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SciCrunch Registry is a curated repository of scientific resources, with a focus on biomedical resources, including tools, databases, and core facilities - visit SciCrunch to register your resource.
http://www.vetmed.lsu.edu/Summer_Scholars_Program.htm
The aim of the Summer Scholars Program is to provide veterinary medical students the opportunity to explore the world of biomedical research, develop and complete a biomedical research project during the summer. The intent is to engage students in a creative, problem-solving research activity and to provide a learning experience that will lead to the discovery of new knowledge in an area of their choosing and identify potential pathways to a career in biomedical research. Research plans will be developed by students with faculty mentor input, on any topic of interest to the student and likely to lead to the discovery of new information. Example topics are: immunology and infectious diseases, cancer biology, molecular epidemiology, experimental studies focused on nutrition and obesity, pharmacology, environmental toxicology, mechanisms of pathogenesis, zoonoses, biomechanics, cardiovascular pathophysiology, and others. The mentor and other advisors will provide guidance to students and an assessment of progress. Students will provide at completion of the study, an oral presentation of their results to their colleagues and all mentors and a presentation of results via posters at the annual Merial NIH National Veterinary Scholars Symposium, to be held in 2010 at the University of Georgia, and at the LSU Phi Zeta Research Emphasis Day. It is noteworthy that one Summer Scholar won an award at the 2008 LSU Phi Zeta Research Emphasis Day. LSU Students will receive elective credit in the curriculum (VMED 5010 or VMED 5463) for successful completion of the program. Students will be strongly encouraged to work with their mentors to publish their findings in peer-reviewed journals separately or as a smaller piece of work with their mentors. Sponsors: The program is funded by a Merial Foundation grant and an NIH T35 training grant.
Proper citation: Merial/NIH Veterinary Scholars Program (RRID:SCR_008301) Copy
Phenote is both a complete piece of software and a software toolkit designed to facilitate the annotation of biological phenotypes using ontologies. It provides an interface and infrastructure to record genotype-phenotype pairs, together with the provenance for the annotation. Typical users of Phenote include literature curators, laboratory researchers, and clinicians looking for a method to record data in a user-friendly and computable way. Features of Phenote include the use of any OBO-format ontology, ontology navigation and term information display, bulk sort, copy, edit, and delete of phenotype-genotype character entries, and a variety of export formats. Phenote is a project of the Berkeley Bioinformatics Open-Source Projects (BBOP).
Proper citation: Phenote: A Phenotype Annotation Tool using Ontologies (RRID:SCR_008334) Copy
http://med.stanford.edu/compmed/education/phd_training.html
THIS RESOURCE IS NO LONGER IN SERVICE, documented on January 27,2022.This program helps address the shortage of veterinarians who are trained for independent research. It supports veterinarians during the first 3 years of their PhD training. Trainees can participate in any graduate program involved in biomedical research at Stanford University: Biochemistry, Biological Sciences, Biophysics, Cancer Biology, Developmental Biology, Genetics, Immunology, Microbiology & Immunology, Molecular & Cellular Physiology, Molecular Pharmacology, Neurosciences, Structural Biology, Bioengineering, and Biomedical Informatics (graduate programs in biomedical research). All share common features: :1. Year 1 focuses on a limited group of courses and laboratory rotations. :2. Subsequent years focus on developing critical thinking via seminars and journal clubs and on independent research. :3. Annual retreats to present and learn about ongoing research in the graduate program. :4. Emphasis on mastering communications skills essential for success in science: oral presentation, writing manuscripts and grant proposals. :5. Developing an appreciation of the role of scientists in the context of society with emphasis on ethical and professional responsibility. Sponsors: It is funded by a T32 training grant from the NIH.
Proper citation: Postdoctoral Program for Veterinarians (RRID:SCR_008296) Copy
http://dsarm.niapublications.org/
THIS RESOURCE IS NO LONGER IN SERVICE, documented on February 18, 2014.
A networking site for investigators using animal models to study aging, developed to provide a venue for sharing information about research models for aging studies. If you have tissue or data from animal models relevant to aging research that you are willing to share with other investigators, D-SARM allows you to identify the model and provides a secure, blinded email contact for investigators who would like to contact you about acquiring tissue or related resources. Investigators looking for resources from a particular model enter search terms describing the model of interest and then use the provided link to send emails to the contacts (names blinded) listed in the search results to initiate dialog about tissue or resources available for sharing. The database is housed on a secure server and admission to the network is moderated by the NIA Project Officer and limited to investigators at academic, government and non-profit research institutions. The goal is to provide a secure environment for sharing information about models used in aging research, promoting the sharing of resources, facilitating new research on aging in model systems, and increasing the return on the investment in research models.
