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SciCrunch Registry is a curated repository of scientific resources, with a focus on biomedical resources, including tools, databases, and core facilities - visit SciCrunch to register your resource.
http://www.med.upenn.edu/gtp/vectorcore/
THIS RESOURCE IS NO LONGER IN SERVICE. Documented on October 30,2023. Core whose main aim is to provide vector technology for preclinical studies and other basic research applications. Its services include rovision of AAV, adenoviral and lentiviral based vectors, consultation and advice in the design of custom vectors and in vector serotype/pseudotype selection, and design, cloning and production of plasmid DNA for the production of custom vectors.
Proper citation: University of Pennsylvania Center for Molecular Therapy for Cystic Fibrosis Vector Core Facility (RRID:SCR_010038) Copy
http://ohsu.eagle-i.net/i/0000012a-24ff-c95f-d994-629180000000
THIS RESOURCE IS NO LONGER IN SERVICE. Documented on December 6,2022. Core facility that provides the following services: Flow cytometry training service, Cell sorting service, Specialized flow cytometric assays. The mission of the Immunology Support Core (ISC) is to develop and provide a wide range of state-of-the-art services, assays, and training in support of NIH-sponsored immunology research involving nonhuman primates (NHP).
Proper citation: OHSU Immunology Support Core Flow Cytometry Unit (RRID:SCR_009981) Copy
http://eagle-i.itmat.upenn.edu/i/00000142-345f-30d3-91c7-0c6080000000
The CTRC Sleep Core provides services in support of clinical sleep research. It is based at two sites: the CHOP Sleep Laboratory, convenient to the CTRC Outpatient Facility on the 7th Floor of Main Hospital and the University of Pennsylvania?s Sleep Laboratory, located on the 11th Floor of the Gates Building which is part of the medical complex of the Hospital of the University of Pennsylvania. The Sleep Core contains a total of six designated research beds, dedicated staff, and state-of-the-art equipment that provides support for a variety of sleep-related research initiatives. Studies performed in the Sleep Core include overnight polysomnography, multiple sleep latency testing, neurobehavioral testing and actigraphy. The Sleep Core��s goals include providing highest-quality sleep studies, extending sleep research to disciplines not traditionally involved in this area, further developing extant multidisciplinary programs, and offering training opportunities for medical students, residents, fellows, and junior faculty in clinical sleep research. The Sleep Core is associated with CHOP?s and UPHS? American Academy of Sleep Medicine-accredited Sleep Center Laboratories. Services for pediatric and adult subjects: * Study Design * Overnight Polysomnography ** Polysomnography Interpretation * Multiple Sleep Latency Testing * Actigraphy * Neurobehavioral testing * Sleep Core Library
Proper citation: Penn/CHOP CTRC Sleep Core (RRID:SCR_010041) Copy
http://upr.eagle-i.net/i/0000012b-00c0-7187-9e37-5ded80000000
Patient Coordinator Services is responsible for scheduling the subjects for the research-related appointments; her goal is to facilitate the participation of the subjects in the clinical studies in collaboration with the research staff and the investigators.
Proper citation: Puerto Rico Clinical and Translational Research Consortium Patients Coordinator Services (RRID:SCR_010045) Copy
http://eagle-i.itmat.upenn.edu/i/00000138-7c65-0571-fbab-3b8480000000
Core facility that provides the following services: Microscope access service, Imaging experimental design consultation service, Confocal microscopy service, Microscopy training service, Scanning electron microscopy sample preparation service, Sputter coating access service, Scanning electron microscope access service. The Cell & Developmental Biology (CDB) Microscopy Core is a full-service facility serving the entire University of Pennsylvania community. Our aim is to provide personalized assistance on all aspects of imaging, from tips on sample preparation to training on one of our microscopes to processing and analysis of image data. Our facility currently houses five confocal and three widefield light microscopes, a scanning electron microscope, and several computers dedicated to image processing and analysis.
