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https://www.urmc.rochester.edu/research/flow-core.aspx

Provides investigators with instrumentation along with expertise. Core instrumentation includes traditional analytical cytometers, full spectrum cytometer, cell sorters, imaging cytometers, small(nano) particle detection system, metabolomics instrument, and mass cytometer.

Proper citation: University of Rochester Medical Center Flow Cytometry Core Facility (RRID:SCR_012360) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/multiphoton-microscopy-core-rochester

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on May 16,2024.The mission of the URSMD Multiphoton Core Facility is to provide state-of-the-art multiphoton imaging capabilities to further the biomedical and bio-optical research at the URSMD and the University of Rochester with emphasis on intravital imaging and systems physiology. The Multiphoton Core Facility provides access to an Olympus Fluoview 1000 AOM-MPM imaging system and a Spectra-Physics MaiTai HP DeepSee Ti:Sa laser system with dispersion compensation. Further capabilities include engineering applications for opto-electronics and spectroscopy. Initial meeting with the director regarding the design of the experiments begins the process. Imaging will be initially performed by highly skilled staff to make sure all features of software are added for the study, thereafter, the investigator is trained until they are able to operate the microscope independently. Also offered is a blood gas analysis machine and supporting equipment.

Proper citation: URMC Multiphoton Microscopy Core (RRID:SCR_012362) Copy   

•   Source: SciCrunch Registry

https://www.moffitt.org/research-science/shared-resources/tissue/

Biorepository resource with mission of proper collection, handling, processing and storage of irreplaceable biological specimens to support spectrum of related basic science, translational and clinical research. Provides expertise in nucleic acid extractions, quantification, aliquoting and quality assurance; liquid specimen centrifugation, processing and aliquoting; histological tissue processing, immunohistochemistry and tissue microarray microtomy; pathologist consultation services. Tissue Core operations are divided into four distinct pillars of service that work collaboratively to ensure specimen quality is maintained from procurement to preservation.

Proper citation: Moffitt Cancer Center Tissue Core Facility (RRID:SCR_012364) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/macromolecular-x-ray-crystallography-core-facility--2

X-ray crystallography is the principal technique used to determine three-dimensional structures of biological macromolecules. The central goal of the UNC Crystallography Core Facility is to provide the support and infrastructure necessary to enable individual investigators of any experience level to initiate and successfully complete a structural biology project. The facility is state of the art, offering a variety of services in these three areas: crystallization, x-ray diffraction, structure determination. The primary mission of the MX Facility is to work with researchers here at UNC, however, we are also able to work with researchers at non-UNC academic institutions and commercial companies.

Proper citation: UNC School of Medicine Macromolecular X-Ray Crystallography Core Facility (RRID:SCR_012327) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/magnetic-resonance-laboratory-georgia-tech

The Nanomedicine Research Institute Magnetic Resonance Laboratory at Georgia Tech operates a Bruker Pharmascan 7T with a magnet bore of 160 mm. We have a large expertise in the use of MRI as a tool in Biomedical and Chemical Engineering. Previous research projects were concerned with: MRI of anatomical preparations; evaluation of tumor growth; bio-compatibility of implants; cardiac MRI; Diffusion Tensor Imaging; pharmacokinetics; fluid ingress and distribution in complex substrates; flow MRI; 1H, 19F and 13P in vivo spectroscopy and relaxometry; development of MRI contrast agents; solid-state MRI.

Proper citation: Georgia Tech Magnetic Resonance Laboratory (RRID:SCR_012326) Copy   

•   Source: SciCrunch Registry

https://www.med.unc.edu/csb/pep/

Core specializes in production of pure, functional proteins for structural, biophysical, and biochemical studies. Has ability to produce and purify milligram amount of protein.

Proper citation: University of North Carolina at Chapel Hill School of Medicine Protein Expression and Purification Core Facility (RRID:SCR_012328) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/east-quad-nmr-facility-hms-harvard

Formerly the NERCE NMR Resource. Nuclear magnetic resonance spectroscopy is a powerful tool for studying structural and conformational parameters of molecules. This tool is vital for the chemical analysis of both small molecules (like those discovered in small-molecule screens) and large molecules, such as carbohydrates and proteins found to have potential biologic importance. This is a user-based NMR facility; users run their own experiments on the NMR spectrometer.