Proper citation: Database for Sharing Aging Research Models (RRID:SCR_008691) Copy
The BioCurrents Research Center (BRC) is an integrated technology resource of the NIH:NCRR. The activities of the Center focus on molecular physiology as it relates to the cell function and disease. Our particular interest is how the dynamics of cell responses are reflected in the chemical profiles of microdomains surrounding single living cells. In order to measure complex cellular boundary layers, the BRC has specialized in the development of extremely sensitive signal acquisition and processing methods along with miniaturized electrochemical sensor designs. The technique is non-invasive and termed self-referencing. Since its establishment in 1996, the BRC has directed its technological research and development to the design and application of ultra-microelectrodes (tip diameters of less than 10m) tailored for the detection of specific chemicals. These have been successfully applied to the boundary layer profiles of many different cell types, with thematic strength in diabetes research, reproductive health and development (see collaborative profiles). More recently, it is changing its focus to technical developments, enhancing the integrative approach to cell function. To understand a cell as a dynamic and integrated whole, BRC must be able to examine responses from different domains as near to real time and as synchronously as possible. To this end, it is developing imaging capabilities to work in parallel with electrochemistry and conventional electrophysiological techniques. Imaging includes a spinning disc confocal, as well as a low light/luminescent imager designed and built within the BRC. The technologies developed or under development are in high demand within the biomedical community. Over 40 investigators work with the Center each year in a collaborative or service capacity. Over 80 of our visitor pool is NIH funded, representing approximately 25 NIH divisions and institutes. As part of our training and dissemination program we host occasional workshops at major national and international meetings, train a significant number of new investigators each year and host graduate students undertaking portions of their thesis dissertation using our technologies. In dissemination we advise on, and install, electrochemical systems in off campus research endeavors, both academic and industrial.
Proper citation: BioCurrents Research Center (RRID:SCR_002020) Copy
http://www.adinstruments.com/products/software/modules/neuro_explorer.php
THIS RESOURCE IS NO LONGER IN SERVICE, documented on May 19, 2018; A provider of computer-based data acquisition and analysis systems for life science. Products enable users to record and analyze life science data quickly and efficiently. ADInstruments product range is based on the PowerLab data acquisition system with LabChart software. The PowerLab system (also MacLab) is used in universities, hospitals, research institutes, pharmaceutical companies, contract research organizations and other private industry research sectors.
Proper citation: ADInstruments - Data Acquisition Systems for Life Science (RRID:SCR_001620) Copy
http://www.immundiagnostik.com
Commercial company that develops and provides laboratory diagnostics and other medical research products.
Proper citation: Immundiagnostik (RRID:SCR_001977) Copy
http://aws.amazon.com/1000genomes/
A dataset containing the full genomic sequence of 1,700 individuals, freely available for research use. The 1000 Genomes Project is an international research effort coordinated by a consortium of 75 companies and organizations to establish the most detailed catalogue of human genetic variation. The project has grown to 200 terabytes of genomic data including DNA sequenced from more than 1,700 individuals that researchers can now access on AWS for use in disease research free of charge. The dataset containing the full genomic sequence of 1,700 individuals is now available to all via Amazon S3. The data can be found at: http://s3.amazonaws.com/1000genomes The 1000 Genomes Project aims to include the genomes of more than 2,662 individuals from 26 populations around the world, and the NIH will continue to add the remaining genome samples to the data collection this year. Public Data Sets on AWS provide a centralized repository of public data hosted on Amazon Simple Storage Service (Amazon S3). The data can be seamlessly accessed from AWS services such Amazon Elastic Compute Cloud (Amazon EC2) and Amazon Elastic MapReduce (Amazon EMR), which provide organizations with the highly scalable compute resources needed to take advantage of these large data collections. AWS is storing the public data sets at no charge to the community. Researchers pay only for the additional AWS resources they need for further processing or analysis of the data. All 200 TB of the latest 1000 Genomes Project data is available in a publicly available Amazon S3 bucket. You can access the data via simple HTTP requests, or take advantage of the AWS SDKs in languages such as Ruby, Java, Python, .NET and PHP. Researchers can use the Amazon EC2 utility computing service to dive into this data without the usual capital investment required to work with data at this scale. AWS also provides a number of orchestration and automation services to help teams make their research available to others to remix and reuse. Making the data available via a bucket in Amazon S3 also means that customers can crunch the information using Hadoop via Amazon Elastic MapReduce, and take advantage of the growing collection of tools for running bioinformatics job flows, such as CloudBurst and Crossbow.
