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Resource Name Proper Citation Abbreviations Resource Type Description Keywords Resource Relationships Related Condition Funding Defining Citation Availability Website Status Alternate IDs Alternate URLs Old URLs Parent Organization Resource ID Synonyms Record Last Update Mentions Count
SeqEM
 
Resource Report
Resource Website
1+ mentions
SeqEM (RRID:SCR_002021) software application, sequence analysis software, data processing software, algorithm resource, software resource, web application, data analysis software Online tool for utilizing a genotype calling algorithm for next-generation sequence data. genotype, algorithm, sequence, rna, dna, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
has parent organization: University of Miami Miller School of Medicine; Florida; USA
PMID:20861027 THIS RESOURCE IS NO LONGER IN SERVICE OMICS_00074, biotools:seqem https://bio.tools/seqem SCR_002021 2026-02-15 09:18:13 1
COnsensus-DEgenerate Hybride Oligonucleotide Primers
 
Resource Report
Resource Website
1+ mentions
COnsensus-DEgenerate Hybride Oligonucleotide Primers (RRID:SCR_002875) software application, data analysis service, data processing software, software resource, service resource, production service resource, analysis service resource, data analysis software This COnsensus-DEgenerate Hybrid Oligonucleotide Primer (CODEHOP) strategy has been implemented as a computer program that is accessible over the World-Wide Web and is directly linked from the BlockMaker multiple sequence alignment site for hybrid primer prediction beginning with a set of related protein sequences. This is a new primer design strategy for PCR amplification of unknown targets that are related to multiply-aligned protein sequences. Each primer consists of a short 3' degenerate core region and a longer 5' consensus clamp region. Only 3-4 highly conserved amino acid residues are necessary for design of the core, which is stabilized by the clamp during annealing to template molecules. During later rounds of amplification, the non-degenerate clamp permits stable annealing to product molecules. The researchers demonstrate the practical utility of this hybrid primer method by detection of diverse reverse transcriptase-like genes in a human genome, and by detection of C5 DNA methyltransferase homologs in various plant DNAs. In each case, amplified products were sufficiently pure to be cloned without gel fractionation. Sponsors: This work was supported in part by a grant from the M. J. Murdock Charitable Trust and by a grant from NIH. S. P. is a Howard Hughes Medical Institute Fellow of the Life Sciences Research Foundation., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on January 15,2026. fractionation, gel, 3', amplification, clone, dna, genome, homolog, human, hybrid, molecule, oligonucleotide, pcr, plant, primer, protein, sequence, transcriptase-methyltransferase is related to: OMICtools
has parent organization: University of Washington; Seattle; USA
THIS RESOURCE IS NO LONGER IN SERVICE nif-0000-25557 SCR_002875 CODEHOP 2026-02-15 09:18:24 8
LAST
 
Resource Report
Resource Website
100+ mentions
LAST (RRID:SCR_006119) LAST software application, data analysis service, software resource, data processing software, service resource, production service resource, analysis service resource THIS RESOURCE IS NO LONGER IN SERVICE. Documented on February 28,2023. Software tool for aligning sequences, similar to BLAST 2 sequences that colour-codes the alignments by reliability. Another useful feature of LAST is that it can compare huge (vertebrate-genome-sized) datasets. Unfortunately, this only applies to the downloadable version of LAST, not the web service. The web service can just about handle bacterial genomes, but it will take a few minutes and the output will be large. LAST can: * Handle big sequence data, e.g: ** Compare two vertebrate genomes ** Align billions of DNA reads to a genome * Indicate the reliability of each aligned column. * Use sequence quality data properly. * Compare DNA to proteins, with frameshifts. * Compare PSSMs to sequences * Calculate the likelihood of chance similarities between random sequences. LAST cannot (yet): * Do spliced alignment., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025. sequence alignment, align, vertebrate, genome, sequence, alignment, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
is related to: RecountDB
has parent organization: National Institute of Advanced Industrial Science and Technology
National Genome Research Network ;
INTEuropean Union Systems Institute ;
Japanese Ministry of Education Culture Sports Science and Technology MEXT
PMID:21209072
PMID:20144198
PMID:20110255
DOI:10.1093/nar/gkq010
THIS RESOURCE IS NO LONGER IN SERVICE nlx_151594, biotools:last, OMICS_15813 https://bio.tools/last
https://sources.debian.org/src/last-align/
SCR_006119 2026-02-15 09:19:08 397
FASTA
 
