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| Resource Name | Proper Citation | Abbreviations | Resource Type |
Description |
Keywords | Resource Relationships | |||||||||||||
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caGWAS Resource Report Resource Website |
caGWAS (RRID:SCR_009617) | caGWAS | software resource | Too that allows researchers to integrate, query, report, and analyze significant associations between genetic variations and disease, drug response or other clinical outcomes. SNP array technologies make it possible to genotype hundreds of thousands of single nucleotide polymorphisms (SNPs) simultaneously, enabling whole genome association studies. Within the Clinical Genomic Object Model (CGOM), the caIntegrator team created a domain model for Whole Genome Association Study Analysis. CGOM-caGWAS is a A semantically annotated domain model that captures associations between Study, Study Participant, Disease, SNP Association Analysis, SNP Population Frequency and SNP annotations. caGWAS APIs and web portal provide: * a semantically annotated domain model, database schema with sample data, seasoned middleware, APIs, and web portal for GWAS data; * platform and disease agnostic CGOM-caGWAS model and associated APIs; * the opportunity for developers to customize the look and feel of their GWAS portal; * a foundation of open source technologies; * a well-tested and performance-enhanced platform, as the same software is being used to house the CGEMS data portal; * accelerated analysis of results from various biomedical studies; and * a single application through which researchers and bioinformaticians can access and analyze clinical and experimental data from a variety of data types, as caGWAS objects are part of the CGOM, which includes microarray, genomic, immunohistochemistry, imaging, and clinical data. | application, computational neuroscience, genetic association, genomic analysis, imaging genomics, java, snp, gene, software, web environment, microarray, genomic, immunohistochemistry, imaging, clinical |
is listed by: NeuroImaging Tools and Resources Collaboratory (NITRC) has parent organization: National Cancer Institute |
BSD License | nlx_155841 | http://www.nitrc.org/projects/cagwas | SCR_009617 | caGWAS (Cancer Genome-Wide Association Studies), Cancer Genome-Wide Association Studies, CGOM-caGWAS | 2026-02-14 02:01:42 | 0 | ||||||
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MagPro Magnetic Stimulator Resource Report Resource Website 10+ mentions |
MagPro Magnetic Stimulator (RRID:SCR_009601) | MagPro | instrument resource | A complete line of non-invasive magnetic stimulation systems designed for clinical examinations and for research in the areas of neurophysiology, neurology, cognitive neuroscience, rehabilitation and psychiatry. | experiment control, hardware, magnetic resonance, response monitoring, stimulus presentation, clinical, neurophysiology, neurology, cognitive neuroscience, rehabilitation, psychiatry, instrument, equipment |
is listed by: NeuroImaging Tools and Resources Collaboratory (NITRC) is provided by: MagVenture |
Commercial license | nlx_155803 | http://www.nitrc.org/projects/magpro | SCR_009601 | MagPro Magnetic Stimulator (TMS) | 2026-02-14 02:01:53 | 10 | ||||||
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EMBASE Resource Report Resource Website 10000+ mentions |
EMBASE (RRID:SCR_001650) | Embase | data or information resource, database | Comprehensive international bibliographic biomedical database that enables users to track and retrieve precise information on drugs and diseases from pre-clinical studies to searches on critical toxicological information. It contains bibliographic records with citations, abstracts and indexing derived from biomedical articles in peer reviewed journals, and is especially strong in its coverage of drug and pharmaceutical research. Embase can help with everything from clinical trials research to pharmacovigilance and is updated online daily and weekly. Its broad biomedical scope covers the following areas: * Drug therapy and research, including pharmaceutics, pharmacology and toxicology * Clinical and experimental (human) medicine * Basic biological science relevant to human medicine * Biotechnology and biomedical engineering, including medical devices * Health policy and management, including pharmacoeconomics * Public, occupational and environmental health, including pollution control * Veterinary science, dentistry, and nursing The Embase Application Programming Interface supports export, RSS feeds, and integration services, making it possible to share data with a wide range of systems. | biomedical, drug, disease, regulatory requirement, drug research, pharmacology, pharmaceutics, toxicology, clinical, experimental medicine, health policy, management, public health, occupational health, environmental health, drug dependence, drug abuse, psychiatry, forensic medicine, biomedical engineering, biomedical instrumentation, nursing, dentistry, veterinary medicine, psychology, alternative medicine, clinical trial, pharmacovigilance, pharmacology, drug safety, adverse drug reaction, chemical, bibliography, FASEB list | is related to: Cochrane Central Register of Controlled Trials | Restricted | nlx_153929 | SCR_001650 | EMBASE: Excerpta Medica, Excerpta Medica Database, Embase: Biomedical Database, EMBASE (Excerpta Medica Database) | 2026-02-14 02:06:05 | 62975 | |||||||
