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http://harvard.eagle-i.net/i/0000012e-9766-17f0-55da-381e80000000

Core facility that provides the following services: DNA extraction from blood and cell lines.

This facility provides processing of cell lines, human blood and tissue samples for DNA, plasma and buffy coat storage and for initiation of lymphoblast and fibroblast cell lines in furtherance of the CHGR mission to promote the use of genetic strategies in basic and clinical research.

Proper citation: MGH CHGR DNA and Tissue Culture Resource (RRID:SCR_009918) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-97d7-0e06-55da-381e80000000

Core facility that provides the following services: Breeding pair service, Mouse Phenotyping Services.

This resource provides to MGH investigators a local source of breeding pairs of the 22 chromosome substitution strains (CSS)* of mice and access to basic phenotyping equipment for mapping of simple or complex traits, to promote the use of genetic mouse-based strategies in basic and clinical research. The CSS Resource comprises 22 mouse lines, each homozygous for a single A/J chromosome (Chr 1-19, X or Y and mitochondria) on a genetic background that is otherwise C57BL/J that were generated by Dr. Joseph Nadeau (Case Western Reserve University) and his colleagues. The CSS mice are available from The Jackson Laboratories. However, to save time and money, the MGH CSS Resource maintains CSS breeding colonies that are housed in the Simches-8 barrier facility, adjacent to a procedure room that will have equipment for basic standardized phenotyping, including behavioral and metabolic measurements.

Proper citation: MGH CHGR Chromosome Substitution Strain Resource (RRID:SCR_009916) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012b-00c0-1e2d-db6e-7a3f80000000

Core facility that provides the following services: Complex protein mixture analysis service, Project consultation service, Data analysis service, Protein identification service, Posttranslational modification site determination service, N-terminal Edman Sequence Analysis Service, C-terminal sequence analysis service, De novo sequence analysis service, Quantitative proteomics service, Labeled quantitative proteomics - SILAC, Labeled quantitative proteomics - ICAT service, Labeled quantitative proteomics - iTRAQ service, Labeled quantitative proteomics - AQUA service, Intact molecular weight determination service, Low resolution GC/MS service, Low resolution GC/MS/MS service, Exact mass MS & MS/MS electrospray for structural elucidation service. The FAS Center for Systems Biology Mass Spectrometry and Proteomics Resource Laboratory provides mass spectrometry and strategic consulting in Proteomics and Small Molecule analysis for Life Science and Chemistry researchers as well as others worldwide. This resource brings together the state-of-the-art expertise and instrumentation of the Microchemistry and Proteomics, CCB Mass Spectrometry, and Bauer Center Core laboratories, leveraging our breadth of experience to provide the best possible support for your research.

Proper citation: Harvard FAS Bauer Core: Mass Spectrometry and Proteomics Core Laboratory (RRID:SCR_009837) Copy   

•   Source: SciCrunch Registry

http://montana.eagle-i.net/i/0000012b-00be-8638-df3b-3fdc80000000

Core facility that provides the following services: Tissue harvest, Inoculation, Surgery, Large research animal husbandry. The MSU Large Animal BSL-2 is a specially designed facility providing research space to house larger research animals (<400 lbs) with BSL-2 containment for immunology and infectious disease experiments.

Proper citation: MSU Large animal BSL-2 (RRID:SCR_009941) Copy   

•   Source: SciCrunch Registry

https://www.ohsu.edu/histopathology-core

Provides routine and customized histology and immunohistochemistry services critical for progress of biomedical research.

Proper citation: OHSU Histopathology Shared Resource Core Facility (RRID:SCR_009977) Copy   

•   Source: SciCrunch Registry

https://www.ohsu.edu/gene-profiling-shared-resource

Full service genomics facility providing research scientists and clinicians with services for RNA expression profiling, DNA variation analysis, and nucleic acid extraction.