Proper citation: Penn Cell and Developmental Biology Microscopy Core (RRID:SCR_010004) Copy
http://eagle-i.itmat.upenn.edu/i/00000138-9a9a-cba0-9cd7-d7e280000000
Core facility that provides the following services: NMR spectrometer access, NMR spectrometer training, NMR spectroscopy service, Consultation service for NMR experimental design. Penn Chemistry NMR Facility provides researchers in the Chemistry and Materials Science and Engineering department access to state-of-the-art instrumentation for high resolution NMR spectroscopy. The Facility provides users extensive training to use spectrometers without supervision and expert advice/consultation on advanced applications of NMR spectroscopy to solve research problems. At present, the Facility operates ten high resolution NMR spectrometers (300-600 MHz) of varying capabilities located in the Chemistry building at the corner of 34th and Spruce street, Philadelphia, PA. Penn Chemistry NMR Facility provides limited solution NMR services (data acquisition and spectrum/structure analysis) to other departments/centers of University of Pennsylvania based on hourly charges. However, these services will be limited to the availability of instrument time and personnel. NMR Facility accepts service samples from outside academic and industrial customers based on per hour charges.
Proper citation: Penn Chemistry NMR Facility (RRID:SCR_010005) Copy
http://eagle-i.itmat.upenn.edu/i/00000138-7ce8-c10b-fbab-3b8480000000
THIS RESOURCE IS NO LONGER IN SERVICE. Documented on June 1,2023. Core facility that provides the following services: Flow cytometry analysis service, Cell sorting and analysis service, Flow cytometer analyzer access, Introductory flow cytometry training, Advanced and customized flow cytometry training, Flow cytometry consultation service, FACSAria training, Flow cytometry data analysis, BSL2+ biohazardous human cell sorting, BSL2+ murine biohazardous cell sorting, BSL2+ murine cell sorting access, Non-infectious cell sorting access. The Flow Cytometry and Cell Sorting Resource Laboratory is currently recognized as one of the largest and most comprehensive flow cytometry laboratories in the US. In 2010 it was designated a laboratory of exceptional merit by the National Cancer Institute. Using state-of-the-art technology, the resource provides a broad array of, instrumentation, support, education and consultation to the research community at the University of Pennsylvania. A wide variety of cell sorting applications are supported, from high-speed multicolor (up to 14 colors) cell sorting to low-speed, large nozzle, improved viability sorting. Additionally, a wide variety of cell analysis services (up to 20 parameters) are offered, from traditional analog, easier to use tabletop analyzers to many-laser, many-color, high-speed, fully-digital modern instrumentation. Currently the facility offers 6 cell sorters and 19 analytical instruments. A very active training and consultation program is in place to support these activities. The Scientific Director, Dr. Jonni Moore, and the Technical Director, each have over 25 years experience in the field of cytomics. Researchers at the University of Pennsylvania are increasingly engaged in research projects that require 8-plus-parameter cell sorting of infectious cells and primary human tissues. Investigators using the Flow Cytometry and Cell Sorting Shared Resource have access to virtually any type of cytometric services required for a vast array of applications.
Proper citation: Penn Flow Cytometry and Cell Sorting Resource Laboratory (RRID:SCR_010011) Copy
http://eagle-i.itmat.upenn.edu/i/00000138-9b39-142c-9cd7-d7e280000000
Core facility that provides the following services: Investigational drug services, Clinical trial support services. The IDS is charged with safe and responsible handling of investigational drugs. The purpose of the IDS is to maintain control and accountability of investigational drug use in the Medical Center to promote maximum benefit and safety for patients enrolled in studies. Investigational drugs are procured, stored, inventoried, dispensed and used through the IDS in compliance with regulations or guidelines of the FDA, JCAHO, ASHP, Code of Federal Regulations, Pennsylvania State Board of Pharmacy, other applicable organizations and in accordance with Hospital, Medical Center and University policies and guidelines.
Proper citation: Penn Investigational Drug Service (RRID:SCR_010012) Copy
http://eagle-i.itmat.upenn.edu/i/00000138-ba32-e90b-9cd7-d7e280000000
Core facility that provides the following services: Illumina sequencing service, 5500xl sequencing service. The recent boon in high-throughput sequencing technologies has offered enormous potential to applications in genome sequencing, transcriptome profiling, epigenetics, metagenomics, discovery of non-coding RNAs and protein binding sites. A primary mission of PGFI is to lead the development of new genomics technologies at the University of Pennsylvania. In response to the ever growing demand for high-throughput sequencing at Penn, PGFI?s HTS facility was established. In this facility, investigators have access to different types of HTS technology: Illumina?s HiSeq and Applied Biosystem?s SOLiD4 and 5500xl. With two HiSeqs, the facility can provide the latest innovation from Illumina featuring up to 3 billion paired-end reads (up to 100x100 bp reads) per flow cell, 8 lanes per flow cell and 2 flow cells per machine. With the SOLiD4, the facility can provide up to 1.4 billion reads per slide, 50 x 25 bp paired-end reads, up to 8 sectors per slide and 2 flow cells per machine. With the 5500xl, the facility can provide up to 180 Gb or more than 2.8 B reads per run. The 5500xl offers 75 bp fragment runs, 75x35 bp paired-end runs and up to 60 bp x 60 bp mate paired runs with the added bonus of pay-as-you-go sequencing. All platforms offer multiplexing capability. Currently Illumina offers 48 barcodes and Life Technologies offers 96 barcodes. The SOLiD 4 system provides greater than 99.94% accuracy due to 2-base encoding. The 5500xl offers up to 99.99% accuracy utilizing 2-base encoding and Exact Call Chemistry.