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Australian New Zealand Clinical Trials Registry Resource Report Resource Website 500+ mentions |
Australian New Zealand Clinical Trials Registry (RRID:SCR_002967) | ANZCTR | data or information resource, database | Register of clinical trials being undertaken in Australia, New Zealand and elsewhere including trials from the full spectrum of therapeutic areas of pharmaceuticals, surgical procedures, preventive measures, lifestyle, devices, treatment and rehabilitation strategies and complementary therapies. In 2007 the ANZCTR was one of the first three trial registries to be recognized by the World Health Organisation International Clinical Trials Registry Platform (WHO ICTRP) as a Primary Registry. WHO recognizes registries as Primary Registries if they fulfill certain criteria with respect to data content, quality and validity, accessibility, unique identification, technical capacity and administration. The ANZCTR contributes data to the WHO ICTRP, which was developed in 2007. Trials from all ICTRP Primary Registries can be searched at: www.who.int/trialsearch Studies should be registered prospectively, i.e. before the first patient is recruited. The registry records a trial's * objectives * main design features * sample size and recruitment status * treatments under investigation * outcomes being assessed * principal investigator * contact person Key points about the ANZCTR * Publicly owned, managed by a not-for-profit organization * All details of trials registered on the ANZCTR are made publicly available * Registration is voluntary, but if a registrant chooses to register a trial, certain fields are mandatory * Registration is free of charge * Responsibility for registration lies with the Sponsor | clinical, clinical trial, registry, pharmaceutical, surgical, lifestyle, treatment, therapy, FASEB list | has parent organization: University of Sydney; Sydney; Australia | National Health and MRC ; Health Research Council of New Zealand |
PMID:23672724 PMID:29915979 |
Public, The community can contribute to this resource | r3d100011164, nif-0000-30135 | https://doi.org/10.17616/R36S5G | SCR_002967 | 2026-02-14 02:05:48 | 887 | |||||
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NCI Metathesaurus Resource Report Resource Website |
NCI Metathesaurus (RRID:SCR_003565) | NCIm | data or information resource, database | A wide-ranging biomedical terminology database that covers most terminologies used by NCI for clinical care, translational and basic research, and public information and administrative activities. NCIm features: * Maps 4,000,000 terms from more than 75 sources into 2,000,000 biomedical concepts that represent their meaning. * Displays preferred terms, synonyms, definitions, and other information from each source. * Links to NCI Thesaurus and other related information sources. * Contains 22,000,000 cross-links between content elements. * Updated frequently by a team of biomedical terminology and subject matter experts. NCIm contains most public domain terminologies from the National Library of Medicine's UMLS Metathesaurus, as well as many other biomedical terminologies created by or of interest to NCI and its partners. Some propriety terminologies are included, with permission, and have restrictions on their use. The current version of the NCI Metathesaurus, based on the UMLS build 2013AA, covers up to National Cancer Institute Thesaurus, 13.12d. A viewer for the UMLS changes document can be downloaded. | biomedical, clinical, terminology |
is related to: NCI Thesaurus has parent organization: National Cancer Institute |
Cancer | nlx_157699 | SCR_003565 | 2026-02-14 02:06:15 | 0 | ||||||||
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Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease Resource Report Resource Website 1+ mentions |
Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (RRID:SCR_000690) | CRISP | clinical trial, resource | A five-year prospective cohort study following 240 patients who have autosomal-dominant polycystic kidney disease (PKD) to determine whether changes in anatomic characteristics of their kidneys as measured by magnetic resonance imaging will be useful in providing surrogate measures for disease progression. CRISP's overall goal is to develop methods that would facilitate shortening the observation period necessary to determine efficacy of treatment interventions in PKD patients. Specific goals of this study are to: * Quantify cyst growth and ascertain severity of renal parenchymal involvement by sequential measurement of total kidney volume and the ratio of intact parenchyma to renal parenchyma occupied by cysts over time * Establish useful clinical correlations of imaging data with other markers of disease progression * Identify and test other potential markers or indices of disease progression, for example, assessment of loss of heterozygosity of renal cells shed in the urine, or other markers, in cohorts of patients with PKD * Gain information about the cost-effectiveness, patient acceptability, and advantages and disadvantages of different imaging techniques used serially in patients with PKD. Some experience has been gained in establishing that repeat imaging of the same PKD patient, using these techniques, yields reproducible estimates of kidney size and the proportion of renal parenchyma occupied by cysts. MRI may also have the advantage of permitting simultaneous estimation of GFR. Ultrasound has the advantage of being more cost-effective and perhaps more acceptable to patients for repetitive studies, but the measurements may be less accurate and reproducible. Nonetheless, there is very limited experience in applying these techniques to follow progression of the renal disease. Development of improved, reproducible imaging methods that assess cyst growth and provide markers of disease progression could markedly improve the feasibility of clinical trials. Participating clinical centers are Emory University, the Mayo Clinic, University of Kansas, and the University of Alabama at Birmingham. The data coordinating and imaging analysis center is at Washington University. (PI has since moved to University of Pittsburgh) The study found that kidney enlargement resulting from the expansion of cysts is continuous, quantifiable, and associated with the decline of renal function. Cystic expansion occurs at a consistent rate per individual, although it is heterogeneous in the population, and that larger kidneys are associated with more rapid decrease in renal function. These anatomic characteristics of patient kidneys may provide useful surrogate measures for disease progression, and hence enhance the development of targeted therapies for autosomal dominant PKD. CRISP III is a five-year prospective cohort study to follow ~170 remaining autosomal dominant polycystic kidney disease (ADPKD) patients who were part of the original CRISP cohort study. CRISP III will verify and extend the preliminary observations of CRISP to determine the extent to which quantitative (kidney volume and blood flow, and hepatic and kidney cyst volume) or qualitative (cyst distribution and character) structural parameters predict renal insufficiency and develop and test new metrics to quantify and monitor disease progression. Urine metabolites and the genome will be correlated with the progression of disease to look for new, predictive disease biomarkers. This information from CRISP III will help determine if the kidney enlargement, blood flow, cyst distribution, or urine metabolites can function as an informative surrogate measure for disease progression. | mri, kidney volume, cyst volume, kidney, renal function, disease progression, measure, blood flow, hepatic cyst volume, kidney cyst volume, renal insufficiency, urine metabolite, surrogate measure, clinical, intervention |
is listed by: NIDDK Information Network (dkNET) has parent organization: University of Pittsburgh; Pennsylvania; USA |
Polycystic kidney disease, Autosomal dominant polycystic kidney disease | NIDDK 5U01DK056961 | THIS RESOURCE IS NO LONGER IN SERVICE | nlx_152795 | SCR_000690 | Consortium of Radiologic Imaging Study of PKD | 2026-02-14 02:07:26 | 3 | |||||
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Look AHEAD Resource Report Resource Website 10+ mentions |
Look AHEAD (RRID:SCR_001490) | Look AHEAD | clinical trial, resource | 16-center, randomized clinical trial investigating the long-term health consequences of an intensive lifestyle intervention program designed to achieve and maintain weight loss by decreased caloric intake and increased physical activity in overweight volunteers with type 2 diabetes. The Look AHEAD cohort comprises approximately 5,000 overweight or obese participants with type 2 diabetes, aged 45-76. Participants were randomized to one of two interventions: an intensive lifestyle intervention designed to produce and sustain weight loss over the long term or a diabetes support and education arm. Participants will be followed for a total of 11 to 13.5 years from randomization. The primary hypothesis is that the incidence rate of the first post-randomization occurrence of a composite outcome, which includes * cardiovascular death (including fatal myocardial infarction and stroke), * non-fatal