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http://www.nia.nih.gov/research/intramural-research-program/dynamics-health-aging-and-body-composition-health-abc

A study that characterizes the extent of change in body composition in older men and women, identifies clinical conditions accelerating these changes, and examines the health impact of these changes on strength, endurance, disability, and weight-related diseases of old age. The study population consists of 3,075 persons age 70-79 at baseline with about equal numbers of men and women. Thirty-three percent of the men are African-Americans as are 46% of the women. All persons in the study were selected to be free of disability in activities of daily living and free of functional limitation (defined as any difficulty walking a quarter of a mile or any difficulty walking up 10 steps without resting) at baseline. The core yearly examination for HEALTH ABC includes measurement of body composition by dual energy x-ray absorptio��������metry (DXA), walking ability, strength, an interview that includes self-report of limitations, a medication survey, and weight (Measurements in the Health ABC Study). Provision has been made for banking of blood specimens and extracted DNA (HealthABC repository). Study investigators are open to collaboration especially for measures focused on obesity and associated weight-related health conditions including osteoporosis, osteoarthritis, pulmonary function, cardiovascular disease, vascular disease, diabetes and glucose intolerance, and depression. The principal goals of the HEALTH ABC are: # To assess the association of baseline body weight, lean body mass, body fat, and bone mineral content, in relation to weight history, with: incident functional limitation; incidence and change in severity of weight-related health conditions; recovery of physical function after an acute event; baseline measures of strength, fitness and physical performance; gender, ethnicity and socioeconomic status # To access the contribution of episodes of severe acute illness in healthier older persons to changes in body weight, bone mineral content, lean body mass and body fat, and the relationship of these episodes to risk of functional limitation and recovery. # To assess the impact of weight-related co-morbid illness on the risk of functional limitation and recovery. # To assess the ways in which physiologic mediators of change in body composition influence and are influenced by changes in health in older adults and contribute to change in body composition; to understand how changes in body composition affect weight-related cardiovascular disease risk factors such as lipids, blood pressure and glucose tolerance. # To assess the interdependency of behavioral factors, such as nutrition and physical activity, co-morbid health conditions, and their association with change in body composition in old age. # To provide a firm scientific basis for understanding issues related to weight recommendations in old age through increased knowledge of the potential trade-offs between weight and risk of functional limitation, disability, morbidity and death; to provide information critical for developing effective strategies for the maintenance of health in older persons.

Proper citation: Dynamics of Health Aging and Body Composition (Health ABC) (RRID:SCR_008813) Copy   

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http://ki.se/sites/default/files/str_artikel_tchad.pdf

Data and biomaterial from a longitudinal study of 1,500 Swedish twin pairs from age 8 to age 20. Twins, parents, and teachers responded to 4 waves of questionnaires (1994, 1999, 2002, 2006) and a clinical interview. In the last follow up (2006) 1325 biological samples for DNA-extraction were collected. A paper that describes the study was published (Lichtenstein, Tuvblad, Larsson, Carlstrom, 2007, Twin Research and Human Genetics). Twins were followed prospectively from childhood to emerging adulthood. The data include a broad spectrum of measures of environments as well as internalizing and externalizing problems behaviors from different informants (twins, parents, teachers, clinical assessments).

Proper citation: Twin Study of Child and Adolescent Development - TCHAD (RRID:SCR_008897) Copy   

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http://hrsonline.isr.umich.edu/

