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http://harvard.eagle-i.net/i/0000012c-60c2-395c-c437-ff0b80000000

Core facility that provides the following services: Cell immortalization through retroviral or lentiviral vectors service, Microscopy training, User-based microscopy service.

Proper citation: BWH Cell Culture and Microscopy Core (RRID:SCR_005562) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-7276-7824-55da-381e80000000

Core facility that provides the following services: Whole genome amplification service, Genotyping service using Illumina GoldenGate and Infinium technologies, SNP Analysis using OpenArray Genotyping, SNP Analysis using Taqman, Custom Illumina GoldenGate genotyping, Illumina Infinium genotyping.

The mission of the High-Throughput Polymorphism Detection Core is to provide services to investigators conducting molecular analyses of somatic DNA collected as part of a wide range of investigations. This Core provides high-throughput assays of specific gene mutations and polymorphisms (SNPs) in the many situations where previously defined specific nucleotide alterations are of interest.

Proper citation: DF/HCC High-Throughput Polymorphism Detection Core (RRID:SCR_009736) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012d-c90c-c8fc-4882-b08d80000000

Core facility that provides the following services: Hematopoietic progenitor cell (HPC) components processing, Tumor cell vaccine generation, Dendritic cell vaccine generation, Validation consultation.

The (Connell and O''Reilly Families) Cell Manipulation Core Facility (CMCF), at Dana-Farber Cancer Institute (DFCI) was created in 1996 to be the manufacturing facility that produces safe and effective novel cellular component therapy that meets regulatory guidelines for clinical use and also facilitates research to be translated from the bench to the bedside. The goal of this facility is to assist DF/HCC investigators in developing new cell-based therapies for cancer and to support clinical research studies designed to evaluate the toxicity and efficacy of these novel treatments. In November 2004, CMCF moved to a newly constructed 6,700 square feet facility on the third floor and ground floor of the Jimmy Fund Building (JFB) at DFCI. The new facility is dedicated to the production of clinical grade cellular products for patients who participate in clinical trials conducted by DF/HCC investigators. All procedures are performed in environmentally controlled conditions according to current Good Manufacturing Practices (cGMP) for cell and tissue processing. The third floor accommodates all of the production areas while space on the ground floor is devoted to the long-term storage of cellular products, tissues and samples in liquid nitrogen and mechanical freezers. The CMCF is available to both clinical and laboratory investigators at all DF/HCC institutions and will provide services to patients at all DF/HCC affiliated hospitals. The staff of the CMCF are committed to working with DF/HCC investigators at all levels of clinical trial development and execution, including pre-clinical development, trial design, DF/HCC and FDA review, data management, quality control, internal and external audits as well as reports and publications. The Cell Manipulation Core Facility (CMCF) has been accredited by the Foundation for the Accreditation of Cellular Therapy (FACT). The CMCF services as a Regulatory Core for Center for Human Cell Therapy and is also a member of the Joint Program in Transfusion Medicine.

Proper citation: DF/HCC Cell Manipulation Core Facility (RRID:SCR_009734) Copy   

•   Source: SciCrunch Registry

http://cdrewu.eagle-i.net/i/00000135-20a3-3d3f-f836-7d1b80000000

The AXIS Biomedical Informatics function is dedicated to providing investigators at Charles Drew University (CDU) with state-of-the-art informatics solutions for their research projects. AXIS Biomedical Informatics comprises a multi-disciplinary team of researchers with backgrounds and interest in clinical medicine, biomedical informatics, medical geography and geographical information systems, computer science, sociotechnical theories and qualitative methods.

Proper citation: CDU AXIS Biomedical Informatics function (RRID:SCR_009699) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012c-f066-ba26-2162-17a280000000

Core facility that provides the following services: Metabolite identification service, PK data analysis and interpretation service.

