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http://www.scienceexchange.com/facilities/penn-microarray-core-facility-upenn

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on May 2,2024. Penn Microarray Facility provides instrumentation and expertise for RNA transcript profiling. DNA microarrays provide a highly parallel means of measuring the abundance of RNA for targeted genes in a biological sample. The Facility supports two microarray formats: oligonucleotide arrays synthesized by Affymetrix Inc. and arrays of probes printed in-house on glass slides. This reflects our goal of offering a range of cost and performance options suitable for a variety of experimental questions.

Proper citation: Penn Microarray Core Facility (RRID:SCR_012610) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/athymic-animal-and-xenograft-core-facility-cwru

The Athymic Animal and Xenograft Core Facility provides facilities for breeding and housing of athymic nude mice (NCRnu/nu) and rats, and other immunodeficient mice. The core provides pathogen-free facilities for experimentation using immunodeficient animal hosts and normal human cells and human tumor cell xenografts. Core staff maintain and monitor animals housed in the facility, and provide users with a variety of services, including transportation, health reports, animal handling, and experimental procedures. The staff will also train users in animal handling and experimental procedures. Entry to the animal facilities is controlled by key card access and is limited to employees who are listed on an IACUC-approved protocol, have enrolled in an animal contact Occupational Health program, and have completed access training. Experimental procedures, listed below, are provided either at the Case facility or in the Animal Tumor Core (ATC) at the Cleveland Clinic Taussig Cancer Institute. The Taussig Cancer Institute ATC was established in 2002 to help principal investigators at the Cleveland Clinic and CWRU perform tumor experiments, angiogenesis studies, and pharmacokinetic studies in mice. The ATC conducts syngeneic murine tumor experiments, and human xenograft (athymic nude mouse) tumor experiments. In addition, the ATC has developed several orthotopic human carcinoma models: HT-29 colon, HCT-116 colon, SW480 colon (all metastasize to liver), ACHN renal, A549 lung, multiple prostate, bladder, melanoma and ovarian tumors. ATC services utilize murine models to facilitate in vivo cancer drug screening, drug evaluation, and drug development. The core''''s goal is to help in evaluation of new pharmacologic agents by providing data on tumor growth, metastasis, angiogenesis, and gene expression. The facility also provides consultation services to assist the investigator in all aspects of animal tumor model development.

Proper citation: CWRU Athymic Animal and Xenograft Core Facility (RRID:SCR_012459) Copy   

•   Source: SciCrunch Registry

https://www.ualberta.ca/chemistry/facilities-and-resources/mass-spectrometry-facility.html

There are currently eleven mass spectrometers housed in the mass spectrometry laboratory covering most ionisation techniques from electron impact to MALDI. 8 or more samples submitted at the same time and run under identical conditions qualify for a 25% discount for GC-coupled, LC-coupled and in-gel digest LC/MS/MS experiments Variable rate for high molecular weight samples (i.e., more than 3000 u), depending on the instrument and operator time required for the analysis. There will be a 50% surcharge for all RUSH orders (queue jumping).

Proper citation: UAlberta Mass Spectrometry Facility - Department of Chemistry (RRID:SCR_012613) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/nucleic-acids-core-facility

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on May 15,2024. Nucleic Acids Core Facility offers automated DNA sequencing with data analysis, custom DNA synthesis, genome project services, gene amplification services, and robotic application custom projects. These services are provided to researchers at the HSC and others in the surrounding scientific community. Our mission is to offer high quality synthesis and sequencing services to researchers through cutting edge instrumentation and a service-oriented and knowledgeable staff.

Proper citation: UTHSCSA Nucleic Acids Core Facility (RRID:SCR_012614) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/ontario-cancer-biomarker-network

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on May 14,2024. OCBN is a not-for-profit corporation that was established in 2005 with a grant from the Ontario Institute for Cancer Research and the Ontario Ministry of Research and Innovation for the purpose of advancing biomarker research. The OCBN is designed to enable the co-ordination and amplification of the proteomic and genomic biomarker research efforts throughout the province of Ontario to better service academia and industry, whether provincially, nationally or internationally. As such, OCBN is much more than simply an academic research consortium. Residing at the core of the network is the OCBN Central Facility, located at the MaRS Incubator www.marsdd.com in the heart of the biomedical research community in Toronto, one of the most vibrant research hubs in the world. The Central Facility functions as the nexus for the network and its academic and industry partners by providing numerous support services for their clinical and basic research scientists in the conduct of their research.