Resource Report
Resource Website
500+ mentions
FASTA (RRID:SCR_011819) FASTA software application, sequence analysis software, data processing software, software resource, data analysis software Software package for DNA and protein sequence alignment to find regions of local or global similarity between Protein or DNA sequences, either by searching Protein or DNA databases, or by identifying local duplications within a sequence. sequence, alignment, DNA, protein, similarity, searching is listed by: OMICtools
is listed by: SoftCite
has parent organization: European Bioinformatics Institute
Free, Freely available OMICS_00994 SCR_011819 Federal Acquisition STreamlining Act 2026-02-15 09:20:24 845
StringTie
 
Resource Report
Resource Website
1000+ mentions
StringTie (RRID:SCR_016323) software application, sequence analysis software, data processing software, software resource, data analysis software Software application for assembling of RNA-Seq alignments into potential transcripts. It enables improved reconstruction of a transcriptome from RNA-seq reads. This transcript assembling and quantification program is implemented in C++ . assembling, RNA, sequence, transcript, gene, alignment, reconstruction, read, analysis, process, bio.tools is listed by: bio.tools
is listed by: Debian
is listed by: OMICtools
the Cancer Prevention and Research Institute of Texas ;
NHGRI R01 HG006677;
NIGMS R01 GM105705;
NHGRI R01 HG006102;
NCI R01 CA120185;
NCI R01 CA134292
PMID:25690850
DOI:10.1038/nbt.3122
Open source, Free, Freely available, Available for download biotools:stringtie, OMICS_07226 https://github.com/gpertea/stringtie
https://bio.tools/stringtie
https://sources.debian.org/src/stringtie/
SCR_016323 2026-02-15 09:21:38 4072
Hinge
 
Resource Report
Resource Website
1+ mentions
Hinge (RRID:SCR_016135) software application, sequence analysis software, data processing software, software resource, data analysis software Software application for long read genome assembly based on hinging. Used in long-read sequencing technologies in genome assemblies to achieve optimal repeat resolution. long, read, genome, assembly, hinging, sequence, optimal, repeat, resolution is listed by: Debian
is listed by: OMICtools
PMID:28320918 Free, Available for download OMICS_12339 https://sources.debian.org/src/hinge/ SCR_016135 2026-02-15 09:21:32 9
FreeContact
 
Resource Report
Resource Website
10+ mentions
FreeContact (RRID:SCR_016113) software application, data processing software, software resource, alignment software, image analysis software Alignment software for large-scale protein contact or protein-protein interaction prediction optimized for speed through shorter runtimes. FreeContact provides the opportunity to compute contact predictions in any environment (desktop or cloud). protein, structure, prediction, sequence, analysis, fast, contact, alignment, multiple is listed by: OMICtools
is related to: Debian
Alexander von Humboldt Foundation ;
German Ministry for Research and Education (BMBF: Bundesministerium fuer Bildung und Forschung) ;
Research Council of Norway 208481
PMID:24669753
DOI:10.1186/1471-2105-15-85
Open source, Free, Available for download OMICS_03520 https://rostlab.org/owiki/index.php/FreeContact
https://sources.debian.org/src/libfreecontact-perl/
SCR_016113 2026-02-15 09:21:02 21
QModeling
 
Resource Report
Resource Website
1+ mentions
QModeling (RRID:SCR_016358) software application, data processing software, software resource, image analysis software, software toolkit, data analysis software Software toolbox for Statistical Parametric Mapping (SPM) to fit reference-region kinetic models (SRTM, SRTM2, Patlak Reference and Logan Reference Plot) are currently available in QModeling to dynamic PET studies. Used for the analysis of brain imaging data sequences. statistical, parametric, mapping, reference, region, kinetic, model, dynamic, analysis, brain, data, imaging, sequence is related to: University of Malaga; Andalusia; Spain
is related to: MATLAB
DOI:10.1007/s12021-018-9384-y Free, Available for download, Available after registration SCR_016358 2026-02-15 09:21:51 1
NanoPipe
 