A data set of a longitudinal panel study of health, retirement, and aging that surveys a representative sample of more than 26,000 Americans over the age of 50 every two years. The HRS explores the changes in labor force participation and the health transitions that individuals undergo toward the end of their work lives and in the years that follow. The study captures a dynamic picture of an aging America''s physical and mental health, insurance coverage, financial status, family support systems, labor market status, and retirement planning. The sample in 2006 numbered over 22,000 persons in 13,100 households, with oversamples of Hispanics, Blacks and Florida residents. Beginning in 2006, half the sample received enhanced face-to-face follow-ups that included the collection of physical measures and biomarkers HRS provides a research data base that can simultaneously support continuous cross-sectional descriptions of the US population over the age of fifty-five, longitudinal studies of a given cohort over a substantial period of time (up to 18 years by 2010 for the original HRS cohort, following them from age 51-61 to age 69-79) and research on cross-cohort trends. By 2010 the HRS will be able to support cross-cohort comparisons of trajectories of health, labor supply, or wealth accumulation for persons who entered their 50s in 1992, 1998 and 2004. The HRS also has provided the sampling frame for targeted sub-studies. The Aging, Demographics, and Memory Study (ADAMS) supplement on dementia involved a field assessment of a sample of about 930 HRS panel members aged 75+ to clinically assess their dementia status and dementia severity. Special topics including consumption and time use, prescription drug use and the impact of Medicare Part D, parents'' human capital investments in children, and diabetes management by self-reported diabetics, have appeared on mail surveys that have used the HRS as a sampling frame. The HRS also can accommodate a number of experimental topics using Internet interviewing. The HRS is also characterized by links to a rich array of administrative data, including: Employer Pension Plans; National Death Index; Social Security Administration earnings and (projected) benefits data; W-2 self-employment data; and Medicare and Medicaid files. The HRS has actively collaborated with other longitudinal studies of aging in other countries (e.g., ELSA, SHARE, MHAS), providing both scientific and technical assistance. Data Availability: All publicly available data may be downloaded after registration. Early Release data files are typically available within three months of the end of each data collection, with the Final Release following at 24 months after the close of data collection activities. Files linked with administrative data are released only as restricted data through an application process, as outlined on the HRS website. * Dates of Study: 1992-present * Study Features: Longitudinal, Minority Oversamples, Anthropometric Measures, Biospecimens * Sample Size: 22,000+ Link * ICPSR: http://www.icpsr.umich.edu/icpsrweb/ICPSR/studies/06854

Proper citation: Health and Retirement Study (RRID:SCR_008930) Copy   

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http://neurogenetics.nia.nih.gov

A suite of web-based open source software programs for clinical and genetic study. The aims of this software development in the Laboratory of Neurogenetics, NIA, NIH are * Build retrievable clinical data repository * Set up genetic data bank * Eliminate redundant data entries * Alleviate experimental error due to sample mix-up and genotyping error. * Facilitate clinical and genetic data integration. * Automate data analysis pipelines * Facilitate data mining for genetic as well as environmental factors associated with a disease * Provide an uniformed data acquisition framework, regardless the type of a given disease * Accommodate the heterogeneity of different studies * Manage data flow, storage and access * Ensure patient privacy and data confidentiality/security. The GERON suite consists of several self contained and yet extensible modules. Currently implemented modules are GERON Clinical, Genotyping, and Tracking. More modules are planned to be added into the suite, in order to keep up with the dynamics of the research field. Each module can be used separately or together with others into a seamless pipeline. With each module special attention has been given in order to remain free and open to the academic/government user., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025.

Proper citation: GERON (RRID:SCR_008531) Copy   

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http://ccr.coriell.org/nia/

A cell repository containing cells and DNA for studies of aging and the degenerative processes associated with it. Scientists use the highly-characterized, viable, and contaminant-free cell cultures from this collection for research on such diseases as Alzheimer's disease, progeria, Parkinson's disease, Werner syndrome, and Cockayne syndrome. The collections of the Repository include DNA and cell cultures from individuals with premature aging disorders, as well as DNA from individuals of advanced age from the the Baltimore Longitudinal Study of Aging at the Gerontology Research Center and other Longevity Collections. The Repository also includes samples from an Adolescent Study of Obesity, Apparently Healthy Controls, Animal Models of Aging, and both human and animal differentiated cell types. The cells in this resource have been collected over the past three decades using strict diagnostic criteria and banked under the highest quality standards of cell culture. Scientists can use the highly-characterized, viable, and contaminant-free cell cultures from this collection for genetic and cell biology research.

