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http://harvard.eagle-i.net/i/0000012a-438e-1d98-3e3e-48fb80000000

Core facility that provides the following services: Sorting or analysis with operator service, Calcium flux measurements service, DNA analysis service, Cell sorting service.

This lab''s mission is to provide high standard cell sorting and analysis services to the research community at the Brigham and Women?s Hospital and the Longwood Medical area.

Proper citation: BWH Flow Cytometry Core Laboratory (RRID:SCR_009683) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012c-654b-2967-c437-ff0b80000000

Core facility that provides the following services: Fluorescence in situ hybridization.

The CytoGenomics Core provides an invaluable technical resource to the investigators of the BWH, MGH, and affiliated institutions. Services are also available to external academic and commercial laboratories; these should contact us via our website for sample submission and pricing. Cytogenetic studies can provide insight into regions of the genome that are pathogenetic in various neoplasms leading to an understanding of the molecular pathways participating in the biology of cancer. It is appropriate to consider cytogenetics as a fundamental adjunct to a variety of investigations underway, including basic and clinical research. For example, a rather simple cytogenetic analysis of mouse ES cells to determine ploidy prior to injections into blastulas leads to a greater success rate in establishing founders for knock-out and knock-in experiments. The primary chromosomal assignment of a gene by a FISH experiment may lead to correlation of a disease with that gene. Other cytogenetic studies may be important in establishing a diagnosis for correlation with clinical outcome. The advent of molecular probes for FISH analysis has facilitated cytogenetic studies in the mouse, and other model organisms and this Core aggressively implements such technologies. In addition to state-of-the-art analyses for human samples, the BWH CytoGenomics Core also performs routine mouse karyotyping and a variety of other molecular cytogenetic analyses, services not easily obtainable elsewhere.

Proper citation: BWH CytoGenomics (RRID:SCR_009681) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012c-64ed-0030-c437-ff0b80000000

Biostatistics support is available to investigators in the Brigham and Women''s and Harvard Medical research community for statistical consulting on issues such as study design and data analysis for manuscripts and grant applications. Resources are limited, so planning ahead is essential. The Biostatistics Consulting Service is part of the Biostatistics Core of the BWH Center for Clinical Investigation (CCI).

Proper citation: BWH Biostatistics Center (RRID:SCR_009680) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012d-b966-5568-4882-b08d80000000

In recognition of the value of small animal imaging to the research community, Children''s Hospital Boston has committed to developing a state-of-the-art Small Animal Imaging Laboratory. The SAIL facility is located within the Department of Radiology''s Kresge Laboratory.

Proper citation: CHB Small Animal Imaging Core Laboratory (RRID:SCR_009719) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012d-c2f2-d124-4882-b08d80000000

The radiopharmaceutical chemistry research program occupies two research laboratories in the Enders research building at Children''s: a radiopharmaceutical chemistry laboratory and a hot laboratory. A separate cell-culture laboratory is also available. The radiopharmaceutical chemistry laboratory contains four fume hoods, approximately 50 linear feet of bench space, and is set up to accommodate three postdoctoral researchers.

Proper citation: CHB Radiopharmaceutical Chemistry Laboratory (RRID:SCR_009718) Copy   

•   Source: SciCrunch Registry

http://dartmouth.eagle-i.net/i/0000012a-24fd-4370-d8a1-249280000000

Core facility that provides the following services: Animal in vivo MRI and MRS Service.

The Biomedical NMR Research Center belongs to the Research Division of the Department of Diagnostic Radiology. Dr. Barjor Gimi is currently Director of the MR center. The Center houses a 7T horizontal bore Varian MR scanner in Vail and a 9.4T horizontal bore Varian MR scanner in Borwell. Research at the Biomedical NMR Research Center aims to advance applications of NMR techniques for tissue characterization in health and disease. We are developing non-invasive MR techniques to reveal unexplored details of anatomy, physiology and biochemistry in vivo. We use multinuclear MR technique both in imaging and spectroscopy modes and work with several animal models to achieve the goals above. Biomedical NMR Research Center provides a wide range of in vivo MR protocols for Dartmouth College and Dartmouth-Hitchcock Medical Center scientists. These include high resolution anatomical and functional MRI scanning procedures from rodents. Localized ��������H and ����������������P NMR spectroscopy can be acquired from several target organs to map, for instance metabolite concentrations, energy state, intracellular pH or tissue temperature.

