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http://globalprojects.ucsf.edu/project/novel-small-molecule-therapies-cystic-fibrosis

Research center that focuses on developing novel therapies for cystic fibrosis, enhancing research projects examining the mechanisms of the disease, and developing new small-molecule therapies that can be translated into the clinic.

Proper citation: Cystic Fibrosis Center - University of California San Francisco (RRID:SCR_015398) Copy   

•   Source: SciCrunch Registry

http://ccr.coriell.org/Sections/Collections/CDC/?SsId=16

A repository which houses DNA samples prepared from reference cell lines and are available for use in molecular genetic testing. The CF samples contain mutations associated with unique populations, combinations of IVS8 poly-thymidine tract variants, and mutations not previously available. Three DNA samples with homozygous MTHFR-related mutations are available. Hemochromatosis-associated samples include a compound HFE heterozygote and other combinations of HFE alleles. DNA samples with triplet repeats at the intermediate-range are available for HD and Fragile X syndrome. Mutations were confirmed in all cell lines from which the DNA has been prepared by reference testing and multi-laboratory pilot testing. Control DNA samples negative for all mutations are also available. Laboratories are encouraged to contact Coriell Cell Repositories to inquire about obtaining samples or donating samples as possible candidates for transformation.

Proper citation: CDC Cell and DNA Repository (RRID:SCR_004680) Copy   

•   Source: SciCrunch Registry

http://www.mdibl.org/

Non-profit research institution that studies marine and non-marine organisms to learn about the basic biology of life. Our scientists make critical discoveries about how organisms adapt to their environment and how environment, health, and genetics are related. They study a wide range of organisms such as sharks, skates, and sea urchins to learn about development and regeneration. They investigate the root causes of diseases like cystic fibrosis, and they examine the mechanisms that make living creatures age. Research at MDIBL takes place within three centers: the Center for Regenerative Biology and Medicine, the Martha and Wistar Morris Center for Environmental Health Sciences, and the John W. and Jean C. Boylan Center for Cellular and Molecular Physiology. Scientists at each center include both permanent MDIBL faculty and adjunct faculty who come to MDIBL for a few weeks or an entire season, often year after year. Short courses, symposia, and fellowships provide research experience and training to students and scientists at all levels, from high school and college through medical school and senior investigators. Our education programs are always hands-on and engage students in meaningful research. MDIBL is the lead institution for the Maine IDeA Network for Biomedical Researcha research and education network linking MDIBL with The Jackson Laboratory and ten Maine colleges and universities.

Proper citation: Mount Desert Island Biological Laboratory (RRID:SCR_004873) Copy   

•   Source: SciCrunch Registry

http://norccentral.org/centers/colorado/

Research center that aims to provide an infrastructure to support ongoing nutrition and obesity research by providing measurements and expertise. It also aims to promote interdisciplinary collaborative, vertically integrated research among members of the Colorado research community, as well as translate basic and clinical research into programs to improve health and wellness and reduce obesity in the community.

Proper citation: University of Colorado Anschutz Medical Campus Nutrition and Obesity Research Center (RRID:SCR_015451) Copy   

•   Source: SciCrunch Registry

https://www.uab.edu/medicine/cysticfibrosis/

Research center that maintains core facilities available for studies of cell biology, ion transport, and translational aspects of cystic fibrosis research.

Proper citation: Gregory Fleming James Cystic Fibrosis Research Center (RRID:SCR_015392) Copy   

•   Source: SciCrunch Registry

http://depts.washington.edu/cfrtc/

Research center that aims to provide resources and expertise to expedite development of potential new therapeutic approaches to correct dysfunctional CFTR and its secondary consequences, enhance understanding of evolving bacterial ecosystems and resultant host response in CF gastrointestinal and respiratory tracts, and how these interactions impact health. It also aims to develop improved assays, new drug screening assays, biomarkers and improved clinical outcome measures, as well as to better understand the metabolic and inflammatory consequences of CFTR dysfunction.

