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http://uccaribe.eagle-i.net/i/00000137-035f-9eba-a53f-a15a80000000

Core facility that provides the following services: Image acquisition training. The TEM laboratory provides access to ultrastructural analysis of biological specimens via a Jeol 100 CX transmission electron microscope. The TEM is equipped with AMT 4 MP digital camera to facilitate image acquisition and 3D reconstruction from serial sections. In addition, to conventional EM procedures of in situ and cell culture specimens the laboratory also offers imunnogold labeling and the visualization of fluorescent dyes after photoconversion.

Proper citation: UCC Transmission Electron Microscopy Laboratory (RRID:SCR_010081) Copy   

•   Source: SciCrunch Registry

https://wistar.org/research-discoveries/shared-resources/bioinformatics-facility

Core provides High Throughput Data Analysis, Customized Bioinformatics Services, Custom Programming, High Performance Computing, Data management. Located in the Center for Systems and Computational Biology. Provides Cancer Center investigators with database management, software application support, expertise in statistical analyses and computational modeling of biomedical research data.

Proper citation: Wistar Bioinformatics Core Facility (RRID:SCR_010203) Copy   

•   Source: SciCrunch Registry

http://famu.eagle-i.net/i/00000136-ea13-62c9-2e84-177780000000

A core facility at the Florida Agricultural and Mechanical University.

Proper citation: FAMU Drug Discovery Core Facility (RRID:SCR_000876) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012c-c7e5-e09d-a061-4a6580000000

Core facility that provides the following services: Flow cytometry assay service, Data management system.

The BD FACSCalibur system combines unique dual-laser technology, an automated sample loader option, and powerful software to provide the high throughput necessary to meet productivity requirements of clinical laboratories. The modularity and innovative technology designed into the BD FACSCalibur system also offers investigators the performance and flexibility required for a variety of research applications. Please note that since the NERCE program will end in February 2014, our ability to support new requests for services is limited.

Proper citation: HMS NERCE FACSCalibur Flow Cytometer Resource (RRID:SCR_000879) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012c-7441-2a90-c437-ff0b80000000

Core facility that provides the following services: Tissue trimming, cassetting, processing, and embedding, Cutting and staining of paraffin-embedded and cryostat sections, Immunohistochemistry for both routine and novel markers, In situ hybridization, using chromogenic or radioactive detection methods, Laser capture microdissection.

Tissue analysis is critical to validation and evaluation of animal models of human cancer, and human cancer tissues serve as the operating system for translational research. The facility supports a wide spectrum of cancer-relevant research, from basic studies on pathogenic mechanisms in cancer to translational research focused on the development of new tests for biomarkers that stratify patients and direct therapy. The Specialized Histopathology (SHP) Core, was created in 2005 by consolidating five histopathology cores into a single unit with two performance sites: Longwood, Directed by Jon Aster and based at the Brigham and Women?s Hospital and MGH, Directed by Anat Stemmer-Rachamimov and based at Massachusetts General Hospital East in Charlestown. The SHP Core provides professional and technical research pathology services to DF/HCC investigators working in diverse organisms (e.g., rodents, fish, and monkeys) or human tissues. The Core also assists in experimental design and the development and interpretation of tests and their results. As of July 2012, the Longwood site offers CLIA Certified services.

Proper citation: DF/HCC Specialized Histopathology Services Core (RRID:SCR_000872) Copy   

•   Source: SciCrunch Registry

http://eagle-i.itmat.upenn.edu/i/0000013c-40b7-7a2a-f162-a2b280000000

Core facility that provides the following services: PET/SPECT/CT image analysis.

Proper citation: Penn Small Animal Imaging Facility: PET/SPECT/CT Sub-Core (RRID:SCR_000890) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-3517-ac53-550e-f59280000000

Core facility that provides metals analytical capabilities to biomedical and non-biomedical researchers and serves as a source for study design consultation and sample QA/QC requirements. The transport, fate, exposure, and toxic effects of heavy metals is a primary focus of research at the Center. It operates as a modified fee-for-service laboratory. Researchers have the option of having the samples run by the Service staff, or of receiving instruction (for themselves or a doctoral or post doctoral trainee) on how to operate the analytical equipment and analyze their own samples. Both options have associated fees and, as with other services, facility access funds can be requested internal or external services when individual grant support is not yet available.