myocardial infarction, * hospitalized angina, and * non-fatal stroke, over a planned follow-up period of up to 13.5 years will be reduced among participants assigned to the Lifestyle Intervention compared to those assigned to the control condition, Diabetes Support and Education. Look AHEAD will also test for reductions in the incidence of three secondary composite outcomes and examine the effect of the intervention on cardiovascular disease risk factors, diabetes control and complications, general health, and quality of life, and psychological outcomes. The cost and cost-effectiveness of the Lifestyle Intervention relative to Diabetes Support and Education will be assessed. The Look AHEAD intensive lifestyle intervention ended September, 2012. Participants continue to be followed to determine the long-term effects of the intervention on health outcomes. | weight loss, caloric intake, physical activity, health outcome, long-term effect, longitudinal, intervention, late adult human, middle adult human, cardiovascular disease, risk factor, diabetes control, diabetes complication, health, quality of life, psychological outcome, clinical |
is listed by: NIDDK Information Network (dkNET) has parent organization: Wake Forest University; North Carolina; USA |
Type 2 diabetes, Overweight, Control | NIDDK U01DK057136 | Restricted | nlx_152745 | https://www.lookaheadtrial.org/public/home.cfm | SCR_001490 | Action for Health in Diabetes, Look AHEAD - Action for Health in Diabetes | 2026-02-14 02:07:45 | 46 | ||||
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Evaluating Predictors and Interventions in Sphincter of Oddi Dysfunction Resource Report Resource Website |
Evaluating Predictors and Interventions in Sphincter of Oddi Dysfunction (RRID:SCR_006897) | EPISOD | clinical trial, resource | A prospective, double-blind, randomized, sham-controlled, multi-center clinical trial that enrolls subjects who have received a prior cholecystectomy and are diagnosed with the clinical syndrome of Sphincter of Oddi Dysfunction III (SOD III) as defined by the Rome III criteria. The goal of the study is to asses the value of endoscopic sphincterotomy as a treatment for adult subjects categorized as SOD III suffering from pain after cholecystectomy and to define the role of manometry in treating these patients. | clinical, treatment, intervention, sphincterotomy, pancreatic, pancreas, pancreatitis, biliary, adult human, male, female, manometry |
is listed by: ClinicalTrials.gov is listed by: NIDDK Information Network (dkNET) is listed by: NIDDK Research Resources |
Cholecystectomy, Sphincter of Oddi Dysfunction | NIDDK | nlx_152824 | http://www.episod.org/ | SCR_006897 | Evaluating Predictors & Interventions in Sphincter of Oddi Dysfunction, Evaluating Predictors & Interventions in Sphincter of Oddi Dysfunction (EPISOD) | 2026-02-14 02:07:57 | 0 | |||||
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Minimally Invasive Surgical Therapies Treatment Consortium for Benign Prostatic Hyperplasia Resource Report Resource Website |
Minimally Invasive Surgical Therapies Treatment Consortium for Benign Prostatic Hyperplasia (RRID:SCR_007126) | MIST for BPH | clinical trial, resource | Randomized clinical trial to determine the efficacy and safety of three treatments for benign prostatic hyperplasia (BPH): transurethral needle ablation (TUNA), transurethral microwave therapy (TUMT), and medical therapy with alfuzosin and finasteride. The study has been terminated. (Inability to recruit required sample size.) | transurethral microwave thermotherapy, transurethral needle ablation, therapy, drug, finasteride, alfuzosin, treatment, clinical, intervention, male, middle adult human, late adult human, prostate |
is listed by: ClinicalTrials.gov is related to: NIDDK Information Network (dkNET) has parent organization: NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases |
Benign Prostatic Hyperplasia | NIDDK | nlx_152844 | SCR_007126 | Minimally Invasive Surgical Therapies (MIST) Treatment Consortium for Benign Prostatic Hyperplasia (BPH), Minimally Invasive Surgical Therapy Consortium for Benign Prostatic Hyperplasia | 2026-02-14 02:07:31 | 0 | ||||||
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Biologic Specimen and Data Repository Information Coordinating Center (BioLINCC) Resource Report Resource Website 100+ mentions |