The Cancer Pharmacology Core provides DF/HCC investigators with the necessary expertise and resources to design and undertake pharmacokinetic studies in the context of phase I and phase II clinical trials, and preclinical investigations. The core has the ability to implement and validate previously developed analytical methods to quantify drugs and their metabolites in biological fluids as well as the capability to modify or develop entirely new assays when warranted. The core also offers comprehensive analysis of pharmacokinetic data as an additional service, including the estimation of pharmacokinetic parameters and identifying their relationship to pathophysiological variables and pharmacodynamic effects.

Proper citation: DF/HCC Cancer Pharmacology Core (RRID:SCR_009732) Copy   

•   Source: SciCrunch Registry

http://ccny-cuny.eagle-i.net/i/00000137-568a-3b40-bb24-040880000000

LSR II A State-of-the-Art RCMI Flow Cytometry Core is located in MR613 with full time technical support, provided by the Flow Technician Mr. Jeffrey Walker. Mr. Walker is BD trained and certified in both analysis and sorting and has extensive experience in sorting both lymphocytes and larger epithelial cells, as well as with specialized applications including cell cycle analysis and calcium flux. Mr. Walker provides training for regular users wishing to perform independent analysis, and is responsible for all sorting.

Proper citation: CCNY Fluorescence Activated Cell Sorting (RRID:SCR_009696) Copy   

•   Source: SciCrunch Registry

http://cau.eagle-i.net/i/00000135-abf1-2607-ecf8-187780000000

CCRTD houses several major instruments to support structural studies of biological molecules, cells, modern cell, and molecular visualization applications. We have an Inverted Digitized Microscope (Zeiss) of general use, plus an advanced Fluorescence-enabled Inverted Digitized Microscope with Z-stacking and Live Cell Imaging modules (Zeiss). For advanced applications including In Situ Hybridization (ISH) and Immunohistochemistry (IHC), in addition to Zeiss microscope above we offer Confocal Fluorescent Microscope (Nikon). The latter is currently undergoing a major upgrade of computer system, software, and optics including addition of lasers.

Proper citation: CAU CCRTD-Structural Biology (RRID:SCR_009694) Copy   

•   Source: SciCrunch Registry

http://cau.eagle-i.net/i/00000135-abe7-77c7-ecf8-187780000000

CCRTD Core Facilities house major equipment for DNA and RNA-based applications. We offer polymerase chain reaction ( PCR ) instruments including Real-Time PCR machine (I-Cycle, Bio-Rad), Liquid Scintillation Counter (Beckman Coulter), Lyophilizer and Freeze-Dryer for biological samples, Cell Porator, high-speed and ultra-high-speed Centrifuges, ultra-sensitive Balances, and other supporting equipment. DNA and RNA quantification can be carried out on Spectrophotometers, both single-cuvette (DU650, Beckman Coulter) and 96-well plate based. DNA and RNA can be visualized, digitized, and quantified using Gel Documentation system (Bio-Rad) or Multi-Mode Imager Typhoon 9410, in fluorescent, luminescent, UV, or visible wavelengths; time-resolved fluorescence option is available on BioTek Plate Imager. For X-Ray imaging, we maintain an Automated X-Ray processor and Dark Room; radioisotope imaging is also supported on Typhoon 9410.

Proper citation: CAU CCRTD-Molecular Biology (RRID:SCR_009692) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000013a-8f55-ae5a-0802-e06e80000000

Core facility that provides the following services: Mouse Long Bone Scans, Mouse Vertebrae Scans. The Harvard School of Dental Medicine under the direction of The Office of Research operates a core facility composed of two micro CT machines.

Proper citation: HSDM Micro CT Core (RRID:SCR_009693) Copy   

•   Source: SciCrunch Registry

http://eagle-i.itmat.upenn.edu/i/00000138-b447-d309-9cd7-d7e280000000

Core facility that provides the following services: DNA sequencing service, Oligonucleotide synthesis portal to IDT service, Oligonucleotide purification service, DNA fragment analysis service. The Nucleic Acid/Protein Research Core Facility, located on the 9th floor of the Abramson Building, provides a centralized source for specialized services, technical expertise and reagents to support investigators'' molecular biology research needs. These services include DNA sequencing analysis, fluorescent fragment analysis (microsatellite genotyping), oligonucleotide synthesis, microarray services, denaturing high-performance liquid chromatography, Affymetrix GeneChip expression analysis, SNP analysis and RNA analysis.

