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SciCrunch Registry is a curated repository of scientific resources, with a focus on biomedical resources, including tools, databases, and core facilities - visit SciCrunch to register your resource.
https://sites.manchester.ac.uk/bioms/
Core offers mass spectrometry services and associated technologies to the University of Manchester and beyond with focus on biological molecules such as proteins and metabolites in proteomics and metabolomics areas.Provides support from experimental design to advanced sample preparation and data processing and interpretation.
Proper citation: University of Manchester BioMS Core Facility (RRID:SCR_020987) Copy
http://www.rockefeller.edu/ddrc/
Core guides researchers in drug discovery by improving efficiency of their bioassays, identifying compounds and targets of function, and in utilizing technologies for measurement of drug/receptor interactions.Center also has spectroscopic and calorimetric equipment for use in studies of interactions of drugs with their targets.
Proper citation: Rockefeller University Fisher Drug Discovery Core Facility (RRID:SCR_020985) Copy
http://www.rockefeller.edu/genomics/
Core offers services and instruments to support genomics research. Houses Illumina NovaSeq, NextSeq, MiSeq sequencers, 10X Genomics Chromium Single Cell System, and Life Technologies QuantStudio 12K flex realtime PCR system. Provides several accessory instruments for sample quantity and quality validation: Agilent Bioanalyzer, Agilent TapeStation, NanoDrop spectrophotometer, and Qubit spectrophotometer.Offers full services for genomic DNA-Seq and RNA-Seq, specializing in preparation of libraries from very small amount of starting total RNA. Users can also prepare their own libraries and use the center�s sequencing-only services. Offers free consultations on experimental designs, library preparation options, sequencer choice, sequencing depth and coverage, and biological replicates.Performs initial sequencing data analysis for all users, and can assist with downstream analysis.
Proper citation: Rockefeller University Genomics Resource Center Core Facility (RRID:SCR_020986) Copy
Centralized, quality controlled facility and biorepository for processing, storage and disbursement of human specimens.Offers high throughput processing of human biospecimens, with specific emphasis on DNA and RNA isolation and purification.Provides laboratory support for investigator initiated large scale clinical, epidemiologic, and other studies.Functions as human specimen biorepository resource for clinicians who wish to store and study samples from unusual or potentially important patients.Biorepository is managed by custom LIMS, with sample accessioning, tracking and audits at each step.Provides scientific resource for investigators seeking advice or consultation on study design including specimen collection and storage methods, and human subject issues. Core staff act as liaison to other UNC core facilities and outside collaborators.
Proper citation: University of North Carolina at Chapel Hill Biospecimen Processing Core Facility (RRID:SCR_021290) Copy
https://pennstatehealthnews.org/topics/cryo-em/
Cryo-electron microscopy (cryo-EM) facility providesTitan Krios cryo-transmission electron microscope that is fully equipped for high-throughput data collection of the utmost quality possible. It has the ability to determine the atomic structure of a single protein or view molecules interacting in their cellular context. Provides guidance, training or data collection for researchers at the College of Medicine.Equipment includes Zeiss LSM 980 Cryo-Confocal Microscope,300 kV Krios Cryo-TEM for SPA and tomography, Equipped with Volta phase plates, bioquantum energy filter and K3 direct electron detector,200 kV thermionic JEOL 2100 for cryo-imaging, cryo-tomography, and standard imaging of stained grids.
Proper citation: Penn State Hershey College of Medicine cryo-EM Core Facility (RRID:SCR_021178) Copy
Core offers high throughput Sanger sequencing for any number of samples with 24 hour turn around time,PCR cleanups and mini-preps as well as sample prep from colonies or pellets.Provides large plasmid repository with over 300,000 constructs.Provides ORFs from MGC, Yeast, Xenopus, Drosophila, mouse, as well as several many other organisms including bacterial species. Accept deposits.