Resource Report
Resource Website
1+ mentions
NanoPipe (RRID:SCR_016852) NanoPipe data analysis service, software resource, data access protocol, web service, service resource, production service resource, analysis service resource Web tool for analysis of MinION (ONT) long sequencing reads. Used for analysis of reads generated by the Oxford Nanopore sequencing devices. Provides alignments to any target of interest, alignment statistics and information about polymorphisms. analysis, MinION, long, sequence, read, Oxford Nanopore, alignment, target, statistics, polymorphism, bio.tools is listed by: Debian
is listed by: bio.tools
has parent organization: University of Muenster; Muenster; Germany
Institute of Bioinformatics Muenster ;
Germany
PMID:30689855 Free, Available for download, Freely Available biotools:NanoPipe https://github.com/IOB-Muenster/nanopipe2
https://bio.tools/NanoPipe
SCR_016852 NanoPipe, nanopipe2 2026-02-15 09:21:49 5
ClonalOrigin
 
Resource Report
Resource Website
1+ mentions
ClonalOrigin (RRID:SCR_016061) software application, sequence analysis software, data processing software, software resource, data analysis software Software package for comparative analysis of the sequences of a sample of bacterial genomes in order to reconstruct the recombination events that have taken place in their ancestry. comparative, analysis, sequence, bacteria, genome, reconstruct, recombination, events, ancestry, bayesian is listed by: Debian
is listed by: OMICtools
is related to: Imperial College London; London; United Kingdom
is related to: Wellcome Trust Sanger Institute; Hinxton; United Kingdom
Wellcome Trust WT082930MA;
National Science Foundation DBI-0630765;
Science Foundation of Ireland 05/FE1/B882
PMID:20923983
DOI:10.1534/genetics.110.120121
Free, Available for download OMICS_18881 https://sources.debian.org/src/clonalorigin/ SCR_016061 2026-02-15 09:21:30 8
GeMoMa
 
Resource Report
Resource Website
100+ mentions
GeMoMa (RRID:SCR_017646) software application, simulation software, software resource Software tool as homology based gene prediction program that predicts gene models in target species based on gene models in evolutionary related reference species. Utilizes amino acid sequence conservation, intron position conservation, and RNA-seq data to accurately predict protein-coding transcripts. Supports combination of predictions based on several reference species allowing to transfer high quality annotation of different reference species to target species. Homology, based, gene, prediction, model, target, evolutionary, related, reference, species, sequence, conservation, intron, position, RNAseq, data, protein, coding, transcript, bio.tools is listed by: bio.tools
is listed by: Debian
works with: GUSHR
PMID:31020559 Free, Available for download, Freely available biotools:gemoma https://bio.tools/gemoma SCR_017646 Gene Model Mapper 2026-02-15 09:21:23 135
PseudoFuN
 
Resource Report
Resource Website
1+ mentions
PseudoFuN (RRID:SCR_017095) data analysis service, database, service resource, production service resource, data or information resource, analysis service resource Software as database and query tool for homologous pseudogene and coding gene families. Collection of human pseudogenes and gene associations. Supports search, graphical visualization and functional analysis of pseudogenes and coding genes based on PGG families. gene, pseudogene, sequence, homology, regulatory, network, miRNA, coexpression, noncoding, RNA, TCGA, cancer has parent organization: Ohio State University; Ohio; USA
has parent organization: Indiana University School of Medicine; Indiana; USA
NLM T15 LM011270 Free, Freely available https://github.com/yanzhanglab/PseudoFuN_app SCR_017095 Pseudogene Functional Networks 2026-02-15 09:21:56 2
Human Experimental/FunctionAL MaPper: Providing Functional Maps of the Human Genome
 
Resource Report
Resource Website
Human Experimental/FunctionAL MaPper: Providing Functional Maps of the Human Genome (RRID:SCR_003506) HEFalMp data or information resource, database, service resource HEFalMp (Human Experimental/FunctionAL MaPper) is a tool developed by Curtis Huttenhower in Olga Troyanskaya's lab at Princeton University. It was created to allow interactive exploration of functional maps. Functional mapping analyzes portions of these networks related to user-specified groups of genes and biological processes and displays the results as probabilities (for individual genes), functional association p-values (for groups of genes), or graphically (as an interaction network). HEFalMp contains information from roughly 15,000 microarray conditions, over 15,000 publications on genetic and physical protein interactions, and several types of DNA and protein sequence analyses and allows the exploration of over 200 H. sapiens process-specific functional relationship networks, including a global, process-independent network capturing the most general functional relationships. Looking to download functional maps? Keep an eye on the bottom of each page of results: every functional map of any kind is generated with a Download link at the bottom right. Most functional maps are provided as tab-delimited text to simplify downstream processing; graphical interaction networks are provided as Support Vector Graphics files, which can be viewed using the Adobe Viewer, any recent version of Firefox, or the excellent open source Inkscape tool. human, map, gene, functional, pathway, disease, genomic, analysis, microarray, dna, protein, sequence has parent organization: Princeton University; New Jersey; USA New Jersey Commission on Cancer Research ;
PhRMA Foundation 2007RSGl9572;
NIGMS R01 GM071966;
NSF DBI-0546275;
NSF IIS-0513552;
NHGRI T32 HG003284;
NIGMS P50 GM071508
PMID:19246570 nif-0000-37186 SCR_003506 Human Experimental / FunctionAL MaPper, Human Experimental/FunctionAL MaPper 2026-02-15 09:18:31 0
Coddle-Codons Optimized to Discover Deleterious LEsions
 