Proper citation: 1000 Genomes Project and AWS (RRID:SCR_008801) Copy
http://www.nitrc.org/projects/bstp/
A free collection of MRI brain images for testing segmentation algorithms. It is available for download to assess the accuracy, reproducibility and sensitivity of MRI segmentation software. It includes data from infants and adults as well as patients with Alzheimer's disease.
Proper citation: Brain Segmentation Testing Protocol (RRID:SCR_009445) Copy
http://www.rand.org/labor/FLS/MHSS.html
A data set of the health and socioeconomic factors that affect the elderly in Matlab, a region of rural Bangladesh. The survey captures measurements and statistics such as adult survival, health status, health care utilization, resource flows between generations and the impact of community services and infrastructure on adult health care. Data was collected through surveys that touch on four topics: household and individual information; determinants of natural fertility; migration out of the community; and community and provider survey of healthcare and education infrastructure.
Proper citation: Matlab Health and Socio-Economic Survey (RRID:SCR_008942) Copy
Membership supported, nonprofit organization established dedicated to improving the lives of persons affected by ataxia through support, education, and research. The Foundation's primary purpose is to support promising ataxia research and to provide vital programs and services for ataxia families. The Foundation first began direct funding of ataxia research through the NAF Research Seed-Money Program. Since that time, the Foundation has established additional research programs which have included programs such as the NAF Young Investigator Award, the NAF Fellowship Award and other research initiatives. NAF research programs continue to fund promising ataxia research studies throughout the world. The Foundation supports research in dominant ataxia (including SCAs), recessive ataxia (including Friedreich's) and sporadic ataxia. The Foundation has developed an extensive library of NAF brochures, fact sheets, books, and videos on ataxia. Also available to its members is the Foundation's quarterly news publication, Generations. This 48 page ataxia news magazine provides the latest information on ataxia research, articles on living with ataxia, personal accounts from ataxia families throughout the United States, and much more.
Proper citation: National Ataxia Foundation (RRID:SCR_002933) Copy
http://rana.lbl.gov/drosophila
A single source for sequences, assemblies, annotations and analyses of the genomes of members of the fruitfly genus Drosophlia. It is meant as resource for Drosophilists and other researchers interested in comparative analysis of these species and their genomes. There are pages for each species, as well as pages for different types of multi-species resources (e.g. alignments). If you have a public resource that will help this project, please consider making it available through this page by emailing multiple_at_fruitfly.org.
Proper citation: Assembly/Alignment/Annotation of 12 Related Drosophila Species (RRID:SCR_002921) Copy
http://proteininformationresource.org/
Integrated public bioinformatics resource to support genomic, proteomic and systems biology research and scientific studies. Provides databases and protein sequence analysis tools to scientific community, including Protein Sequence Database which grew out from the Atlas of Protein Sequence and Structure. Conducts research in biomedical text mining and ontology, computational systems biology, and bioinformatics cyberinfrastructure. In 2002 PIR, along with its international partners, EBI (European Bioinformatics Institute) and SIB (Swiss Institute of Bioinformatics), were awarded a grant from NIH to create UniProt, a single worldwide database of protein sequence and function, by unifying the PIR-PSD, Swiss-Prot, and TrEMBL databases. Currently, PIR major activities include: i) UniProt (Universal Protein Resource) development, ii) iProClass protein data integration and ID mapping, iii) PRO protein ontology, and iv) iProLINK protein literature mining and ontology development. The FTP site provides free download for iProClass, PIRSF, and PRO.