Proper citation: Penn High-Throughput Sequencing Facility (RRID:SCR_010015) Copy
http://eagle-i.itmat.upenn.edu/i/00000138-e7cd-3f54-eb5b-b63c80000000
Core facility that provides the following services: Immunohistochemistry (IHC) staining service, Tissue processing and sectioning service, Staining service. The Histology and Gene Expression Core Facility provides expert professional services for members of the Cardiovascular Institute. Services for non- Institute investigators are available on a fee-for-service basis as time permits. The Histology and Gene Expression Core offers all histology-related services include tissue processing, embedding, sectioning, staining, immunocytochemistry and InSitu Hybridization.
Proper citation: Penn Histology and Gene Expression Core (RRID:SCR_010017) Copy
http://eagle-i.itmat.upenn.edu/i/00000138-ba97-298d-9cd7-d7e280000000
Core facility that provides the following services: ELISA AND ELISpot assays, Multi-color flow cytometry immunophenotyping and proliferation assays, Luminex multiplex and Cytometric Bead immunological assays, Peripheral blood mononuclear cell isolation, Intraepithelial lymphocyte isolation from intestinal biopsy, Cryopreservation, Immunological assay training. The Human Immunology Core will provide expertise and instrumentation for the analysis of immune function in patients during treatment with anticancer drugs and immunotherapy. The Core will serve as a central facility for incorporating the newest technologies and performing validated immunology assays for phase I/II clinical studies, while also offering expert scientific and technical consultations to users interested in conducting this kind of innovative research.
Proper citation: Penn Human Immunology Core (RRID:SCR_010018) Copy
http://eagle-i.itmat.upenn.edu/i/00000139-5064-ad11-4778-6c3080000000
Core facility that provides the following services: Mass spectrometer access. The Mass Spectrometry Facility is part of the Shared Instrument Facilities of the Department of Chemistry. It provides low and high resolution mass spectra to Penn Chemistry and to other research groups throughout the university community for the determination of elemental composition and purity of a wide variety of compounds. Investigators interested in using the facility are encouraged to call and discuss their project. Usage fees will be quoted at this time. Fees depend upon the instrument involved in the analysis, complexity of the project, training, etc.
Proper citation: Penn Mass Spectrometry Facility (RRID:SCR_010021) Copy
https://www.bioinformatics.upenn.edu/
Core facility that provides the following services: Desktop sequence analysis tools subscription, Database and web applications support, Genomic-scale sequencing analysis, Sequence analysis application support, Transcript profiling consultation service, Transcript profiling application support, Transcript profiling data analysis, Automating large or repetitive tasks, Web space for biological databases, Bioinformatics/genomics resource identification, and Data storage. The bioinformatics staff of the Penn Molecular Profiling Facility is available to provide experimental design and analytical services to users of the Facility and the basic and biomedical research community. Additional services are provided, including grant support, data management and custom computational projects. This facility provides one-on-one training and hosts instructional workshops. Their goal is to ensure that scientists across the University are able to exploit existing and emerging computational technologies, especially related to their genomics scale datasets.
Proper citation: University of Pennsylvania Molecular Profiling Facility Bioinformatics (RRID:SCR_010022) Copy
http://eagle-i.itmat.upenn.edu/i/0000013c-48fd-355f-f162-a2b280000000
The Histology and Cellular Localization Core provides training and research support in microscopy, anatomy and histology of chemosensory systems. Core personnel work with Monell researchers to develop and optimize in-house procedures and to establish cutting-edge techniques in histology and cell anatomy. The Core provides centralized services such as tissue sectioning and in situ probe preparation. The Core facility is equipped with cryostats, fluorescence microscopes, confocal microscopes, and a two-photon microscope.