Proper citation: HSPH Trace Metals Laboratory (RRID:SCR_002819) Copy   

•   Source: SciCrunch Registry

http://biology.hunter.cuny.edu/index.php?option=com_content&view=article&id=138&Itemid=117

Facility which provides instruments and instrument resources for analyzing DNA, RNA, protein, and radio-labeled substances.

Proper citation: Hunter Genomic Facility (RRID:SCR_001983) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/specimen-bank-bwh-harvard

Core facility that provides the following services: Open repositories service, Sample processing service, Medical/pathology informatics support service, BWH tissue repository service.

The Specimen Bank provides materials to investigators with IRB-approved protocols. Staff are available to assist with selection of samples appropriate for downstream applications, development of processing protocols or preparation of derivatives from clinical materials. IT Staff are also available to assist researchers with creation of queries for prospective sample collection or queries to select samples from specific cohorts. Their goal is to drive quality research in an efficient and cost-effective manner. Each year they provide tens of thousands of samples to area researchers. Getting started: Partners investigators and study staff may request a Crimson user account to help manage studies and collected materials.

Proper citation: BWH Specimen Bank (RRID:SCR_012316) Copy   

•   Source: SciCrunch Registry

http://eagle-i.itmat.upenn.edu/i/0000013f-8b15-e20f-a468-831a80000000

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on May 22,2024.Core facility that provides the following services: Tissue culture suite access, Biological assay development for screening experiments, High-throughput-screening service, Post-screening studies. The Wistar Molecular Screening Facility is a shared resource facility open to Wistar and non-Wistar scientists. The laboratory operates on a fee-for-service basis, providing expertise in bridging automated technology with the development of innovative, robust biochemical or cell-based assays for high-throughput chemical and functional genomic screens. The laboratory strives to possess the flexibility to accommodate diverse biological systems and a variety of investigator-developed assay types. While service is the primary role of the laboratory, the staff will also develop and implement new technology as needed to fulfill the needs of its users. Education and training is also part of the laboratory''s mission, as trainees apply high-throughput screening experiments to their investigations. The ultimate goal of the laboratory is to enable scientists to apply cutting edge technology and unique resources to discover agents (i.e. small molecules, siRNA) to further study the functions of poorly understood proteins, signaling pathways, and cells in complex biological process relevant to human physiology and disease. The combinations of these activities will provide scientists opportunities to develop new innovative basic and translational research, preliminary data for hypothesis driven research grant applications, and public-private partnerships. The Wistar Molecular Screening Facility was developed with support from the Lankenau Institute for Medical Research, the Commonwealth of Pennsylvania Department of Community and Economic Development Keystone Innovation Zone initiative, The F. M. Kirby Foundation, The CLAWS Foundation, The Florence & Daniel Green Foundation, The McClean Contributionship, From The Heart Foundation, and the Noreen O?Neill Foundation for Melanoma Research.

Proper citation: Wistar Molecular Screening Facility (RRID:SCR_010208) Copy   

•   Source: SciCrunch Registry

http://eagle-i.itmat.upenn.edu/i/0000013f-8bde-1d59-a468-831a80000000

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on May 22,2024.Core facility that provides the following services: Recombinant plasmid DNA engineering, Recombinant protein production via Baculovirus expression systems (BVES), Recombinant protein production in prokaryotic systems, Recombinant protein purification, Retrovirus production service. The Protein Expression Facility is a shared resource laboratory that provides Wistar Cancer Center Members and non-Wistar scientists technical assistance with viral vector preparation and the expression and purification of recombinant proteins. The Facility has greater than 20 years of experience in recombinant protein expression with special expertise in the use of baculovirus expression systems (BVES). The Facility offers the following services: 1. Recombinant plasmid DNA engineering 2. Viral vector production (i.e. baculovirus and retrovirus) 3. Analytical and preparative scale expression of nascent or epitope-tagged recombinant proteins 4. Protein purification These goals are accomplished by a centralized laboratory with dedicated, experienced staff, which enables high-throughput, economy of scale, virus preparation and protein expression services, including quality assurance and control procedures to ensure efficient, consistent production and purification of recombinant proteins and viral vectors. Many recombinant proteins produced by the facility have been used for crystallization efforts, analytical biochemistry studies designed to investigate enzymatic properties, structure-function relationships between protein-protein, protein-nucleic-acid, and protein-small molecule interactions, custom antibody production, experimental cancer vaccines, and development of miniaturized assays for small molecule screening. The facility is supported in part by an NCI Cancer Center Support Grant and a grant from the NIH National Institute of Aging (PO1 AG031862).