Proper citation: Harvard Medical School DNA Resource Core Facility (RRID:SCR_021292) Copy
https://cancer.dartmouth.edu/scientists-researchers/molecular-biology-resource
Genomics Section provides services and instrumentation that enable DNA/RNA extraction and quality control, next-generation Illumina and Nanopore sequencing, epigenetic profiling, and microarray analysis on a whole-genome scale, from the level organisms to single cells. Molecular Biology Section provides DNA fragment analysis qPCR, Sanger sequencing and NanoString Technology.
Proper citation: Dartmouth Genomics and Molecular Biology Shared Resource (GMBSR) (RRID:SCR_021293) Copy
https://www.unmc.edu/vcr/cores/vcr-cores/compchem/index.html
Core offers wide variety of services, including access to the Schrodinger platform and high-throughput computing. Services include examining molecular structures and mechanisms in atomic detail and provide graphically rich analysis suitable for inclusion in publications and grants.
Proper citation: University of Nebraska Medical Center Computational Chemistry Core Facility (RRID:SCR_021023) Copy
https://miap.eu/miap-unit/life-imaging-center/
Central core facility open to members of all faculties and the university clinic. Consists of 14 rooms in the Center for Integrative Signalling Analysis with 9 microscopy rooms with 20 microscope set-ups (3D-STED, confocal FLIM, two 2-photon confocal microscopes, 4 conventional confocal microscopes, lightsheet microscope, 4 high-end widefield ratio-imaging set-ups, 4 fluorescence stereo microscopes, 3 special set-ups for screening. LIC microscopes are hosted in Biosafety level S2 and S1 environments, connected to a large wet lab area and a cell culture room, both Biosafety level S2 classified. Additionally, the LIC offers a large computer lab with 12 high-end workstations for image processing and analysis. The LIC also covers two additional rooms, hosting 3 LSM systems in a neighboring building of the Signalling Campus Freiburg (SCF).
Proper citation: University of Freiburg Life Imaging Center Core Facility (RRID:SCR_020968) Copy
https://www.cityofhope.org/patients/departments-and-services/pathology
Department of Pathology at City of Hope combines state-of-the-art laboratories equipped with the latest diagnostic techniques and advanced instrumentation with superior investigative skills to accurately and rapidly identify even the rarest and most complex diseases. Our experts provide comprehensive services, from initial diagnosis to monitoring of prognostic indicators throughout the treatment process.
Proper citation: City of Hope Department of Pathology Core Facility (RRID:SCR_020974) Copy
https://www.umass.edu/ials/light-microscopy
Core provides resources for imaging model organisms, tissue, cells, biomaterials, and artificial structures and houses equipment including almost every light microscopy imaging modality presently available. Cell culture facilities are also available nearby as well as other routine items necessary for biological imaging and material imaging. This facility has been designated Nikon Centers of Excellence, thus providing unique opportunity for training, demonstration, instrument development, and research.We excel in use of telemicroscopy through use of remote imaging sessions, remote control of all instruments, and remote data analysis sessions available to all users.Provides training to all users that plan to conduct experimentation. Following an initial consultation in which experimental requirements, expected outcomes, and careful scrutiny of feasibility, training and/or access is arranged through the Director.
Proper citation: University of Massachusetts Light Microscopy Core Facility (RRID:SCR_021148) Copy
https://www.rockefeller.edu/cemrc/
Offers new cryo-electron microscopy tools available to University researchers, allowing for visualization of three-dimensional structures of molecules and macromolecular complexes in solution.
Proper citation: Rockefeller University Cryo Electron Microscopy Resource Center Core Facility (RRID:SCR_021146) Copy
https://www.bmh.manchester.ac.uk/research/facilities/electron-microscopy/
Offers expertise and equipment tailored for biological samples mostly. Houses four electron microscopes.Preparation laboratory includes range of specialised room temperature and cryo sample preparation equipment, ultramicrotomes and suite of computer workstations for image processing.Electron microscopy staff are available to train and assist.
