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http://harvard.eagle-i.net/i/0000012e-a5c0-aef8-55da-381e80000000

Core facility that provides the following services: Mouse breeding management, Mouse irradiation service, Technical services for laboratory animal experimentation, Veterinary care, Animal care training.

The facility provides services and resources for investigators looking to accomplish animal research objectives. This includes housing mice and rats, purchasing animals, training researchers regarding proper animal care and use, and monitoring the safety of all personnel with laboratory animal contact in conjunction with Dana-Farber?s Environmental Health and Safety and Occupational Health Services. Dana-Farber has established an Institutional Care and Use Committee (IACUC) to oversee the Institute?s animal program, facilities, and projects involving the use of animals. The IACUC serves as the approval body for all protocols involving animal research, and assists faculty, students and staff in upholding Dana-Farber?s commitment to providing the finest care and most humane utilization of laboratory animals. In addition to basic husbandry services, the ARF staff provides technical and veterinary services, mouse breeding management and mouse irradiation.

Proper citation: DFCI Animal Resources Facility (RRID:SCR_009745) Copy   

•   Source: SciCrunch Registry

http://www.dfhcc.harvard.edu/core-facilities/tissue-microarray-and-imaging-pathology/

Core facility that provides the following services: Construction of standard and custom TMA service, Nucleic acid isolation from paraffin embedded tissue service, Immunofluorescent staining service, Access to the Automated Quantitative Analysis (AQUA) system, Tissue microarray consultation service.

The mission of the Tissue Microarray and Imaging Core is to generate tissue microarrays by allowing placement of up to 480 0.6 mm diameter tissue samples into a single standard tissue block, allowing hundreds of tumors and samples to be evaluated on a single slide. The DF/HCC Tissue Microarray & Imaging (TMI) Core is dedicated to the construction and evaluation of high quality TMAs for cancer research. In addition, the Core performs high-throughput isolation of DNA and RNA from formalin-fixed paraffin-embedded tissues. The Core also provides web-based digital pathology services using the Aperio system. These services include slide scanning, image viewing and storage, and quantitative image analysis, which facilitate tissue-based research. Finally, the Core provides access to the Automated Quantitative Analysis (AQUA) system.

Proper citation: DF/HCC Tissue Microarray and Imaging Core Facility (RRID:SCR_009743) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012c-6056-ed57-c437-ff0b80000000

Core facility that provides the following services: Protein development/cloning, Western blot service, ELISA service, Flow cytometry service.

The mission of the DF/HCC Monoclonal Antibody Core (MAC) is to produce novel monoclonal antibodies that are directed against antigens of interest to Dana-Farber, the Harvard Cancer Center, and affiliated investigators. These monoclonal antibodies may be useful for basic research, drug discovery and clinical applications including diagnosis, surrogate markers for disease status, response to therapy or drug toxicity. Given the diverse research needs of investigators at DFCI and the Harvard Community, the MAC should strive to support a wide range of antibody requests. A key component of the DF/HCC MAC is the ability to explore and develop new technologies that facilitate generation of monoclonal antibodies. The DF/HCC MAC should be capable of supporting all basic functions of generating, screening, storing and producing monoclonal antibodies.

Proper citation: DF/HCC Monoclonal Antibody Core (RRID:SCR_009740) Copy   

•   Source: SciCrunch Registry

http://dartmouth.eagle-i.net/i/0000013e-6135-0e20-8e79-05bd80000000

The BCC provides essential statistical and quantitative methods support to Dartmouth investigators, helping to remove impediments to initiating new clinical translational research programs for young physicians and other scientists. Specialized support for statistical genetics/genomics, decision sciences and comparative effectiveness research, health services research, mathematical demography, psychometrics, geographic information systems, and imaging applications. The BCC also provides statistical expertise related to critical data management, in cooperation with the SYNERGY Biomedical Informatics Core, and fully supports statistical education initiatives throughout SYNERGY

Proper citation: Dartmouth SYNERGY: Biostatistics Consultation Core (RRID:SCR_009773) Copy   

•   Source: SciCrunch Registry

http://dartmouth.eagle-i.net/i/0000012b-00c4-3214-6a59-ec4e80000000

Core facility that provides the following services: Genotyping service, DNA sequencing service, DNA fragment analysis.

