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SciCrunch Registry is a curated repository of scientific resources, with a focus on biomedical resources, including tools, databases, and core facilities - visit SciCrunch to register your resource.
Data acquisition software for TriKinetics activity monitors. TriKinetics systems quantify animal movement over time, and can be used to measure behaviors such as circadian rhythm, sleep, longevity, social interaction, geotaxis, phototaxis, learning, and drug response in various species.
Proper citation: DAMSystems308 (RRID:SCR_016191) Copy
http://www.broad.mit.edu/mammals/dog
The genome of the domesticated dog, a close evolutionary relation to human, is a powerful new tool for understanding the human genome. Comparison of the dog with human and other mammals reveals key information about the structure and evolution of genes and genomes. The unique breeding history of dogs, with their extraordinary behavioral and physical diversity, offers the opportunity to find important genes underlying diseases shared between dogs and humans, such as cancer, diabetes, and epilepsy. The Canine Genome Sequencing Project produced a high-quality draft sequence of a female boxer named Tasha. By comparing Tasha with many other breeds, the project also compiled a comprehensive set of SNPs (single nucleotide polymorphisms) useful in all dog breeds. These closely spaced genomic landmarks are critical for disease mapping. By comparing the dog, rodent, and human lineages, researchers at the Broad Institute uncovered exciting new information about human genes, their evolution, and the regulatory mechanisms governing their expression. Using SNPs, researchers describe the strikingly different haplotype structure in dog breeds compared with the entire dog population. In addition, they show that by understanding the patterns of variation in dog breeds, scientists can design powerful gene mapping experiments for complex diseases that are difficult to map in human populations. Contribute Although the astounding generosity of Eli and Edythe L. Broad and several other venture philanthropists empowers our scientists to tackle many of the most important problems at the cutting edge of genomic medicine, there are many other critical challenges that they cannot yet pursue because of limited resources. We need additional visionary partners to join the Broads and the Broad Institute in transforming medicine with the power of genomics.
Proper citation: Dog Genome Project (RRID:SCR_008486) Copy
http://rgd.mcw.edu/rgdCuration/?module=portal&func=show&name=nuro
THIS RESOURCE IS NO LONGER IN SERVICE. Documented on May 12,2023. Portal that provides researchers with easy access to data on rat genes, QTLs, strain models, biological processes and pathways related to neurological diseases. This resource also includes dynamic data analysis tools.
Proper citation: Rat Genome Database: Neurological Disease Portal (RRID:SCR_008685) Copy
http://www.dukecancerinstitute.org/
One of 40 centers in the country designated by the National Cancer Institute (NCI) as a comprehensive cancer center, it combines cutting-edge research with compassionate care. Its vision is to accelerate research advances related to cancer and improve Duke''s ability to translate these discoveries into the most advanced cancer care to patients by uniting hundreds of cancer physicians, researchers, educators, and staff across the medical center, medical school, and health system under a shared administrative structure.
Proper citation: Duke Cancer Institute (RRID:SCR_004338) Copy
A web portal that aggregates information and educational materials about the brain and brain diseases. Resources such as videos, key brain concepts, and hands-on activities may be used and shared with the public.