Proper citation: Dartmouth Biomedical NMR Research Center (RRID:SCR_009759) Copy   

•   Source: SciCrunch Registry

https://cancer.dartmouth.edu/researchers/bioinformatics-resource.html

THIS RESOURCE IS NO LONGER IN SERVICE.Documented on July 29,2022. Core to support the implementation of bioinformatics resources for cancer research at Dartmouth. Provides consultation and collaboration for research projects of NCCC members, regular workshops, seminars, services including applied bioinformatics and data mining, computer programming and software engineering, database development and programming and high performance computing and systems administration.

Proper citation: Dartmouth-Hitchcock Bioinformatics Shared Resource (RRID:SCR_009758) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-9679-113e-55da-381e80000000

Core facility that provides the following services: Gene expression profiling service, Single nucleotide polymorphism analysis service, Tiling arrays service.

The Microarray Core provides services for genome-wide analysis of gene expression, nucleotide variation, copy number variation, and chromatin protein binding sites. The core platforms include microarrays and next generation sequencing. Consultation on experimental design, and assistance with data analysis are also available. The Microarray Core carries out gene expression profiling on 3'' arrays and on Exon arrays; genotyping and comparative genomic hybridization both on single nucleotide polymorphism (SNP) arrays, and Chromatin ImmunoPrecipitation localization (ChIP-on-Chip). All services use oligonucleotide microarrays. Biostatistical support to assist in analyzing the data is available. The services of the Core are accessible to DFCI investigators and to investigators outside of DFCI.

Proper citation: DFCI Microarray Core Facility (RRID:SCR_009753) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-59aa-00d7-55da-381e80000000

Core facility that provides the following services: Mass spectrometry service.

The Blais Proteomics Center develops and applies state-of-the-art proteomics, informatics, and related technologies for direct interrogation of protein expression, modification, and function in response to biological perturbation in cell-based models of human cancer and primary tissues. The Blais Proteomics Center serves as a valuable resource to support individual research labs at the Dana-Farber and throughout the surrounding research community. As a key component of Dana-Farber?s Strategic Plan for Research, Blais Proteomics actively participates with other Dana-Farber Strategic Research Centers in large-scale studies, designed to leverage disparate capabilities in pursuit of novel, in-depth, and otherwise unattainable insights into human biology and disease. Consistent with our role as a world-class, center of excellence in proteomics science, members of the Blais Proteomics center contribute to the teaching mission at Harvard Medical School and participate in outreach activities designed to introduce and train young scientists and others who may not otherwise have access to these advanced technologies.

Proper citation: DFCI Blais Proteomics Center (RRID:SCR_009748) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-599e-1dc8-55da-381e80000000

Core facility that provides the following services: Separation of plasma and serum from blood samples, Mononuclear cell counting and isolation, DNA isolation, 24 hour urine volume and aliquoting, Research specimen processing, Bone marrow aspiration and blood fixation, Research specimen storage.

The Clinical Research Laboratory (CRL) utilizes protocol-driven standard operating procedures for the processing of pharmacokinetics, pharmacodynamic, and biomarker samples. This includes the processing, storage, and tracking of all research specimens to ensure the successful completion of clinical trials associated with patient treatment. The CRL is dedicated to the highest standards of specimen handling to maintain the integrity of data procurement and analysis for clinical trials.

