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http://harvard.eagle-i.net/i/0000012d-9ff6-5676-4882-b08d80000000

Core facility that provides the following services: Flow cytometry analysis service, Cell cycle analysis, Cell sorting service, Side population cell sorting, Zebrafish cell sorting and analysis. The Stem Cell Core Facility has been part of the IDDRC center for more than 30 years fostering collaboration and innovation among IDDRC investigators and members of the academic research community. It was used to develop chromosome sorting for human chromosome specific recombinant libraries and these techniques were utilized by others to generate large scale libraries for the early genome project. The facility was the first to develop cell sorting of fetal cells in the maternal circulation as a means to detect fetal genetic abnormalities. Throughout its history the Stem Cell Core has provided careful and accurate cell cycle analysis via DNA content analysis using Hoechst dye uptake. This service is still used today by investigators. The facility was among the first to take advantage of the ability to express GFP in cells transfected with vectors and induced to express GFP in transgenic animals conditionally expressing a specific gene promoter. This ability allowed IDDRC investigators to isolate neurons, muscle cells and other cell types which express GFP from those which do not. IDDRC investigators were among the first to subsequently culture sorted neurons. Based on the extensive experience of the core using Hoechst dye for cell cycle analysis, the core was able to help IDDRC investigators prepare side population cells (tissue derived potential multipotent progenitor cells) based on Hoechst dye efflux. These methods have allowed the isolation of different muscle side population cells and have facilitated experiments that aim to use the cells for treating muscle disease. The interactive and collaborative nature of the core has fostered these developments, and the interests of the core director, advisory committee, manager and IDDRC investigators will continue to make this core as innovative in the future as it has been in the past. The overall goal of the Stem Cell Core Facility is to provide both IDDRC and non-IDDRC researchers comprehensive analytical flow cytometry and cell sorting services in a timely, dependable and cost-effective manner., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025.

Proper citation: CHB Cell Sorter Core (RRID:SCR_009706) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012a-2513-a940-5617-794280000000

Core facility that provides the following services: Gene targeting service, Transgenics service. The Transgenic Core centralizes the production of genetically altered mice for MRRC investigators in a cost-effective and efficient manner. The Core also provides expert assistance in the additional areas required for generating genetically altered mice, including transgene and targeting construct production, and transgenic mouse colony management. Core personnel are available to train investigators in all of the techniques required for the generation of genetically modified mice.

Proper citation: CHB Transgenic Core Laboratory (RRID:SCR_009707) Copy   

•   Source: SciCrunch Registry

http://cdrewu.eagle-i.net/i/00000135-82ef-5677-1a88-e81c80000000

Core facility that provides the following services: Assay analysis consulting services, Sandwich immunoassays, Competitive immunoassays, Hormone immunoassay service, Inflammation marker immunoassay service, Oxidative stress immunoassay service, Cancer marker immunoassay service, Kidney function immunoassay service, Cardiovascular immunoassay service, DNA damage/repair assay service, Metabolic profile assay service, Apoptosis/ survival pathways assay service. Since its inception fifteen years ago, the Technology Core Laboratory has surpassed its goals in new assay development and assay refinement. It has provided top-quality services, been innovative in developing new assays, and has encouraged collaborations between molecular biologists and clinical investigators. This core laboratory has an outstanding record of accomplishments and has supported many high-impact, peer-reviewed publications.

Proper citation: CDU Metabolic and Oxidative Stress Core Laboratory (RRID:SCR_009702) Copy   

•   Source: SciCrunch Registry

http://cdrewu.eagle-i.net/i/00000135-82f1-6b82-1a88-e81c80000000

A 3,000 square foot Exercise Physiology Lab is located in the ERC Business Park approximately one mile from KDMC. It is fully equipped with Keiser pneumatic resistance training equipment, free weights, treadmills, stationary exercise cycles, as well as state-of-the-art, computerized equipment for measuring muscle performance, cardiopulmonary response, and body composition. These tools are available for utilization by investigators working the field of health disparities related to endocrine metabolism and exercise physiology.