Resource Report
Resource Website
10+ mentions
Coddle-Codons Optimized to Discover Deleterious LEsions (RRID:SCR_003003) CODDLE service resource, analysis service resource, data analysis service, production service resource THIS RESOURCE IS NO LONGER IN SERVICE, documented August 22, 2016. Web-accessible program that identifies the region(s) of a user-selected gene and of its coding sequence (CDS) where the anticipated point mutations are most likely to result in deleterious effects on the gene's function. CODDLe separately handles 1) the prediction of changes which should truncate the protein and destabilize the RNA - nonsense changes and splice junction changes, and 2) the prediction of missense changes which should alter function of the gene product - those in conserved amino acid blocks in the CDS. Because the region(s) identified will be PCR amplified by the user and that amplicon will be used for polymorphism discovery, the application delivers primer pairs selected by Primer3 (Steve Rozen, Helen J. Skaletsky (1996,1997,1998)Primer3.) After selecting a primer pair, CODDLe returns a window with the selected amplicon and tabulates the effects of all possible polymorphisms which could be detected in that amplicon. CODDLe will not identify the regions of a gene where polymorphisms are most likely to be discovered. Others have shown that naturally occurring SNPs are found more often in the untranslated regions of a gene. codon, deleterious lesion, gene, coding, sequence, mutation, primer, protein sequence, cdna, sequence alignment, coding sequence is listed by: 3DVC
has parent organization: Fred Hutchinson Cancer Center
DOE ;
Office of Energy Research
THIS RESOURCE IS NO LONGER IN SERVICE nif-0000-30262 SCR_003003 Choosing codons to Optimize Discovery of Deleterious Lesions, Codons Optimized to Discover Deleterious LEsions 2026-02-15 09:18:27 16
BiSearch: Primer Design and Search Tool
 
Resource Report
Resource Website
50+ mentions
BiSearch: Primer Design and Search Tool (RRID:SCR_002980) BiSearch service resource, analysis service resource, data analysis service, production service resource BiSearch is a primer-design algorithm for DNA sequences. It may be used for both bisulfite converted as well as for original not modified sequences. You can search various genomes with the designed primers to avoid non-specific PCR products by our fast ePCR method. This is especially recommended when primers are designed to amplify the highly redundant bisulfite treated sequences. It has the unique property of analyzing the primer pairs for mispriming sites on the bisulfite-treated genome and determines potential non-specific amplification products with a new search algorithm. The options of primer-design and analysis for mispriming sites can be used sequentially or separately, both on bisulfite-treated and untreated sequences. In silico and in vitro tests of the software suggest that new PCR strategies may increase the efficiency of the amplification. dna, sequence, primer, design, algorithm, analysis, priming, bisulfite, genome, amplification, in vitro, in silico, amplification, epcr, cytosines has parent organization: Hungarian Academy of Sciences; Budapest; Hungary PXE International Inc. GVOP-3.1.1-2004-05-0143/3.0;
Boolyai Janos Scholarship ;
OTKA T34131;
OTKA D42207
PMID:17022803
PMID:15653630
nif-0000-30170 SCR_002980 2026-02-15 09:18:27 50
TFSEARCH: Searching Transcription Factor Binding Sites
 
Resource Report
Resource Website
100+ mentions
TFSEARCH: Searching Transcription Factor Binding Sites (RRID:SCR_004262) service resource, analysis service resource, data analysis service, production service resource The TFSEARCH searches highly correlated sequence fragments against TFMATRIX transcription factor binding site profile database in the "TRANSFAC" databases developed at GBF-Braunschweig, Germany. The TFSEARCH program was written by Yutaka Akiyama (Kyoto University, currently at RWCP) in 1995. vertebrate, arthropod, plant, yeast, dna, sequence, FASEB list is related to: TFFACTOR
has parent organization: Computational Biology Research Center Core Facility
PMID:9399875 nlx_27602 http://www.cbrc.jp/research/db/TFSEARCH.html SCR_004262 TFSEARCH: DNA Transcription Factor Binding Site Prediction, Transcriptional Factor Search, TFSEARCH 2026-02-15 09:18:43 214
MG-RAST
 