Proper citation: OHSU Gene Profiling Shared Resource Core Facility (RRID:SCR_009975) Copy   

•   Source: SciCrunch Registry

http://psm.eagle-i.net/i/00000136-2b31-7276-7d04-928480000000

Core facility that provides the following services: HIV viral load test, Immunoprofile assay, HIV genotype by sequencing assay, Virtual phenotyping assay, RNA and DNA tropism, HCV genotyping, HCV qualitative and quantitative test, HIV ELISA. The Ponce School of Medicine (PSM) RCMI AIDS Research Infrastructure Program (ARIP) proposes to further upgrade its core laboratory units in order to best meet the needs of current and prospective ARIP faculty members. It also proposes to facilitate the institution of career development programs specifically designed to meet the identified requirements of the ARIP faculty members; the current mentoring and partnership program will be strengthened to support their careers. The proposed ARIP Phase V activities will revolve around three specific aims. Specific Aim #1: To further improve and expand the research capabilities of the AIDS research core laboratories in viral genetics, immunology, and drugs of abuse. ARIP cores will be made accessible to the AIDS/HIV investigators from other institutions and countries in order to facilitate the development of high caliber collaborative research that will share the same technologies. The advanced technologies and instrumentation offered by ARIP will enable investigators to study the characteristics of the AIDS/HIV infection in the Caribbean region. Sophisticated instruments and equipment will be made available in real time to investigators from other institutions (via an Internet-2 connection) in an ongoing effort to foster collaboration. By accessing the institution website (www.psm.edu), interested investigators can take part in online training sessions as well as reserve instruments. Specific Aim #2: To implement a career development program (tailor-made for individual ARIP faculty members) that will include research & career mentoring, research consultation, and partnership development. A concerted effort will be made to develop a viable institutional faculty retention plan, which will include faculty incentives through research enterprise activities; in the past, lack of effective faculty development and retention programs has caused the loss of key members. Critical self-analyses were performed to identify the needs of current faculty members so that specific plans might be designed around the requirements of each individual. Specific Aim #3: To implement additional AIDS/HIV-related research programs at PSM as well as at the island?s other three RCMI-sponsored institutions. PSM currently has eight faculty members with actively funded AIDS-related independent research projects (representing the greatest number among the PR RCMI institutions). ARIP members have been active in pursuing the possibility of developing CFAR and CTSA proposals via the program?s ongoing partnership with the consortium of U-FL, USF, FCU, and FSU.

Proper citation: Ponce School of Medicine and Health Sciences AIDS Research Infrastructure Core (RRID:SCR_010047) Copy   

•   Source: SciCrunch Registry

http://psm.eagle-i.net/i/00000136-e4fa-520b-d2c1-4d1680000000

Core facility that provides the following services: Pavlovian fear conditioning, Freezing response analysis, Insertion of cannula. The goals of this core are to enhance the neuroscience-related projects currently being undertaken by PSM investigators and to stimulate further neuroscience research through enhanced scientific interactions between basic scientists at PSM. In addition, this neuroscience core facility will also serve as a tool for attracting strong new recruits.

Proper citation: Ponce School of Medicine and Health Sciences Behavioral Core Facility (RRID:SCR_010048) Copy   

•   Source: SciCrunch Registry

http://hawaii.eagle-i.net/i/00000130-67c9-6302-d176-1f5c80000000

The Microscopy and Imaging Core at the University of Hawaii Cancer Center (CC) provides access to a wide range of imaging instruments to UHCC member, and will soon extend the service to non-members. The facility also offers access to a licensed MetaMorph software package for the processing and analysis of microscopy images. Currently, the core houses four major instruments and three microscopes for routine fluorescence and brightfield use. The core is also in charge of maintenance and service of an IVIS Lumina (Caliper Life Sciences). This is a highly sensitive system to image fluorescent and/or bioluminescent reporters both in vivo and in vitro.

Proper citation: UH Manoa Microscopy and Imaging Core (RRID:SCR_010050) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/00000139-53f7-02d1-9072-1e4280000000

Core facility that provides the following services: Flow Cytometric Cell Sorting. The mission of Ragon Institute Imaging Core, Flow Cytometry Division is to provide training and access to flow cytometers with up to 18 parameters, as well as cell sorting of biohazardous samples. As an MGH Core Facility, the Ragon Institute Imaging Core serves the greater MGH community. Since the Ragon Institute is also a collaboration between MGH, Harvard, and MIT, so too does the facility welcome members of the MIT and Harvard communities. The facility is equipped with three LSR2?s, an LSR Fortessa, a FACSCalibur, and a FACSAria IIu cell sorter in a biosafety cabinet. The core also serves as a resource for addressing a variety of flow cytometry needs including consultation on topics related to experimental design and sample preparation.