DNA Sequencing, DNA Fragment Analysis

Proper citation: Dartmouth Molecular Biology Shared Resource (RRID:SCR_009766) Copy   

•   Source: SciCrunch Registry

http://dartmouth.eagle-i.net/i/00000135-59ea-7c4f-a5f8-842480000000

Core facility that provides the following services: Multi-photon imaging. This SynergyT1 Shared Resource Core includes two microscopes sharing two femtosecond pulsed Ti:Sapphire lasers (tunable between 690 and 1080 nm) for imaging fluorescently-tagged molecules in tissues in vivo and in vitro.

Proper citation: Dartmouth Multi-Photon Imaging (RRID:SCR_009767) Copy   

•   Source: SciCrunch Registry

http://dartmouth.eagle-i.net/i/0000012a-24fd-03f4-d8a1-249280000000

Core facility that provides the following services: Electron micrscopy facility access.

The EM Facility is an institutional resource to meet the electron microscopy needs of faculty, staff and students of the Dartmouth College community, including the College, Thayer School of Engineering, the Dartmouth Medical School, and the Dartmouth-Hitchcock Medical Center. The instruments are housed in the EM wing of Remsen. Because the facility is intended to provide service to all the campus, yet has limited personnel, a major effort is made to provide training in the use of appropriate instruments to enable users to do their own microscopy. In addition to this training, there will be service assistance available for those unable to spend time on the microscopes, and for processing of biopsy samples from DHMC.

Proper citation: Dartmouth Electron Microscope Facility (RRID:SCR_009762) Copy   

•   Source: SciCrunch Registry

http://dms.dartmouth.edu/dgml

Core facility that provides the following services: Illumina Bead Array service, Affymetrix Microarray service.

The Genomics Shared Resource provides technologies to the Norris Cotton Cancer Center and Dartmouth community investigators that enable profiling of gene expression, miRNA, GpC Island, and CGH on a whole-genome scale. The long-term goal of the Genomics Shared Resource is to provide an efficient and affordable fee-for-service operation that will provide high quality genomics and microarray data for the growing number of Cancer Center investigators who require this service.

Proper citation: Dartmouth Genomics Shared Resource (RRID:SCR_009763) Copy   

•   Source: SciCrunch Registry

http://dartmouth.eagle-i.net/i/0000012b-43eb-535f-bd3e-55f580000000

Core facility that provides the following services: Cigarette smoke exposure analysis service.

Our lab is interested in the innate immune system at the mucosal surfaces of the female reproductive and respiratory tracts. A special focus of this work is to determine the effects of cigarette smoke on changes in immune protection. The relationship of cigarette smoke exposure to increased risk of infection is well established, however the mechanisms involved are not. Our research shows that cigarette smoke exposure reduces production of a key antimicrobial chemokine, CCL20. Ongoing research in the lab seeks to determine if similar responses to cigarette smoke exposure underlie increased rates of infection and how cigarette smoke exposure associated infection is linked to the development of cancer. Consulting; training; planning; experimental management assistance. Banked tissue samples available for preliminary studies. Small animal cigarette exposure.

Proper citation: Dartmouth Cigarette Smoke Exposure Analysis Laboratory (RRID:SCR_009761) Copy   

•   Source: SciCrunch Registry

http://core.iddrc.org/molecular-genetics/

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on October 8,2024. Core facility that provides the following services: DNA sequencing (standard) service, Taqman gene expression service, Taqman SNP genotyping, Digital PCR service, Genomic mapping facility standard service, DNA purification from blood and saliva, RNA purification service, Master 96-well plate sample preparation, Gene expression service, SNP genotyping service, Bioanalysis of RNA and DNA, Next-generation sequencing service, Sequenom SNP genotyping, SNP and qPCR 7900HT instrument access. The Molecular Genetics Core Facility (MGCF) is a non-profit core laboratory in the Program in Genomics and Genetics Division of Children''s Hospital Boston offering genomics services for academic research institutions. The majority of MGCF users are investigators from Children''s Hospital Boston and the surrounding Harvard affiliates, but the MGCF also serves laboratories throughout the entire United States. The MGCF is comprised of a compilation of smaller cores partially supported by private and federal funds. Funding is provided in part through The Intellectual and Developmental Disabilities Research Center, The Manton Center for Orphan Disease Research, The Wellstone Center for Muscular Dystrophy, and The Neuromuscular Disease Project of the Program in Genomics at Children''s Hospital Boston. The overall objective of the MGCF is to provide a location where researchers can have access to high quality, low cost genomic technology services and expertise in a timely, affordable manner. The services offered include DNA sequencing, Next-Gen sequencing, Affymetrix and Illumina whole-genome expression and genotyping microarray technology, microsatellite genotyping, high-throughput qPCR and SNP services on the Fluidigm Biomark System, multiplex SNP genotyping on the Sequenom MassARRAY, and sample extraction and banking. The MGCF also assists investigators with project design and collaborates on linkage and association study analysis.

