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SciCrunch Registry is a curated repository of scientific resources, with a focus on biomedical resources, including tools, databases, and core facilities - visit SciCrunch to register your resource.

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Resource Name Proper Citation Abbreviations Resource Type Description Keywords Resource Relationships Related Condition Funding Defining Citation Availability Website Status Alternate IDs Alternate URLs Old URLs Parent Organization Resource ID Synonyms Record Last Update Mentions Count
BWH Transgenic Core Facility
 
Resource Report
Resource Website
BWH Transgenic Core Facility (RRID:SCR_009688) service resource, access service resource, core facility Core facility that provides the following services: ES cell transfection (electroporation), Thawing/expansion of targeted ES cells, Microinjection of ES cells into blastocysts, Microinjection of DNA constructs into egg pronuclei for generating transgenic mice, Microinjection of BAC DNAs, DNA injection and microdissection, Lentiviral transgenics service, Injection of induced pluripotent stem cells for testing totipotency, Tail biopsy service, Breeding services, Mouse manipulation consultation. The Brigham & Women''s Hospital Transgenic Core Facility provides services for generating transgenic and knockout mice. Established in 1992, the BWH Core Facility has been providing gene targeting and microinjection services using state-of-the-art facilities and equipment. Dr. Lina Du, formerly a plastic surgeon in Beijing and an expert in microvascular surgery, performs both blastocyst and pronuclear injections. She has over 15 years of experience in embryo manipulation and the generation transgenic mice. The Core Facility has all of the equipment necessary for generation of transgenic mice including a Nikon Diaphot microscope equipped with Nomarski Optics and Narishige micromanipulators for microinjections, Nikon surgical microscopes for egg isolation ad transfer, a sutter needle puller and a de Fonbrune microforge. The facility maintains mice necessary for egg donors, egg recipients, and vasectomized males. This is a non-profit facility and charges are based upon anticipated mouse costs, maintenance of mice and equipment, and purchase of necessary surgical supplies and chemicals. The ES cell culture service has been offered for 6 years. Our staff carries out electroporation of targeting vectors into ES cells and provides investigators with DNA to identify ES cells carrying the desired recombination events. Then they expand the appropriate ES Cells for microinjection into blastocysts by the BWH Transgenic Core. embryonic stem cell electroporation, embryonic stem cell culture, blastocyst injection, transgenic mouse model generation, oocyte injection, microdissection, viral infection, tail biopsy, laboratory animal care is listed by: Eagle I nlx_156147 http://brighamandwomens.org/research/depts/pathology/transgenic/default.aspx SCR_009688 2026-02-17 10:01:15 0
CHOP CTRC Behavioral Neurosciences Core
 
Resource Report
Resource Website
CHOP CTRC Behavioral Neurosciences Core (RRID:SCR_009721) service resource, access service resource, core facility Core facility that provides the following services: Development of assessment methods for pediatric psychological, neuropsychological, and psychiatric research, Intervention development and implementation. The Behavioral Neurosciences Core provides consultation and assistance to investigators regarding psychological, neuropsychological, and psychiatric components of research studies involving pediatric subjects. Together, the services provided by the Behavioral Neurosciences Core offer research infrastructure support across the entire process of research, from pre-design consultation to development and analysis of behavioral data, and across multiple domains of functioning and outcomes. clinical trial technique, treatment portion of study execution is listed by: Eagle I
has parent organization: University of Pennsylvania; Philadelphia; USA
nlx_156183 http://www.itmat.upenn.edu/ctrc/neurobehavioral_related_core.shtml SCR_009721 2026-02-17 10:01:32 0
BWH Flow Cytometry Core Laboratory
 
Resource Report
Resource Website
BWH Flow Cytometry Core Laboratory (RRID:SCR_009683) service resource, access service resource, core facility Core facility that provides the following services: Sorting or analysis with operator service, Calcium flux measurements service, DNA analysis service, Cell sorting service.

This lab''s mission is to provide high standard cell sorting and analysis services to the research community at the Brigham and Women?s Hospital and the Longwood Medical area.
flow cytometry assay, fluorescence activated cell sorting (facs) is listed by: Eagle I nlx_156142 http://sites.google.com/site/bwhflowcytometry/
http://www.partners.org/researchcores/cytometry/cytometry_BWH.html
SCR_009683 2026-02-17 10:01:15 0
BWH CytoGenomics
 
Resource Report
Resource Website
BWH CytoGenomics (RRID:SCR_009681) service resource, access service resource, core facility Core facility that provides the following services: Fluorescence in situ hybridization.