Proper citation: CHOP Nucleic Acid/Protein Core (RRID:SCR_009728) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012d-56f2-62b7-2162-17a280000000

Core facility that provides the following services: Ultrasound/sonography access service. Ultrasound, which is also known as sonography, is a painless, non-invasive imaging technique that lets us look inside your child''s body without the use of radiation. It uses high-frequency sound waves to create pictures of organs, bones, tissues and blood vessels.

Proper citation: CHB Ultrasound (RRID:SCR_009608) Copy   

•   Source: SciCrunch Registry

http://eagle-i.itmat.upenn.edu/i/0000013b-9b4b-434b-83a0-df0880000000

Core facility that provides the following services: Tissue microarray construction service, Unstained slides preparation service, H&E staining (on unstained slide) service, Special stain (from slide) service, TUNEL labeling service, IHC stain from slide service, In situ hybridization RNAscope service, New antibody workup service, Decalcification service, Laser capture service, Histopathology-related techniques training, Histopathology technical consultation service, Basic imaging workstation access, Laser capture microdissection microscope access. The Pathology Core Laboratory at the Children''s Hospital of Philadelphia Research Institute provides basic histopathology, research immunohistochemistry, tissue microarray, and laser capture microdissection services to researchers at Children''s Hospital and within the surrounding academic community. We are located on the 7th Floor of the Leonard and Madlyn Abramson Pediatric Research Center in room 706. The Pathology Core Laboratory unites three core components in a single core facility: histopathology, tissue microarray and laser capture microdissection. The core offers a full range of histopathology services including tissue processing, embedding, and cutting, for both paraffin and frozen tissue. We also perform most standard stains as well as immunohistochemistry, antibody workup, fluorescence, in situ hybridization and TUNEL. Tissue microarrays can be constructed using a Beacher Arrayer. Sophisticated imaging instrumentation is available for virtual microscopy (ScanScope from Aperio) and image analysis (Image ProPlus, Volocity). Specialized software is available to image and analyze tissue microarrays, and to manage and store array data.

Proper citation: CHOP Pathology Core Laboratories (RRID:SCR_009729) Copy   

•   Source: SciCrunch Registry

http://eagle-i.itmat.upenn.edu/i/00000139-02ae-1aca-eb5b-b63c80000000

Core facility that provides the following services: Flow cytometer access, Non-infectious cell sorting, BSL2 biohazardous cell sorting, FlowJo workstation access, Flow cytometry online scheduling service, Sample processing and flow cytometry analysis service, Functional flow cytometry assay service, Cytometric Bead Array service, Flow cytometry data analysis service, Flow cytometer training, Flow cytometry consultation service. The Research Flow Cytometry Core Laboratory of the Children''s Hospital of Philadelphia Research Institute is located on the 12th floor of the Leonard and Madlyn Abramson Pediatric Research Center in room 1207. The laboratory offers state of the art instrumentation and professional technical assistance for performing flow cytometry analyses. We focus on providing services to members of the research community of The Children''s Hospital of Philadelphia and the University of Pennsylvania but users from outside the campus are welcome to our lab. The facility is equipped with three analyzers (LSRFortessa, Accuri C6 and FACSCalibur) and one cell sorter (MoFlo XDP). The analyzers are available 24 hours a day to users carrying a CHOP ID. Users not affiliated with CHOP may access the facility during business hours. Cell sorting services are offered on a fee-for-service basis. The core lab also offers full-service flow cytometry testing, including sample processing and immunophenotyping of blood samples from clinical studies as well as functional flow cytometry assays. The core is under the direction of Dr. Florin Tuluc and the daily activities in the lab are supervised by Eric Riedel., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025.