Proper citation: CHB Molecular Genetics Core Facility (RRID:SCR_009715) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/00000130-0977-e10a-de5a-673e80000000

Core facility that provides the following services: Lipoprotein analysis, Biliary lipid concentrations analysis, Biliary particle analysis, Quantitative real-time PCR, Sequential ultracentrifugation for lipoproteins, Radiolabeling of lipoproteins, Fluorescence labeling of lipoproteins, Purification of biliary lipid aggregatesfrom model biles, Preparation of recombinant proteins, Protein identification from gel bands, Protein Identification from complex mixtures. The Molecular and Cellular Biochemistry Core is dedicated to providing HDDC investigators and their trainees with access to a variety of methods to determine the compositions of tissues, as well as their cellular and subcellular specimens. The Core Scientists offer a broad range of analyses and preparatory services including Proteomics. Importantly, the Core also provides training in the application of state-of-the-art techniques in molecular analysis of proteins, lipids and nucleic acids. The main Core laboratory is located at Brigham and Women?s Hospital (BWH) and the satellite Core laboratory is located at Children?s Hospital Boston (CHB). We perform a broad array of biochemical and analytical assays that are not typically available within laboratories of HDDC members. These have generally been adapted so that they may be performed in large numbers on microplates. These include quantification of lipids, mRNA and protein and a full array of mass spectroscopy services for protein analysis (and soon to be expanded for lipidomics). We also offer both analytical and preparatory separations by a variety of methods.

Proper citation: CHB Molecular and Cellular Biochemistry Core (RRID:SCR_009716) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012d-a575-496e-4882-b08d80000000

Core facility that provides the following services: Magnetic resonance imaging (MRI) access. Magnetic Resonance Imaging (MR or MRI) at Children''s Hospital Boston performs pediatric MRIs in a friendly, child-centered environment designed to make your child''s experience as pleasant as possible. Our dedicated staff has years of experience imaging children and teens. Physicians order MRI studies to rule out or diagnose diseases. The technology produces incredibly detailed pictures of your child''s organs, bones and tissues without using ionizing radiation (X-rays). Instead, it uses strong magnets, radiofrequency waves and powerful computers to generate 2- and 3-dimensional images of a given organ or body part. We use protocols and procedures developed specifically for babies and children, which means age-appropriate care for your child and the best possible images for the radiologist.

Proper citation: CHB Magnetic Resonance Imaging (RRID:SCR_009714) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012d-b8ed-227f-4882-b08d80000000

Within Children''s Hospital Boston''s Department of Radiology, Diagnostic Radiology offers standard radiography (conventional X-rays) and fluoroscopy, an imaging technique that uses X-rays to create real-time images of the body. We perform more than 135,000 exams each year in Boston and at our satellite locations, which makes us one of the country''s largest general diagnostic centers for children.

Proper citation: CHB Diagnostic Radiology Core (RRID:SCR_009711) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012a-2517-1d49-5617-794280000000

Core facility that provides the following services: Data acquisition service, Data storage service.

The Research Electronic Data Collection Core can help you capture research data by supporting all aspects of data acquisition, storage and retrieval. The core is designed to significantly improve the efficiency, cost structure and overall quality of research data collection. The Data Collection Core will provide expert services including: study forms design and implementation; training in all aspects of using TELEform software; database construction and exporting / preparing data for statistical applications such as SAS and SPSS; and technical assistance with scanners and computers running electronic form capture process.

Proper citation: BIDMC eData Collection Core (RRID:SCR_009679) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012a-2512-776b-5617-794280000000

Computed Tomography (CT) at Children''s Hospital Boston helps doctors quickly answer urgent questions about your child''s health. In just seconds or minutes, CT scans can produce incredibly detailed, three-dimensional images of your child''s bone, tissue and blood vessels. CT exams in our powerful multi-detector scanners are quick, painless and non-invasive. Located at two locations: Boston and Waltham. Should be contacted about scanner technology, image acquisition, etc., but not for actual access to the facility.