Proper citation: CDU Exercise Physiology Laboratory (RRID:SCR_009700) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-020d-f054-b2b9-4d8780000000

Core facility that provides the following services: DNA extraction from whole blood, saliva, isolated cell pellet, RNA extraction from whole blood with PaxGene tubes, Lymphoblast transformation, Isolation and cryo-preservation of white blood cells. The BioSample Services Facility (BSF) provides sample handling and preparation resources to investigators in the Partners research community. Our goal is to efficiently and effectively process specimens enabling the generation of high quality data via down stream processes. All projects containing subject samples and submitted to the BSF for handling must be IRB approved in advance. All specimens must be entered into our Laboratory Information Management System (GIGPAD) prior to delivery to the BSF. Our staff will work with you to design an implementation plan that would best fit your research needs.

Proper citation: Harvard PCPGM Biosample Services Facility (RRID:SCR_009856) Copy   

•   Source: SciCrunch Registry

http://howard.eagle-i.net/i/00000134-a527-eb04-bf4c-ca4080000000

Core facility that provides the following services: Imaging training, Imaging equipment access. The Molecular Imaging Laboratory?s research focuses on small animal in vivo imaging using MRI, and optical fluorescent and bioluminescent imaging. In particular, we are interested in using molecular imaging techniques to study mechanisms of image contrast enhancement, improvement of sensitivity and specificity of tumor detection, and applications of diagnostics using small animal disease models.

Proper citation: Howard Imaging Core Facility: Molecular Imaging Laboratory (RRID:SCR_009857) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-9c1a-059b-55da-381e80000000

Core facility that provides the following services: Microscope access service, Microscope training service. Confocal and multiphoton are modern fluorescence techniques in microscopy for generating optical sections from live or fixed biological specimens. In general, both techniques employ a point scanning and point detecting design. The confocal microscope achieves point detection by using a confocal pinhole to block off out-of-focus emission from the specimen. The multiphoton microscope, on the other hand, generates intrinsic point emission directly from the in-focus spot, thereby eliminating the need for a confocal pinhole. Subsequent scanning of the entire field of view results in an optical section. Computer reconstruction of serial optical sections, collected at consecutive axial (z) positions, can reveal the spatial localization of cells and tissues (sometime subcellular molecules) in 3D. The ability to see biochemical processes in live cells, in real time, sheds light on the vastly complex molecular world of cells and may allow IDI scientists to identify new targets for drugs that will treat exposure to dangerous toxins and bacteria as well as fight a wide variety of diseases.

Proper citation: Harvard PCMM Optical Microscopy Core (RRID:SCR_009854) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-0214-5945-b2b9-4d8780000000

The Partners Biorepository for Medical Discovery (PBMD), operated by the Partners HealthCare Center for Personalized Genetic Medicine, aims to foster collaborations among investigators, physicians and patients seen at Partners HealthCare institutions. This Partners-wide project is at the forefront of developing the tools needed to expedite the discovery and introduction of new ways to fight disease. As we advance the age of personalized medicine, it is critical that physicians and scientists work with large numbers of patients to advance the delivery of healthcare. The Biorepository provides an opportunity for patients to interact with investigative studies ? safely, securely and privately ? in ways that could have an enormous benefit for us all. The Biorepository continues in a development phase, and is actively working with a number of groups at BWH and MGH who are consenting patients for clinical and translational research studies. Samples are maintained in an institution-wide repository which is a growing resource available to Partners investigators and research groups.

Proper citation: Harvard PCPGM Biorepository for Medical Discovery (RRID:SCR_009855) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012c-e1a8-0ec0-2162-17a280000000

Core facility that provides the following services: Introduction to the GE In Cell Analyzer 1000 for High Content Analysis (HCA). In collaboration with GE Healthcare Bio-sciences, the NeuroDiscovery Center has established a program centered around the IN Cell Analyzer 1000 - a flexible and easy to use sub-cellular analysis system suitable for medium-throughput screening, assay development and basic research. Based in the NeuroDiscovery Laboratory for Drug Discovery in Neurodegeneration, the IN Cell Analyzer 1000 is available for use by NeuroDiscovery members. (While priority is given to members investigating neurodegenerative diseases and the central nervous system, we welcome enquiries from all investigators.)