Proper citation: Aging Cell Repository (RRID:SCR_007320) Copy   

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http://ki.se/en/research/spotlight-on-parkinsons-disease

The primary purpose is to assess the importance of environmental factors for Parkinson's Disease (PD) in a population-based sample of Swedish twins. In PD discordant twin pairs, what are the environmental factors that contribute to the disease in the affected twin and or protect the unaffected twin? Second, we want to investigate whether the earlier reports of low heritability for elderly male twins can be confirmed for female pairs. All twins 55 years of age and older in the Swedish Twin Registry have been screened for most complex diseases. 626 twins have screened positive for PD and most pairs are discordant. To establish diagnosis, a physician will examine all potential cases and their co-twins and their medical records will be reviewed. Environmental factors will be studied through the use of discordant pairs, where genetic susceptibility to the disease can be controlled. Environmental exposures are being secured with telephone interviews and from a questionnaire collected 30 years ago. Recent results indicate that genetic factors play a very small role. A better understanding of the etiology of PD is important for the possibility of delaying onset or even preventing the disease, as well as for providing guidance for molecular biology studies. Types of samples * DNA Number of sample donors: 333 (sample collection completed)

Proper citation: KI Biobank - Parkinson (RRID:SCR_008866) Copy   

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http://dsarm.niapublications.org/

THIS RESOURCE IS NO LONGER IN SERVICE, documented on February 18, 2014.

A networking site for investigators using animal models to study aging, developed to provide a venue for sharing information about research models for aging studies. If you have tissue or data from animal models relevant to aging research that you are willing to share with other investigators, D-SARM allows you to identify the model and provides a secure, blinded email contact for investigators who would like to contact you about acquiring tissue or related resources. Investigators looking for resources from a particular model enter search terms describing the model of interest and then use the provided link to send emails to the contacts (names blinded) listed in the search results to initiate dialog about tissue or resources available for sharing. The database is housed on a secure server and admission to the network is moderated by the NIA Project Officer and limited to investigators at academic, government and non-profit research institutions. The goal is to provide a secure environment for sharing information about models used in aging research, promoting the sharing of resources, facilitating new research on aging in model systems, and increasing the return on the investment in research models.

Proper citation: Database for Sharing Aging Research Models (RRID:SCR_008691) Copy   

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http://coordinatingcenter.ucsf.edu/pride/

Randomized controlled trial being conducted at two clinical centers in the United States to learn more about the effects of weight loss on urinary incontinence. About 330 overweight women aged 30 or older will participate and will be followed for 18 months. Efficacy of weight reduction as a treatment for urinary incontinence will be examined at 6 months following the intensive weight control program, and the sustained impact of the intervention will be examined at 18 months. To increase the maintenance of weight reduction and facilitate evaluation of the enduring impact of weight loss on urinary incontinence, they propose to study a motivation-based weight maintenance program. At the end of the intensive weight control program, women randomized to the weight loss program will be randomized to either a 12-month skill-based maintenance intervention or to a motivation-based maintenance intervention. The maintenance interventions maximize the potential for sustained weight loss and will allow them to determine if long-term weight reduction will produce continued improvement in urinary incontinence.

Proper citation: Program to Reduce Incontinence by Diet and Exercise (RRID:SCR_009018) Copy   

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https://www.accordtrial.org/public

Study testing whether strict glucose control lowers the risk of heart disease and stroke in adults with type 2 diabetes. In addition the study is exploring: 1) Whether in the context of good glycemic control the use of different lowering lipid drugs will further improve these outcomes and 2) If strict control of blood pressure will also have additional beneficial effects on reducing cardiovascular disease. The design was a randomized, multicenter, double 2 X 2 factorial trial in 10,251 patients with type 2 diabetes mellitus. It was designed to test the effects on major CVD events of intensive glycemia control, of fibrate treatment to increase HDL-cholesterol and lower triglycerides (in the context of good LDL-C and glycemia control), and of intensive blood pressure control (in the context of good glycemia control), each compared to an appropriate control. All 10,251 participants were in an overarching glycemia trial. In addition, one 2 X 2 trial addressed the lipid question in 5,518 of the participants and the other 2 X 2 trial addressed the blood pressure question in 4,733 of the participants. The glycemia trial was terminated early due to higher mortality in the intensive compared with the standard glycemia treatment strategies. The results were published in June 2008 (N Eng J Med 2008;358:2545-59). Study-delivered treatment for all ACCORD participants was stopped on June 30, 2009, and the participants were assisted as needed in transferring their care to a personal physician. The lipid and blood pressure results (as well as the microvascular outcomes and eye substudy results) were published in 2010. All participants are continuing to be followed in a non-treatment observational study.