Proper citation: brainfacts.org (RRID:SCR_003514) Copy
http://clinicalinformatics.stanford.edu/projects/cdw.html
Research and development project at Stanford University to create a standards-based informatics platform supporting clinical and translational research. STRIDE consists of three integrated components: a clinical data warehouse, based on the HL7 Reference Information Model (RIM), containing clinical information on over 1.6 million pediatric and adult patients cared for at Stanford University Medical Center since 1995; an application development framework for building research data management applications on the STRIDE platform and a biospecimen data management system. STRIDE's semantic model uses standardized terminologies, such as SNOMED, RxNorm, ICD and CPT, to represent important biomedical concepts and their relationships. STRIDE receives clinical data for research use via HL7 feeds from both SUMC hospitals: Lucile Packard Children's Hospital and Stanford Hospital and Clinics. This clinical data is used to support a wide variety of translational research services including: * Anonymized Patient Research Cohort Discovery * Electronic Chart Review for Research * IRB-Approved Clinical Data Extraction * Biospecimen Data Management * Multimedia Research * Data Management and Research Registries STRIDE is a highly secure environment utilizing encryption, fine-grained access control, robust auditing and detailed data segregation. Additionally, STRIDE has a robust access control framework with well-defined access granting authorities and access control groups. Consequently STRIDE meets or exceeds the requirements of the HIPAA Privacy and Security regulations. Privacy protection is further enhanced by requiring IRB approval for all research projects using STRIDE clinical data. From a technology and standards perspective, STRIDE is hosted on the Oracle 11g database platform. STRIDE application software provides access to the web services of a three-tier infrastructures using SSL encryption with strong authentication. These programs are cross-platform, self-updating thick-client applications that provides a rich user interface for data entry, retrieval and review as well as image manipulation and annotation. STRIDE makes extensive use of XML technologies for representation of structured meta data, distributed systems technologies using JSON for secure remote communication between client and server, and Swing graphical interface components providing a rich widget-set as well as advanced imaging and graphing capabilities. Users of the STRIDE Research Desktop Client can perform rapid data entry into structured fields, compose complex queries, and interact securely with clinical, research and imaging data.
Proper citation: Stanford Translational Research Integrated Database Environment and Clinical Data Warehouse (RRID:SCR_003453) Copy
Portal to support researchers and practitioners searching for information related to alcohol research including links to a number of databases, journals, and Web sites focused on alcohol research and related topics. Also included is a link to the archived ETOH database, the premier Alcohol and Alcohol Problems Science Database, which contains over 130,000 records and covers the period from 1972 through 2003. Included in ETOH are abstracts and bibliographic references to journal articles, books, dissertation abstracts, conference papers and proceedings, reports and studies, and chapters in edited works. ETOH's scope reflects the multidisciplinary nature of the alcohol research field. The range of subject areas contained in ETOH includes: medicine, biochemistry, psychology, psychiatry, epidemiology, sociology, anthropology, treatment, prevention, education, accidents and safety, legislation, criminal justice, public policy, and health services research. The ETOH database is indexed with vocabulary from the Alcohol and Other Drug Thesaurus: A Guide to Concepts and Terminology in Substance Abuse and Addiction (AOD Thesaurus), Third Edition. More than 5,000 terms in the AOD Thesaurus are used as ETOH descriptors. The Databases/Resources section includes databases and resources for alcohol researchers and practitioners. It includes an introduction to the National Library of Medicine's PubMed and some sample searches on alcohol to run in the PubMed database; descriptions of and links to the various databases of the National Clearinghouse for Alcohol and Drug Information (NCADI); a selection of alcohol and other drug databases with their descriptions and links; links to peer-reviewed journals most often used by alcohol researchers; and links to a selection of Web sites pertinent to the substance abuse field.
Proper citation: Alcohol and Alcohol Problems Science Database (RRID:SCR_003768) Copy
Catalog of data sets that are generated and held by the Federal Government, including data, tools and resources to conduct research, develop web and mobile applications, design data visualizations, etc. Data.gov provides descriptions of the Federal datasets (metadata), information about how to access the datasets, and tools that leverage government datasets. The data catalogs will continue to grow as datasets are added. Federal, Executive Branch data are included in the first version of Data.gov.
Proper citation: Data.gov (RRID:SCR_004712) Copy
A research forum portal for ALS-related resources targeted specifically towards academic and industry-based researchers. The aim of the ALS Forum is to identify existing research resources and build new tools to help veteran researchers accelerate their work and to help those new to the ALS field quickly get up to speed. It currently consists of content developed through a partnership with the Alzforum and filtered for its relevance to ALS, as well as links to ALS review articles, and a dynamic listing of current drug development efforts relevant to ALS.