Proper citation: Ragon Institute Imaging Core Flow Cytometry (RRID:SCR_010056) Copy   

•   Source: SciCrunch Registry

https://www.ohsu.edu/multiscale-microscopy-core

Multiscale Microscopy Core at OHSU is electron microscopy core that provides services and training to academic and corporate users.

Proper citation: Oregon Health and Science University Multiscale Microscopy Core Facility (RRID:SCR_009969) Copy   

•   Source: SciCrunch Registry

http://ohsu.eagle-i.net/i/0000012b-00cd-fe8a-79a3-373680000000

THIS RESOURCE IS NO LONGER IN SERVICE.December 6,2022. Core facility that provides the following services: Abortus, stillbirth, and neonatal death specimen chromosomal analysis, Amniotic fluid chromosomal analysis, Angelman genetic diagnostic testing, Blood chromosomal analysis, Blood chromosomal analysis, high resolution, Bone marrow chromosomal analysis, Chorionic villus sample chromosomal analysis, Chromosome breakage study, Cystic hygroma fluid chromosomal analysis, DiGeorge/velocardiofacial syndrome screening, Fibroblast chromosomal analysis, Fibroblast culture and storage, Fibroblast retrieval from storage, Fluorescent in-situ hybridization (FISH), HER2 testing by FISH, Kallman Syndrome (X-linked) testing, Microarray comparative genomic hybridization, Miller-Dieker lissencephaly syndrome testing, Neoplastic tissue chromosomal analysis, Pleural fluid chromosomal analysis, Prader-Willi diagnostic testing, Tissue culture for biochemical/DNA testing, Unstimulated peripheral blood chromosomal analysis, Williams syndrome screening, BCR-ABL RNA Quantitative PCR, Lymphoma complete surface marker panel. The OHSU Clinical Cytogenetics Laboratory specializes in high-resolution chromosome analysis. Emphasis has consistently focused on the highest quality preparations in order to provide the patient with the most accurate diagnosis. Certifications: CLIA; CAP; American Board of Medical Genetics; Clinical Cytogenetics; Medical Genetics

Proper citation: OHSU Clinical Cytogenetics Laboratory (RRID:SCR_009967) Copy   

•   Source: SciCrunch Registry

http://ohsu.eagle-i.net/i/0000012b-36a8-3feb-62b8-f47280000000

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on December 6, 2022. Core facility that provides the following services: Embyro stem cell tissue culture service. The Assisted Reproductive Technologies (ART) and Embryonic Stem Cell (ESC) Laboratory provides researchers with nonhuman primate gametes, embryos, follicular cells, embryonic stem cells, and other ART/ESC-related services in support of studies on gamete and follicular development, fertilization and contraception, early embryogenesis, pregnancy initiation, fetal development, stem cell biology, cell-based therapy of human disease, and the creation of disease models in non-human primates. The Core conducts research projects to investigate new areas of technology for creating or propagating valuable founder animals, including genetically modified and genetically identical monkeys and derivation, characterization, and transplantation of autologous, immunocompatible, pluripotent cells. In addition, the ART/ESC laboratory provides expertise and training in all aspects of the nonhuman primate ARTs and ESCs to scientists around the world.

Proper citation: OHSU Assisted Reproductive Technologies and Embryonic Stem Cell Laboratory (RRID:SCR_009962) Copy   

•   Source: SciCrunch Registry

https://www.ohsu.edu/advanced-light-microscopy-core

Provides confocal image analysis and presentation training, microscope training, microscope access service, deconvolution training, super resolution imaging and training service. Offers research scientists access to high-end instrumentation for fluorescence microscopy. Offers support with image acquisition, processing, analysis and presentation.

Proper citation: OHSU Advanced Light Microscopy Core Facility (RRID:SCR_009961) Copy   

•   Source: SciCrunch Registry

https://www.ohsu.edu/xd/research/research-cores/advanced-computing-center/index.cfm

Provides technology solutions to meet non enterprise IT needs across OHSU for healthcare including limited clinical research project support, academic, and research missions. ACC is also home to Exacloud HPC cluster.

