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http://eagle-i.ea.vanderbilt.edu/i/00000139-a1a9-3071-b4bd-8a1180000000

Core facility that provides the following services: Hematology Services, Parasitology Services, Chemistry Analysis Services, Cell Line Testing, Customizable Chemistry Analysis, Phenotyping Services, Infertility evaluation in male mice, Veterinary Pathologist Consultation. Access to consented and de-identified human tissue specimens; Comprehensive, state of the art diagnostic, necropsy and comparative pathology services for animal model systems with specific expertise and focus on mouse models; Research histology including advanced techniques, immunohistochemistry, immunofluorescence, laser capture micro-dissection and tissue micro-array preparation; Access to experts in veterinary and human pathology.

Proper citation: Vanderbilt Translational Pathology Shared Resource (RRID:SCR_010201) Copy   

•   Source: SciCrunch Registry

http://eagle-i.ea.vanderbilt.edu/i/00000139-362c-e975-dacb-da6080000000

The Chemical Synthesis Core was established within the Vanderbilt Institute of Chemical Biology with the goal of supporting the organic and medicinal chemistry needs of investigators. The primary focus of the core is to facilitate biology-orientated projects within the medical center and the university by assisting with the chemistry aspect of the project. The core works independently or in collaboration with the VICB High Throughput Screening Center on the synthesis of literature-cited compounds (including patented ones) as well as full scale lead optimization of a compound.

Proper citation: Vanderbilt Chemical Synthesis Core Laboratory (RRID:SCR_010169) Copy   

•   Source: SciCrunch Registry

http://eagle-i.ea.vanderbilt.edu/i/00000139-1107-96fa-dacb-da6080000000

The current zebrafish facility is composed of approximately 100 research tanks available for short and long-term studies, and a significant expansion project is underway. The facility enables investigator access to the unique advantages of the zebrafish model, which provides hundreds of mutant and transgenic zebrafish with unique properties suited for specific experiments. This core?s essential mission is to provide a reliable mechanism for incorporation and propagation of new and existing zebrafish lines into the core.

Proper citation: Vanderbilt Zebrafish Aquatic Facility (RRID:SCR_010202) Copy   

•   Source: SciCrunch Registry

https://www.wistar.org/resources/genomics-facility/

Core facility that provides the following services: Microarray services, RNA amplification service, ABI 7900 Real-time qPCR service, Capillary DNA sequencing and microsatellite analysis, Illumina HiSeq 2000 sequencing service, Illumina Genome Analyzer services. The Wistar Genomics Facility serves as a hub for consultation and scientific interactions relating to nucleic-acid based methods and provides expertise and support to insure the best possible use of emerging nucleic-acid technologies. In addition to consultation and collaboration with Wistar Cancer Center members, the Facility provides services to the greater scientific community. The establishment of this facility was supported in part by an NCI Cancer Center Support Grant and equipment grants from the Commonwealth of Pennsylvania, The Pew Charitable Trusts and the National Cancer Institute.

Proper citation: Wistar Genomics Core Facility (RRID:SCR_010205) Copy   

•   Source: SciCrunch Registry

https://www.wistar.org/resources/biomedical-research-support-facility/histotechnology/

Core facility that provides the following services: Paraffin sectioning service, Frozen sectioning service, Histology staining services. This facility provides basic histology services. These include fixing, processing and paraffin embedding of all types of tissues for light microscopy (i.e. routine stains, immunohistochemistry or in situ hybridization). Routine hematoxylin and eosin staining as well as special staining is done in the lab. Slides are prepared for immunohistochemistry and in situ and immunohistochemistry. Frozen sectioning is also available. It is advisable to contact the facility about freezing techniques so the best sections can be obtained.