Proper citation: ALS Forum (RRID:SCR_007160) Copy
http://physionet.org/physiobank/
Archive of well-characterized digital recordings of physiologic signals and related data for use by the biomedical research community. PhysioBank currently includes databases of multi-parameter cardiopulmonary, neural, and other biomedical signals from healthy subjects and patients with a variety of conditions with major public health implications, including sudden cardiac death, congestive heart failure, epilepsy, gait disorders, sleep apnea, and aging. The PhysioBank Archives now contain over 700 gigabytes of data that may be freely downloaded. PhysioNet is seeking contributions of data sets that can be made freely available in PhysioBank. Contributions of digitized and anonymized (deidentified) physiologic signals and time series of all types are welcome. If you have a data set that may be suitable, please review PhysioNet''s guidelines for contributors and contact them.
Proper citation: Physiobank (RRID:SCR_006949) Copy
http://hearingimpairment.jax.org/screening.html
The fairly common occurrence of hearing-loss or deafness in both humans and mice, and the anatomical and functional similarities of their inner ears, attest to the potential of mice as models to study hereditary hearing loss. Hundreds of standard inbred, recombinant inbred, and congenic strains are maintained at The Jackson Laboratory, as well as hundreds of inbred strains with spontaneous or induced mutations. To assess hearing impairment in inbred and mutant strains of mice we measure auditory-evoked brainstem response (ABR) thresholds.
Proper citation: The Jackson Laboratory Hearing Research Program (RRID:SCR_007196) Copy
INFOMINE is a virtual library of Internet resources relevant to faculty, students, and research staff at the university level. It contains useful Internet resources such as databases, electronic journals, electronic books, bulletin boards, mailing lists, online library card catalogs, articles, directories of researchers, and many other types of information. It is librarian built. Librarians from the University of California, Wake Forest University, California State University, the University of Detroit - Mercy, and other universities and colleges have contributed to building INFOMINE.INFOMINE is a unique Web resource featuring well organized access to important university level research and educational tools on the Internet. A virtual library, INFOMINE is notable for its collection of annotated and indexed links. Information in INFOMINE is easy to find given the multiplicity of access points provided (ways of finding the information contained). It contains over 100,000 links (26,000 librarian created links and 75,000 plus robot/crawler created links). Substantive databases, electronic journals, guides to the Internet for most disciplines, textbooks and conference proceedings are among the many types of resources included. The life sciences INFOMINE alone, for example, provides interactive access to several hundred databases. Separate virtual collections or INFOMINEs exist in most major areas of university level research and educational interests. Click here to see the Database Content Information. It began in January of 1994 as a project of the Library of the University of California, Riverside. It was one of the first Web resources of any type offered by a Library. It was also one of the first Web-based, academic virtual libraries as well as one of the first to develop a system combining the advantages of the hypertext and multi-media capabilities of the Web with those of the organizational and retrieval functions of a database manager. We now include focused, automatic Internet crawling as well as automatic text extraction and metadata creation functions to assist our experts in content creation and users in searching. Many of INFOMINE''s important features and services, described below, remain unique among Internet resource collections. INFOMINE, as mentioned, provides a great number of access points, BROWSE (What''s New, Title, Table of Contents, Subject -- LCSH, Subject - LCC, Search -- Research Discipline, Key Word, Megatopics - Keyword in context, Title, Author, hyperlinked indexing) and SEARCH (Title, Subject -- LCSH, Key Word, Author, Description, Full-text), and LIMIT search (Resource Type, Resource Origin and Access) modes. Searching in fielded and full-text mode allows the user to quickly find high quality resources on the chosen subject(s). Nested, boolean searching capabilities are featured as is exact searching. Search results come back in the form of dynamically created Web pages. Results within these can be ranked by relevance to the search or alphabetically by title. Displays available include title only, regular display, long display and full