The CytoGenomics Core provides an invaluable technical resource to the investigators of the BWH, MGH, and affiliated institutions. Services are also available to external academic and commercial laboratories; these should contact us via our website for sample submission and pricing. Cytogenetic studies can provide insight into regions of the genome that are pathogenetic in various neoplasms leading to an understanding of the molecular pathways participating in the biology of cancer. It is appropriate to consider cytogenetics as a fundamental adjunct to a variety of investigations underway, including basic and clinical research. For example, a rather simple cytogenetic analysis of mouse ES cells to determine ploidy prior to injections into blastulas leads to a greater success rate in establishing founders for knock-out and knock-in experiments. The primary chromosomal assignment of a gene by a FISH experiment may lead to correlation of a disease with that gene. Other cytogenetic studies may be important in establishing a diagnosis for correlation with clinical outcome. The advent of molecular probes for FISH analysis has facilitated cytogenetic studies in the mouse, and other model organisms and this Core aggressively implements such technologies. In addition to state-of-the-art analyses for human samples, the BWH CytoGenomics Core also performs routine mouse karyotyping and a variety of other molecular cytogenetic analyses, services not easily obtainable elsewhere.
fluorescent in situ hybridization is listed by: Eagle I nlx_156140 http://cytogenomics.bwh.harvard.edu/ SCR_009681 2026-02-17 10:01:26 0
BWH Biostatistics Center
 
Resource Report
Resource Website
BWH Biostatistics Center (RRID:SCR_009680) service resource, access service resource, core facility Biostatistics support is available to investigators in the Brigham and Women''s and Harvard Medical research community for statistical consulting on issues such as study design and data analysis for manuscripts and grant applications. Resources are limited, so planning ahead is essential. The Biostatistics Consulting Service is part of the Biostatistics Core of the BWH Center for Clinical Investigation (CCI). is listed by: Eagle I nlx_156137 http://biostatistics.bwh.harvard.edu/ SCR_009680 2026-02-17 10:01:31 0
CHB Small Animal Imaging Core Laboratory
 
Resource Report
Resource Website
CHB Small Animal Imaging Core Laboratory (RRID:SCR_009719) service resource, access service resource, core facility In recognition of the value of small animal imaging to the research community, Children''s Hospital Boston has committed to developing a state-of-the-art Small Animal Imaging Laboratory. The SAIL facility is located within the Department of Radiology''s Kresge Laboratory. is listed by: Eagle I nlx_156179 http://childrenshospital.org/cfapps/research/data_admin/Site2245/mainpageS2245P0.html SCR_009719 2026-02-17 10:01:34 0
CHB Radiopharmaceutical Chemistry Laboratory
 
Resource Report
Resource Website
CHB Radiopharmaceutical Chemistry Laboratory (RRID:SCR_009718) service resource, access service resource, core facility The radiopharmaceutical chemistry research program occupies two research laboratories in the Enders research building at Children''s: a radiopharmaceutical chemistry laboratory and a hot laboratory. A separate cell-culture laboratory is also available. The radiopharmaceutical chemistry laboratory contains four fume hoods, approximately 50 linear feet of bench space, and is set up to accommodate three postdoctoral researchers. is listed by: Eagle I nlx_156178 http://www.childrenshospital.org/sites/Site2575/mainpageS2575P38sublevel84.html SCR_009718 2026-02-17 10:01:27 0
Penn Laser Confocal Microscope Core
 
Resource Report
Resource Website
Penn Laser Confocal Microscope Core (RRID:SCR_009533) service resource, access service resource, core facility Core facility that provides the following services: Laser confocal microscope access. Penn Dental Medicine houses a Radiance 2100 laser confocal microscope available for use by researchers throughout the School as well as others inside and outside the University. time lapse confocal microscopy, confocal microscopy, fluorescent microscopy, phase contrast microscopy, differential interference contrast microscopy is listed by: Eagle I
has parent organization: University of Pennsylvania; Philadelphia; USA
nlx_156488 SCR_009533 2026-02-17 10:01:30 0
Arnold Arboretum of Harvard University: Weld Hill Growth Facilities
 
Resource Report
Resource Website
Arnold Arboretum of Harvard University: Weld Hill Growth Facilities (RRID:SCR_009649) service resource, access service resource, core facility The Weld Hill Growth Facilities consist of 12 individually controlled greenhouses and several types of Conviron growth chambers for precise control of growing conditions. is listed by: Eagle I
has parent organization: Harvard University; Cambridge; United States
nlx_156116 http://arboretum.harvard.edu/research/policies-and-instrumentation/growth-chambers/ SCR_009649 2026-02-17 10:01:25 0
Penn Automated Claims and Medical Record Databases
 