Proper citation: University of Manchester Electron Microscopy Core Facility (RRID:SCR_021147) Copy
Coordinated, centralized, and dedicated program for procuring, processing, dispersing and assessing all types of biospecimens together with downstream histology services. CAP Accredited.
Proper citation: University of Chicago Human Tissue Resource Center Core Facility (RRID:SCR_019199) Copy
https://www.ualberta.ca/medicine/research/corefacilities/flow-cytometry-facility/index.html
Flow Cytometry Facility offers analytical flow cytometry, cell sorting and data analysis.Instruments include FACSArias, FACSCanto II, LSR-Fortessas, Attune NxT, and Amnis ImageStream mkII.
Proper citation: University of Alberta Faculty of Medicine and Dentistry Flow Cytometry Core Facility (RRID:SCR_019195) Copy
https://voices.uchicago.edu/confocal/
Offers microscopy imaging, including bright field color and DIC, fluorescence multi-dimension,TIRFM including bleaching, ablation, FLIM and high resolution, highspeed, high sensitivity, confocal, and physiologic techniques, STED, GSD3D, lightsheet selective plane illumination and lattice lightsheet structured illumination super resolution microscopy.
Proper citation: University of Chicago Integrated Light Microscopy Core Facility (RRID:SCR_019197) Copy
http://njms.rutgers.edu/research/mfrweb/
THIS RESOURCE IS NO LONGER IN SERVICE. Documented on August 18,2022. Provides services in molecular biology with DNA sequencing, capillary and high throughput services, single cell sequencing services using 10X genomics and Drop-Seq platforms, Luminex, oligonucleotide synthesis (IDT), HPLC analysis and purification, real time PCR and others.
Proper citation: Rutgers New Jersey Medical School Molecular Resource Core Facility (RRID:SCR_019169) Copy
https://med.nyu.edu/research/scientific-cores-shared-resources/cryo-electron-microscopy-laboratory/
Shared resource hosting advanced cryo–electron microscopes fitted with direct detectors as well as equipment for sample preparation.
Proper citation: New York University School of Medicine Langone Health Cryo-Electron Microscopy Laboratory Core Facility (RRID:SCR_019202) Copy
https://www.chemistry.ucsc.edu/research/facilities/index.html
Shared research facility dedicated to improving human health by finding next generation of therapeutic agents against wide variety of diseases. The CSC is driving innovation in drug discovery by bringing together experts in drug screening with cell and molecular biologists engaged in disease research. Has assembled diverse collection of compounds derived from marine organisms, setting our facility apart as a leader in the discovery of therapeutic natural products.
Proper citation: University of California, Santa Cruz Chemical Screening Center Core Facility (RRID:SCR_021114) Copy
Core provides professional scientific expertise in light microscopy. Offers access to hardware and software as well as expert guidance at any step of imaging project, from experimental design to image analysis.Comprises eight microscope systems including two laser scanning confocal microscopes including one Olympus inverted confocal microscope system (FV1000) and one Zeiss inverted confocal microscope system (LSM-980) equipped with Airy scan 2 for super resolution and 2-photon technology for in-vivo deep imaging with temperature controlled chamber. One spinning disk confocal including Nikon inverted spinning disk microscope system with incubation chamber (Eclipse Ti with Yokogawa disk CSU-W1), two Zeiss widefield microscopes for brightfield and epifluorescence illumination (Zeiss Apotome and Zeiss Colibri), three macroscopes systems to observe large samples or complete model organisms in brightfield and epifluorescence including one Olympus stereomicroscope system (MVX10) and two Zeiss stereomicroscope systems (SteREO Discovery V12), fully automated and one AxioZoom V16 , fully automated with ApoTome attachment.
Proper citation: Mount Desert Island Biological Laboratory Light Microscopy Core Facility (RRID:SCR_019166) Copy
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