Proper citation: Ontario Cancer Biomarker Network (RRID:SCR_012616) Copy   

•   Source: SciCrunch Registry

https://research.wustl.edu/core-facilities/mouse-cardiovascular-phenotyping-core/

Core that was established in 1998 and currently provides approximately 3,000 surgical, imaging and functional cardiovascular physiology services annually to its academic and industry partners throughout the world. With an experienced staff of 4 dedicated investigators, each with over 10 years of animal physiology experience, the MCPC provides a focused, systematic approach to the study of the basal physiology and pathophysiology of the mouse cardiovascular system.

Proper citation: WUSTL Mouse Cardiovascular Phenotyping Core (RRID:SCR_012673) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/immune-monitoring-core-facility-usc

The mission of the USC Arnold and Mabel Beckman Center for Immune Monitoring is to provide the USC community and external customers with the highest quality support for clinical trials for immunotherapy of human cancers; facilitate basic, translational, and clinical research with an immunological monitoring component; and provide immunological assay training and education. The IM core provides quality assessments of immunological function necessary for the study of pathogenesis, treatment, and prevention of cancer and other human diseases. Supporting clinical trials for immunotherapy of human cancer: For physicians involved in clinical trials for immunotherapy of human cancer, the Beckman Center for Immune Monitoring Core offers several assays to assess patient immune responses. Such assays provide a highly sensitive and quantitative means of measuring the efficacy of an experimental treatment as a surrogate endpoint or as a correlative to clinical responses. It can help establish proof of principle that a treatment works, and suggest changes to adapt a standard treatment protocol to individual patient needs. Besides the Gold Standard of Immune monitoring: the ELISPOT assay for detection of cytokines released by activated T cells, we also perform intracellular cytokine staining and can detect tumor specific T cells by MHC tetramer analysis. Helper and killer T cells can be separated, and proliferative and cytotoxic responses are quantified in radioactive assays. The monitoring protocol of choice is tailor made to fit the needs and the possibilities of each treatment protocol. The core offers freezing and storage capacity for clinical samples and full analytical support for monitoring assays. It is also possible to send in samples for post-assay analysis using our state-of-the-art ELISPOT reader. Facilitating research with an immune monitoring component: For researchers within travel distance of our facility, we offer equipment and technical assistance for performance and/or analysis of ELISPOT assays, flow cytometry-based assays, radioisotope-based proliferation and cytotoxicity assays, multiplexing ELISA assays, and molecular-based quantitative PCR assays. Our lab has equipment for controlled rate freezing and storage of cryopreserved peripheral blood cells, tissue culture facilities and an ELISPOT reader to analyze your 96 well plates. Assays and technical support are also available to support translational projects that utilize in-vitro systems and in vivo animal models.

Proper citation: USC Immune Monitoring Core Facility (RRID:SCR_012672) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/bone-histomorphometry-lab

Evaluations at the tissue level are critical to musculoskeletal research. The Bone Histomorphometry Lab in the Department of Orthopedics has a rich history of conducting such in situ evaluations in both human and animal tissue. The primary expertise of the Bone Histo Lab is the processing of skeletal tissue in its calcified state for the preparation of histology slides.

Proper citation: Mayo Clinic Bone Histomorphometry Lab (RRID:SCR_012439) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/embryonic-stem-cell-core

The Murine Embryonic Stem Cell Core has been created to help you create mutations in murine embryonic stem cells. The core has several missions including development of state-of-the-art reagents for the production of targeted mutations in embryonic stem cells, the creation of quality-controlled embryonic stem cell lines, and the teaching of methods for embryonic stem cell culture and manipulation. The core utilizes quality-controlled cells developed here at Washington University.

Proper citation: WUSTL School of Medicine Embryonic Stem Cell Core (RRID:SCR_012441) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/brains-on-line

Our mission at Brains On-Line is to provide preclinical research services to facilitate the development of new drugs that target the central nervous system. Brains On-Line benefits from its intimate connections with academia, as well as with several associated contract research organizations (CRO). Using our expertise, we aim to give full insight in the possibilities of your compound.