display. Many of the displays feature indexing terms that are viewable and in hyperlink form and, when clicked upon, allow further broadening or narrowing of the search as desired. Noteworthy as well is that INFOMINE is augmenting its content with a large, second-tier collection of automatically selected and described resources that should complement its first-tier collection of expert created records and allow the user more detail in searching and a greater number of useful results. Finally, on the Advanced Search page, we have browsing indexes which cover all topics and more. These include: * Subjects -- LCSH (Library of Congress Subject Headings), Table of Contents (LCSH with titles filing under each heading), LCC (Library of Congress Classifications) and Research Disciplines * Keywords -- MegaTopics (keyphrases drawn from our title, subject, keyword and annotation fields) and standard Keywords * Other Indexes: Authors, Titles, Resource Types and What''s New Among the contributions of INFOMINE is the essential enrichment or value added service, as mentioned, of providing concise descriptive information (e.g., an annotation as well as in-depth indexing terminology including Library of Congress Subject Headings) for each record. This greatly helps users to quickly retrieve a focused results set, examine the relevance of individual records and then choose among them immediately prior to accessing thus saving considerable time. Librarian collection expertise and concerns regarding resource comprehensiveness, quality and general usefulness from an academic perspective guide all INFOMINE resource selection activities. Also a crucial behind-the-scenes contribution from INFOMINE is that we are addressing the challenge of better subject portal scaling (keeping up with the growth of important resources on the Internet) by semi-automating or automating a number of collection building tasks (e.g., identification of significant resources for collecting and developing metadata descriptions of these resources). This will help us save crucial resources and redirect them into creating a better and larger collection. In-depth description and indexing, careful selection, a considerable number of options in browsing/searching, and ample help in usage mean that faculty, students and staff can find important, relevant Internet resources quickly and easily via INFOMINE. Sponsors: INFOMINE is supported by the University of California, Riverside.
Proper citation: INFOMINE: Scholarly Internet Resource Collections (RRID:SCR_008195) Copy
http://www.nia.nih.gov/research/dn
A funding resource that supports the research and training for understanding the structure and function of the aging nervous system, with an emphasis on studies involving Alzheimer's disease and age-related dementia. There is an emphasis on brain-behavior relationships. This program is composed of three branches: Neurobiology, Neuropsychology, and Dementias of Aging. The overall aim of this program is to understand the aging nervous system to minimize mental decline and improve the lives of older patients. This resource also includes links to sites for Alzheimer's disease (AD) studies that include: specimen repositories, genetic materials, bio-markers, data, policies on NIA and AD genetics sharing plans, and additional aging or other AD related links.
Proper citation: National Institute on Aging, Division of Neuroscience (RRID:SCR_008257) Copy
A portal to educate, engage and create an online community. The Fisher Center for Alzheimer''s Research Foundation, founded in 1995, was created in answer to the recommendations of three U.S. Senate commissioned symposia held in the 1990s by the National Institutes of Health (NIH) to gather information on the cause, care and cure of Alzheimer''s disease. The Fisher Center was created following this design. The funding initiatives of the Foundation are appropriated accordingly to the three areas cited by the NIH task force cause, care and cure. The primary resources of the Foundation are directed toward scientific research into the cause and hopefully the cure of Alzheimer''s disease. To this end, the Foundation under the direction of its founder, Zachary Fisher, and in collaboration with David Rockefeller, constructed the Fisher Center for Alzheimer''s Disease Research at The Rockefeller University, headed by 2000 Nobel Prize winner, Paul Greengard, Ph.D. The 10,000 square foot laboratory is the most advanced facility of its kind in the country equipped with the latest in equipment necessary to undertake an interdisciplinary assault on this disease. The Fisher Center also has collaborative programs at the University of Genoa and supports the work of well over 60 scientists and researchers across the United States and in 17 foreign countries. The Foundation