Biologic Specimen and Data Repository Information Coordinating Center (BioLINCC) (RRID:SCR_013142) | BioLINCC | data or information resource, database | Repository that serves to coordinate searches across data and biospecimen collections from participants in numerous clinical trials and epidemiologic studies and to provide an electronic means for requests for additional information and the submission of requests for collections. The collections, comprising data from more than 80 trials or studies and millions of biospecimens, are available to qualified investigators under specific terms and conditions consistent with the informed consents provided by the individual study participants. Some datasets are presented with studies and supporting materials to facilitate their use in reuse and teaching. Datasets support basic research, clinical studies, observational studies, and demonstrations. Researchers wishing to apply to submit biospecimen collections to the NHLBI Biorepository for sharing with qualified investigators may also use this website to initiate that process. | cardiovascular, pulmonary, hematology, clinical, clinical trial, blood, lung, heart, biological specimen, health, disease, medicine, epidemiology, epidemiologic study, FASEB list |
is listed by: One Mind Biospecimen Bank Listing is listed by: DataCite is listed by: NIH Data Sharing Repositories is listed by: Connected Researchers is listed by: NIDDK Information Network (dkNET) is related to: NIH Data Sharing Repositories is related to: Framingham Heart Study has parent organization: National Heart Lung and Blood Institute |
NHLBI | Public, The community can contribute to this resource | nlx_151758 | https://biolincc.nhlbi.nih.gov/ https://biolincc.nhlbi.nih.gov/ |
SCR_013142 | NHLBI Biorepository | 2026-02-14 02:06:23 | 250 | |||||
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Jackson Laboratory Clinical Knowledgebase Resource Report Resource Website 10+ mentions |
Jackson Laboratory Clinical Knowledgebase (RRID:SCR_014965) | CKB | data or information resource, database | Semi-automated and manually curated database of gene/variant annotations, therapy knowledge, diagnostic/prognostic information, and oncology clinical trials. Users can search CKB via gene, gene variants, drug, drug class, indication, and clinical trials. | cancer, database, knowledgebase, clinical trial, clinical, gene, gene annotation, variant annotation, therapy, diagnosis | Cancer | PMID:26772741 | Available to the research community, For educational and research purposes only, Not intended to be used for medical advice/diagnosis or treatment | SCR_014965 | Jackson CKB | 2026-02-14 02:06:52 | 27 | |||||||
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Attie Lab Diabetes Database Resource Report Resource Website 1+ mentions |
Attie Lab Diabetes Database (RRID:SCR_016639) | data or information resource, database | Interactive database of gene expression and diabetes related clinical phenotypes. Allows to search gene expression in tissues as a function of obesity, strain, and age, in a mouse. | interactive, database, gene, expression, diabetes, related, clinical, phenotype, mouse |
is listed by: OMICtools has parent organization: University of Wisconsin-Madison; Wisconsin; USA |
diabetes | Free, Freely available | SCR_016639 | 2026-02-14 02:06:54 | 3 | |||||||||
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National Death Index Resource Report Resource Website 10+ mentions |
National Death Index (RRID:SCR_016369) | NDI | data or information resource, database | Database of death record information on file in state vital statistics offices. Working with these state offices, the National Center for Health Statistics (NCHS) established the NDI as a resource to aid epidemiologists and other health and medical investigators with their mortality ascertainment activities. | death, mortality, epidemic, statistic, epidemiology, clinical, terminal illness, dead, deceased | has parent organization: Centers for Disease Control and Prevention | CDC | Application required | SCR_016369 | National Mortality Index, Death Index | 2026-02-14 02:06:23 | 17 | |||||||
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TalkBank Resource Report Resource Website 10+ mentions |
TalkBank (RRID:SCR_003242) | training material, data or information resource, database, narrative resource | Databases of transcript and media data collected from conversations with adults and older children to foster fundamental research in the study of human and animal communication. Conversations with children are available from CHILDES. All of the data is transcribed in CHAT and CA/CHAT formats. Databases of the following types are included in the collection: Aphasia patient speech, Child speech, Study of Phonological Development, Conversation Analysis, and Bilingualism and Second Language Acquisition. TalkBank will use these databases to advance the development of standards and tools for creating, sharing, searching, and commenting upon primary materials via networked computers. | aphasia, aphasiabank, bilingbank, cabank, phonbank, psychology, speech, communication, clinical, transcript, audio track, video, talk, voice, language, conversation, discourse, adult human, child, second language, audiology, media, animal communication, conversation analysis, discourse analysis, gesture, code switching, bilingualism, linguistic, phonological development, danish |
