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http://dartmouth.eagle-i.net/i/0000012a-24fd-03f4-d8a1-249280000000

Core facility that provides the following services: Electron micrscopy facility access.

The EM Facility is an institutional resource to meet the electron microscopy needs of faculty, staff and students of the Dartmouth College community, including the College, Thayer School of Engineering, the Dartmouth Medical School, and the Dartmouth-Hitchcock Medical Center. The instruments are housed in the EM wing of Remsen. Because the facility is intended to provide service to all the campus, yet has limited personnel, a major effort is made to provide training in the use of appropriate instruments to enable users to do their own microscopy. In addition to this training, there will be service assistance available for those unable to spend time on the microscopes, and for processing of biopsy samples from DHMC.

Proper citation: Dartmouth Electron Microscope Facility (RRID:SCR_009762) Copy   

•   Source: SciCrunch Registry

http://dms.dartmouth.edu/dgml

Core facility that provides the following services: Illumina Bead Array service, Affymetrix Microarray service.

The Genomics Shared Resource provides technologies to the Norris Cotton Cancer Center and Dartmouth community investigators that enable profiling of gene expression, miRNA, GpC Island, and CGH on a whole-genome scale. The long-term goal of the Genomics Shared Resource is to provide an efficient and affordable fee-for-service operation that will provide high quality genomics and microarray data for the growing number of Cancer Center investigators who require this service.

Proper citation: Dartmouth Genomics Shared Resource (RRID:SCR_009763) Copy   

•   Source: SciCrunch Registry

http://dartmouth.eagle-i.net/i/0000012b-43eb-535f-bd3e-55f580000000

Core facility that provides the following services: Cigarette smoke exposure analysis service.

Our lab is interested in the innate immune system at the mucosal surfaces of the female reproductive and respiratory tracts. A special focus of this work is to determine the effects of cigarette smoke on changes in immune protection. The relationship of cigarette smoke exposure to increased risk of infection is well established, however the mechanisms involved are not. Our research shows that cigarette smoke exposure reduces production of a key antimicrobial chemokine, CCL20. Ongoing research in the lab seeks to determine if similar responses to cigarette smoke exposure underlie increased rates of infection and how cigarette smoke exposure associated infection is linked to the development of cancer. Consulting; training; planning; experimental management assistance. Banked tissue samples available for preliminary studies. Small animal cigarette exposure.

Proper citation: Dartmouth Cigarette Smoke Exposure Analysis Laboratory (RRID:SCR_009761) Copy   

•   Source: SciCrunch Registry

http://core.iddrc.org/molecular-genetics/

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on October 8,2024. Core facility that provides the following services: DNA sequencing (standard) service, Taqman gene expression service, Taqman SNP genotyping, Digital PCR service, Genomic mapping facility standard service, DNA purification from blood and saliva, RNA purification service, Master 96-well plate sample preparation, Gene expression service, SNP genotyping service, Bioanalysis of RNA and DNA, Next-generation sequencing service, Sequenom SNP genotyping, SNP and qPCR 7900HT instrument access. The Molecular Genetics Core Facility (MGCF) is a non-profit core laboratory in the Program in Genomics and Genetics Division of Children''s Hospital Boston offering genomics services for academic research institutions. The majority of MGCF users are investigators from Children''s Hospital Boston and the surrounding Harvard affiliates, but the MGCF also serves laboratories throughout the entire United States. The MGCF is comprised of a compilation of smaller cores partially supported by private and federal funds. Funding is provided in part through The Intellectual and Developmental Disabilities Research Center, The Manton Center for Orphan Disease Research, The Wellstone Center for Muscular Dystrophy, and The Neuromuscular Disease Project of the Program in Genomics at Children''s Hospital Boston. The overall objective of the MGCF is to provide a location where researchers can have access to high quality, low cost genomic technology services and expertise in a timely, affordable manner. The services offered include DNA sequencing, Next-Gen sequencing, Affymetrix and Illumina whole-genome expression and genotyping microarray technology, microsatellite genotyping, high-throughput qPCR and SNP services on the Fluidigm Biomark System, multiplex SNP genotyping on the Sequenom MassARRAY, and sample extraction and banking. The MGCF also assists investigators with project design and collaborates on linkage and association study analysis.

