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Resource Name Proper Citation Abbreviations Resource Type Description Keywords Resource Relationships Related Condition Funding Defining Citation Availability Website Status Alternate IDs Alternate URLs Old URLs Parent Organization Resource ID Synonyms Record Last Update Mentions Count
Penn Diabetes Research Center Mouse Phenotyping Physiology and Metabolism Core
 
Resource Report
Resource Website
Penn Diabetes Research Center Mouse Phenotyping Physiology and Metabolism Core (RRID:SCR_000888) core facility, access service resource, service resource, resource Core which provides researchers with resources for performing metabolic studies in mice. It also provides services, innovative techniques, and helpful consultation to both experienced and novice investigators with regards to metabolic questions. mouse phenotyping, metabolism research is listed by: Eagle I
is listed by: NIDDK Information Network (dkNET)
has parent organization: University of Pennsylvania; Philadelphia; USA
has parent organization: Penn Diabetes Research Center
is organization facet of: Penn Diabetes Research Center
Diabetes NIDDK P30DK19525 Available to the DRC community, Acknowledgement requested nlx_156493 SCR_000888 2026-02-14 02:07:47 0
National Diabetes Education Program
 
Resource Report
Resource Website
10+ mentions
National Diabetes Education Program (RRID:SCR_001477) NDEP training resource, resource Federal government public education program that promotes diabetes prevention and control. They aim to reduce the morbidity and mortality associated with diabetes and its complications. The NDEP is jointly sponsored by the National Institutes of Health and the Centers for Disease Control and Prevention and over 200 partner organizations. Target audiences include people with diabetes and those at risk, including the racial and ethnic populations disproportionately affected by the disease, health care providers and payers and purchasers of health care. treatment, outcome, diabetes, diagnosis, prevention, blood glucose level, complication, education, disease-related portal is listed by: NIDDK Information Network (dkNET)
has parent organization: NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases
Type 1 diabetes, Type 2 diabetes, Diabetes NIDDK N02DK72927-8-0-1 Free, Freely available nlx_152708 SCR_001477 2026-02-14 02:07:18 38
Diabetes Prevention Program Outcomes Study
 
Resource Report
Resource Website
Diabetes Prevention Program Outcomes Study (RRID:SCR_001502) DPPOS data or information resource, clinical trial, database, resource Observational clinical trial studying the long term effect of diet and exercise and the diabetes medication, metformin, on the delay of type 2 diabetes in participants of the Diabetes Prevention Program (DPP). The Diabetes Prevention Program (DPP) was a multi-center trial examining the ability of an intensive lifestyle or metformin to prevent or delay the development of diabetes in a high risk population due to the presence of impaired glucose tolerance (IGT). The DPP has ended early demonstrating that lifestyle reduced diabetes onset by 58% and metformin reduced diabetes onset by 31%. The DPPOS is designed to take advantage of the scientifically and clinically valuable DPP participants. This group of participants is nearly 50% minority and represents the largest IGT population ever studied. Clinically important research questions remain that focus on 1)durability of the prior DPP intervention, 2) determination of the clinical course of precisely known new onset diabetes, in particular regarding CVD, CVD risk factors and atherosclerosis and microvascular disease, 3)close examination of these topics in men vs women and in minority populations. More than 87% of the original surviving DPP cohort has joined DPPOS as of December, 2007 and, to date, after 5 years of DPPOS and 10 years of combined DPP/DPPOS, 93% of the DPPOS cohort continue to attend annual follow-up visits. Interim analyses performed after 5 years of DPPOS have demonstrated a durable effect of diabetes prevention associated with the lifestyle and metformin interventions with 34 and 19% reductions in diabetes incidence, respectively, compared with the placebo group. Interim analyses also reveal significant reductions from baseline in CVD risk factors in the lifestyle intervention group, but with decreased utilization of glucose-lowering and lipid-lowering medications. Analyses of the participants in the placebo group who have developed diabetes during DPP/DPPOS, compared with those who have remained non-diabetic, reveal an increased frequency of retinopathy and microalbuminuria. The current, updated protocol describes the DPPOS including the revisions incorporated to complete the second five-years of the study. DPPOS participants have blood samples stored at the time of each annual visit. Specimens are stored at the study CBL until after the primary study outcomes are reported. DNA samples were previously collected and are stored at the NIDDKsample repository for DPP participants. adult human, late adult human, male, female, caucasian, african-american, hispanic american, asian, pacific islander-american, american indian, metformin, microangiopathic, neuropathic, outcome, placebo, diabetic retinopathy, diabetic neuropathy, albuminuria, renal failure, macrovascular disease, cardiovascular disease, atherosclerosis, risk factor, amputation, hospitalization, physical activity, nutrition, body mass, obesity, dietary behavior, exercise behavior, physical functioning, quality of life, health care cost, cognitive performance, urinary incontinence, observational, microvascular disease, blood, dna is listed by: ClinicalTrials.gov
is listed by: NIDDK Information Network (dkNET)
is listed by: NIDDK Central Repository
has parent organization: George Washington University; Washington D.C.; USA
Type 2 diabetes, Diabetes NIDDK U01DK048514;
NIDDK U01DK048437;
NIDDK U01DK048413;
NIDDK U01DK048406;
NIDDK U01DK048380;
NIDDK U01DK048397
Free, Freely available nlx_152800 SCR_001502 2026-02-14 02:07:27 0
Southwestern NMR Center for In Vivo Metabolism
 