Proper citation: Cystic Fibrosis Center - University of Washington (RRID:SCR_015401) Copy   

•   Source: SciCrunch Registry

http://www.biogrid.org.au

A federated data sharing platform and infrastructure that provides access to real-time clinical, imaging and biospecimen data across jurisdictions, institutions and diseases. The web-based platform provides a secure infrastructure that advances health research by linking privacy-protected and ethically approved data among a wide network of health collaborators. Access to de-identified health records data is granted to authorized researchers after an application process so patient privacy and intellectual property are protected. BioGrid Australia''s approved researchers are provided access to multiple institutional databases, via the BioGrid interface, preventing gaps in patient records and research analysis. This legal and ethical arrangement with participating collaborators allows BioGrid to connect data through a common platform where data governance and access is managed by a highly skilled team. Data governance, security and ethics are at the core of BioGrid''s federated data sharing platform that securely links patient level clinical, biospecimen, genetic and imaging data sets across multiple sites and diseases for the purpose of medical research. BioGrid''s infrastructure and data management strategies address the increasing need by authorized researchers to dynamically extract and analyze data from multiple sources whilst protecting patient privacy. BioGrid has the capability to link data with other datasets, produce tailored reports for auditing and reporting and provide statistical analysis tools to conduct more advanced research analysis. In the health sector, BioGrid is a trusted independent virtual real-time data repository. Government investment in BioGrid has facilitated a combination of technology, collaboration and ethics approval processes for data sharing that exist nowhere else in the world.

Proper citation: BioGrid Australia (RRID:SCR_006334) Copy   

•   Source: SciCrunch Registry

https://www.med.unc.edu/marsicolunginstitute/core-facilities/histology-core

Core that provides light microscopy services like prosection, tissue fixation, processing, embedding, sectioning, staining and cover slipping of paraffin, frozen and soft plastic tissue sections, as well as specialized and routine fixation, tissues processing, ultramicrotomy, staining, photomicrograph production, and analysis.

Proper citation: Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center Histology Core (RRID:SCR_015385) Copy   

•   Source: SciCrunch Registry

https://www.med.unc.edu/marsicolunginstitute/core-facilities/mousemodelscore

Core that provides support and expertise for mouse colony maintenance, breeding strategies, mouse lung phenotyping protocols, and submission of live-animal applications to maintain compliance with IACUC guidelines.

Proper citation: Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center Mouse Models Core (RRID:SCR_015389) Copy   

•   Source: SciCrunch Registry

https://www.uab.edu/medicine/cysticfibrosis/about/translational-core

Core that provides human primary nasal airway epithelial cells and bronchial airway epithelial cells, expertise in the nasal potential difference measurement, and a means to understand pathogenesis of cystic fibrosis and other metabolic diseases.

Proper citation: Gregory Fleming James Cystic Fibrosis Research Center Cystic Fibrosis Clinical and Translational Core (RRID:SCR_015399) Copy   

•   Source: SciCrunch Registry

https://www.uab.edu/medicine/cysticfibrosis/about/animal-core

Core that assists in mouse line generation by both oocyte micro-injection and by embryonic stem cell gene targeting technologies. It also establishes breeding colonies of cystic fibrosis mice, and genotypes and provides these to UAB investigators and furnishes electrophysiology tests of CFTR activation, including murine nasal potential difference assays and intestinal short circuit current measurements.

Proper citation: Gregory Fleming James Cystic Fibrosis Research Center Cystic Fibrosis Animal Models Core (RRID:SCR_015396) Copy   

•   Source: SciCrunch Registry

https://www.uab.edu/medicine/cysticfibrosis/about/cftr-expression-core

Core that maintains a repository of reagents for studying CFTR and assists with expression technologies using vaccinia, adenovirus and other methodologies and antibody based detection of cystic fibrosis related gene products.

Proper citation: Gregory Fleming James Cystic Fibrosis Research Center Cystic Fibrosis Transmembrane Conductance Regulator Expression Core (RRID:SCR_015397) Copy   

•   Source: SciCrunch Registry

http://www.med.upenn.edu/gtp/vectorcore/

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on October 30,2023. Core whose main aim is to provide vector technology for preclinical studies and other basic research applications. Its services include rovision of AAV, adenoviral and lentiviral based vectors, consultation and advice in the design of custom vectors and in vector serotype/pseudotype selection, and design, cloning and production of plasmid DNA for the production of custom vectors.