Proper citation: ACCORD (RRID:SCR_009015) Copy   

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http://ohsu.eagle-i.net/i/0000012b-00ce-7b4f-79a3-373680000000

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on December 6,2022. The Neuropathology Core of the Layton Center for Aging and Alzheimer?s Disease Center is dedicated to studying, through autopsy, the brains of individuals who have been followed longitudinally in the Oregon Alzheimer?s Disease Center Clinical Core. Requests for tissue from the Oregon Brain Bank should be directed to Dr. Randall Woltjer. Dr. Woltjer will be glad to communicate with investigators regarding their tissue needs and to assist them in identifying suitable materials for their studies. Material Transfer Agreements between the requesting and sending institutions are needed before shipment.

Proper citation: OHSU Neuropathology Core (RRID:SCR_009988) Copy   

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https://github.com/gaow/genetic-analysis-software/blob/master/pages/AGEINF.md

THIS RESOURCE IS NO LONGER IN SERVCE, documented September 22, 2016. Software application used to infer the age of a rare, selectively-neutral mutation.

Proper citation: AGEINF (RRID:SCR_009039) Copy   

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http://mayoresearch.mayo.edu/mayo/research/biobank/index.cfm

A collection of blood samples and health information donated by volunteers, not focusing on any specific disease. Unlike many biobanks already in existence at Mayo Clinic and elsewhere, the Mayo Clinic Biobank is NOT focused on any particular disease. Rather, this biobank will collect samples and health information on patients and volunteers regardless of their health history. The only requirement is that they be 18 years of age or older, have a Mayo Clinic number, and be able to give informed consent. Once a participant becomes a part of the Biobank, they will be a part of ongoing health research conducted at Mayo Clinic indefinitely. The Biobank was established at Mayo Clinic, Rochester, and recruitment began in April of 2009. The goal of this project is to enroll 20,000 Mayo Clinic patients over the course of a three-year period in an effort to support a wide array of health-related research studies throughout the Institution.

Proper citation: Mayo Clinic Biobank (RRID:SCR_010723) Copy   

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http://www.lifelines.net/

Overall aim of the LifeLines Study is to unravel the interaction between genetic and environmental factors in the development of multifactorial diseases, their concurrent development in individuals and their complications as a complex trait. The LifeLines database contains questionnaire data, physical measurements and biological samples from different health examinations. Collaboration is encouraged as it helps to maximize the scientific value of the wealth of epidemiologic data made possible by the participation of more than 165,000 individuals in the LifeLines Cohort Study. Primary objectives of the LifeLines Cohort Study are: a. Which are the disease overriding risk factors which predict the development of a multifactorial disease during lifetime? b. How are these universal risk factors modified, or what determines the effect of a universal risk factor in an individual? Specific research questions will focus on risk factors and modifiers (genetic, environmental and combined or complex factors) for single and multiple diseases. In addition to co-morbidity, LifeLines focuses on co-determinants. The primary endpoints include measures of aging, metabolic and endocrine diseases, cardiovascular and renal diseases, pulmonary and musculoskeletal diseases, and psychopathology. Secondary aims include the assessment of the prevalence and incidence of multifactorial diseases, their risk factors and their treatment in individuals as well as in families. The burden of disease for the society will be quantified in terms of care needed, and total costs of care. Until November 3, 2011, almost 68,000 subjects have been included in the study. The 60,000th participant was screened in the beginning of September 2011. Recruitment rate at present is between 700 and 800 subjects per week. The laboratory measurements which are performed has changed. As of October 2011, LifeLines will continue to measure: hematologic parameters, including hemoglobin, white blood cells, platelets, WBC differentiation, blood glucose, cholesterol, HDL-cholesterol, triglycerides, serum creatinin and sodium/potassium. Liver enzymes, thyroid hormones, calcium, phosphate, albumin, uric acid and microalbuminuria will not be measured routinely. The samples that are available for almost all participants, are: # serum (taken either with or without gel separator) # EDTA plasma # citrate plasma # DNA # early morning urine sample # urine samples of 24-hour urine collection Any researcher who is member of an internationally recognized academic institution and who is interested in utilizing the research possibilities, data and materials of LifeLines may apply for access. The applicant who is acting as Principal Investigator must be connected to a department or institution with the competence to carry out the research project to term. A contract will give the right to use the data for a pre-determined period of time. This contract also comprises the costs for the LifeLines Biobank which the investigator needs to reimburse. To apply for access, refer to the electronic application process.