Proper citation: Brains On-Line (RRID:SCR_012565) Copy   

•   Source: SciCrunch Registry

http://cancer.dartmouth.edu/res/transgenics_genetic.html

Core facility that provides the following services: Cigarette smoke exposure analysis service, Oocyte injection for transgenic animal production, Transgenic mice consultation, Generation of chimeric mice from ES cells, Transgenic lines establishment, Genotyping service, Tail biopsies and other services, Humanized mice production. The mission of the TGCSR is to support the generation and utilization of genetically modified mice by members of the Dartmouth research community. The support starts with intellectual support in planning and designing transgenic experiments provided by consultation with the TGCSR director. The TGCSR is now able to offer not only assistance with design of genetic constructs but also the production of genetic constructs for use in transgenic animal production through recombineering in either yeast or E. coli. TGCSR provides a full range of ES cell manipulation services. The tasks of manipulating the mouse embryo are fully provided by the TGCSR either in house or through an established relationship with the University of Vermont. Jackson labs is now providing cryopreservation services to protect and preserve valuable transgenic mouse lines. The TGCSR can also provide genotyping and mouse husbandry services. As currently organized, the TGCSR can provide the full range of services required to design, generate and maintain transgenic mouse lines. TGCSR currently maintains two specialized transgenic lines that express Cre or Flp in the germline for genetic manipulation of transgene/knockouts in vivo. TGCSR has a fully equipped embryo manipulation laboratory in the Borwell animal facility and an adjoining 4 room suite of mouse husbandry rooms.

Proper citation: Dartmouth Transgenics and Genetic Constructs Shared Resource (RRID:SCR_012443) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/histopathology-and-tissue-shared-resource-georgetown

The HTSR offers a full complement of histology services through our combined Human Tissue Bank, histology, and IHC departments. The Human Tissue Bank supports tissue procurement and the retrieval of fresh frozen and archival paraffin blocks. The Histology laboratory provides processing, embedding and microtomy services both for fresh frozen and fixed tissues. The Histology lab also provides numerous routine and non-routine histological stains. The Immunohistochemistry (IHC) laboratory supports colorimetric and fluorescent IHC staining for established antibodies as well as the development of protocols for new antibodies. The IHC lab also supports TUNEL labeling and novel labeling techniques.

Proper citation: Georgetown Histopathology and Tissue Shared Resource (RRID:SCR_012489) Copy   

•   Source: SciCrunch Registry

https://rhslab.pitt.edu/services

Research Histology Services is located in the Thomas E. Starzl Biomedical Science Tower at the University of Pittsburgh. RHS lab serves as the Core Liver and Kidney Laboratory for the Immune Tolerance Network (ITN) and the Core Heart Lab for the Clinical Trials in Organ Transplantation in Children (CTOTC04), providing histology services for ongoing clinical patient research studies throughout the United States and Canada. Provides range of histological research techniques that include decalcification, standard tissue processing, biopsy processing, paraffin embedding, OCT embedding of frozen tissues, serial sectioning, step/level sectioning, and cryostat sectioning. A wide spectrum of assays is available in addition to the routine hematoxylin and eosin (H&E) stain. Special histochemical stains routinely provided include; Masson Trichrome, PAS (periodic acid Schiff), Prussian Blue (Iron), Verhoff''''s Elastin Stain, Cresyl Violet, Toluidine Blue, and Luxol Fast Blue; additional histochemical staining is done upon request. Wide arrays of Immunoperoxidase and Immunofluorescent staining and apoptosis/ tunel stains are also available. Our goal is to return quality work in the shortest time possible.

Proper citation: University of Pittsburgh Research Histology Services Core Facility (RRID:SCR_012648) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/respiratory-disease-immunology-core-laboratory-rdicl-uc-davis

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on April 24,2024. Respiratory Disease Immunology Core Laboratory is to provide technical expertise and resources to investigators interested in the immunological evaluation of rhesus macaque models for lung disease. Studies are primarily carried out in conjunction with the Inhalation Exposure Core and the Computational Imaging Core at UCDavis, in order to provide a comprehensive evaluation of pathophysiological responses in the lung. Services provided by the RDICL include assistance with experimental design, allergen characterization and preparation (through Resource Services), evaluation of allergen-specific IgE and IgG, and quantitation of histamine. We also provide technical support for sample processing, including bronchoalveolar lavage, lung tissue, and blood. Flow cytometry and molecular analysis of lung and blood samples are coordinated with the Flow Cytometry Core Laboratory and the Infectious Disease Immunology Core Laboratory. In addition to immunological evaluation, the Respiratory Disease Immunology Core Laboratory can provide investigators with primary cell isolates and in vitro culture of rhesus lung epithelial cells and fibroblasts. The Core does not conduct studies with human lung cultures. Please inquire for additional assays that are in development. In the future, immunohistochemistry of lung samples will be offered in conjunction with the Computational Imaging Core at UCDavis.

Proper citation: UC Davis Respiratory Disease Immunology Core Laboratory (RRID:SCR_012647) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/division-of-comparative-pathology-miami

The Division of Comparative Pathology is a full service veterinary pathology laboratory with both clinical pathology and histology services. Routine hematology and serum biochemistry testing is available for multiple species; we work well with low volume samples. Specialized testing is available or can be implemented as needed. Routine histology services including processing, embedding, and sectioning are available with many routine and special staining options.