Proper citation: Wistar Histotechnology Core Facility (RRID:SCR_010206) Copy   

•   Source: SciCrunch Registry

https://www.wistar.org/resources/imaging-facility/

Core facility that provides the following services: Live-cell time-lapse microscopy, Low magnification and photomacrography? service, Confocal microscopy service, Two-photon microscopy, Small animal whole body luminescence and fluorescence imaging?, 2, 3, 4, and 5D image analysis, Imaging consultation service, Imaging equipment, image processing, and image analysis training, In-lab microscopy assistance and maintenance service, Imaging Facility instrument access. The Imaging Facility is a shared resource with the primary goal of providing exceptional microscopy and imaging services, as well as individual access to a variety of state-of-the-art imaging resources for members of the Wistar research community. The imaging systems have been designed to be extremely flexible to reflect a broad range of challenging scientific questions and specimens. Each system provides a combination of illumination, optics and image capture options. Diverse subjects ranging from fluorescently tagged live cell cultures and stained tissue sections, to 3D tumor spheroids and low magnification explanted tissues, can be accommodated with available systems. Current equipment includes standard upright and inverted fluorescence microscopes, a customized live-cell time lapse microscope capable of 6D imaging, a laser scanning confocal microscope, a 2-photon microscope designed for in vivo imaging, a small animal, whole body luminescence and fluorescence imager, special low magnification (photomacrography) systems as well as a variety of traditional photographic cameras, lenses and lighting equipment. Users of the facility may be trained for unassisted use of all core assets, or they may elect assisted service with the facility staff performing the imaging. The Imaging staff also provides assistance to researchers with additional aspects of their imaging requirements. Ideal approaches to specimen documentation are often unique to the experiment and the staff can help design the most effective imaging protocols to answer a particular question. On-site assistance is available to help investigators get the most out of their own systems. Image analysis and specialized Photoshop training, creative imaging for journal covers, and guidance on digital imaging ethics help to round out the services available from the facility.

Proper citation: Wistar Imaging Core Facility (RRID:SCR_010207) Copy   

•   Source: SciCrunch Registry

http://eagle-i.ea.vanderbilt.edu/i/00000139-c643-b905-b341-4bb480000000

An Core facility

Proper citation: Vanderbilt Clinical Trials Center (RRID:SCR_010171) Copy   

•   Source: SciCrunch Registry

http://eagle-i.ea.vanderbilt.edu/i/00000139-c637-b593-b341-4bb480000000

The primary mission of the Clinical Trials Shared Resource (CTSR), as identified in the Cancer Center Support Grant (CCSG), is to assist Cancer Center investigators develop, activate and complete scientifically-meritorious clinical trials in an efficient, cost-effective and technically-sound manner.

Proper citation: Vanderbilt Clinical Trials Shared Resource (RRID:SCR_010172) Copy   

•   Source: SciCrunch Registry

http://chgr.mc.vanderbilt.edu/page/computational-genomics-core

THIS RESOURCE IS NO LONGER IN SERVCE, documented January 25, 2019. Core provides software and hardware support for computing activities related to genetics and biology, as well as statistical analysis for human genetics data generated from both microsatellite markers and SNPs. Bioinformatics support, resources, and expertise are available in storing and managing demographic, clinical, genotypic, microarray, proteomic and biospecimen data.

Proper citation: Vanderbilt University Center for Human Genetics Research Computational Genomics Core (RRID:SCR_010173) Copy   

•   Source: SciCrunch Registry

http://eagle-i.ea.vanderbilt.edu/i/00000139-b673-9ac0-b341-4bb480000000

Core facility that provides the following services: Biospecimen acquisition. The Cooperative Human Tissue Network- Western Division at Vanderbilt University Medical Center is one of six institutions throughout the country funded by the National Cancer Institutes to procure and distribute remnant human tissues to biomedical researchers throughout the United States and Canada. CHTN operates through a shared networking system which allows investigators greater access to available research specimens. CHTN offers a variety of preparation and preservation techniques to ensure investigators are receiving the quality specimens needed for research. Remnant tissues are obtained from surgical resections and autopsies and are procured to the specifications of the investigator.