Proper citation: Lifelines Biobank (RRID:SCR_010730) Copy   

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http://www.flinders.edu.au/sabs/fcas/alsa/alsa_home.cfm

The general purpose of ALSA is to examine how social, biomedical, psychological, economic, and environmental factors are associated with age-related changes in the health and wellbeing of persons aged 70 years and older. The aim is to analyze the complex relationships between individual and social factors and changes in health status, health care needs and service utilization dimensions, with emphasis given to the effects of social and economic factors on morbidity, disability, acute and long-term care service use, and mortality. The study was designed to have common instrumentation with US studies. ALSA collected data from a random, stratified sample of all persons (both community and institution-dwelling) aged 70 years and older living in the metropolitan area of Adelaide, South Australia, using the State Electoral Database as the sampling frame. Spouses aged 65 and older and other household members aged 70 years and older also were invited to participate. The initial baseline data collection for ALSA began in September 1992 and was completed in March 1993. In the first wave, personal interviews were carried out for 2,087 participants, including 566 couples (that is, persons 70 years of age and over and their spouse, if 65 and over). Clinical assessments were obtained for 1,620 of the participants. Respondents were recontacted by telephone a year after initial interview (wave 2). The third wave of the study began in September 1994 and involved a complete reassessment, with a total of 1,679 interviews and 1,423 clinical assessments. To date, eleven waves of data have been collected, with the latest collection in May 2010, from 168 participants. Six of these waves were conducted via face-to-face interviews and clinical assessments, and five were telephone interviews. Future waves are planned, however are dependent on grant funding. Ancillary data collection has been ongoing since the initiation of the study, e.g., from secondary providers. Lists of ALSA participants are compared biannually with the agencies'' lists to determine the prevalence and incidence of receipt of services from these organizations. Another source of information has been the collection of data from the participants'' general practitioners about the respondent''s health status, history of services received, medication use, referrals to specialists, and current services provided. Baseline Sample Size: 2087 Dates of Study: 1992����������2010 (potentially ongoing) Study Features: * Longitudinal * International * Anthropometric Measures * Biospecimens Waves 1-5 (ICPSR), http://www.icpsr.umich.edu/icpsrweb/ICPSR/studies/06707 Wave 6 (ICPSR), http://www.icpsr.umich.edu/icpsrweb/ICPSR/studies/03679

Proper citation: ALSA - The Australian Longitudinal Study of Ageing (RRID:SCR_013146) Copy   

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http://www.ohsu.edu/xd/education/schools/school-of-medicine/departments/clinical-departments/pathology/research/oregon-brain-bank.cfm

Brain bank that harvests, banks and disperses postmortem tissue for use in brain and medical research. It also provides neuropathologic diagnoses of organic dementia in a cohort of NIH sponsored research subjects. The bank includes tissue primarily from patients with Alzheimer's but also includes Huntington's, Parkinson's, and other disorders.

Proper citation: Oregon Brain Bank (RRID:SCR_013085) Copy   

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http://brainslab.wordpress.com/

I''m studying how the brain works on various levels; this blog chronicles some of my informal notes along the way. I previously went to Vassar College, majoring in Neuroscience and Behavior with a minor in Math. Now I work at a biology lab in Maryland. I appreciate any feedback that you may have, good or bad. You can email me at amckenz at g mail dot com. What I write on here is obviously my opinion. Everything on the site is filed under a Creative Commons License v. 3.0. That means that you can copy and re-publish this stuff anywhere without my permission. Thanks for reading. Essay titles include: * A Loss of Agency Following Use of ADHD Medications in College Aged Adults * An Evolutionary Account of the Environmentally Programmed Stress Response * Changes in protein structure of myelin sheaths throughout vertebrate evolution * Effect of Glucocorticoids on the Attenuation in Neurogenesis due to Sleep Deprivation * Insulin sensitivity and age-related memory changes due to caloric restriction * Is Neurogenesis in the Hippocampus Linked to Depression? * Novelty-Seeking and Associative Learning of Chemotaxis in C. Elegans * The Effects of D2 Receptors on the Inverted U-Shape Response Curve to Psychostimulants * Three Applications of Optogenetics The author has included some tricks and illusions from around the web that reveal fascinating facets of our thought processes including: The Checker, Sensory Homonculus Picture, A Blindspot Demonstration, A Ball in a Box, Iterated Choices, The Max Plank Institute for Biological Cybernetics, The Motion Aftereffect Illusion, The Phi Phenomenon, The Common Fate Phenomenon, A Double Face, The Troxler Effect