Proper citation: OHSU Advanced Computing Center Core Facility (RRID:SCR_009959) Copy   

•   Source: SciCrunch Registry

http://eagle-i.itmat.upenn.edu/i/00000138-babb-5786-9cd7-d7e280000000

Core facility that provides the following services: Sequencing sample preparation service, Illumina sequencing service, Initial analysis of sequencing data, Next-generation sequencing data delivery. The NGSC offers ultra high throughput sequencing services for the Perelman School of Medicine research community. We offer library quality assessments, sequencing, and optional preliminary data analysis for a wide variety of experimental protocols including ChIP-seq, RNA-Seq, HITS-CLIP, miR-Seq, exome capture, and BIS-seq. We offer limited library preparation services, but can advise on library preparation techniques. We have two Illumina hiSeq2000s for large-scale sequencing and a MiSeq for sample evaluation or library testing. To get started, visit our website, create an account for yourself, then create a new experiment and we will contact you.

Proper citation: Penn Next-Generation Sequencing Core (RRID:SCR_010026) Copy   

•   Source: SciCrunch Registry

http://eagle-i.itmat.upenn.edu/i/00000140-2b21-9c5c-6ba0-cf2f80000000

The Penn Regional Nanotechnology Facility (PRN) is a full-service center equipped with a wide range of state-of-the-art instrumentation for materials analysis. Nanoscale characterization of polymers, ceramics, composites, metals, electronics, and thin films is conducted using scanning, transmission, and scanning-transmission electron microscopes, atomic force microscopes, and ion scattering techniques. A wide range of specimen preparation equipment is used including cryo-ultramicrotomy, jet electrolytic polishing, mechanical dimpling, ion beam thinning, tripod polishing, vacuum evaporation, sputter-coating and replication. Both analog and digital output are produced and in-house hardware and software are available for a wide range of image and spectrum processing tasks and for the calculation/simulation of electron-beam specimen interactions and microscope performance. The Nanotech Facility is setup to accommodate both academic and corporate users. Users have the option of working with a staff member or they may take advantage of our comprehensive user training in order to work independently on the instrument of their choice. Please feel free to contact us for any questions or comments about our facility.

Proper citation: Penn Regional Nanotechnology Facility (RRID:SCR_010029) Copy   

•   Source: SciCrunch Registry

http://eagle-i.itmat.upenn.edu/i/0000013a-64b2-be79-01af-beb880000000

Core facility that provides the following services: Metabolomics profiling service. This core provides sophisticated analytical services based on liquid chromatography-mass spectrometry.

Proper citation: Penn Mass Spectrometry Molecular Profiling Core (RRID:SCR_009990) Copy   

•   Source: SciCrunch Registry

http://eagle-i.itmat.upenn.edu/i/0000013c-4084-fd89-f162-a2b280000000

The Small Animal Imaging Facility (SAIF) of the University of Pennsylvania provides multi-modality radiological imaging and image analysis for cells, tissues, and small animals. The SAIF combines state-of-the-art instrumentation and a nationally recognized staff to assist investigators with a wide range of imaging based experimental approaches. The SAIF currently provides a comprehensive suite of imaging modalities including: magnetic resonance imaging (MRI) and spectroscopy (MRS), optical imaging (including bioluminescence, fluorescence, and near-infrared imaging), computed tomography (CT), positron emission tomography (PET), single photon emission computed tomography (SPECT), and ultrasound (US). In addition, dedicated housing is available for mice and rats undergoing longitudinal imaging studies. Ancillary facilities and resources of the SAIF are devoted to chemistry, radiochemistry, image analysis and animal tumor models, including assistance with animal handling.

Proper citation: Penn Small Animal Imaging Facility (RRID:SCR_010030) Copy   

•   Source: SciCrunch Registry

http://eagle-i.itmat.upenn.edu/i/0000013f-5341-6a43-a468-831a80000000

Core facility that provides the following services: Contrast enhanced sonography, Quantitative analysis of images, Small animal ultrasound imaging, Blood flow velocity measurement, Tissue motion measurement. The Ultrasound Sub-Core of the SAIF offers an array of research services for pre-clinical research including quantitative image analysis and consultation. Our state-of-the-art ultrasound scanners are available as a resource for conducting your research studies. This rich resource for ultrasound imaging is available at nominal hourly fees for various categories of study. Ultrasound Research Services provides services to a host of groups working on diverse projects such as the measurement of angiogenesis, vascularity, tissue elasticity, the effects of various pharmaceuticals on these measures and more. Such research encompasses a variety of clinical areas including radiology, oncology, cardiology, gynecology, and hematology, among others.

Proper citation: Penn Small Animal Imaging Facility: Ultrasound Sub-Core (RRID:SCR_010034) Copy   

•   Source: SciCrunch Registry