Resource Report
Resource Website
Penn Automated Claims and Medical Record Databases (RRID:SCR_009643) Penn ACARD service resource, access service resource, core facility A core facility in the Center for Pharmacoepidemiology Research and Training created to foster epidemiologic research into therapeutics, using large population-based automated claims databases (Medicaid/Medicare) and medical records databases (GPRD and THIN), and the FDA''s adverse event reporting system (FAERS) database. Goals: * Encourage investigators with diverse training to conduct studies focused on translational therapeutics and drug safety * Provide access to large databases that allow for rapid and cost-effective research on therapeutics and drug safety * Foster collaboration with CTSA sites outside of Penn who wish to use these databases for clinical research epidemiology, therapeutics is listed by: Eagle I
has parent organization: University of Pennsylvania; Philadelphia; USA
nlx_156115 SCR_009643 2026-02-17 10:01:32 0
CHB Molecular Genetics Core Facility
 
Resource Report
Resource Website
CHB Molecular Genetics Core Facility (RRID:SCR_009715) service resource, access service resource, core facility THIS RESOURCE IS NO LONGER IN SERVICE. Documented on October 8,2024. Core facility that provides the following services: DNA sequencing (standard) service, Taqman gene expression service, Taqman SNP genotyping, Digital PCR service, Genomic mapping facility standard service, DNA purification from blood and saliva, RNA purification service, Master 96-well plate sample preparation, Gene expression service, SNP genotyping service, Bioanalysis of RNA and DNA, Next-generation sequencing service, Sequenom SNP genotyping, SNP and qPCR 7900HT instrument access. The Molecular Genetics Core Facility (MGCF) is a non-profit core laboratory in the Program in Genomics and Genetics Division of Children''s Hospital Boston offering genomics services for academic research institutions. The majority of MGCF users are investigators from Children''s Hospital Boston and the surrounding Harvard affiliates, but the MGCF also serves laboratories throughout the entire United States. The MGCF is comprised of a compilation of smaller cores partially supported by private and federal funds. Funding is provided in part through The Intellectual and Developmental Disabilities Research Center, The Manton Center for Orphan Disease Research, The Wellstone Center for Muscular Dystrophy, and The Neuromuscular Disease Project of the Program in Genomics at Children''s Hospital Boston. The overall objective of the MGCF is to provide a location where researchers can have access to high quality, low cost genomic technology services and expertise in a timely, affordable manner. The services offered include DNA sequencing, Next-Gen sequencing, Affymetrix and Illumina whole-genome expression and genotyping microarray technology, microsatellite genotyping, high-throughput qPCR and SNP services on the Fluidigm Biomark System, multiplex SNP genotyping on the Sequenom MassARRAY, and sample extraction and banking. The MGCF also assists investigators with project design and collaborates on linkage and association study analysis. polymerase chain reaction, dna sequencing, gene expression analysis assay, genotyping assay, microsatellite analysis, dna purification, purification, sample preparation for assay, rna quality analysis, dna quality analysis, next generation sequencing, real-time pcr, single-nucleotide polymorphism analysis is listed by: Eagle I THIS RESOURCE IS NO LONGER IN SERVICE nlx_156175 http://harvard.eagle-i.net/i/0000012c-bcb1-7724-02c0-2b6880000000, http://core.iddrc.org/molecular-genetics/ SCR_009715 2026-02-17 10:01:34 0
CHB Molecular and Cellular Biochemistry Core
 