Resource Report
Resource Website
1000+ mentions
MG-RAST (RRID:SCR_004814) MG RAST service resource, analysis service resource, data analysis service, production service resource An automated analysis platform for metagenomes providing quantitative insights into microbial populations based on sequence data. The server primarily provides upload, quality control, automated annotation and analysis for prokaryotic metagenomic shotgun samples. metagenome, base pair, sequence, phylogenetic, functional analysis, data sharing, metadata, protein, micro biome, analysis platform, bio.tools is listed by: OMICtools
is listed by: Human Microbiome Project
is listed by: Debian
is listed by: bio.tools
has parent organization: Argonne National Laboratory
NIAID contract HHSN272200900040C;
DOE contract DE-AC02-06CH11357
PMID:18803844 Acknowledgement requested, Public, Account required OMICS_01456, biotools:mg-rast http://metagenomics.nmpdr.org
https://bio.tools/mg-rast
SCR_004814 The Metagenomics RAST server, Metagenomics RAST, MG-RAST - metagenomics analysis server 2026-02-15 09:18:49 1137
Human Splicing Finder
 
Resource Report
Resource Website
500+ mentions
Human Splicing Finder (RRID:SCR_005181) HSF service resource, analysis service resource, data analysis service, production service resource Software tool to help study pre-mRNA splicing and to better understand intronic and exonic mutations leading to splicing defects. To calculate the consensus values of potential splice sites and search for branch points, new algorithms were developed. Furthermore, they have integrated all available matrices to identify exonic and intronic motifs, as well as new matrices to identify hnRNP A1, Tra2-? and 9G8. splicing, mutation, splicing signal, sequence, transcript, nucleotide, exon, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
is related to: Ensembl
has parent organization: National Institute of Health and Medical Research; Rennes; France
PMID:19339519 Acknowledgement requested biotools:human_splicing_finder, OMICS_00176 https://bio.tools/human_splicing_finder http://www.umd.be/HSF/ SCR_005181 2026-02-15 09:19:02 963
PRED-CLASS
 
Resource Report
Resource Website
PRED-CLASS (RRID:SCR_006216) PRED-CLASS service resource, analysis service resource, data analysis service, production service resource A system of cascading neural networks that classifies any protein, given its amino acid sequence alone, into one of four possible classes: membrane, globular, fibrous, mixed. classification, protein, fibrous, globular, protein class, membrane, sequence, algorithm, protein classification, neural network, transmembrane, genome annotation, genome-wide analysis is related to: DAM-Bio
has parent organization: University of Athens Biophysics and Bioinformatics Laboratory
European Union ERBFMRXCT960019 PMID:11455609 nlx_151762 SCR_006216 PRED-CLASS - Classification of proteins into one of four possible classes 2026-02-15 09:19:11 0
ProbeExplorer
 
Resource Report
Resource Website
ProbeExplorer (RRID:SCR_007116) ProbeExplorer service resource, analysis service resource, data analysis service, production service resource Probe Explorer is an open access web-based bioinformatics application designed to show the association between microarray oligonucleotide probes and transcripts in the genomic context, but flexible enough to serve as a simplified genome and transcriptome browser. Coordinates and sequences of the genomic entities (loci, exons, transcripts), including vector graphics outputs, are provided for fifteen metazoa organisms and two yeasts. Alignment tools are used to built the associations between Affymetrix microarrays probe sequences and the transcriptomes (for human, mouse, rat and yeasts). Search by keywords is available and user searches and alignments on the genomes can also be done using any DNA or protein sequence query. Platform: Online tool bioinformatics, microarray, oligonucleotide probe, transcript, genomic, genome, transcriptome, alignment, affymetrix, probe sequence, dna, protein, sequence, statistical analysis is listed by: Gene Ontology Tools
is related to: Gene Ontology
has parent organization: University of Salamanca; Salamanca; Spain
Open unspecified license - Free for academic use nlx_149275 SCR_007116 Probe Explorer 2026-02-15 09:19:27 0

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