also funds projects for the care of people with Alzheimer''s disease and their caregivers. The Fisher Alzheimer''s Disease Education and Resources Program at the New York University School of Medicine was established under the direction of Barry Reisberg, M.D., internationally known expert in the care of Alzheimer''s patients. The Foundations Alzheimer''s Information Program was created in 2001 to answer the primary need of caregivers for comprehensive, easily accessible information. Our goals are to: Understand the Cause of Alzheimer''s To find a Cure for this devastating disease Improve the Care of people living with the disease to enhance their quality of life and that of their caregivers and families About Our Research Beating Back Beta Amyloid Improving the Quality of Life for Alzheimers Patients Reversing Nerve Cell Damage Using Hormones to Slow the Progress of Disease Curing Early-Onset Alzheimers The Science of Caregiving Scientific Studies
Proper citation: Fisher Center For Alzheimers Research Foundation: ALZinfo.org (RRID:SCR_008255) Copy
http://nirc.louisiana.edu/index.html
NIRC maintains and provides available research facilities accredited by the Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC) International; a ready source of chimpanzees of mixed ages and sex for use in biomedical and behavioral sciences, and also provides professional staff necessary to support investigators with their research needs. Current Research: Vaccine development and testing; pharmacokinetic, pharmacodynamic, preclinical safety, and efficacy studies. Services Provided: The University of Louisiana at Lafayette-New Iberia Research Center (UL Lafayette-NIRC) is an AAALAC-International-accredited nonhuman primate research facility dedicated to the support of basic and applied biomedical and behavioral research. All proposed programs must be approved by the presenting institution and the UL Lafayette-NIRC animal care and use committees. State-of-the-art biomedical support facilities are available that include access to ultrasound, radiography with automatic processor and computer imagery for diagnostic enhancement, and endoscopy and laparoscopy with video monitors, camera and color photo imagery. Diagnostic Laboratory: A 12,000-square-foot laboratory is available for investigators'' research support requirements. Capabilities within the laboratory include but are not limited to hematology, chemistry, microbiology, urinalysis, parasitology, and histology. Among the investigator support procedures are Ficoll gradient isolation of peripheral blood mononuclear cells, platelet aggregation profiles, nonhuman primate lymphocyte proliferation assay, and flow cytometry (lymphocyte enumeration). Emergency generator power is accessible in each laboratory unit and for all major instrumentation and critical freezers. Animals: The center cares for approximately 360 chimpanzees and 5,500 New and Old World species of nonhuman primates. In addition to chimpanzees, the following species of nonhuman primates are being bred at the center: Vervet monkey (Chlorocebus aethiops), cynomolgus macaque (Macaca fascicularis), pigtailed macaque (M. nemestrina), rhesus macaque (M. mulatta).
Proper citation: New Iberia Research Center (RRID:SCR_008279) Copy
http://dpcpsi.nih.gov/orip/cm/chimpanzee_management_program.aspx
Center that supports long-term, cost-effective housing and maintenance at NCRR-supported facilities for chimpanzees. NCRR provides programmatic oversight of the facilities and ensures they comply with the Animal Welfare Act, and policies concerning laboratory animal care and use.
Proper citation: Chimpanzee Management Program (RRID:SCR_008377) Copy
http://www.ncrr.nih.gov/comparative_medicine/resource_directory/primates.asp#alamo
THIS RESOURCE IS NO LONGER IN SERVICE, documented on July 17, 2013. It houses chimpanzees that have been used in biomedical research, but no active, invasive research is conducted on the site. The APF provides for the long-term care and husbandry of chimpanzees that have been used in biomedical research. Charles River Laboratories Inc. operates the facility under contract with the National Institutes of Health. To be used in continuing virological research, the animals must be transferred to active chimpanzee research settings. All chimpanzees at the APF have been exposed to various microorganisms, such as hepatitis C virus and HIV. For this reason, they may be candidates for studies related to these diseases. The National Center for Research Resources (NCRR) may remove infected animals from the APF to other accredited chimpanzee facilities for research purposes. Investigators interested in the chimpanzees at the APF should contact Dr. Harold Watson in NCRR''s Division of Comparative Medicine to discuss research requirements.