Proper citation: CHB Molecular Genetics Core Facility (RRID:SCR_009715) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/00000130-0977-e10a-de5a-673e80000000

Core facility that provides the following services: Lipoprotein analysis, Biliary lipid concentrations analysis, Biliary particle analysis, Quantitative real-time PCR, Sequential ultracentrifugation for lipoproteins, Radiolabeling of lipoproteins, Fluorescence labeling of lipoproteins, Purification of biliary lipid aggregatesfrom model biles, Preparation of recombinant proteins, Protein identification from gel bands, Protein Identification from complex mixtures. The Molecular and Cellular Biochemistry Core is dedicated to providing HDDC investigators and their trainees with access to a variety of methods to determine the compositions of tissues, as well as their cellular and subcellular specimens. The Core Scientists offer a broad range of analyses and preparatory services including Proteomics. Importantly, the Core also provides training in the application of state-of-the-art techniques in molecular analysis of proteins, lipids and nucleic acids. The main Core laboratory is located at Brigham and Women?s Hospital (BWH) and the satellite Core laboratory is located at Children?s Hospital Boston (CHB). We perform a broad array of biochemical and analytical assays that are not typically available within laboratories of HDDC members. These have generally been adapted so that they may be performed in large numbers on microplates. These include quantification of lipids, mRNA and protein and a full array of mass spectroscopy services for protein analysis (and soon to be expanded for lipidomics). We also offer both analytical and preparatory separations by a variety of methods.

Proper citation: CHB Molecular and Cellular Biochemistry Core (RRID:SCR_009716) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012d-a575-496e-4882-b08d80000000

Core facility that provides the following services: Magnetic resonance imaging (MRI) access. Magnetic Resonance Imaging (MR or MRI) at Children''s Hospital Boston performs pediatric MRIs in a friendly, child-centered environment designed to make your child''s experience as pleasant as possible. Our dedicated staff has years of experience imaging children and teens. Physicians order MRI studies to rule out or diagnose diseases. The technology produces incredibly detailed pictures of your child''s organs, bones and tissues without using ionizing radiation (X-rays). Instead, it uses strong magnets, radiofrequency waves and powerful computers to generate 2- and 3-dimensional images of a given organ or body part. We use protocols and procedures developed specifically for babies and children, which means age-appropriate care for your child and the best possible images for the radiologist.

Proper citation: CHB Magnetic Resonance Imaging (RRID:SCR_009714) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012d-b8ed-227f-4882-b08d80000000

Within Children''s Hospital Boston''s Department of Radiology, Diagnostic Radiology offers standard radiography (conventional X-rays) and fluoroscopy, an imaging technique that uses X-rays to create real-time images of the body. We perform more than 135,000 exams each year in Boston and at our satellite locations, which makes us one of the country''s largest general diagnostic centers for children.

Proper citation: CHB Diagnostic Radiology Core (RRID:SCR_009711) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012a-2512-776b-5617-794280000000

Computed Tomography (CT) at Children''s Hospital Boston helps doctors quickly answer urgent questions about your child''s health. In just seconds or minutes, CT scans can produce incredibly detailed, three-dimensional images of your child''s bone, tissue and blood vessels. CT exams in our powerful multi-detector scanners are quick, painless and non-invasive. Located at two locations: Boston and Waltham. Should be contacted about scanner technology, image acquisition, etc., but not for actual access to the facility.

Proper citation: CHB Computed Tomography Core Imaging Facilities (RRID:SCR_009710) Copy   

•   Source: SciCrunch Registry

https://iccb.med.harvard.edu/

Facility is small molecule and functional genomics high-throughput screening laboratory. It is built around modular work stations and most assays are performed in 384-well plates. There are over 500,000 small molecules available for screening at ICCB-Longwood and compound collection is continuously growing. Whole human and mouse genome siRNA libraries, arrayed sgRNA libraries, lncRNA siRNA libraries, as well as miRNA mimic and inhibitor libraries, are also available for screening. These libraries can be screened at the genome level or in focused subsets.