Proper citation: Vanderbilt Cooperative Human Tissue Network (RRID:SCR_010174) Copy   

•   Source: SciCrunch Registry

http://eagle-i.ea.vanderbilt.edu/i/00000139-c646-d984-b341-4bb480000000

BioVU is a research resource providing a View into biology at the level of DNA and other important macromolecules. BioVU has two major components. The first is a repository of DNA samples (extracted from discarded blood samples) that are coded solely by a Research Unique Identifier (RUI) derived from the Medical Record Number (MRN) using a one-way hash function. This is a computer algorithm that creates a transformation of each MRN such that the resulting RUI (which is in this instance is a 512 byte identifier) is unique, and has the property that it is not possible to infer or compute the MRN that generated it. As of early 2009, over 50,000 DNA samples were in the biobank, with new samples being added at the rate of approximately 700 per week.

Proper citation: Vanderbilt DNA Databank (RRID:SCR_010175) Copy   

•   Source: SciCrunch Registry

http://eagle-i.ea.vanderbilt.edu/i/00000139-a249-859f-b4bd-8a1180000000

The Eicosanoid Core Laboratory facility employs mass spectrometry to quantify lipid oxidation products produced in a variety of vascular (and other) disorders including prostaglandins, leukotrienes, isoprostanes, and their urinary metabolites.

Proper citation: Vanderbilt Eicosanoid Core Laboratory (RRID:SCR_010177) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000013e-5708-120e-7db7-114480000000

The Core''s capabilities include six Computer Numerical Control (CNC) milling centers (one of which is a five-axis micro-milling machine), two 3D printers, a waterjet cutter, a laser cutter, and a sinker Electrical Discharge Machining (EDM) tool. The Core has three full time machinists with experience in both industrial and academic machine shops, creating prototypes for varied applications. In addition to fabrication, these experts help researchers during the design phase, enabling development from a simple concept into real prototypes.

Proper citation: Wyss Institute Machine Shop / 3D Prototyping Core (RRID:SCR_010212) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/00000137-b920-a047-d807-77a880000000

The Wyss Institute Materials Characterization Core is dedicated to promoting leading edge biologically inspired research by providing users with a wide range of state-of-the-art materials characterization equipment and analysis software. These tools help support the characterization of a material?s unique physical, chemical, and mechanical properties. The Materials Characterization Core team provides exceptional hands on training, method development, and technical expertise. We also proactively stride to introduce the latest innovations in materials characterization to the Wyss Institute community and our affiliated partners. Our current techniques include chromatography, mass spectrometry, UV-Vis spectroscopy, particle sizing, quartz crystal microbalance, electrochemical testing, rheology, and nanoindentation.

Proper citation: Wyss Institute Materials Characterization Core (RRID:SCR_010213) Copy   

•   Source: SciCrunch Registry

http://xula.eagle-i.net/i/00000139-25f8-4557-8dd7-9ade80000000

Core facility that provides the following services: Drug Dosage Form Development. The center is focused on understanding and overcoming barriers to efficient oral, colonic, parenteral, pulmonary and vaginal delivery of drugs in the hopes of developing new treatments for chronic diseases such as cancer. Numerous new technologies are coming out of the Center as relationships have been formed with small, advanced technology businesses.

Proper citation: XULA Center for Nanomedicine and Drug Delivery (RRID:SCR_010215) Copy   

•   Source: SciCrunch Registry

http://xula.eagle-i.net/i/00000134-fc0b-ad1d-77e4-a45080000000

Core facility that provides the following services: X-ray crystallography service. A Molecular Structure and Modeling Core laboratory has been established to provide technical services to support faculty researchers involved in cancer research and drug design at Xavier University. Drug design methods use molecular structure information and modeling methods to determine structure patterns among active and inactive compounds, identify and compare potential active sites, and screen databases to identify new leads. X-ray crystallography provides structure coordinates for druglike, organic compounds and small peptides. The goal of this core laboratory is to provide small molecule X-ray crystallographic services as well as to support ligand-based and structure-based drug design projects at any stage. The long term goal is to develop resources in order to enhance cancer related biomedical research capability at Xavier University. To achieve this goal, the Molecular Structure and Modeling Core Laboratory has set the following specific aims: 1. To provide salary support for a Core Scientist to provide molecular modeling services and training in support of Xavier faculty research projects 2. To establish new collaborations with faculty at other local and RCMI institutions who might benefit from molecular modeling services 3. To provide small molecule x-ray crystallography services 4. To provide support and maintenance costs for equipment in the MSM Core