Proper citation: CHB Computed Tomography Core Imaging Facilities (RRID:SCR_009710) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012a-2519-e7a3-5617-794280000000

Core facility that provides the following services: Mouse breeding service, Mouse genotyping service, Tail vein injections service, Tissue service, Cancer mouse model service, Human tumor xenografts service.

Proper citation: BIDMC Preclinical Murine Pharmacogenetics Core (RRID:SCR_009675) Copy   

•   Source: SciCrunch Registry

http://bidmc.org/Research/CoreFacilities/MassSpectrometryCore.aspx

Core facility that provides the following services: Mapping of post-translational modifications by LC/MS/MS, Protein (complex) identification by LC/MS/MS, Relative quantification of peptides by LC/MS/MS, SILAC, iTRAQ, and Isotope-free ratio quantification service, Metabolomics profiling service.

The Mass Spectrometry Core Facility has been serving the BIDMC community since 2004. We specialize in a targeted mass spectrometry based proteomics approach for isolated proteins and protein complexes, especially phosphorylation and other post-translational modifications involved in cellular signaling using cutting edge instrumentation. Our trained staff offers the highest quality and reliable service with meticulous attention to detail for each sample. We routinely provide services including protein identification, post-translational modification mapping, and relative peptide/protein quantification by stable isotope labeling and label free methods using highly sensitive microcapillary LC/MS/MS techniques at nanoliter flow rates. Several different types of mass spectrometry are utilized depending upon the needs of the researcher including a fast scanning and highly sensitive 2D linear ion trap and a high resolution/high mass accuracy LTQ-Oribitrap mass spectrometer acquired in 2007. In 2005, in agreement with Harvard Medical School''s Pathology Dept., the BIDMC Mass Spectrometry Core became part of the NRB Mass Spectrometry and Proteomics Core, expanding its services and became part of the Cancer Proteomics Core for the Dana Farber Harvard Cancer Center. We serve all institutions regardless of affiliation and have an interest in samples related to many diseases such as cancer and diabetes.

Proper citation: BIDMC Mass Spectrometry Core (RRID:SCR_009672) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/00000131-09f6-d7d6-6a45-990480000000

Core facility that provides the following services: Multi-Gene transcriptional profiling (MGTP) service.

Multi-Gene Transcriptional Profiling (MGTP) is a real-time PCR based technique, developed in our lab, for quantifying mRNA copy numbers per cell with high reproducibility and accuracy. Primary Goals of the MGTP Core: * To make MGTP services available to investigators, and assist them in advancing their research and obtaining grants; * To assist studies of molecular signaling mechanisms and pathways, discovery of biomarkers, and development of clinical assays; and * To share the resources of our primer library, which currently includes about 2400 pre-validated human, and mouse genes. The MGTP Core makes these unique and powerful capabilities available to biomedical researchers. Thousands of pre-validated primers are available for use, and others can be designed on demand.

Proper citation: BIDMC Multi-Gene Transcriptional Profiling Core (RRID:SCR_009673) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012a-2513-1465-5617-794280000000

Core facility that provides the following services: User-based microscopy service, Microscopy training service. The Imaging Core provides access to standard digital and laser scanning confocal microscopy, multiphoton microscopy, unbiased stereology, and automated confocal microscopy for large scale genome-wide screens. In addition, the Core has substantial capabilities in quantitative and three-dimensional volumetric image reconstruction.

Proper citation: CHB Cellular Imaging Core (RRID:SCR_009671) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012b-00c7-c357-db6e-7a3f80000000

Core facility that provides the following services: Rapid golgi staining service, Luxol fast blue service, Electron microscopy service, Electron microscopy embedding service, Electron microscopy sectioning service, H&E and cresyl violet staining service, Golgi Cox service, Cryostat, vibratome, and microtome usage service, Ultramicrotome usage service. The core allows investigators to perform diverse types of histological studies at several levels, including light and electron microscopy. Furthermore, since mental retardation may not be associated with structural abnormalities visible at the light microscopic level, analysis of protein expression by immunohistochemistry and gene expression by in situ hybridization are also facilitated by this Core.

Proper citation: CHB Cellular Neuroscience Core Laboratory (RRID:SCR_009708) Copy   

•   Source: SciCrunch Registry