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Integrated Animals is a virtual database currently indexing available animal strains and mutants from: AGSC (Ambystoma), BCBC (mice), BDSC (flies), European Xenopus Resource Center (frog), The National Xenopus Resource (frog), Xenopus Express (frog), CWRU Cystic Fibrosis Mouse Models (mice), DGGR (flies), FlyBase (flies), IMSR (mice), MGI (mice), MMRRC (mice), NSRRC (pig), RGD (rats), Sperm Stem Cell Libraries for Biological Research (rats), Tetrahymena Stock Center (Tetrahymena), WormBase (worms), XGSC (Xiphophorus), ZFIN (zebrafish), and ZIRC (zebrafish). Note, the IMSR data is linked, but users may need to re-execute the search if the top mouse is not returned properly.
Note: BCBC is no longer in service, so the links may not be functional.
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=150521661
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Notes: The transgene contains Cre recombinase reporter rat expressing mCherry driven by the EF1 alpha promoter. Expresses mCherry in cells of the brain transduced with a Cre-expression virus. Currently in SD background generated by backcrossing to LE-Tg(DIO-mCherry)2Ottc Rat Resource and Research Center
Proper citation: RRID:RRRC_00928 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=14695083
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: inbred
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Notes: Wistar rats maintained at the animal facility of the Ribeirao Preto School of Medicine at the University of Sao Paulo, Brazil, were tested for audiogenic seizures, using as criteria an SI and the L1 (ref. RGD:14695082). The WAR colony foundation stock was produced by mating animals displaying at least procursive behaviors in three consecutive tests, one every 4 days (two males and four females). Each couple produced two or three lit-ters, from which selected individuals displaying the highest SI and shortest L1 were mated, at adult age,with their fathers and mothers. From the second generation on, brother and sister matings were done, in a ratio of one male to two females, selected accordingto the criteria above. Rat Resource and Research Center
Proper citation: RRID:RRRC_00697 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=14694999
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Notes: This mutant strain was generated by injecting TALEN targeting rat Sdhb into NTac:SD embryo. The resulting mutant is a 6 bp-deletion in Sdhb. Rat Resource and Research Center
Proper citation: RRID:RRRC_00854 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=14694847
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Notes: A double-stranded DNA plasmid donor was synthesized to introduce self-cleaving peptide 2A (P2A),followed by Flpo recombinase,and the V5 peptide tag (GKPIPNPLLGLDST) before the termination codon in exon 5 of rat Parvalbumin. The CRISPR/Cas9 system was used to knock in the plasmid into the targeted gene in the Crl:LE embryo. (ref:bioRxiv preprint first posted online Aug. 7, 2018; doi: http://dx.doi.org/10.1101/386474. ) Rat Resource and Research Center
Proper citation: RRID:RRRC_00859 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=9854711
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: congenic
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Notes: This congenic strain was generated by introgressing the desired fragment from WKY/NCruk onto the genetic background of SHR/NCruk Rat Resource and Research Center
Proper citation: RRID:RRRC_00739 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=14695086
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: inbred
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Notes: The original background strain derived from Sherman and Merck stock M rats (13 M strain). Obese animals produced by crossing homozygous obese males to heterozygous lean females. Rat Resource and Research Center
Proper citation: RRID:RRRC_00740 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=11081149
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Notes: Zinc finger nuclease targeting of exon 4 of the rat estrogen receptor-2 gene resulting in the deletion of exon 4 Rat Resource and Research Center
Proper citation: RRID:RRRC_00742 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=14390082
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Notes: The lacZ gene was inserted between NcoI and SalI sites in exon 4 of the murine Fos gene . The linearized DNA was then microinjected into fertilized rat oocytes and line 1-8 was chosen for continuation. Rats were rederived from frozen embryos in 2002 and bred onto SD background for >35 generations at NIDA IRP (Bruce Hope lab) Rat Resource and Research Center
Proper citation: RRID:RRRC_00865 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=150521617
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: inbred