Proper citation: HMS East Quad NMR Facility (RRID:SCR_012295) Copy   

•   Source: SciCrunch Registry

http://nextgen.mgh.harvard.edu

Core facility that provides the following services: NextGen sequencing, Data Analysis. The NextGen Core is a collaboration between the Department of Molecular Biology, the Center for Human Genetics Research, the Center for Computational Biology, and the Executive Committee on Research (ECOR). Currently, the Core operates using a single Ilumina HiSeq instrument, accompanied by Illumina''''s cBot for cluster generation. This upgrade from our Genome Analyzer II doubled our capacity and greatly increased the data amount, quality, and stability over extra-long reads. The Core is located in the state-of-the-art Richard Simches Research Center on Cambridge St. as part of the MGH main campus in Boston. The many multi-investigator groups in the building - including those that study human genetics, stem cells, genomics, and more - make it the perfect location for the Core to service the researchers in those groups. The majority of customers come from MGH, but they also service customers at other academic medical centers and industry.

Proper citation: MGH NextGen Sequencing Core (RRID:SCR_012294) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/antibody-core-facility

The primary objective of our facility is to produce monoclonal antibody-producing hybridoma cell lines for UNC investigators. The core develops monoclonal antibodies in mice, rats and hamsters. The core can assist in the screening of hybridomas of interest by ELISA or flow cytometry. The facility can also produce large amounts of crude antibody in vitro for investigators as well as purify both polyclonal and monoclonal antibodies from tissue culture media or ascites.

Proper citation: UNC School of Medicine Antibody Core Facility (RRID:SCR_012330) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/yale-pathology-tissue-services

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on April 15,2024. Mission- Developmental Histology The mission of the Developmental Histology unit is to provide 1. Timely high quality histology services to the Yale community 2. Access to tissue services from Yale Pathology archives 3. To maximize the value of the resources in the Yale Pathology Tissue Archive. 4. To provide Tissue Microarrays to assess multiple tissue samples Mission- Yale Pathology Tissue Services To provide the maximum amount and quality of human tissue for research at Yale University without impacting diagnostic quality, accuracy and safety in anatomic pathology.

Proper citation: Yale Pathology Tissue Services (RRID:SCR_012290) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/proteomics-shared-resource-facility-brown

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on April 25,2024. Proteomics Shared Resource Facility's mission is to provide well-maintained, state-of-the-art instrumentation and fundamental proteomics expertise to the Brown University and Rhode Island-EPSCoR scientific communities. It aims to be a focal point of intellectual activity in proteomics by enabling nationally recognized proteomics research within Rhode Island. As an NSF EPSCoR funded laboratory, the Proteomics Facility has a broadly-inclusive philosophy to ensure rapid and equal access to the facility's services for the entire Rhode Island research community. In addition to the acquisition of instrumentation, the Proteomics Core Facility will undertake the training of research in emerging proteomic techniques, a component that is essential to maintaining a productive and professional level of service. The Proteomics Facility has a strong commitment to be at the leading edge of current and developing technologies and provides consultation on their application.

Proper citation: Brown Proteomics Shared Resource Facility (RRID:SCR_012219) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/high-throughput-and-high-content-screening-core-facility

The High Throughput and High Content Screening (HTS/HCS) Core Facility specializes in chemical biology as it relates to drug discovery, biological probe discovery, and phenotypic characterization of small-molecule effects on cellular systems. In addition to housing the instrumentation and robotics required for traditional HTS, the Core houses a cutting-edge High Content image-based system for next-generation small-molecule discovery research and analysis in fixed or live cells and cellular systems.

Proper citation: CU Denver High Throughput and High Content Screening Core Facility (RRID:SCR_012218) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/analytical-ultracentrifugation-facility

The Analytical Ultracentrifugation Facility located at the University of Connecticut engages in collaborative research as well as training scientists, technicians, and students. The Facility has three Beckman XL-I ultracentrifuges along with associated instruments, hardware and computers. In addition, University scientists are on hand to provide user support and advice.

Proper citation: UConn Analytical Ultracentrifugation Facility (RRID:SCR_012340) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/electron-microscopy-and-histology-core-facility-cornell

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on August 8,2025. The EM & H Core Facility functions as a merger of the facility at WCMC and the Analytical Microscopy Facility at HSS. The microscopes are located at WCMC in the Department of Cell & Developmental Biology. The HSS facility staff performs the TEM specimen preparation for their clients and then comes to WCMC to use the TEM. SEM sample preps for both client groups may be performed in the facility at WCMC.