Proper citation: CHOP Flow Cytometry Core Laboratory (RRID:SCR_009726) Copy   

•   Source: SciCrunch Registry

http://eagle-i.itmat.upenn.edu/i/00000142-47d2-2012-91c7-0c6080000000

The Clinical and Translational Research Center (CTRC) offers ophthalmological testing services for children. The Ophthalmology Core at CHOP?s CTRC was established t**provide clinical and translational research services in ophthalmology for the assessment of visual function and structure. Services provided include: * Eye exams (includes visual, recognition and grating acuity; anterior segment, fundus exam, refraction) **Contrast sensitivity **Color vision testing * Optical coherence tomography (OCT) tests of the: **Anterior segment **Posterior segment ? optic nerve **Posterior segment ? retin A* Visual field measures: **Using Humphrey **Using Goldman * Full field sensitivity testing * Electroretinography * Visual evoked potential * Fundus photography * Ocular ultrasound * Professional interpretation of all tests is als**available

Proper citation: CHOP CTRC Ophthalmology Core (RRID:SCR_009724) Copy   

•   Source: SciCrunch Registry

http://eagle-i.itmat.upenn.edu/i/0000013a-bc4e-ecdd-d69a-d90d80000000

Core facility that provides the following services: Clinical trials consultation service, Document storage service, Investigational new drug or investigational device exemption application support service, Institutional Review Board submission service, Additional regulatory submissions support service, Protocol development service, Human subject recruitment support service, Study feasibility service, Study placement service. The Clinical Trials Office (CTO) at The Children''s Hospital of Philadelphia is a centralized office that provides resources and assistance to clinical research investigators, enabling them to carry out clinical research in a manner consistent with the Hospital''s goals ? excellent patient care, top-quality education, and innovative research. The CTO has expertise in implementing, conducting, and monitoring clinical trials and provides a variety of services that benefit both novice and experienced clinical researchers. The CTO is designed to ensure the excellence and compliance of an investigator''s clinical research trial. The Children''s Hospital of Philadelphia established the CTO in 1999 as part of the institution''s emphasis on clinical research. Since then, the CTO has experienced rapid growth. The CTO advances the quality and quantity of clinical research at Children''s Hospital and its associated network. Specifically, the CTO supports research at the Hospital by developing and completing submissions to the Hospital''s Institutional Review Board; assisting in the preparation of Investigational New Drug and Investigational Device exemption application submissions to the Federal Drug Administration; conducting clinical research studies under the guidance of principal investigators; and developing budgets and providing research training for investigators, study coordinators, and administrative staff. The CTO staff works in partnership with investigators to ensure the protection of human subjects in accordance with Good Clinical Practice, federal, state and/or local regulations and the requirements of the study sponsor.

Proper citation: CHOP Clinical Trials Office (RRID:SCR_009725) Copy   

•   Source: SciCrunch Registry

http://eagle-i.itmat.upenn.edu/i/00000142-3843-baeb-91c7-0c6080000000

The Nutrition Assessment Unit of the Nutrition Core is a state-of-the-art facility for the assessment of growth and body dimensions, body composition (the amount of muscle, fat and bone in the body), energy expenditure, bone density, and muscle strength. The Unit has two locations and four experienced technicians for performing research assessments.

Proper citation: CHOP CTRC Nutrition Core Nutrition Assessment (RRID:SCR_009723) Copy   

•   Source: SciCrunch Registry

http://cau.eagle-i.net/i/00000135-abef-4d3d-ecf8-187780000000

We are equipped for proteomics research including Cell Fractionation on one floor and tabletop Ultracentrifuges (Beckman Coulter) , Fast Protein Liquid Chromatography (FPLC), Two-Dimensional Protein Electrophoresis (Protean II, Biorad), and Gel Documentation Systems (one Bio-Rad and one Fuji Medical). Protein quantification can be done using UV-Vis spectrophotometry ( DU650, Beckman Coulter) or multimode Plate Spectrophotometers in both 96-well and 384-well micro well plate formats. Protein gels can also be visualized, digitized, and documented on Multi-Mode Imager Typhoon 9410.