Proper citation: Harvard NeuroDiscovery Center - Cell-based Assays Core (RRID:SCR_009852) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012c-e198-9f3f-2162-17a280000000

High quality statistical support is important in the preparation of grant applications or study protocols for clinical trials. Such support typically is not readily available to investigators who are new to clinical trials. To address this weakness, the NeuroDiscovery Center provides consulting and collaborative services to its members who are engaged in clinical research applicable to neurodegenerative disease.

Proper citation: Harvard NeuroDiscovery Center - Biostatistics Consultation (RRID:SCR_009850) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012b-00c4-8067-db6e-7a3f80000000

Core facility that provides the following services: Transgene microinjection service, Embryonic stem cell gene targeting service, Blastocyst injection service, Cryopreservation of embryos and sperm, Genotyping service, Mouse consulting service. The Genome Modification Facility (GMF) provides transgenic, gene targeting, and other services to investigators of Harvard University and its affiliated institutions, as well as to investigators within the US and abroad. The GMF performs microinjections of DNA into fertilized embryos to generate transgenic mice, DNA transfection into ES cells for the creation of recombinant ES cell clones, injection of gene-targeted ES cells into host blastocysts to generate gene knock-out or knock-in mice, teratoma formation studies, and other related ES cell-based services. Other services include cryopreservation of mouse sperm and embryos, in vitro fertilization (IVF), recovery of cryopreserved mouse sperm and embryos, rederivation of pathogen free mouse lines, and derivation ES cell lines from wild type and mutant mice with a variety of genetic backgrounds. Our staff provides general consultations on experimental designs and vectors for gene modification-related projects, DNA preparation, recombinant ES clones, mouse genotyping, colony breeding and husbandry. We can also customize services as requested to support development of animal models of human diseases.

Proper citation: Harvard Genome Modification Facility Harvard University (RRID:SCR_009849) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-021d-e404-b2b9-4d8780000000

Core facility that provides the following services: ABI Prism Taqman Allelic Discrimination Assay, OpenArray SNP genotyping, Illumina genotyping, Custom Illumina GoldenGate genotyping, Illumina Infinium genotyping analysis, Illumina methylation analysis. The Partners Genotyping Facility, part of the Partners HealthCare Center for Personalized Genetic Medicine (PCPGM), provides flexible, high quality, high-throughput SNP genotyping to the Harvard-Partners research community, including Harvard Medical School, hospitals in the Partners HealthCare network, investigators in the Dana-Farber-/ Harvard Cancer Center, and the Harvard School of Public Health. The portfolio of Genotyping methods at PCPGM now includes Illumina, TaqMan and TaqMan OpenArrays. Note: DF/HCC members will receive the DF/HCC discount on both genotyping and sequencing services from our facility

Proper citation: Harvard PCPGM Genotyping Facility (RRID:SCR_009846) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012b-00bf-9941-db6e-7a3f80000000

Core facility that provides the following services: Macromolecular X-ray diffraction service, Charge density analysis, Single-Crystal service, Crystal mounting service, Cambridge structural database access, Inorganic crystal structure database access. The X-ray diffraction facility in Harvard University offers single crystal X-ray data collection, structure solution and refinement of small molecule structures.

Proper citation: Harvard FAS Center for Crystallographic Studies (RRID:SCR_009843) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012f-e9e7-e67c-de5a-673e80000000

Core facility that provides the following services: Access to fabrication lab. Technological advances hold a key to greater understanding of the structure and function of complex neural circuits. Neuroengineering is a core facility that provides customized engineering solutions to neuroscience problems faced by our members. Assistance with experimental design, electronics, machining, and software development, are all services provided.

Proper citation: Harvard FAS Center for Brain Science - Neuroengineering Core Facility (RRID:SCR_009841) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012f-0d5e-aceb-cb22-be8c80000000

Implements and maintains specialized computer facilities required by the DERC investigators. A major emphasis of JoslinResearch.org is to provide dynamic web applications that serve essential informational needs of the research community at the Joslin Diabetes Center. These applications provide such functions as automating media provisioning services to DERC laboratories, distributing DERC event schedule information, providing access to troubleshooting information, fully-searchable call schedules with contact information, text messaging services, and access to information about Section, Investigator and Fellow projects and affiliations. All applications adhere to the JoslinResearch.org paradigm of distributed administration without requiring knowledge of web design or web programming. For DERC use only.