Proper citation: DFCI Clinical Research Laboratory (RRID:SCR_009749) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-a5f8-a043-55da-381e80000000

The Biocontainment Core Facility supports researchers whose experiments require a Biosafety Level 2 enhanced (BL2+) containment level. The Biocontainment Core adheres to Biosafety Level 3 (BL3) practices. Protective apparel, equipment, and other materials are provided by the core. Two core facilities are available: one is located at the Jimmy Fund building at Dana Farber; the second at The Center for Life Science. Authorized core users may have access to both facilities. Use of the facility is limited to researchers who receive training in BL3 procedures and comply with authorized user requirements. Training is provided by the Biosafety Officer, Core Manager, and authorized users.

Proper citation: DFCI Biohazard Containment Core Facility (RRID:SCR_009746) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-a5c0-aef8-55da-381e80000000

Core facility that provides the following services: Mouse breeding management, Mouse irradiation service, Technical services for laboratory animal experimentation, Veterinary care, Animal care training.

The facility provides services and resources for investigators looking to accomplish animal research objectives. This includes housing mice and rats, purchasing animals, training researchers regarding proper animal care and use, and monitoring the safety of all personnel with laboratory animal contact in conjunction with Dana-Farber?s Environmental Health and Safety and Occupational Health Services. Dana-Farber has established an Institutional Care and Use Committee (IACUC) to oversee the Institute?s animal program, facilities, and projects involving the use of animals. The IACUC serves as the approval body for all protocols involving animal research, and assists faculty, students and staff in upholding Dana-Farber?s commitment to providing the finest care and most humane utilization of laboratory animals. In addition to basic husbandry services, the ARF staff provides technical and veterinary services, mouse breeding management and mouse irradiation.

Proper citation: DFCI Animal Resources Facility (RRID:SCR_009745) Copy   

•   Source: SciCrunch Registry

http://www.dfhcc.harvard.edu/core-facilities/tissue-microarray-and-imaging-pathology/

Core facility that provides the following services: Construction of standard and custom TMA service, Nucleic acid isolation from paraffin embedded tissue service, Immunofluorescent staining service, Access to the Automated Quantitative Analysis (AQUA) system, Tissue microarray consultation service.

The mission of the Tissue Microarray and Imaging Core is to generate tissue microarrays by allowing placement of up to 480 0.6 mm diameter tissue samples into a single standard tissue block, allowing hundreds of tumors and samples to be evaluated on a single slide. The DF/HCC Tissue Microarray & Imaging (TMI) Core is dedicated to the construction and evaluation of high quality TMAs for cancer research. In addition, the Core performs high-throughput isolation of DNA and RNA from formalin-fixed paraffin-embedded tissues. The Core also provides web-based digital pathology services using the Aperio system. These services include slide scanning, image viewing and storage, and quantitative image analysis, which facilitate tissue-based research. Finally, the Core provides access to the Automated Quantitative Analysis (AQUA) system.

Proper citation: DF/HCC Tissue Microarray and Imaging Core Facility (RRID:SCR_009743) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012c-6056-ed57-c437-ff0b80000000

Core facility that provides the following services: Protein development/cloning, Western blot service, ELISA service, Flow cytometry service.

The mission of the DF/HCC Monoclonal Antibody Core (MAC) is to produce novel monoclonal antibodies that are directed against antigens of interest to Dana-Farber, the Harvard Cancer Center, and affiliated investigators. These monoclonal antibodies may be useful for basic research, drug discovery and clinical applications including diagnosis, surrogate markers for disease status, response to therapy or drug toxicity. Given the diverse research needs of investigators at DFCI and the Harvard Community, the MAC should strive to support a wide range of antibody requests. A key component of the DF/HCC MAC is the ability to explore and develop new technologies that facilitate generation of monoclonal antibodies. The DF/HCC MAC should be capable of supporting all basic functions of generating, screening, storing and producing monoclonal antibodies.