Proper citation: Harvard Medical School ICCB-Longwood Screening Core Facility (RRID:SCR_009798) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-a18b-7386-55da-381e80000000

Characterization of mineralized tissues, natural or synthetic, is a challenging task, since these materials are comprised of organic and mineral constituents, each with strikingly different physical and chemical properties. The function of the Forsyth Mineralized Tissue Analysis (MTA) Core is to provide a comprehensive structural, physical, and chemical analysis of wild type, mutant and engineered mineralized tissues, including teeth (enamel, dentin, cementum), cartilage and bone. The strengths of the MTA Core include a unique combination of specialized instrumentation, techniques, and expertise based on more than 30 years of experience in this field.

Proper citation: Forsyth Mineralized Tissue Analysis Core Facility (RRID:SCR_009791) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/00000130-08fe-236a-de5a-673e80000000

Core facility that provides the following services: Flow cytometer equipment access, Flow cytometry consultation, Immunofluorescence analysis, Cellular sorting, Measurement of intracellular calcium signaling, DNA cell cycle analysis, Apoptosis assay service.

The purpose of this Immunology Flow Cytometry Core of the Boston Area Diabetes Endocrinology Research Center (BADERC) is to provide flow cytometric techniques in a cost effective manner to the diabetes research community. The core is committed to providing to investigators both training and a diversity of state-of-the-art flow cytometric techniques. The Core will assist investigators in applying a variety of tough and cumbersome immunologic techniques and offers in-depth training of new methods.

Proper citation: HMS BADERC Flow Cytometry Core (RRID:SCR_009792) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/00000139-68dd-9dd3-f016-703c80000000

The Forsyth Institute established the micro computed tomography core in 2011. The Facility is located in the 4th floor of the Forsyth research building. The core now accepts samples from outside academic institutions and for-profit organizations.

Proper citation: Forsyth Micro Computed Tomography (RRID:SCR_009790) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012b-00c7-c357-db6e-7a3f80000000

Core facility that provides the following services: Rapid golgi staining service, Luxol fast blue service, Electron microscopy service, Electron microscopy embedding service, Electron microscopy sectioning service, H&E and cresyl violet staining service, Golgi Cox service, Cryostat, vibratome, and microtome usage service, Ultramicrotome usage service. The core allows investigators to perform diverse types of histological studies at several levels, including light and electron microscopy. Furthermore, since mental retardation may not be associated with structural abnormalities visible at the light microscopic level, analysis of protein expression by immunohistochemistry and gene expression by in situ hybridization are also facilitated by this Core.

Proper citation: CHB Cellular Neuroscience Core Laboratory (RRID:SCR_009708) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012d-9ff6-5676-4882-b08d80000000

Core facility that provides the following services: Flow cytometry analysis service, Cell cycle analysis, Cell sorting service, Side population cell sorting, Zebrafish cell sorting and analysis. The Stem Cell Core Facility has been part of the IDDRC center for more than 30 years fostering collaboration and innovation among IDDRC investigators and members of the academic research community. It was used to develop chromosome sorting for human chromosome specific recombinant libraries and these techniques were utilized by others to generate large scale libraries for the early genome project. The facility was the first to develop cell sorting of fetal cells in the maternal circulation as a means to detect fetal genetic abnormalities. Throughout its history the Stem Cell Core has provided careful and accurate cell cycle analysis via DNA content analysis using Hoechst dye uptake. This service is still used today by investigators. The facility was among the first to take advantage of the ability to express GFP in cells transfected with vectors and induced to express GFP in transgenic animals conditionally expressing a specific gene promoter. This ability allowed IDDRC investigators to isolate neurons, muscle cells and other cell types which express GFP from those which do not. IDDRC investigators were among the first to subsequently culture sorted neurons. Based on the extensive experience of the core using Hoechst dye for cell cycle analysis, the core was able to help IDDRC investigators prepare side population cells (tissue derived potential multipotent progenitor cells) based on Hoechst dye efflux. These methods have allowed the isolation of different muscle side population cells and have facilitated experiments that aim to use the cells for treating muscle disease. The interactive and collaborative nature of the core has fostered these developments, and the interests of the core director, advisory committee, manager and IDDRC investigators will continue to make this core as innovative in the future as it has been in the past. The overall goal of the Stem Cell Core Facility is to provide both IDDRC and non-IDDRC researchers comprehensive analytical flow cytometry and cell sorting services in a timely, dependable and cost-effective manner., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025.