Resource Report
Resource Website
CHB Molecular and Cellular Biochemistry Core (RRID:SCR_009716) service resource, access service resource, core facility Core facility that provides the following services: Lipoprotein analysis, Biliary lipid concentrations analysis, Biliary particle analysis, Quantitative real-time PCR, Sequential ultracentrifugation for lipoproteins, Radiolabeling of lipoproteins, Fluorescence labeling of lipoproteins, Purification of biliary lipid aggregatesfrom model biles, Preparation of recombinant proteins, Protein identification from gel bands, Protein Identification from complex mixtures. The Molecular and Cellular Biochemistry Core is dedicated to providing HDDC investigators and their trainees with access to a variety of methods to determine the compositions of tissues, as well as their cellular and subcellular specimens. The Core Scientists offer a broad range of analyses and preparatory services including Proteomics. Importantly, the Core also provides training in the application of state-of-the-art techniques in molecular analysis of proteins, lipids and nucleic acids. The main Core laboratory is located at Brigham and Women?s Hospital (BWH) and the satellite Core laboratory is located at Children?s Hospital Boston (CHB). We perform a broad array of biochemical and analytical assays that are not typically available within laboratories of HDDC members. These have generally been adapted so that they may be performed in large numbers on microplates. These include quantification of lipids, mRNA and protein and a full array of mass spectroscopy services for protein analysis (and soon to be expanded for lipidomics). We also offer both analytical and preparatory separations by a variety of methods. material component separation, high performance liquid chromatography, real-time pcr, centrifugation, radiolabeling, immunofluorescence microscopy assay, purification, recombinant protein production, mass spectrometry assay, protein identification is listed by: Eagle I nlx_156176 http://www.hms.harvard.edu/hddc/services/proteomic/ SCR_009716 2026-02-17 10:01:16 0
CHB Magnetic Resonance Imaging
 
Resource Report
Resource Website
CHB Magnetic Resonance Imaging (RRID:SCR_009714) service resource, access service resource, core facility Core facility that provides the following services: Magnetic resonance imaging (MRI) access. Magnetic Resonance Imaging (MR or MRI) at Children''s Hospital Boston performs pediatric MRIs in a friendly, child-centered environment designed to make your child''s experience as pleasant as possible. Our dedicated staff has years of experience imaging children and teens. Physicians order MRI studies to rule out or diagnose diseases. The technology produces incredibly detailed pictures of your child''s organs, bones and tissues without using ionizing radiation (X-rays). Instead, it uses strong magnets, radiofrequency waves and powerful computers to generate 2- and 3-dimensional images of a given organ or body part. We use protocols and procedures developed specifically for babies and children, which means age-appropriate care for your child and the best possible images for the radiologist. magnetic resonance imaging is listed by: Eagle I nlx_156174 http://www.childrenshospital.org/clinicalservices/Site2131/mainpageS2131P0.html SCR_009714 2026-02-17 10:01:27 0
CHB Diagnostic Radiology Core
 
Resource Report
Resource Website
CHB Diagnostic Radiology Core (RRID:SCR_009711) service resource, access service resource, core facility Within Children''s Hospital Boston''s Department of Radiology, Diagnostic Radiology offers standard radiography (conventional X-rays) and fluoroscopy, an imaging technique that uses X-rays to create real-time images of the body. We perform more than 135,000 exams each year in Boston and at our satellite locations, which makes us one of the country''s largest general diagnostic centers for children. is listed by: Eagle I nlx_156171 http://www.childrenshospital.org/clinicalservices/Site2119/mainpageS2119P0.html SCR_009711 2026-02-17 10:01:34 0
BIDMC eData Collection Core
 
Resource Report
Resource Website
BIDMC eData Collection Core (RRID:SCR_009679) service resource, access service resource, core facility Core facility that provides the following services: Data acquisition service, Data storage service.

The Research Electronic Data Collection Core can help you capture research data by supporting all aspects of data acquisition, storage and retrieval. The core is designed to significantly improve the efficiency, cost structure and overall quality of research data collection. The Data Collection Core will provide expert services including: study forms design and implementation; training in all aspects of using TELEform software; database construction and exporting / preparing data for statistical applications such as SAS and SPSS; and technical assistance with scanners and computers running electronic form capture process.
data acquisition, data storage is listed by: Eagle I nlx_156136 http://bidmc.org/Research/CoreFacilities/eDataCollectionCore.aspx SCR_009679 2026-02-17 10:01:15 0
UAF Alaska Stable Isotope Facility
 
Resource Report
Resource Website
UAF Alaska Stable Isotope Facility (RRID:SCR_009556) service resource, access service resource, core facility Core facility that provides the following services: Stable isotope analysis service. The Alaska Stable Isotope Facility is a state-of-the-art laboratory conducting stable isotope analyses of wide range of sample types for researchers from all over Alaska, the USA and the globe. Sample types include organic samples (C, N, O and H isotopes), inorganic samples (e.g. carbonate for C and O) and water (O and H). high throughput sample analysis, stable isotope analysis is listed by: Eagle I
has parent organization: University of Alaska Fairbanks; Alaska; USA
nlx_156536 SCR_009556 2026-02-17 10:01:24 0
CHB Computed Tomography Core Imaging Facilities
 