Proper citation: WCMC Electron Microscopy and Histology Core Facility (RRID:SCR_012222) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/drug-discovery-development-and-delivery-core

The Drug Discovery, Development and Delivery (D4) Core provides investigators with access to technological expertise enabling biochemical (100,000+ compounds) and siRNA library screening. We have expertise in development and screening, in both biochemical and cell-based assays. Our mission is to work with investigators to unlock the potential to discover chemical agents that affect cellular targets involved in human diseases.

Proper citation: Penn State Drug Discovery Development and Delivery Core (RRID:SCR_012221) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/center-for-protease-research-ndsu

We specialize in the synthesis of small molecules for biological applications and variety of analytical services. The facility works primarily with investigators from Center for Protease Research (CPR). However, we have always extended our services to neighboring institutions and other places all across US when possible. The facility enjoys a successful track record of achievements through service, collaborations, and interdisciplinary interactions.

Proper citation: NDSU Center for Protease Research (RRID:SCR_012223) Copy   

•   Source: SciCrunch Registry

http://it.med.harvard.edu/ris

Core facility that positions digital imaging resources right where the research is being done: in Harvard Medical School''s quad-based basic science departments. The convenience of these locations makes it easy for researchers to access digital imaging expertise when faced with research imaging questions. This accessibility and convenience is supplemented by substantial web-based assistance, making Research Imaging Solutions a 24/7 resource. Seminars, Workshops and printed training materials guide faculty, students, post-docs and lab personnel on supported imaging hardware and software products. Supported hardware and software packages includes: Adobe products including Acrobat, Photoshop, and Illustrator; ACD Canvas; Microsoft Office applications including Word, PowerPoint and Excel; film recorders, slide and flatbed scanners, and color output devices such as color laser printers, poster printers and photo quality printers.

Proper citation: HMS Research Imaging Solutions (RRID:SCR_012302) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/experimental-therapeutics-program

The Experimental Therapeutics Program (ETP) is a program established within the unique MNI environment to pursue a mission of bridging basic research in neurobiology and immunology with human studies of neurological and immune-mediated diseases. The ETP accomplishes this mission through the establishment of core laboratory platforms that integrate fundamental research activities with rigorous studies on human biological samples derived from well-characterized patient populations. The goal of the program is to expedite the development and formal evaluation of emerging therapies aimed at halting and ultimately reversing disability caused by neurological disease.

Proper citation: McGill Experimental Therapeutics Program (RRID:SCR_012306) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/protein-production-analysis-core

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on April 25,2024. Sanford-Burnham''s Protein Production Core offers state-of-the-art resources with advanced biochemical engineering and bioprocessing capabilities. Specialized protein production scale-up services (65L bacterial or 25-50L insect/mammalian cell production) include optimization of production runs. Analytical services include measurement of protein-protein and protein-small molecule interactions using a variety of approaches such as surface plasmon resonance and isothermal titration calorimetry. Assistance in experimental design and technical support are also provided by the Core''s knowledgeable staff.

Proper citation: Sanford-Burnham Protein Production and Analysis Core (RRID:SCR_012272) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/meg-mcgill

MEG (Magnetoencephalography) is a neuroimaging technology for cognitive and clinical brain research. In a nutshell, MEG measures non-invasively the tiny magnetic fields generated by neuronal currents. A unique asset of MEG imaging is its unrivaled temporal resolution, reaching the millisecond time scale across the entire brain volume. On the clinical side, MEG has been typically indicated for the pre-surgical work-up of severe, drug-resistant epilepsy and the functional pre-surgical mapping of brain tumors. There is however great potential to use MEG as an instrument of choice to investigate other neurological syndromes and neuropsychiatric disorders (e.g., stroke, dementia, movement disorders, depression, etc.). Overall, MEG has strong value in revealing the dynamics of brain activity involved in subject''''s perception, cognition and responses: it has provided unique insight on the time-resolved processes ruling brain functions (resting-state dynamics, language, motor control, visual and auditory perception, etc.) and dysfunctions (movement disorders, tinnitus, chronic pain, dementia, etc.). MEG(at)McGill provides a full-suite of services related to MEG and MEG/EEG studies. This includes a variety of training programs for use of the MEG and related data acquisition and analysis software, Brainstorm.

Proper citation: MEG(at)McGill (RRID:SCR_012277) Copy   

•   Source: SciCrunch Registry