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Notes: BDIX/IFZ rats have been inbred in the Institute of Cell Biology, Essen and later in the Central Animal Facility,Essen for about 45 years. The BDIX/Ifz rats are extremely susceptible to ENU-induced development of tumors of the peripheral and central nervous system. Rat Resource and Research Center
Proper citation: RRID:RRRC_00900 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=9588559
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Sperm; Cryorecovery
References:
Synonyms:
Notes: The transgene contains Cre recombinase reporter rat expressing the red fluorescent protein gene (iRFP) driven by the EF1 alpha promoter. Optogenetics and Transgenic Technology Core, Rat Resource and Research Center
Proper citation: RRID:RRRC_00747 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=150521614
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: congenic
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Notes: The BDIX.BDIV-D10Got1-D10Rat45/Zte congenic strain was produced by crossing BDIX (tumor-susceptible) and BDIV (tumor resistant) and then selecting for strains carrying homozygous segments of the BDIV chromosome on a BDIX background. Rat Resource and Research Center
Proper citation: RRID:RRRC_00902 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=150520183
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: congenic
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Notes: strain haboring on a BDIX background a 22,3 MB BDIV Fragment called Mss1c which covers part of the Mss1 fragment. Homozygous rats of both sexes display resistence towards ENU-induced development of PNS tumors in terms of survival time and incidence. Rat Resource and Research Center
Proper citation: RRID:RRRC_00904 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=150521612
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: congenic
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Notes: strain haboring on a BDIX background two BDIV Fragments generated by a double recombination, 37,3 and 20,0 Mb long,Mss1b1 and Mss1b2 both covering parts of the Mss1 fragment. Homozygous rats of both sexes display susceptibility towards ENU-induced development of PNS tumors in terms of survival time and incidence. Through the Mss1b1 and Mss1b2 fragments and the Mss1c fragment the Mss1 locus was fine-mapped between 82.9 and 85.2Mb Rat Resource and Research Center
Proper citation: RRID:RRRC_00905 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=626469556
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Notes: Crispr/Cas9 mediated 206 bp deletion associated with Exon 2 and the second intron of the Adm gene Rat Resource and Research Center
Proper citation: RRID:RRRC_01046 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=6903912
Source Database: Rat Genome Database (RGD)
Genetic Background: congenic
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Notes: This is a congenic substrain developed by crossing SS.SHR-(D9Mco72-D9Mco93)/Mco to SS/Jr to get F2 which were again crossed with SS/Jr to duplicate the recombinant region
Proper citation: RRID:RGD_6903912 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=6903879
Source Database: Rat Genome Database (RGD)
Genetic Background: inbred
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Notes: 1962: Dr. L. K. Dahl found the mutant rat from SD at NIH; 1989: Moved to Eisai (Eisai Co., Ltd.); 1991: Moved to BMR Institute for breeding; 1994: Started selling by SLC, Shizuoka, Japan
Proper citation: RRID:RGD_6903879 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=6903917
Source Database: Rat Genome Database (RGD)
Genetic Background: congenic
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Notes: This is a congenic substrain developed by crossing SS.SHR-(D9Mco72-D9Mco93)/Mco to SS/Jr to get F2 which were again crossed with SS/Jr to duplicate the recombinant region
Proper citation: RRID:RGD_6903917 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=5688049
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Notes: ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders.
Proper citation: RRID:RGD_5688049 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=6903920
Source Database: Rat Genome Database (RGD)
Genetic Background: congenic
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Notes: This is a congenic substrain developed by crossing SS.SHR-(D9Mco72-D9Mco93)/Mco to SS/Jr to get F2 which were again crossed with SS/Jr to duplicate the recombinant region
Proper citation: RRID:RGD_6903920 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=6903922
Source Database: Rat Genome Database (RGD)
Genetic Background: congenic
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Notes: This is a congenic substrain developed by crossing SS.SHR-(D9Mco72-D9Mco93)/Mco to SS/Jr to get F2 which were again crossed with SS/Jr to duplicate the recombinant region
Proper citation: RRID:RGD_6903922 Copy
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