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Integrated Animals is a virtual database currently indexing available animal strains and mutants from: AGSC (Ambystoma), BCBC (mice), BDSC (flies), European Xenopus Resource Center (frog), The National Xenopus Resource (frog), Xenopus Express (frog), CWRU Cystic Fibrosis Mouse Models (mice), DGGR (flies), FlyBase (flies), IMSR (mice), MGI (mice), MMRRC (mice), NSRRC (pig), RGD (rats), Sperm Stem Cell Libraries for Biological Research (rats), Tetrahymena Stock Center (Tetrahymena), WormBase (worms), XGSC (Xiphophorus), ZFIN (zebrafish), and ZIRC (zebrafish). Note, the IMSR data is linked, but users may need to re-execute the search if the top mouse is not returned properly.
Note: BCBC is no longer in service, so the links may not be functional.
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=11667081
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: inbred
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Sperm (as of 2017-01-26)
References:
Synonyms:
Notes: Point mutation in Myo5a (Chromosome 8, end of exon 4)identified in In Berlin-Druckrey (BDIV) shaker rats Rat Resource and Research Center
Proper citation: RRID:RRRC_00784 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=11667088
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Sperm (as of 2017-01-26)
References:
Synonyms:
Notes: zinc finger nucleases were used to generate a 482 bp deletion in Esr1 gene, resulting in a knock out. Rat Resource and Research Center
Proper citation: RRID:RRRC_00701 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=12743630
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Sperm (as of 2017-02-10)
References:
Synonyms:
Notes: Retinae display marked rosett formation in the outer nuclear layer; in the funduscopy irregular, dark pigment flecks are observed, which cannot be identified in the histology. Linkage analysis indicating at least two genes interacting. Rat Resource and Research Center
Proper citation: RRID:RRRC_00703 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=9685759
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: congenic
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Embryo; Cryopreserved Sperm (as of 2017-01-26)
References:
Synonyms:
Notes: Segment of interest from chr 13 and chr 16 of WKY/NCrl were introgressed into LEW/SsNHsd National BioResource Project for the Rat in Japan, Rat Resource and Research Center
Proper citation: RRID:RRRC_00709 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=12738457
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: congenic
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Sperm (as of 2017-02-06)
References:
Synonyms:
Notes: DA/BklArb rats through 8 backcrosses into DA/BklArb rats followed by 7 additional backcrosses into DA/BklArbNsi rats. Heterozygous DA.F344(Cia5a5)(D10Got152-D10Mcw1) rats were brother-sister mated, and the recombinant strain was maintained in the homozygous state thereafter. Rat Resource and Research Center
Proper citation: RRID:RRRC_00675 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=12738455
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: congenic
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Sperm (as of 2017-02-06)
References:
Synonyms:
Notes: The Cia5a10 (D10Got155-D10Nsi55) interval was introgressed from F344 into DA/BklArb rats through 8 backcrosses into DA/BklArb rats followed by 7 additional backcrosses into DA/BklArbNsi rats. Heterozygous DA.F344(Cia5a10) rats were brother-sister mated, and the recombinant strain was maintained in the homozygous state thereafter. Rat Resource and Research Center
Proper citation: RRID:RRRC_00674 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=14695063
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: congenic
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Sperm; Cryorecovery (as of 2024-01-11)
References:
Synonyms:
Notes: Severe osteopetrosis with numerous non-functioning osteoclasts. Locus on chromosome 10. Homozygotes not fertile, need to test breed to ID heterozygotes. Homozygotes have no teeth, require ground food. One of only 4 osteopetrotic mutations in rat. Genetic lesion is not yet known but mutation is inherited in an autosomal recessive manner. The candidate gene region has been localized to Chr 10 between D10Rat258 and D10Rat51. original background strain is LEW/Ssn. Deposited at Rat Resource and Research Center
Proper citation: RRID:RRRC_00752 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=126781843
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Embryo; Cryorecovery (as of 2024-01-05)
References:
Synonyms:
Notes: The CRISPR/Cas9 system was injected to the Crl:CD(SD)embryo to induce the knock-in Cre-ERT2 cassette at the 3' end of Gad1 (Gad67) gene linked by 2A peptide. This model is used to lineage tracing of glutamate decarboxylase 1 expressing cells such as GABAergic neurons, islet cells and spermatocytes. Rat Resource and Research Center
Proper citation: RRID:RRRC_00874 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=149735364
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Affected Genes:
Genomic Alteration:
Availability: Live Animals (as of 2021-07-19)
References:
Synonyms:
Notes: The CRISPR/Cas9 system was injected to the Crl:CD(SD)embryo to induce the knock-in Cre-ERT2 cassette at the 3' end of Tie2 gene linked by 2A peptide. This model is used to lineage tracing of vascular endothelial cells by tissue specific expression of creERT2 deposited at Rat Resource and Research Center
Proper citation: RRID:RRRC_00877 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=126781844
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Affected Genes:
Genomic Alteration:
Availability: Live Animals (as of 2024-01-04)
References:
Synonyms:
Notes: This mutant strain was created by injecting embryos from 'docking site ready (DSR)' rat strains. The DSR rat strain, or TARGAT /TM rat strain was generated using CRISPR/Cas9. The DSR embryos were microinjected with integrase, a mixture of TARGATT Cre DNA constructs containing rabbit smooth muscle myosin heavy chain (SMHC) gene promoter, and a fluorescent reporter mCherry in the Cre cassette linked by a T2A sequence. The vascular smooth muscle tissue-specific expression of a CreERT2 is tamoxifen-dependent." Rat Resource and Research Center
Proper citation: RRID:RRRC_00878 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=14695547
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Embryo; Cryopreserved Sperm; Cryorecovery (as of 2019-07-08)
References:
Synonyms:
Notes: This strain was made by pronuclear injection into LEW/Crl embryos. The embryos were co-injected with DNA fragments containing the HLA-B*2705 human gene and the human beta-2-microglobulin gene. The strain carries 55 copies of HLA-B*2705 and 29 copies of human beta-2-microglobulin gene. The transgenic strain was transferred from Dr. Joel Taurog, University of Texas Southwestern Medical School in Dallas to the Rat Resource and Research Center . Rat Resource and Research Center
Proper citation: RRID:RRRC_00624 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=14695548
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Embryo; Cryopreserved Sperm; Cryorecovery (as of 2019-07-08)
References:
Synonyms:
Notes: This strain was made by pronuclear injection into LEW/Crl embryos. The embryos were co-injected with DNA fragments containing the HLA-B*2705 human gene and the human beta-2-microglobulin gene. The strain carries 150 copies of HLA-B*2705 and 90 copies of human beta-2-microglobulin gene. The transgenic strain was transferred from Dr. Joel Taurog, University of Texas Southwestern Medical School in Dallas to the Rat Resource and Research Center . Rat Resource and Research Center
Proper citation: RRID:RRRC_00622 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=10412325
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Affected Genes:
Genomic Alteration:
Availability: Live Animals (as of 2019-03-18)
References:
Synonyms:
Notes: The transgene expresses BAC transgenic using rat dopamine receptor 1 promoter to express Cre recombinase in D1R neurons Optogenetics and Transgenic Technology Core, Rat Resource and Research Center
Proper citation: RRID:RRRC_00767 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=10412327
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Affected Genes:
Genomic Alteration:
Availability: Live Animals (as of 2019-03-18)
References:
Synonyms:
Notes: The transgene expresses BAC transgenic using rat dopamine receptor 2 promoter to express Cre recombinase in D2R neurons Optogenetics and Transgenic Technology Core, Rat Resource and Research Center
Proper citation: RRID:RRRC_00768 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=14695004
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: congenic
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Embryo; Cryopreserved Sperm; Cryorecovery (as of 2019-06-27)
References:
Synonyms:
Notes: 3 Mb of F344 DNA introgressed on Chr.4 between D4Mgh24 (73.75 Mb) and D4Rhw6 (76.83 Mb), and BB diabetes prone (DP) DNA introgressed from D4Rhw6 to D4Rhw10 (the most distal marker the end of the chromosome) Rat Resource and Research Center
Proper citation: RRID:RRRC_00458 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=14695026
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Affected Genes:
Genomic Alteration:
Availability: Live Animals (as of 2021-02-12)
References:
Synonyms:
Notes: Cre recombinase has been inserted into the genome under the control of the Crh promoter. Generated on Wistar and backcrossed to Wistar every generation. Rat Resource and Research Center
Proper citation: RRID:RRRC_00852 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=9999145
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: inbred
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Notes: The F344/NCr rat strain was received into the NIH Genetic Resources program in 1987, now maintained at NCI Animal production program Rat Resource and Research Center
Proper citation: RRID:RRRC_00734 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=14398499
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Live Animals (as of 2021-02-12)
References:
Synonyms:
Notes: The CRISPR system was used to created target insertion of iCre recombinase to the Drd1 (Drd1a) locus of the embryos of BluHsd:LE. Rat Resource and Research Center
Proper citation: RRID:RRRC_00856 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=14398734
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Live Animals (as of 2021-02-12)
References:
Synonyms:
Notes: The CRISPR system was used to created target insertion of iCre recombinase immediately after Adora2a gene, with P2A linker, of the embryos of BluHsd:LE. Rat Resource and Research Center
Proper citation: RRID:RRRC_00857 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=53621137
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Affected Genes:
Genomic Alteration:
Availability: Live Animals (as of 2024-01-10)
References:
Synonyms:
Notes: The CRISPR/Cas9 system was injected to the Crl:CD(SD)embryo to induce the knock-in Cre-ERT2 cassette at the 3' end of Wnt1 gene linked by 2A peptide. This model is used to lineage tracing of neural crest cells by tissue specific expression of creERT2 Rat Resource and Research Center
Proper citation: RRID:RRRC_00868 Copy
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