Proper citation: Alamogordo Primate Facility (RRID:SCR_008376) Copy
THIS RESOURCE IS NO LONGER IN SERVICE, documented August 23, 2016. Vision Science is a large discipline at the ANU that is found in several teaching and research faculties and several large research institutes. About 85 research staff participate in all forms of vision science from machine vision, to neurophysiology, behaviour and cognition. The scale of analysis ranges from molecular to systems approaches and covers insect, vertebrate and human visual systems. Topics such as disease and development of the human visual system are also covered. CVS works to connect and sustain the component parts of the ANU vision science community.
Proper citation: Centre for Visual Sciences (RRID:SCR_008324) Copy
http://depts.washington.edu/adai/
The Alcohol and Drug Abuse Institute is a multidisciplinary research center at the University of Washington. Its mission is to support and facilitate research and research dissemination in the field of alcohol and drug abuse. Recognizing the need to address the enormous problems caused by alcohol and drug abuse, the University of Washington established the Alcohol and Drug Abuse Institute in October of 1973 as an interdisciplinary research center in the Warren G. Magnuson Health Sciences Center. From its beginning, the mission of the Institute has been to conduct and support substance abuse research at the University of Washington, and disseminate research findings in substance abuse. The activities of the Institute may be described under three general headings: Intramural research by ADAI Research Scientists supported through federal, state, and other grants and contracts; Stimulation and support of research by ADAI Research Affiliates and faculty in departments throughout the University through a Small Grants Program. Since 1973, ADAI has awarded almost three million dollars to researchers in 40 University departments, for approximately 300 projects. Many of those funded projects led to outside funding for expanded research. Dissemination of research findings through its Library and Information Service, publications and presentations by ADAI scientists, web page, listservs, newsletters, and symposia. The Institute receives financial support from the State of Washington under state Initiative 171, which mandates that a portion of fees collected for state liquor licenses be allocated to the two state research universities for research on alcohol and drug abuse, and dissemination of research information. The University of Washington provides additional funding. Research studies are funded primarily through grants and contracts awarded by federal and state agencies and private foundations. The Alcohol and Drug Abuse Institute serves as a focal point for alcohol and drug abuse research at the University of Washington and in the region, benefiting the citizens of Washington State by expanding our knowledge and making information available to health and social service professionals and policy makers. The Institute''s multidisciplinary staff of clinical and social psychologists, sociologists, epidemiologists, public health experts, educators, and librarians plays a key role in working to understand and reduce the harm caused by alcohol and drug abuse. Dennis M. Donovan, Ph.D. has been the Director of the Alcohol and Drug Abuse Institute since 1993. Dr. Donovan is a Professor in the Department of Psychiatry and Behavioral Sciences and an Adjunct Professor in the Department of Psychology.
Proper citation: Alcohol and Drug Abuse Institute, University of Washington (RRID:SCR_008283) Copy
http://connectomics.org/viewer
Extensible, scriptable, pythonic software tool for visualization and analysis in structural neuroimaging research on many spatial scales. Employing the Connectome File Format, diverse data such as networks, surfaces, volumes, tracks and metadata are handled and integrated. The field of Connectomics research benefits from recent advances in structural neuroimaging technologies on all spatial scales. The need for software tools to visualize and analyze the emerging data is urgent. The ConnectomeViewer application was developed to meet the needs of basic and clinical neuroscientists, as well as complex network scientists, providing an integrative, extensible platform to visualize and analyze Connectomics data. With the Connectome File Format, interlinking different datatypes such as hierarchical networks, surface data, volumetric data is easy and might provide new ways of analyzing and interacting with data. Furthermore, ConnectomeViewer readily integrates with: * ConnectomeWiki: a semantic knowledge base representing connectomics data at a mesoscale level across various species, allowing easy access to relevant literature and databases. * ConnectomeDatabase: a repository to store and disseminate Connectome files.
Proper citation: ConnectomeViewer: Multi-Modal Multi-Level Network Visualization and Analysis (RRID:SCR_008312) Copy
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