Proper citation: CHB Cell Sorter Core (RRID:SCR_009706) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012a-2513-a940-5617-794280000000

Core facility that provides the following services: Gene targeting service, Transgenics service. The Transgenic Core centralizes the production of genetically altered mice for MRRC investigators in a cost-effective and efficient manner. The Core also provides expert assistance in the additional areas required for generating genetically altered mice, including transgene and targeting construct production, and transgenic mouse colony management. Core personnel are available to train investigators in all of the techniques required for the generation of genetically modified mice.

Proper citation: CHB Transgenic Core Laboratory (RRID:SCR_009707) Copy   

•   Source: SciCrunch Registry

http://cdrewu.eagle-i.net/i/00000135-82ef-5677-1a88-e81c80000000

Core facility that provides the following services: Assay analysis consulting services, Sandwich immunoassays, Competitive immunoassays, Hormone immunoassay service, Inflammation marker immunoassay service, Oxidative stress immunoassay service, Cancer marker immunoassay service, Kidney function immunoassay service, Cardiovascular immunoassay service, DNA damage/repair assay service, Metabolic profile assay service, Apoptosis/ survival pathways assay service. Since its inception fifteen years ago, the Technology Core Laboratory has surpassed its goals in new assay development and assay refinement. It has provided top-quality services, been innovative in developing new assays, and has encouraged collaborations between molecular biologists and clinical investigators. This core laboratory has an outstanding record of accomplishments and has supported many high-impact, peer-reviewed publications.

Proper citation: CDU Metabolic and Oxidative Stress Core Laboratory (RRID:SCR_009702) Copy   

•   Source: SciCrunch Registry

http://cdrewu.eagle-i.net/i/00000135-82f1-6b82-1a88-e81c80000000

A 3,000 square foot Exercise Physiology Lab is located in the ERC Business Park approximately one mile from KDMC. It is fully equipped with Keiser pneumatic resistance training equipment, free weights, treadmills, stationary exercise cycles, as well as state-of-the-art, computerized equipment for measuring muscle performance, cardiopulmonary response, and body composition. These tools are available for utilization by investigators working the field of health disparities related to endocrine metabolism and exercise physiology.

Proper citation: CDU Exercise Physiology Laboratory (RRID:SCR_009700) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-a5a6-62bc-55da-381e80000000

The Biostatistics Core collaborates with clinical and laboratory investigators providing support for experimental design, statistical methods, data analysis and data management for epidemiologic studies, clinical trials and laboratory investigations. Collaborations have included Center grants, Program Projects and numerous individual investigator grants. These studies have largely focused on oral health research, particularly dental caries and periodontitis, with an emphasis on the microbial and immunologic aspects as well as diagnosis and treatment of these conditions and use of high throughput technologies in their evaluation.

Proper citation: Forsyth Biostatistics Core Facility (RRID:SCR_009784) Copy   

•   Source: SciCrunch Registry

http://famu.eagle-i.net/i/00000137-56ac-3ab0-f0f1-ede280000000

Core facility that provides the following services: Protein analysis, 2D gel electrophoresis service.

Proper citation: FAMU Proteomics Laboratory (RRID:SCR_009782) Copy   

•   Source: SciCrunch Registry

http://famu.eagle-i.net/i/00000137-3c72-e8a6-f0f1-ede280000000

An Core facility

Proper citation: FAMU Molecular biology research laboratory (RRID:SCR_009780) Copy   

•   Source: SciCrunch Registry