Proper citation: Protein Information Resource (RRID:SCR_002837) Copy
http://www.fda.gov/nctr/science/centers/toxicoinformatics/maqc/
The National Center for Toxicological Research (NCTR), FDA's internationally recognized research center, plays a critical role in FDA's mission. The unique scientific expertise of NCTR is critical in supporting FDA product centers and their regulatory roles. The NCTR is an important research component of the FDA that plays a critical role in the missions of FDA and DHHS to promote and protect public health. * NCTRin partnership with researchers from government, academia, and industrydevelops, refines, and applies current and emerging technologies to improve safety evaluations of FDA-regulated products. * NCTR fosters national and international collaborations to improve and protect public health and enhance the quality of life for the American people. Through the training of scientists from around the world, as well as FDA staff, NCTR researchers spread the principles of regulatory science globally. * NCTR conducts FDA research with the goal to develop a scientifically sound basis for regulatory decisions and reduce risks associated with FDA-regulated products. NCTR represents the FDA on key committees of the National Toxicology Program (NTP), a program that evaluates the effects of chemicals on health. Over the past 30 years, the NTP and NCTR have conducted studies on FDA-nominated compounds, providing data to support science-based regulatory decisions.
Proper citation: National Center for Toxicological Research (RRID:SCR_002943) Copy
The mission of Pathway Genomics is to empower you with the most secure, comprehensive and affordable personal genomic information available and to become your partner in utilizing that information to improve your health and wellness. Pathway is the only DNA testing service with an on-site federal and state CLIA-licensed laboratory. This means it offers: - Better Science: Its certified geneticists are on-staff and on-site in our own state-of-the-art laboratory in California. Their 10,600 square foot, high-complexity CLIA licensed lab facility is equipped with the latest high-throughput robotics and Affymetrix, Illumina and Sequenom genotyping equipment. As scientists committed to staying on the cutting-edge, they diligently monitor all new developments in the rapidly evolving DNA research field allowing us to provide you immediate access to more meaningful markers than any other DNA testing firm. - Better Security: Because Pathway Genomics has its own laboratory, your DNA never leaves the building, and is never shared with third parties. At Pathway Genomics the integrity of your genetic material and information are protected. Instead, enjoy the security of our proprietary DNA Lockbox. Everyone has the right to know the secrets hidden within their own DNA. That's why Pathway has created the most secure, comprehensive and affordable way to unlock those secrets. This way you can: - Identify genetic health and drug response - Personalize your medical care - Help your doctor help you - Uncover your ancestral path - Explore the traits that make you unique With Personal DNA Testing, you can take preventative steps to improve your future, and even extend your life. Pathway Genomics provides cutting-edge research and easy-to-read scientific information customized for you, and you alone, based on your genes and your lifestyle. For the first time in human history, modern science has made it possible for you to learn your genetic predisposition for more than 90 diseases and conditions, drug responses and pre-pregnancy carrier status. With this powerful knowledge and our easy-to-understand guidance, you can modify your health regime so that you may live a healthier, longer life. DNA testing will discover more about your personal heritage than you ever thought possible. We uncover your deep ancestry by taking giant leaps into the past, going back more than 10,000 years. We test both your mitochondrial DNA, which is passed down from mother to child and reveals your direct maternal ancestry; and your Y chromosome (males only), which is passed down from father to son and reveals your direct paternal ancestry. If you're like most people, you've always wondered about the genes you have inherited and what traits you will pass on to future generations. Discover your genetically inherited predispositions and characteristics and whether they are beneficial or potentially harmful. You may also find that some traits are simply fun to uncover.
Proper citation: Pathway Genomics (RRID:SCR_002883) Copy
http://www.cephalopod.org/DBMR.cfm
THIS RESOURCE IS NO LONGER IN SERVICE, documented on July 17, 2013. The center serves the biomedical research community's increased needs for alternative invertebrate models by maintaining a consistent year-round supply of live cephalopod mollusks. These animals are suitable for a wide range of physiological and molecular biological investigations. Investigations are being conducted in the area of life history related to improved animal husbandry. Further studies focus on improving culture system design through development of computer automation and innovative water filtration technology. Current biomedical research on cephalopods includes neurophysiology of the giant axon; anatomy and neurophysiology of the equilibrium receptor organ as a comparative model of the vestibular system of invertebrates; chemoreception, basic nutrition, and protein metabolism; cellular receptor function; and brain, behavior, and learning. Services Provided: The center has built a computer-automated, environmentally controlled, recirculating seawater laboratory for the purpose of culturing cephalopods. The tank systems can be used to conduct a variety of experiments never before possible with cephalopods. Visiting researchers have access to dedicated facilities, including wet and dry laboratory space, office space, computer support and accommodations, as well as priority access to all available live animal resources. Off-site investigators can have live animals, dissected animal tissues/body fluids from all life stages, and a variety of molecular reagents (gene libraries and clones) delivered year-round. Staff expertise and an extensive literature library are available. All life stages of the squid (Sepioteuthis lessoniana) and the common cuttlefish (Sepia officinalis) are available year-round from laboratory culture populations. The sepiolid squid (Euprymna scolopes) can also be cultured on request. The squid Lolliguncula brevis is available year-round from local waters; the squids Loligo opalescens, L. pealeii, and L. plei can be obtained seasonally on request. The chambered nautilus, Nautilus pompilius, and Octopus bimaculoides are available on request. Animal costs vary by species and size. Any tissue or body fluid from these animals can also be provided. Fees for special services are negotiated on a case-by-case basis.