Proper citation: JDC Computer Resource (RRID:SCR_009877) Copy   

•   Source: SciCrunch Registry

http://hunter-cuny.eagle-i.net/i/00000136-7e06-6aac-949b-425080000000

The Flow-Cytometry (FACS) facility is located on the ninth floor of the Hunter North building. This facility provides analyses of up to 7 parameters in eukaryotic cell populations and sorts cells under sterile conditions. These analyses can be used to identify and isolate rare cell populations, determine chromosome ploidy in individual cells, study apoptosis, and study cell-signaling among other applications.

Proper citation: Hunter Flow Cytometry Facility (RRID:SCR_009870) Copy   

•   Source: SciCrunch Registry

http://hunter-cuny.eagle-i.net/i/00000136-8336-80a6-949b-425080000000

Core facility that provides the following services: Bio-imaging instrumentation training, Bio-Imaging data analysis service. The Bio-Imaging facility currently provides optical and video microscopy services.The facility is equiped with two confocal microscopes, a Leica TCS SP2, and a Perkin Elmer UltraVIEW ERS Spinning Disc confocal . In addtion to confocal microscopy the facility is also equipped for bright field, phase contrast, modulation contrast and epi fluorescence microscopy. The facility has two separate wide field image analysis stations. A Nikon Optiphot microscope equipped with a color video system and Compix imaging software, and a Nikon Eclipse TE200 inverted scope. This inverted scope in specially configured to perform calcium ratio imaging is equipped with Molecular Devices Meta Fluor software The facility has recently expanded with the aquisition of a JEOL JEM-100C/CX Transmission Electron Microscope. The facility also is equiped with Typhoon 9410 scanner for the quantitation and localization of sub cellular fluorescent and radioactive molecules. In addition a Densitometer allows for the analysis of 1 and 2 D gels, Southern, northern and western blots and RFPL gels. The facility is also equipped with color and B&W laser printers for the production of publication quality graphics and presentation materials.

Proper citation: Hunter Bio-Imaging Facility (RRID:SCR_009869) Copy   

•   Source: SciCrunch Registry

http://howard.eagle-i.net/i/00000134-a517-1426-bf4c-ca4080000000

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on October 27,2023. Core for bioinformatics consultation and software access. Laboratory of Molecular Computations and Bioinformatics (LMCB) is a resource facility dedicated to the support of computational biomedical research at Howard University. Provides molecular modeling, molecular dynamics, bioinformatics, and computational quantum chemistry capabilities and support to a variety of research projects at Howard University.

Proper citation: Howard University Center for Computational Biology and Bioinformatics Core Facility (RRID:SCR_009864) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/00000139-4a28-1319-4d8e-943b80000000

The Partners Research Computing Core was created by Enterprise Research Infrastructure & Services (ERIS) to offer dedicated services, consultation, and support within the teaching hospitals. Please check the service catalog as new services are added, or contact us if you need a consultation. Initial discussion is at no charge.

Proper citation: Harvard Partners Research Computing Core (RRID:SCR_009861) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000013e-8557-6524-8a53-38db80000000

There is a growing need for animal models to carry out in vivo developmental and regenerative medicine studies of human cells, tissues and organs. The Humanized Neonatal Mouse Center (HNMC) was created to accelerate research in the stem cell field by providing humanized mouse models to study human stem cell engraftment and differentiation in regenerative medicine. We have over 4 years of experience in constructing different types of humanized mouse models, including neonatal heart, lung and kidney injury models. We have extensive experience in hematopoietic stem cell reconstruction. It is our goal at HNMC to facilitate collaborative research in human stem cell biology, where physiologically relevant microenvironments (niches) may be created in vivo to study human stem cell fate and function under experimental settings where disease, damage or degenerative conditions can be controlled. We can provide customized humanized mouse models to the HSCI research community, to collaborate on research studies of common interest, and to advance the general use of these models for a broad range of translational and preclinical studies.

Proper citation: HSCI Humanized Neonatal Mouse Center (RRID:SCR_009815) Copy   

•   Source: SciCrunch Registry