is listed by: re3data.org is related to: PhonBank has parent organization: Carnegie Mellon University; Pennsylvania; USA has parent organization: University of Pennsylvania; Philadelphia; USA works with: Child Language Data Exchange System (CHILDES) |
Aphasia, Dementia, Bilingualism | NIDCD R01 DC008524; NICHD R01 HD23998; NICHD R01 HD051698 |
Free, Freely available | nif-0000-00626, r3d100010551 | https://doi.org/10.17616/R3XW38 | SCR_003242 | 2026-02-15 09:18:31 | 31 | ||||||
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Sage Bionetworks Resource Report Resource Website 100+ mentions |
Sage Bionetworks (RRID:SCR_003384) | nonprofit organization | Non-profit biomedical research organization developing predictors of disease and accelerating health research through creation of open systems, incentives, and standards. Formed to coordinate and link academic and commercial biomedical researchers through Commons that represents new paradigm for genomics intellectual property, researcher cooperation, and contributor evolved resources. | bionetwork, medical, research, human, treatment, disease, biological, biomedical, genomic, development, diagnostic, therapeutic, molecular, meta-data, model, clinical, bioinformatics, drug, consortium, data sharing, software |
is listed by: Consortia-pedia is parent organization of: CommonMind Consortium is parent organization of: Sage Bionetworks Podcasts is parent organization of: Key Driver Analysis is parent organization of: Synapse |
Free, Freely available | Wikidata: Q891621, nif-0000-32903, grid.430406.5, SCR_004425, ISNI: 0000 0004 6023 5303, nlx_42820 | https://ror.org/049ncjx51 | http://sagebase.org/commons/repository.php | SCR_003384 | 2026-02-15 09:18:30 | 119 | |||||||
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Biomedical Diagnostics Institute Resource Report Resource Website |
Biomedical Diagnostics Institute (RRID:SCR_004022) | BDI | data or information resource, topical portal, portal | An academic-business-clinical partnership that sponsors research programs focused on the development of next-generation biomedical diagnostic devices. They aim to transform healthcare by pioneering advances in the science and technology of diagnostics and by translating these advances into clinical use. Building on key scientific insights, the BDI will now apply its established capabilities to create integrated Point-of-Care solutions, which will have major impacts on diagnosing disease and sustaining human health. | device development, product development, device, diagnostic, microfluidics, molecular assay, signal detection, biomarker, custom antibody, clinical, healthcare, diagnostic device, antibody, consortium |
is listed by: Consortia-pedia is related to: Dublin City University; Dublin; Ireland is related to: National University of Ireland; Galway; Ireland is related to: Royal College of Surgeons in Ireland; Dublin; Ireland is related to: Trinity College Dublin; Dublin; Ireland has parent organization: Dublin City University; Dublin; Ireland |
Science Foundation Ireland ; Industry partners |
nlx_158448 | SCR_004022 | 2026-02-15 09:18:37 | 0 | ||||||||
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Agilent Technologies Resource Report Resource Website 10000+ mentions |
Agilent Technologies (RRID:SCR_013575) | reagent supplier, material resource, commercial organization, antibody supplier | Company provides laboratories worldwide with analytical instruments and supplies, clinical and diagnostic testing services, consumables, applications and expertise in life sciences and applied chemical markets. | instrument, service, software, supply, expertise, life science, clinical, diagnostic, testing, reagent, market, |
is parent organization of: Seahorse Wave is parent organization of: Agilent Feature Extraction Software is parent organization of: Agilent Masshunter Quantitative Analysis software is parent organization of: Agilent ChemStation Software is parent organization of: Agilent MassHunter WorkStation - Qualitative Analysis for GC/MS has organization facet: Dako |
nlx_152258 | SCR_013575 | 2026-02-15 09:20:30 | 45936 | ||||||||||
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Renin Angiotensin System Study Resource Report Resource Website 1+ mentions |