Proper citation: Wistar Protein Expression Facility (RRID:SCR_010210) Copy   

•   Source: SciCrunch Registry

https://www.wistar.org/resources/proteomics-metabolomics-facility/

Core facility that provides the following services: In-gel protease digestion service, LC-MS/MS protein identification service, Gel/LC-MS/MS Comprehensive analysis of a subproteome or proteome, MudPIT (LC/LC-MS/MS) analyis?comprehensive analysis of a subproteome or proteome, Reverse phase microbore HPLC peptide mapping service, MALDI mass spectrometry, ESI of intact proteins, Post-translational modification identifications, Custom proteomics database creation, Custom proteomics data analysis, Proteomics methods development. The Wistar Proteomics Facility provides mass spectrometry (MS) and sequence analysis of proteins and peptides at maximum sensitivity using state-of-the-art instruments and methods. The most commonly used services are identifications of either purified proteins or complex protein mixtures, such as sub-proteomes or complete proteomes, using electrospray ionization tandem mass spectrometry (ESI MS/MS). Typically, either individual bands are excised from 1-D SDS gels, or the entire gel lane is analyzed by slicing it into uniform fractions followed by trypsin digestion and nanocapillary HPLC interfaced directly with hybrid ion trap mass spectrometry (Gel/LC-MS/MS). Data is analyzed and filtered to produce low false-positive rates. Several options are available for quantitatively comparing protein changes in related samples, and additional options will be implemented in the future. Complementary services include reverse-phase microbore HPLC peptide mapping with UV detection and mass measurements of intact peptides and proteins using MALDI MS or ESI MS. Posttranslational modification (PTM) analyses including identifications of specific modified residues also are provided, although investigators should recognize that in most cases these studies are quite complex and require substantial effort. These studies, as well as analyses of complex protein mixtures, usually require preparation of custom sequence databases and/or custom data analyses, which can be provided by the facility as needed.

Proper citation: Wistar Proteomics and Metabolomics Core Facility (RRID:SCR_010211) Copy   

•   Source: SciCrunch Registry

http://eagle-i.ea.vanderbilt.edu/i/00000138-e822-c8d3-dacb-da6080000000

Ascertainment for genetic studies is a crucial and labor-intensive effort. The Genetic Studies Ascertainment Core offers a variety of services to Vanderbilt clinical and basic researchers interested in or currently conducting research involving genetic analysis of complex disorders. We can aid in the development and coordination of individual and family based genetic studies. The faculty and staff have expertise in the issues that need to be considered when setting up a genetic study and are qualified to discuss with individuals issues that might be raised by participation in a genetic study. We can provide services for you or assist you in developing your own program. Study consultations are available to determine cost, time, and personnel needs as well as the best method of ascertainment for your project.

Proper citation: Vanderbilt Genetic Studies Ascertainment Core (RRID:SCR_010179) Copy   

•   Source: SciCrunch Registry

http://xula.eagle-i.net/i/00000135-585e-7c1a-77e4-a45080000000

Core facility that provides the following services: Animal husbandry. To provide the best husbandry and environment for housing, maintaining, and caring for research and laboratory animals used at Xavier University, with in all applicable guidelines, and to assist users by providing information and support for handling and care of animals.