Proper citation: Brains Lab (RRID:SCR_010534) Copy   

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http://www.nitrc.org/projects/atag/

This atlas takes advantage of ultra-high resolution 7T MRI to provide unprecedented levels of detail on structures of the basal ganglia in-vivo. The atlas includes probability maps of the Subthalamic Nucleus (STh) using T2*-imaging. For now it has been created on 13 young healthy participants with a mean age of 24.38 (range: 22-28, SD: 2.36). We recently also created atlas STh probability maps from 8 middle-aged participants with a mean age of 50.67 (range: 40-59, SD: 6.63), and 9 elderly participants with a mean age of 72.33 (range: 67-77, SD: 2.87). You can find more details about the creation of these maps in the following papers: Young: http://www.ncbi.nlm.nih.gov/pubmed/22227131 Middle-aged & Elderly: http://www.ncbi.nlm.nih.gov/pubmed/23486960 Participating institutions are the Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, and the Cognitive Science Center Amsterdam, University of Amsterdam, the Netherlands.

Proper citation: Atlasing of the basal ganglia (RRID:SCR_009431) Copy   

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http://lgsun.grc.nia.nih.gov/cDNA/cDNA.html

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 23,2022. Project portal housing NIA Mouse EST Project, NIA Mouse cDNA Clone Sets, a NIA Mouse Gene Index, NIA Mouse cDNA Database, and NIA Mouse Microarrays. Characteristics of NIA 15K Mouse cDNA Clone Set * ~15,000 unique cDNA clones were rearrayed among 52,374 ESTs from pre- and periimplantation embryos, E12.5 female gonad/mesonephros, and newborn ovary. * Up to 50% are derived from novel genes. * ~1.5 kb average insert size. * Clones were sequenced from 5' and 3' termini to obtain longer reads and verify sequence. Sequence information is available at this Web Site. Clone names are from H3001A01 to H3159G07. * Handling of NIA 15k cDNA Clone Set(June3, 2000) Characteristics of NIA mouse 7.4K cDNA Clone Set * ~7407 cDNA clones with no redundancy within the set or with NIA Mouse 15K. * ~1.5 kb average insert size for short insert clones and ~2.5-3.0 kb average insert size for long-insert enriched clones.. * Clones were sequenced from 5' and 3' termini to obtain longer reads and verify sequence. Sequence information is available at this Web Site. Clone names are from H4001A01 to H4079G07. * Handling of NIA mouse 7.4k cDNA Clone Set (similar to handling of NIA mouse 15K, to be updated) Individual Clones are available from ATCC and MRC geneservice, UK. To obtain Clone, search the database using either the rearrayed clone name or GenBank accession number at the Key Word Search page. Follow the link to the sequence information page for the rearrayed clone to obtain source clone ATCC number. Clicking the ATCC number will bring up the ATCC ordering page for the source clone. There is essentially no overlap between the two clone sets (7.4K and 15K) said Minoru S.H. Ko, M.D., Ph.D., head of the Developmental Genomics and Aging Section in the NIA's Laboratory of Genetics. In addition, all cDNA clones in the NIA 7.4K set were purified by single colony isolation and sequence-verified, and more than half were prepared by a new procedure that yields long full-length cDNAs (average size 3-4 kb). The NIA Mouse 15k and 7.4k Clone Set Data and Published Microarray Data are available for download. NIA Mouse Microarrays *Microarray Data Download * 60-mer Oligo Array Platform ** (A) NIA 22k Oligo Microarray Gene List (21939 gene features) ( Carter et al 2003 ) ** (B) Agilent Mouse Development Oligo Microarray Gene List ** ( Subset of Microarray (A): 20,280 gene features ) * Data Analysis Tools