Proper citation: University of Pennsylvania Center for Molecular Therapy for Cystic Fibrosis Vector Core Facility (RRID:SCR_010038) Copy   

•   Source: SciCrunch Registry

https://medicine.uiowa.edu/genetherapy/vector-core

Core facility which provides support to cystic fibrosis investigators in gene transfer technologies through consultation, development of novel vectors, collaborative testing of vectors for function and purity, and routine vector preparations.

Proper citation: University of Iowa Center for Gene Therapy Vectore Core (RRID:SCR_015417) Copy   

•   Source: SciCrunch Registry

http://www.med.upenn.edu/gtp/morphology.shtml

Core facility which provides a range of technologies for morphologically based studies and technically more complex support in the detection of transgenes and transgene products using techniques of in situ hybridization and immunohistochemistry.

Proper citation: University of Pennsylvania Center for Molecular Therapy for Cystic Fibrosis Cell Morphology Core (RRID:SCR_015416) Copy   

•   Source: SciCrunch Registry

http://depts.washington.edu/cfrtc/microbiology/

Core facility which provides tools, reagents, and training for microbiological researchers investigating cystic fibrosis. They specifically provide resources for research in anti-bacterial therapies,

Proper citation: Cystic Fibrosis Center - University of Washington Microbiology Core (RRID:SCR_015403) Copy   

•   Source: SciCrunch Registry

http://depts.washington.edu/cfrtc/genomics/

Core provides genomics-based tools, data management and analysis tools, and creates platforms that integrate data from the Clinical and Immunology Cores for human samples and bacterial isolates. Services include consultation and experimental design assistance for using new-generation sequencing technology, data analysis, bioinformatic support, data access and storage, high throughput and new-generation whole-genome sequencing, and RNA-seq analysis of transcriptomes.

Proper citation: University of Washington Genomics Core Cystic Fibrosis Research Translation Center and Research Development Program (RRID:SCR_015404) Copy   

•   Source: SciCrunch Registry

http://www.med.upenn.edu/gtp/immunology.shtml

Core facility which provides a variety of assay services to evaluate cell-mediated and humoral responses to in animal models of gene therapies.

Proper citation: University of Pennsylvania Center for Molecular Therapy for Cystic Fibrosis Immunology Core (RRID:SCR_015409) Copy   

•   Source: SciCrunch Registry

https://medicine.uiowa.edu/genetherapy/research-cores/cells-and-tissue-core

Core that provides centralized access to non-cystic fibrosis and cystic fibrosis tissue specimens and airway cells used for model systems to assess gene transfer to the airway and pathophysiology in cystic fibrosis.

Proper citation: University of Iowa Center for Gene Therapy Cell Tissue Core (RRID:SCR_015410) Copy   

•   Source: SciCrunch Registry

http://tcag.ca/index.html

Service and training support for academic, government, and private sector scientists worldwide in genomics, including laboratory experimentation, statistical analysis, and comprehensive bioinformatics support, including large-scale genome comparisons, algorithm and tools development, and database curation, annotation and hosting. The Centre for Applied Genomics hosts a variety of databases related to ongoing supported projects: *Autism Chromosome Rearrangement Database *Cystic Fibrosis Mutation Database *The Lafora Progressive Myoclonus Epilepsy Mutation and Polymorphism Database *Database of Genomic Variants *The Chromosome 7 Annotation Project *Human Genome Segmental Duplication Database *Non-Human Segmental Duplication Database Healthy control DNA samples from the Ontario Population Genomics Platform are available. The Biobanking and Databasing Facility provides DNA extraction from lymphoblasts, fibroblasts and other cell types, archiving of white cell pellets, preparation and immortalization of cell lines, and comprehensive databasing and tracking of samples and/or cell lines within the facility.

Proper citation: TCAG (RRID:SCR_001840) Copy   

•   Source: SciCrunch Registry