Proper citation: DF/HCC Monoclonal Antibody Core (RRID:SCR_009740) Copy   

•   Source: SciCrunch Registry

http://dartmouth.eagle-i.net/i/0000013e-6135-0e20-8e79-05bd80000000

The BCC provides essential statistical and quantitative methods support to Dartmouth investigators, helping to remove impediments to initiating new clinical translational research programs for young physicians and other scientists. Specialized support for statistical genetics/genomics, decision sciences and comparative effectiveness research, health services research, mathematical demography, psychometrics, geographic information systems, and imaging applications. The BCC also provides statistical expertise related to critical data management, in cooperation with the SYNERGY Biomedical Informatics Core, and fully supports statistical education initiatives throughout SYNERGY

Proper citation: Dartmouth SYNERGY: Biostatistics Consultation Core (RRID:SCR_009773) Copy   

•   Source: SciCrunch Registry

http://dartmouth.eagle-i.net/i/0000012b-00c4-3214-6a59-ec4e80000000

Core facility that provides the following services: Genotyping service, DNA sequencing service, DNA fragment analysis.

DNA Sequencing, DNA Fragment Analysis

Proper citation: Dartmouth Molecular Biology Shared Resource (RRID:SCR_009766) Copy   

•   Source: SciCrunch Registry

http://dartmouth.eagle-i.net/i/00000135-59ea-7c4f-a5f8-842480000000

Core facility that provides the following services: Multi-photon imaging. This SynergyT1 Shared Resource Core includes two microscopes sharing two femtosecond pulsed Ti:Sapphire lasers (tunable between 690 and 1080 nm) for imaging fluorescently-tagged molecules in tissues in vivo and in vitro.

Proper citation: Dartmouth Multi-Photon Imaging (RRID:SCR_009767) Copy   

•   Source: SciCrunch Registry

http://dartmouth.eagle-i.net/i/0000012a-24fd-03f4-d8a1-249280000000

Core facility that provides the following services: Electron micrscopy facility access.

The EM Facility is an institutional resource to meet the electron microscopy needs of faculty, staff and students of the Dartmouth College community, including the College, Thayer School of Engineering, the Dartmouth Medical School, and the Dartmouth-Hitchcock Medical Center. The instruments are housed in the EM wing of Remsen. Because the facility is intended to provide service to all the campus, yet has limited personnel, a major effort is made to provide training in the use of appropriate instruments to enable users to do their own microscopy. In addition to this training, there will be service assistance available for those unable to spend time on the microscopes, and for processing of biopsy samples from DHMC.

Proper citation: Dartmouth Electron Microscope Facility (RRID:SCR_009762) Copy   

•   Source: SciCrunch Registry

http://dms.dartmouth.edu/dgml

Core facility that provides the following services: Illumina Bead Array service, Affymetrix Microarray service.

The Genomics Shared Resource provides technologies to the Norris Cotton Cancer Center and Dartmouth community investigators that enable profiling of gene expression, miRNA, GpC Island, and CGH on a whole-genome scale. The long-term goal of the Genomics Shared Resource is to provide an efficient and affordable fee-for-service operation that will provide high quality genomics and microarray data for the growing number of Cancer Center investigators who require this service.

Proper citation: Dartmouth Genomics Shared Resource (RRID:SCR_009763) Copy   

•   Source: SciCrunch Registry

http://dartmouth.eagle-i.net/i/0000012b-43eb-535f-bd3e-55f580000000

Core facility that provides the following services: Cigarette smoke exposure analysis service.

Our lab is interested in the innate immune system at the mucosal surfaces of the female reproductive and respiratory tracts. A special focus of this work is to determine the effects of cigarette smoke on changes in immune protection. The relationship of cigarette smoke exposure to increased risk of infection is well established, however the mechanisms involved are not. Our research shows that cigarette smoke exposure reduces production of a key antimicrobial chemokine, CCL20. Ongoing research in the lab seeks to determine if similar responses to cigarette smoke exposure underlie increased rates of infection and how cigarette smoke exposure associated infection is linked to the development of cancer. Consulting; training; planning; experimental management assistance. Banked tissue samples available for preliminary studies. Small animal cigarette exposure.

Proper citation: Dartmouth Cigarette Smoke Exposure Analysis Laboratory (RRID:SCR_009761) Copy   

•   Source: SciCrunch Registry