Proper citation: Monell Histology and Cellular Localization Core (RRID:SCR_009958) Copy
http://eagle-i.itmat.upenn.edu/i/0000013c-48fe-e044-f162-a2b280000000
The Chemosensory Receptor Signaling Core will provide training, advice and research support in molecular biological techniques used to analyze gene expression in cell culture and manipulate the genomes of rodent model organisms. The Core will centralize labor-intensive construct generation common to multiple users and provide users with technical expertise in molecular biological manipulations both in vitro and in vivo. The Core facility has all equipment, reagents, and expertise needed to carry out the following manipulations of RNA, DNA, and protein: RNA isolation, cDNA production, antisense RNA amplification, cloning, subcloning, recombineering, gel electrophoresis, transfection and tissue culture.
Proper citation: Monell Chemosensory Receptor Signaling Core (RRID:SCR_009956) Copy
http://eagle-i.itmat.upenn.edu/i/00000138-7c77-053b-fbab-3b8480000000
Core facility that provides the following services: Tissue processing and paraffin embedding, Cell processing and paraffin embedding, Cryosectioning service, Paraffin-embedded sectioning, Hematoxylin and eosin staining, Immuno-staining (IHC) of tissue sections, Histological staining service. The Cancer Histology Core is a non-profit, research-oriented resource core supported by the Abramson Cancer Center. It offers all histology-related services to all members of the Abramson Cancer Center with high quality, low cost, fast turnout, and easy interaction. Service will be open to all life sciences investigators at Penn, but priority will be given to full members of the Abramson Cancer Center.
Proper citation: Penn Cancer Histology Core (RRID:SCR_010001) Copy
http://eagle-i.itmat.upenn.edu/i/00000138-7bcc-1f66-fbab-3b8480000000
Core facility that provides the following services: Antibody screening by ELISA, Cell Culture Training, Production and Purification of Antibodies from Hybridoma Lines, Endotoxin Testing, EBV Transformation, Special media production, Liquid N2 storage, Freezing Cells. Cell Center Services Facility is the service component of the Cell Center, provides training and services in various cell culture and associated procedures including Mycoplasma and Endotoxin testing. The cell culture service includes cell culture at various scales, large scale growth of hybridoma and other cell lines followed by antibody purification by protein G column and the generation of lymphoblastoid cell lines by EBV induced transformation of lymphocytes. In addition, the facility prepares specialized cell culture media, drosophila media, and various molecular biological reagents. Recently cell transfection and selection service has been introduced at the facility.
Proper citation: Penn Cell Center Services Facility (RRID:SCR_010002) Copy
http://eagle-i.ea.vanderbilt.edu/i/00000138-7bdf-33f8-480b-864680000000
This core has several components. The DNA bank receives specimens from various studies, extracts DNA, and provides storage. Quality control, organization, and efficiency are critical. Genotyping services provide the necessary speed, efficiency, and accuracy to perform genomic screens (with standard markers) in as little time as possible.
Proper citation: Vanderbilt DNA Resources Core (RRID:SCR_010176) Copy
http://eagle-i.ea.vanderbilt.edu/i/00000139-c63d-d3da-b341-4bb480000000
The purpose of the Vanderbilt Clinical Research Center is to provide the resources needed by clinical and translational investigators to carry out their research in an environment optimized for safety, comfort and convenience of the patient or volunteer, with the facilities and expertise to provide the most advantageous milieu in which to address the investigator''s experimental requirements. This includes outpatient space, inpatient beds, laboratories, equipment and supplies for clinical research by the faculty of Vanderbilt University, Meharry Medical College, and their collaborating investigators. The use of the center is justified on the basis of the quality and significance of the research and the special need for the Center''s facilities.
Proper citation: Vanderbilt Clinical Research Center (RRID:SCR_010170) Copy
http://hawaii.eagle-i.net/i/0000012f-4c48-855d-12ab-077c80000000
Laboratory Support supplies support services for laboratory-based programs at the University of Hawai?i Cancer Center. This resource is operated in order to streamline and make more centralized common laboratory needs.
Proper citation: UH Manoa Laboratory Support Shared Resources (RRID:SCR_010101) Copy
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