
Notes: presses LacZ under the transcriptional control of the mouse metallothionein regulatory sequences. Transgene expression in germ cells is constitutive; expression of the transgene can be induced in liver by zinc or cadmium. Rat Resource and Research Center
Proper citation: RRID:RRRC_00540 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=11667079
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Sperm (as of 2017-01-26)
References:
Synonyms:
Notes: zinc finger nucleases were used to generate a 136 bp deletion within the first exon of the progesterone receptor, resulting in a frameshift, premature stop codon, and a null. Rat Resource and Research Center
Proper citation: RRID:RRRC_00720 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=11667096
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Embryo; Cryopreserved Sperm (as of 2017-01-26)
References:
Synonyms:
Notes: Male Wistar rats with inbred congenital unilateral right hydronephrosis were bred from the colony described in 1979 by Friedman et al. Rat Resource and Research Center
Proper citation: RRID:RRRC_00721 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=14392784
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown (as of 2019-02-28)
References:
Synonyms:
Notes: This strain was produced by backcrossing the ZFN induced 482 deletion allele (Esr1em1Soar) in HsdHot:SD to the ACI/SegHsd background for 12 generations. ACI strain is particularly sensitive to Estrogen-induced tumorigenesis. Rat Resource and Research Center
Proper citation: RRID:RRRC_00849 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=10401201
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Affected Genes:
Genomic Alteration:
Availability: Live Animals; Cryopreserved Sperm (as of 2017-05-31)
References:
Synonyms:
Notes: Cre gene was introduced immediately before the ATG of the mouse tyrosine hydroxylase (Th) gene on BAC RP23-350E13 Rat Resource and Research Center
Proper citation: RRID:RRRC_00659 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=11667072
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: inbred
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Embryo; Cryopreserved Sperm (as of 2017-01-26)
References:
Synonyms:
Notes: This phenotype arose spontaneously during the third generation of selective breeding for decreased intravenous drug self-administration in Wistar rats (see RGD:6482259). After 10 weeks of age no drug administration is needed to see phenotype in which animals exhibits motor abnormalities with degenerative changes in cerebellar Purkinje cells. It appears to be transmitted in an autosomal recessive pattern. Animals have an abnormal swaying gait, which is readily identified as a slow (2 to 3 cycles per second) tremor. Rat Resource and Research Center
Proper citation: RRID:RRRC_00538 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=12738212
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Sperm (as of 2017-08-22)
References:
Synonyms:
Notes: These rats were created using BAC constructs consisting of the entire 144kb human LRRK2 locus containing the R1441C mutation and fused to a YPet reporter tag. Rat Resource and Research Center
Proper citation: RRID:RRRC_00775 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=13592602
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Sperm; Cryorecovery (as of 2018-05-14)
References:
Synonyms:
Notes: These rats were created using BAC constructs consisting of the entire 144kb human LRRK2 locus containing the G2019S mutation and fused to a YPet reporter tag. Rat Resource and Research Center
Proper citation: RRID:RRRC_00776 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=150519896
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Notes: CRISPR/Cas9 mediated single nucleotide deletion resulting in a frameshift that creates a premature stop and generates a null allele. This strain serves as a model for Alexander disease - nulls are of interest for traumatic brain injury and many other studies of CNS disease and astrocyte response. Rat Resource and Research Center
Proper citation: RRID:RRRC_00931 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=13592603
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Sperm; Cryorecovery (as of 2018-05-14)
References:
Synonyms:
Notes: These rats were created using BAC constructs consisting of the entire 144kb human wild type LRRK2 locus fused to a YPet reporter tag. Rat Resource and Research Center
Proper citation: RRID:RRRC_00778 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=12790962
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: congenic
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Sperm (as of 2017-02-22)
References:
Synonyms:
Notes: Congenic strain which was generated using the speed congenic strategy by backcrossing SS/JrHsd and SR/JrHsd parental strains. The SR chromosome 1 region from rs106908358 to rs105920659 was introgressed on the genetic background of SS. Rat Resource and Research Center
Proper citation: RRID:RRRC_00609 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=14695052
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Sperm (as of 2019-07-01)
References:
Synonyms:
Notes: F344-Tg(ROSA26-ALPP)EpsRrrc (RGD:1566458) received in 1999 from Dr. Eric Sandgren, Univ. Wisconsin-Madison. Since 1999 bred on ACI background. Rat Resource and Research Center
Proper citation: RRID:RRRC_00817 Copy
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