Resource Report
Resource Website
CHB Computed Tomography Core Imaging Facilities (RRID:SCR_009710) service resource, access service resource, core facility Computed Tomography (CT) at Children''s Hospital Boston helps doctors quickly answer urgent questions about your child''s health. In just seconds or minutes, CT scans can produce incredibly detailed, three-dimensional images of your child''s bone, tissue and blood vessels. CT exams in our powerful multi-detector scanners are quick, painless and non-invasive. Located at two locations: Boston and Waltham. Should be contacted about scanner technology, image acquisition, etc., but not for actual access to the facility. is listed by: Eagle I nlx_156170 http://www.childrenshospital.org/clinicalservices/Site1947/mainpageS1947P0.html SCR_009710 2026-02-17 10:01:27 0
BIDMC Preclinical Murine Pharmacogenetics Core
 
Resource Report
Resource Website
BIDMC Preclinical Murine Pharmacogenetics Core (RRID:SCR_009675) service resource, access service resource, core facility Core facility that provides the following services: Mouse breeding service, Mouse genotyping service, Tail vein injections service, Tissue service, Cancer mouse model service, Human tumor xenografts service.

laboratory animal care, genotyping assay, tail vein injection, tissue procurement, tissue sectioning, transgenic mouse model generation, xenotransplantation is listed by: Eagle I nlx_156132 http://bidmc.org/Research/CoreFacilities/PreclinicalMurinePharmacogeneticsCore.aspx SCR_009675 2026-02-17 10:01:15 0
BIDMC Mass Spectrometry Core
 
Resource Report
Resource Website
BIDMC Mass Spectrometry Core (RRID:SCR_009672) service resource, access service resource, core facility Core facility that provides the following services: Mapping of post-translational modifications by LC/MS/MS, Protein (complex) identification by LC/MS/MS, Relative quantification of peptides by LC/MS/MS, SILAC, iTRAQ, and Isotope-free ratio quantification service, Metabolomics profiling service.

The Mass Spectrometry Core Facility has been serving the BIDMC community since 2004. We specialize in a targeted mass spectrometry based proteomics approach for isolated proteins and protein complexes, especially phosphorylation and other post-translational modifications involved in cellular signaling using cutting edge instrumentation. Our trained staff offers the highest quality and reliable service with meticulous attention to detail for each sample. We routinely provide services including protein identification, post-translational modification mapping, and relative peptide/protein quantification by stable isotope labeling and label free methods using highly sensitive microcapillary LC/MS/MS techniques at nanoliter flow rates. Several different types of mass spectrometry are utilized depending upon the needs of the researcher including a fast scanning and highly sensitive 2D linear ion trap and a high resolution/high mass accuracy LTQ-Oribitrap mass spectrometer acquired in 2007. In 2005, in agreement with Harvard Medical School''s Pathology Dept., the BIDMC Mass Spectrometry Core became part of the NRB Mass Spectrometry and Proteomics Core, expanding its services and became part of the Cancer Proteomics Core for the Dana Farber Harvard Cancer Center. We serve all institutions regardless of affiliation and have an interest in samples related to many diseases such as cancer and diabetes.
mass spectrometry assay, post translational modification identification by mass spectrometry, metabolite profiling is listed by: Eagle I nlx_156129 http://www.bidmcmassspec.org http://harvard.eagle-i.net/i/0000012a-2519-b5d3-5617-794280000000 SCR_009672 BIDMC Mass Spectrometry (Proteomics / Metabolomics) Core, BIDMC Mass Spectrometry Facility 2026-02-17 10:01:31 0
BIDMC Multi-Gene Transcriptional Profiling Core
 
Resource Report
Resource Website
BIDMC Multi-Gene Transcriptional Profiling Core (RRID:SCR_009673) service resource, access service resource, core facility Core facility that provides the following services: Multi-Gene transcriptional profiling (MGTP) service.

Multi-Gene Transcriptional Profiling (MGTP) is a real-time PCR based technique, developed in our lab, for quantifying mRNA copy numbers per cell with high reproducibility and accuracy. Primary Goals of the MGTP Core: * To make MGTP services available to investigators, and assist them in advancing their research and obtaining grants; * To assist studies of molecular signaling mechanisms and pathways, discovery of biomarkers, and development of clinical assays; and * To share the resources of our primer library, which currently includes about 2400 pre-validated human, and mouse genes. The MGTP Core makes these unique and powerful capabilities available to biomedical researchers. Thousands of pre-validated primers are available for use, and others can be designed on demand.
real-time pcr is listed by: Eagle I nlx_156130 http://cvbr.hms.harvard.edu/CORErealtimePCR.html SCR_009673 2026-02-17 10:01:26 0

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