Proper citation: XULA RCMI Molecular Structure and Modeling Core (RRID:SCR_010219) Copy   

•   Source: SciCrunch Registry

http://eagle-i.ea.vanderbilt.edu/i/00000139-3637-992d-dacb-da6080000000

Core facility that provides the following services: Cytometric Bead Array, Meso Scale Discovery''s Multi-Array��, Cytometry protein measurements, Elispot Assays, Phenotypic analysis with flow cytometry, Multifunctional/Polychromatic flow cytometry (7-14 color), Cell proliferation assays, Tetramer/pentamer staininng, Influenza hemagglutination inhibition assay, Bordetella pertussis ELISA IgG / IgA, Commercial ELISA. The Immunology Core provides assistance to investigators with sample processing, storage, shipping, documentation, assay design, assay development and evaluation of immune responses. It is the goal of the core to monitor immune responses during clinical trials using the latest advances in technology and provide practical applications of this technology to evaluating immune responses. We continue to develop new immune monitoring technology with industry and academic collaborators. The Immunology Core has extensive experience in assay development and optimization, and will assist in the selection of appropriate assays and antigens during the protocol/developmental phase of a study or trial.

Proper citation: Vanderbilt Human Immunology Core Laboratory (RRID:SCR_010182) Copy   

•   Source: SciCrunch Registry

http://eagle-i.ea.vanderbilt.edu/i/00000139-c63a-c759-b341-4bb480000000

The mission of the Innovative Translational Research Shared Resource (ITR) is to advance the translation of basic and clinical research into improved clinical therapies by facilitating clinical discoveries and managing laboratory and clinical data exchange between researchers. The ITR has partnered with the Personalized Cancer Medicine Initiative (PCMI) and the Vanderbilt-Ingram Cancer Center (VICC) to characterize the molecular changes present in tumors. With a focus in clinical sample preparation and tumor genetic analyses, the ITR uses the most advanced laboratory techniques to uncover the genetic uniqueness of each patient''s tumor for research. This knowledge will lead to improved clinical therapies and a more personalized cancer care that will save lives and improve patient outcomes. The ITR gives scientific and technical assistance to clinical and laboratory researchers interested in experimentation using human tumor tissues or cell lines. In addition to our expertise in genetic analyses, the ITR is also interested in partnering with clinical investigators to study clinical phenotypes in a research laboratory. These studies are tailored to the needs of the clinical investigator.

Proper citation: Vanderbilt Innovative Translational Research Shared Resource (RRID:SCR_010183) Copy   

•   Source: SciCrunch Registry

http://eagle-i.ea.vanderbilt.edu/i/00000138-7bc7-c4a0-480b-864680000000

The Vanderbilt Institute of Nanoscale Science and Engineering (VINSE) is a University institute focused on new science and technology based on nanoscale materials. We carry out frontier science and technology by teaming locally and globally, and providing an environment where physicists, chemists, biologists, and all engineers may collaboratively solve forefront problems and create new scientific understanding.

Proper citation: Vanderbilt Institute of Nanoscale Science and Engineering (RRID:SCR_010187) Copy   

•   Source: SciCrunch Registry

http://eagle-i.ea.vanderbilt.edu/i/00000139-b69c-150b-b341-4bb480000000

Mass spectrometry is used to analyze the complex array of lipids in cellular membranes in an effort to dissect precursor-product relationships in lipid signaling networks.

Proper citation: Vanderbilt Lipidomics Core Laboratory (RRID:SCR_010188) Copy   

•   Source: SciCrunch Registry