Proper citation: CAU CCRTD-Proteomics (RRID:SCR_009687) Copy   

•   Source: SciCrunch Registry

http://eagle-i.itmat.upenn.edu/i/00000138-7cdd-51df-fbab-3b8480000000

Core facility that provides the following services: Data management/information technology subcore services, Statistical analysis and database consulting service, Limited statistical analysis service. The Biostatistics and Data Management Core (BDMC) at The Children''s Hospital of Philadelphia (CHOP) supports investigators from virtually all subspecialties of pediatric medicine and supports studies ranging from small, narrowly defined basic science projects to large, multi-site clinical trials. The Biostatistics and Data Management Core currently supports more than 50 funded studies and collaborates with investigators on numerous grant applications each year. The BDMC is staffed by a Scientific Director, Deputy Director, and data management/information technology managers, as well as approximately 20 additional staff members representing the disciplines of biostatistics, data management, information technology and administration. The BDMC is located on the CHOP campus (3535 Market Street), and is operated and supported by Westat, a large health research organization with extensive biostatistics, data management and information technology capabilities.

Proper citation: CHOP Biostatistics and Data Management Core (RRID:SCR_009720) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-e30c-f348-cb22-be8c80000000

Core facility that provides the following services: Immunoassay expertise for several methodologies, Specialty hormone analysis. The Specialty Assay Research Core Lab (CLIA certified laboratory) is an analytical research core designed to provide scientific and analytical services to the Partners and non-Partners research communities. The primary objective of the core is to provide sensitive, cost-effective, and reproducible clinical research assays to investigators for endocrine, diabetes, bone markers, inflammatory and sleep medicine related research in both human and animal clinical research protocols. The core hopes to collaborate with investigators in biomarkers discovery and to offer new tools to the scientific community. The core also serves as a central laboratory for multisite studies. The SARC facility offers tests for any investigators (local or national) or industry, but preference may be given to internal users. Different rates may apply.

Proper citation: BWH Specialty Assay Research Core Laboratory (RRID:SCR_009686) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000013c-2506-8388-e81d-064c80000000

Core facility that provides the following services: PSG Procedures, PSG Data Archiving, PSG Training to Staff, PSG Data Processing and Analysis Support. The Sleep & EEG Core within the Division of Sleep Medicine (DSM) provides an integrated infrastructure and knowledge base in support of research projects that use polysomnography (PSG), quantitative EEG analysis and related methodologies. The Core consists of a team of specialists lead by the Core director and a chief PSG technologist. The Core provides support and services in different areas: # It provides basic training and certification in PSG and EEG instrumentation to technicians and investigators, particularly those conducting studies at the Center for Clinical Investigation (CCI) at Brigham and Women?s Hospital. # It acts as liaison between DSM investigators and CCI technical staff, and implements and monitors quality assurance measures. # It carries out standard vigilance state scoring of PSG recordings and different types of waking EEG and electrooculogram analyses. # It carries out spectral analysis of sleep and waking EEG. # It evaluates, acquires, and maintains PSG and EEG equipment used by investigators of the CCI. # It carries out PSG procedures such as sleep screens and multiple sleep latency tests. # It assists investigators in the analysis and interpretation of sleep and EEG data. Over the years, the Sleep & EEG Core has been a central part of many projects funded by NIH, the Air Force Office of Scientific Research (AFOSR), and the National Space Biomedical Research Institute (NSBRI) that had a main focus on the physiology of human sleep-wake regulation. Scientifically, the Core has contributed by providing investigators with important quantitative measures of homeostatic and circadian components of the human sleep-wake regulatory system.

Proper citation: BWH Sleep and EEG Core (RRID:SCR_009684) Copy   

•   Source: SciCrunch Registry