Resource Report
Resource Website
1+ mentions
Southwestern NMR Center for In Vivo Metabolism (RRID:SCR_001429) Southwestern NMR Center biomedical technology research center, training resource Biomedical technology research center that develops and applies new methods for analysis of metabolic networks in intact tissues, animals and human patients. The importance of understanding abnormal metabolism in common diseases such as cancer, diabetes and heart disease has long been appreciated. Because of constraints in technology, however, much of this research has been conducted in isolated systems where clinical relevance may be uncertain. Progress in magnetic resonance technology provides a foundation for major advances towards new ways of imaging metabolism in patients. These new techniques offer the advantage of imaging biochemical pathways without radiation. The focus of this Resource is to bring these technologies to a level where clinical research is feasible through the development of new MR contrast agents, NMR spectroscopy at high fields, and imaging of hyperpolarized 13C. metabolic network, tissue, imaging, metabolism, nuclear magnetic resonance, magnetic resonance, nuclear magnetic resonance spectroscopy has parent organization: University of Texas Southwestern Medical Center; Texas; USA Cancer, Diabetes, Heart disease NIBIB 5P41EB015908-28 Free, Freely Available nlx_152653 SCR_001429 Southwestern NMR Center for in vivo Metabolism - NIBIB 2026-02-14 02:07:27 1
A Whole Genome Admixture Scan for Type 2 Diabetes in African Americans
 
Resource Report
Resource Website
1+ mentions
A Whole Genome Admixture Scan for Type 2 Diabetes in African Americans (RRID:SCR_006984) data or information resource, data set Genomic data set on Type 2 Diabetes in African-Americans derived via admixture mapping, a method for genome-wide association analysis based on admixture-generated linkage disequilibrium. This collaborative group has identified 1,478 African Americans with Type 2 Diabetes (T2D) from the Jackson Heart Study and Multiethnic Cohort Study, as well as 498 controls from the Jackson Heart Study who are normoglycemic despite high body mass index and older age. All samples were genotyped (using the Illumina BeadLab platform) for 1,291 polymorphic markers chosen to be extremely different in frequency between west Africans and European Americans. Evidence for association to diabetes at each marker as reported by the ANCESTRYMAP software are reported in the downloadable table. They calculate that this study has statistical power to detect loci where African or European ancestry on average confers multiplicative increased risk of 1.35-fold or more. The fact that they did not detect a statistically significant signal of association in the scan suggests that any genetic risk factors for T2D do not confer different risks due to ancestry that differ by this factor. The genome scan results are publicly available (Excel file) prior to publication so that researchers interested in the genetics of T2D can use the results of the scan to prioritize follow-up of any regions of interest. admixture, genome, gwas, disequilibrium, normoglycemic, genotyped, polymorphic, marker, diabetes, clinical study, phenotype, african american, aging is related to: Jackson Heart Study
has parent organization: Massachusetts Institute of Technology; Massachusetts; USA;
Diabetes Eli and Edythe L. Broad Genome scan is available for download as CSV nif-0000-30020 SCR_006984 Diabetes Genetics Initiative 2026-02-14 02:07:23 1
University of Pennsylvania School of Medicine Penn Diabetes Research Center Pancreatic Islet Cell Biology Core Facility
 