Proper citation: UM Miller School of Medicine Division of Comparative Pathology (RRID:SCR_012492) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/institute-for-behavioral-genetics

The Institute for Behavioral Genetics (IBG) is an organized research unit of the University of Colorado Graduate School dedicated to conducting and facilitating research on the genetic and environmental bases of individual differences in behavior. Founded in 1967, IBG is one of the top research facilities in the world for genetic research on behavior. Data collection and analysis is ongoing for several internationally renowned studies including the Colorado Adoption Project, the Colorado Twin Registry, the National Youth Survey Family Study, the Colorado Learning Disabilities Research Center, and the National Longitudinal Study of Adolescent Health. IBG is home to one of the nation''''s largest DNA repositories for research on human behavior, as well as housing a wide array of behaviorally and genetically defined lines of selected, recombinant inbred, transgenic, and knockout-gene mice. Current research includes studies of aging ( The Johnson Lab, The Link Lab), psychopathology, reading disability, cognition, substance abuse, behavioral development, and evolution. In addition to our research, we provide training opportunities for graduate students in affiliated programs at the University of Colorado campuses in Boulder and Denver. IBG receives funding from several federal agencies, principally through the National Institutes of Health, as well as a broad spectrum of Associations, Foundations and Programs. Welcome to our site, please feel free to contact us with any questions about our research or programs.

Proper citation: CU Boulder Institute for Behavioral Genetics (RRID:SCR_012495) Copy   

•   Source: SciCrunch Registry

https://www.mayo.edu/research/core-resources/proteomics-core/overview

Proteomics involves analysis and identification of protein structure and function. Through Proteomics Core, investigators at Mayo Clinic and elsewhere have access to a broad range of proteomics services, technologies and guidance to help them answer scientific questions. Toward a goal of improving patient care, the core offers services and conducts research in the areas of mass spectrometry-based differential proteomics, peptide synthesis, protein and peptide purification, and protein identification, characterization and expression.

Proper citation: Mayo Clinic Proteomics Core Facility (RRID:SCR_012653) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/genomics-and-epigenomics-shared-resource-gesr-georgetown

The Genomics & Epigenomics Shared Resource (GESR) provides services for various high throughput experiments including gene expression profiling, SNP genotyping, CNV analysis, DNA methylation, microRNA expression profiling, siRNA screening, DNA/RNA isolation, RNA quality assessment, DNA plating and assay preparation, DNA sequencing, and fragment analysis. GESR uses state-of-the-art instruments and assays to provide these services. These include Affymetrix Microarray System, Agilent Microarray System, Applied Biosystems TaqMan assays, Illumina BeadXpress, Qiagen PyromarkMD, Qiagen Qiacube, Agilent Bioanalyzer, Beckman Multimek NXP Robotic Liquid Handling System, and Applied Biosystems Sequence Analyzer. In addition, GESR houses several user-operated specialized instruments for which the shared resource personnel provide technical support and training.

Proper citation: Georgetown Genomics and Epigenomics Shared Resource (RRID:SCR_012498) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/microarray-resource-core-bu

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on May 22,2024. Microarray Resource Core offers the full line of microarray products available from Affymetrix. This includes expression profiling, miRNA, exon, genotyping, resequencing, and tiling arrays. As part of our standard service, the resource provides assistance with experimental design and data analysis. Arrays for other organisms are available; please contact us for with specific requests.

Proper citation: Boston University Microarray Resource Core (RRID:SCR_012491) Copy   

•   Source: SciCrunch Registry

https://siperg.las.iastate.edu/stable-isotope-lab-sil/

Core performes continuous flow isotopic and elemental analyses of carbon, nitrogen, oxygen and hydrogen in organic and inorganic substrates (solids, liquids, and gases). Supports research in oceanography, paleoclimatology, geology, ecology, agronomy, and chemistry. Laboratory consists of ThermoFinnigan Delta Plus XL mass spectrometer coupled with several sample introduction systems, including GasBench II with CombiPal autosampler, Costech elemental analyzer and TC/EA with Conflo III interface. Additionally, the SIL operates Picarro L2130-i Isotopic Liquid Water Analyzer with autosampler for rapid measurements of deuterium and oxygen.

Proper citation: Iowa State University SIPERG Stable Isotope Lab Core Facility (RRID:SCR_012541) Copy   

•   Source: SciCrunch Registry