Proper citation: National Resource Center for Cephalopods (RRID:SCR_002864) Copy
http://celeganskoconsortium.omrf.org
THIS RESOURCE IS NO LONGER IN SERVCE, documented September 2, 2016. The mission of the C. elegans Gene Knockout Consortium is to facilitate genetic research of this important model system through the production of deletion alleles at specified gene targets. We choose targets based on investigator requests. Strains produced by the consortium are freely available with no restrictions to any investigator. At one time, our capacity dictated that we restrict requests to five per lab. This restriction no longer holds. Investigators are encouraged especially to register requests for functionally related groups of genes. Consortium strains are distributed by the C. elegans Genetic Center (CGC). In most cases, when you use the Consortium web site to request an existing allele, your request is forwarded automatically to the CGC. However, if you indicate that an existing allele is not satisfactory for your research, (for whatever reason), you may request that we generate another allele for the same target. Any information generated by the Consortium is entered into the official C. elegans data repository, WormBase.
Proper citation: C. elegans Gene Knockout Consortium (RRID:SCR_003000) Copy
Non-profit biomedical research organization developing predictors of disease and accelerating health research through creation of open systems, incentives, and standards. Formed to coordinate and link academic and commercial biomedical researchers through Commons that represents new paradigm for genomics intellectual property, researcher cooperation, and contributor evolved resources.
Proper citation: Sage Bionetworks (RRID:SCR_003384) Copy
A web portal that aggregates information and educational materials about the brain and brain diseases. Resources such as videos, key brain concepts, and hands-on activities may be used and shared with the public.
Proper citation: brainfacts.org (RRID:SCR_003514) Copy
http://clinicalinformatics.stanford.edu/projects/cdw.html
Research and development project at Stanford University to create a standards-based informatics platform supporting clinical and translational research. STRIDE consists of three integrated components: a clinical data warehouse, based on the HL7 Reference Information Model (RIM), containing clinical information on over 1.6 million pediatric and adult patients cared for at Stanford University Medical Center since 1995; an application development framework for building research data management applications on the STRIDE platform and a biospecimen data management system. STRIDE's semantic model uses standardized terminologies, such as SNOMED, RxNorm, ICD and CPT, to represent important biomedical concepts and their relationships. STRIDE receives clinical data for research use via HL7 feeds from both SUMC hospitals: Lucile Packard Children's Hospital and Stanford Hospital and Clinics. This clinical data is used to support a wide variety of translational research services including: * Anonymized Patient Research Cohort Discovery * Electronic Chart Review for Research * IRB-Approved Clinical Data Extraction * Biospecimen Data Management * Multimedia Research * Data Management and Research Registries STRIDE is a highly secure environment utilizing encryption, fine-grained access control, robust auditing and detailed data segregation. Additionally, STRIDE has a robust access control framework with well-defined access granting authorities and access control groups. Consequently STRIDE meets or exceeds the requirements of the HIPAA Privacy and Security regulations. Privacy protection is further enhanced by requiring IRB approval for all research projects using STRIDE clinical data. From a technology and standards perspective, STRIDE is hosted on the Oracle 11g database platform. STRIDE application software provides access to the web services of a three-tier infrastructures using SSL encryption with strong authentication. These programs are cross-platform, self-updating thick-client applications that provides a rich user interface for data entry, retrieval and review as well as image manipulation and annotation. STRIDE makes extensive use of XML technologies for representation of structured meta data, distributed systems technologies using JSON for secure remote communication between client and server, and Swing graphical interface components providing a rich widget-set as well as advanced imaging and graphing capabilities. Users of the STRIDE Research Desktop Client can perform rapid data entry into structured fields, compose complex queries, and interact securely with clinical, research and imaging data.
Proper citation: Stanford Translational Research Integrated Database Environment and Clinical Data Warehouse (RRID:SCR_003453) Copy
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