Proper citation: XULA Animal Care Facility (RRID:SCR_010214) Copy   

•   Source: SciCrunch Registry

http://xula.eagle-i.net/i/00000134-f6b4-e33e-77e4-a45080000000

Core facility that provides the following services: Bioassays service, Functional studies service, Gene expression service, Molecular biology service, Mass spectrometry based global scale protein profiling, 2D Gel Electrophoresis, Data analysis services. The RCMI Cell and Molecular Biology Core (CMB Core) provides focused services using cell and molecular biological techniques. It also provides access, upkeep and training on ?state of the art? equipment. Funding by the RMCI allows these services to be offered at minimal cost to users of the core. Technical services and necessary consumable supplies are provided to support cancer research projects at Xavier University. The long term goal of the Cell and Molecular Biology Core is to enhance the overall biomedical research capabilities at Xavier University.

Proper citation: XULA RCMI Cell and Molecular Biology Core (RRID:SCR_010218) Copy   

•   Source: SciCrunch Registry

http://eagle-i.ea.vanderbilt.edu/i/00000138-7ba8-f7ee-480b-864680000000

VIIBRE''s Automated Biosystems Core (VIIBRE-ABC) provides a powerful technical foundation for the study of dynamic cellular metabolism, signaling, and control, with more than $4.7 million received from the Defense Threat Reduction Agency (DTRA), the National Institute on Drug Abuse (NIDA), the NIH Shared Instrumentation Program, and Vanderbilt University. An important focus of this effort is to explore dynamic host responses to chemical agents, toxins, and microbial pathogens. The ABC comprises two major instruments: a custom Omni-Omics system built around a Waters Synapt G2 UPLC/GC/ESI/nESI Ion Mobility-Mass Spectrometer, and a microfluidics-enabled high-content screening system built around a Perkin Elmer Opera QEHS Automated Confocal Microscopy System.

Proper citation: Vanderbilt Institute for Integrative Biosystems Research and Education Automated Biosystems Core Laboratory (RRID:SCR_010184) Copy   

•   Source: SciCrunch Registry

http://eagle-i.ea.vanderbilt.edu/i/00000138-7bb9-c509-480b-864680000000

Core facility that provides the following services: Photolithography Laboratory, Device Fabrication Laboratory, VIIBRE Machine Shop, VIIBRE Electronics Shop. The VIIBRE Microfabrication Core offers facilities and expertise for the design, manufacture, and implementation of micro- and small-scale electronic, mechanical and fluidic devices. Typical products include fluidic networks,pumps and valves, arrays of microfabricated traps for cellular study, implantable devices for in vivo imaging, liquid and gas control systems, biological habitats, environments and microbioreactors, and more.

Proper citation: Vanderbilt Institute for Integrative Biosystems Research and Education Microfabrication Core (RRID:SCR_010186) Copy   

•   Source: SciCrunch Registry

http://eagle-i.ea.vanderbilt.edu/i/00000139-10e5-048c-dacb-da6080000000

Our mission is to provide cost effective, state-of-the-art instrumentation to students, fellows and faculty for identification and structural analysis of biological molecules and for qualitative and quantitative assays of drugs and metabolites in physiologic fluids. Our aim is to provide a collegial and cooperative environment in which to do research.

Proper citation: Vanderbilt Mass Spectrometry Core Lab (RRID:SCR_010189) Copy   

•   Source: SciCrunch Registry

https://labnodes.vanderbilt.edu/community/profile/id/2230

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on October 30,2023. Core facility that supports diabetes, endocrine, and metabolic research across a range of species. Its objective is to provide sensitive, reproducible, and inexpensive analyses of hormones, amino acids, and other relevant chemicals.

Proper citation: Vanderbilt Diabetes Research and Training Center Hormone Assay and Analytical Services Core Facility (RRID:SCR_010181) Copy   

•   Source: SciCrunch Registry

http://eagle-i.ea.vanderbilt.edu/i/00000138-7be3-69fb-480b-864680000000

Vanderbilt Transgenic Mouse/Embryonic Stem Cell Shared Resource (TMESCSR) provides services that facilitate the generation, storage and regeneration of genetically altered mice.

Proper citation: Vanderbilt Transgenic Mouse/Embryonic Stem Cell Shared Resource (RRID:SCR_010200) Copy   

•   Source: SciCrunch Registry