Proper citation: NIA Mouse cDNA Project Home Page (RRID:SCR_001472) Copy   

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http://www.mhasweb.org/

A dataset of a prospective panel study of health and aging in Mexico. The study was designed to ensure comparability with the U.S. Health and Retirement Study in many domains, and the NHANES III. The baseline survey in 2001 is nationally representative of the 13 million Mexicans born prior to 1951. The six Mexican states which are home to 40% of all migrants to the U.S. were over-sampled at a rate of 1.7:1. Spouse/partners of eligible respondents were interviewed also, even if the spouse was born after 1950. Completed interviews were obtained in 9,862 households, for a total of 15,186 individual interviews. All interviews were face-to-face, with average duration of 82 minutes. A direct interview (on the Basic questionnaire) was sought, and Proxy interviews were obtained when poor health or temporary absence precluded a direct interview. Questionnaire topics included the following: * HEALTH MEASURES: self-reports of conditions, symptoms, functional status, hygienic behaviors (e.g., smoking & drinking history), use/source/costs of health care services, depression, pain, reading and cognitive performance; * BACKGROUND: Childhood health and living conditions, education, ability to read/write and count, migration history, marital history; * FAMILY: rosters of all children (including deceased children); for each, demographic attributes, summary indicators of childhood and current health, education, current work status, migration. Parent and sibling migration experiences; * TRANSFERS: financial and time help given to and received by respondent from children, indexed to specific child; time and financial help to parent; * ECONOMIC: sources and amounts of income, including wages, pensions, and government subsidies; type and value of assets. All amount variables are bracketed in case of non-response. * HOUSING ENVIRONMENT: type, location, building materials, other indicators of quality, and ownership of consumer durables; * ANTHROPOMETRIC: for a 20% sub-sample, measured weight, height; waist, hip, and calf circumference; knee height, and timed one-leg stands. Current plans are to conduct another two follow-up surveys in 2012 and 2014 and will field the 3rd and 4th waves of survey data collection in Mexico. For the 2012 wave, interviews will be sought for: every person who was part of the panel in 2003 and their new spouse / partner, if applicable, and a new sample of persons born between 1952 and 1962. For the 2014 wave, we will follow-up the whole sample from 2012. Interviews will be conducted person-to-person. Direct interviews will be sought with all informants, but proxy interviews are allowed for those unable to complete their own interview for health or cognitive reasons. A next-of-kin interview will be completed with a knowledgeable respondent for those who were part of the panel but have died since the last interview. A sub-sample will be selected to obtain objective markers such as blood sample and anthropometric measures. Data Availability: The 2001 baseline data, 2003 follow-up data, and documentation can be downloaded. * Dates of Study: 2001-2003 * Study Features: Longitudinal, International, Anthropometric Measures * Sample Size: 2001: 15,186 (Baseline) Link: * ICPSR: http://www.icpsr.umich.edu/icpsrweb/ICPSR/studies/00142

Proper citation: Mexican Health and Aging Study (RRID:SCR_000818) Copy   

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http://eagle-i.itmat.upenn.edu/i/0000013f-8bde-1d59-a468-831a80000000

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on May 22,2024.Core facility that provides the following services: Recombinant plasmid DNA engineering, Recombinant protein production via Baculovirus expression systems (BVES), Recombinant protein production in prokaryotic systems, Recombinant protein purification, Retrovirus production service. The Protein Expression Facility is a shared resource laboratory that provides Wistar Cancer Center Members and non-Wistar scientists technical assistance with viral vector preparation and the expression and purification of recombinant proteins. The Facility has greater than 20 years of experience in recombinant protein expression with special expertise in the use of baculovirus expression systems (BVES). The Facility offers the following services: 1. Recombinant plasmid DNA engineering 2. Viral vector production (i.e. baculovirus and retrovirus) 3. Analytical and preparative scale expression of nascent or epitope-tagged recombinant proteins 4. Protein purification These goals are accomplished by a centralized laboratory with dedicated, experienced staff, which enables high-throughput, economy of scale, virus preparation and protein expression services, including quality assurance and control procedures to ensure efficient, consistent production and purification of recombinant proteins and viral vectors. Many recombinant proteins produced by the facility have been used for crystallization efforts, analytical biochemistry studies designed to investigate enzymatic properties, structure-function relationships between protein-protein, protein-nucleic-acid, and protein-small molecule interactions, custom antibody production, experimental cancer vaccines, and development of miniaturized assays for small molecule screening. The facility is supported in part by an NCI Cancer Center Support Grant and a grant from the NIH National Institute of Aging (PO1 AG031862).

Proper citation: Wistar Protein Expression Facility (RRID:SCR_010210) Copy   

•   Source: SciCrunch Registry