Renin Angiotensin System Study (RRID:SCR_013385) | RASS/B-RASS, RASS | clinical trial, resource | Randomized, multicenter, double-blind study to determine if renin angiotensin medications, either losartan (angiotensin II blocker) or enalapril (converting enzyme inhibitor), can prevent or delay the onset of diabetic kidney disease in patients with type 1 diabetic patients who do not have hypertension, diabetic nephropathy, or predictive levels of microalbuminuria. Two hundred eight five patients ages 16-61 with 2-20 yrs of Type 1 Diabetes Mellitus and no renal functional abnormalities were randomized into a parallel, double-blind, placebo-controlled study involving 3 groups (95 patients/group). Each group received an angiotensin-converting enzyme inhibitor (ACEI) (enalapril), or an angiotensin II receptor blocker (Losartan), or placebo. All patients had their usual Diabetes Mellitus (DM) management. Baseline studies included measures of glomerular filtration rate (GFR), urinary albumin excretion rate (UAE), blood pressure (BP), and a percutaneous renal biopsy. Patients were followed by quarterly measures of BP, HbA1C, UAE, and drug compliance. There were annual measures of GFR and a repeat renal biopsy after 5 yrs in the study. The main endpoint is kidney structural changes over time, especially mesangial fractional volume (v(Mes/glom)). Secondary endpoints will be other DN structural measures and measures of kidney function (UAE, GFR). These studies will determine whether rennin angiotensin system blockage in the early stages of DN can prevent the early kidney structural changes in this important disorder. Ancillary studies will evaluate the effects of treatment group on the development and progression of diabetic retinopathy and will develop predictors of study participants'''' compliance. Baseline, 2.5 and 5 year retinal fundus photographs in the RASS patients were obtained. | enalapril, drug, losartan, angiotensin, medication, kidney, intervention, clinical, adolescent, adult human, renal biopsy, renin-angiotensin system, diabetic nephropathy, kidney, placebo, glomerular filtration rate, urinary albumin excretion rate, blood pressure |
is related to: NIDDK Information Network (dkNET) has parent organization: ClinicalTrials.gov has parent organization: University of Minnesota Twin Cities; Minnesota; USA |
Type 1 diabetes, Diabetic kidney disease, Retinopathy, Nephropathy, Diabetes | NIDDK | PMID:19571282 | nlx_152849 | SCR_013385 | Renin Angiotensin System Blockage-DN (RASS), Renin Angiotensin System Study (RASS/B-RASS) | 2026-02-14 02:07:56 | 1 | |||||
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Exacerbations of Chronic Pulmonary Disease Tool Resource Report Resource Website |
Exacerbations of Chronic Pulmonary Disease Tool (RRID:SCR_003718) | EXACT | material resource, assessment test provider | An electronically administered patient-reported outcome (PRO) measure that is a qualified measure of symptoms of acute bacterial exacerbation of chronic bronchitis in patients with chronic obstructive pulmonary disease (ABECB-COPD), for use in phase 2 trials. Refer to the proposed context of use, http://www.fda.gov/downloads/Drugs/DevelopmentApprovalProcess/DrugDevelopmentToolsQualificationProgram/UCM399682.pdf. Its intent to quantify frequency, severity, and duration of acute exacerbations in clinical trials of COPD including those with chronic bronchitis. It is designed as an electronic diary made up of fourteen items to be completed by the patient each evening just prior to bedtime. (An item-reduction statistical analysis narrowed the questions from 23 to 14.) For more information see, http://www.fda.gov/downloads/Drugs/DevelopmentApprovalProcess/DrugDevelopmentToolsQualificationProgram/UCM386248.pdf | patient-reported outcome measure, clinical outcome assessment, drug development, clinical, drug, patient-reported outcome, clinical trial, antibacterial drug, instrument, antibacterial, questionnaire, gold standard |
is recommended by: U.S. Food and Drug Administration has parent organization: Drug Development Tools Qualification Programs |
Chronic Pulmonary Disease, Acute Bacterial Exacerbation, Chronic Bronchitis, Chronic Obstructive Pulmonary Disease | Public | nlx_157894 | SCR_003718 | Exacerbation of Chronic Pulmonary Disease Tool Patient Reported Outcome Instrument, EXACT-PRO, Exacerbation of Chronic Pulmonary Disease Tool Patient Reported Outcome (EXACT-PRO) Instrument, Exacerbations of Chronic Pulmonary Disease Tool (EXACT) | 2026-02-14 02:07:04 | 0 | ||||||
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Patient-Reported Outcomes Measurement Information System Resource Report Resource Website 1000+ mentions |
Patient-Reported Outcomes Measurement Information System (RRID:SCR_004718) | PROMIS | material resource, assessment test provider | Repository of person centered measures that evaluates and monitors physical, mental, and social health in adults and children. | adult, child, assessment, clinical, anger, pain, fatigue, physical function, depression, anxiety, social function, patient reported outcome, health, measure |
is recommended by: National Library of Medicine has parent organization: University of Washington; Seattle; USA |
NCCIH ; NCI ; NHLBI ; NIA ; NIAMS ; NIDA ; NIDCD ; NIDDK ; NIMH ; NINDS ; NINR ; OD |
nlx_143881 | http://www.healthmeasures.net/index.php?option=com_content&view=category&layout=blog&id=71&Itemid=817 | SCR_004718 | PROMIS, Patient Reported Outcomes Measurement Information System | 2026-02-14 02:06:37 | 2881 |
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