Resource Report
Resource Website
University of Pennsylvania School of Medicine Penn Diabetes Research Center Pancreatic Islet Cell Biology Core Facility (RRID:SCR_008265) core facility, access service resource, service resource, resource Core that gives support including experimental design, islet isolation, and performance of and training in an expansive range of assays for physiological and morphometric assessment of pancreatic islet function and growth. It contributes to the basic and translational research activities of the Institute of Diabetes, Obesity and Metabolism (IDOM) at the Perelman School of Medicine of the University of Pennsylvania. Its services include perform individual islet and single cell fluorescence imaging, respirometry with islet batches using a Seahorse Extracellular Flux Analyzer, perifusion coupled with respirometry, and closed respirometry experiments for our investigators. calcium imaging, mitochondrial function, morphometry, islet isolation is listed by: Eagle I
is listed by: NIDDK Information Network (dkNET)
has parent organization: University of Pennsylvania; Philadelphia; USA
has parent organization: Penn Diabetes Research Center
is organization facet of: Penn Diabetes Research Center
Diabetes NIDDK P30DK19525 Available to the DRC community, Fee for service nlx_156487 SCR_008265 Penn Diabetes Research Center Pancreatic Islet Cell Biology Core 2026-02-14 02:07:32 0
Ohio U Diabetes Endocrine Biorepository
 
Resource Report
Resource Website
Ohio U Diabetes Endocrine Biorepository (RRID:SCR_013435) Ohio University Diabetes/Endocrine Diseases Biorepository biomaterial supply resource, material resource Plasma and cell fractions obtained from patients with Diabetes and endocrine diseases and their first degree relatives who agreed to participate in the development of the biorepository. Plasma is aliquoted into multiple specimen containers and stored at -80C. Cell fractions are subjected to DNA and RNA fractionation, aliquoted into multiple specimen containers, and frozen at -70 to -80 degrees centigrade. Anyone who would like to obtain samples from the Biorepository must provide evidence that they have adequate training in the use of bloodborne pathogens, as outlined by OSHA. The investigator must agree to indemnify and hold harmless the Ohio University Diabetes/Endocrine Diseases Biorepository, the Appalachian Rural health Institute, and the Ohio University College of Osteopathic Medicine from any claims, liability, costs, and damages. blood, plasma, cell fraction, dna, rna, frozen, diabetes, endocrine disease is listed by: One Mind Biospecimen Bank Listing
has parent organization: Ohio University; Ohio; USA
Diabetes, Endocrine disease Available to qualified researchers nlx_66534 SCR_013435 Ohio University Diabetes / Endocrine Diseases Biorepository, Diabetes / Endocrine Diseases Biorepository 2026-02-14 02:06:55 0
Harvard Bioinformatics Core at Joslin Diabetes Center
 
Resource Report
Resource Website
Harvard Bioinformatics Core at Joslin Diabetes Center (RRID:SCR_009827) core facility, access service resource, service resource Core for data driven projects related to basic, clinical and translational research, with a particular emphasis on diabetes. Aims to ensure that researchers take advantage of the most modern and robust methods available in the field of Bioinformatics and Biostatistics. computational, core, data, analysis, diabetes is listed by: Eagle I
is related to: Joslin Diabetes Center
has parent organization: Harvard University; Cambridge; United States
Diabetes nlx_156298 http://www.joslin.org/bioinformatics.html SCR_009827 The Bioinformatics and Biostatistics Core at Joslin Diabetes Center, Bioinformatics and Biostatistics Core at Joslin Diabetes Center 2026-02-14 02:07:28 0
Penn Diabetes Research Center Transgenic and Chimeric Mouse Core Facility
 
Resource Report
Resource Website
Penn Diabetes Research Center Transgenic and Chimeric Mouse Core Facility (RRID:SCR_010036) core facility, access service resource, service resource Mouse core which generates transgenic and gene-targeted mouse lines for diabetes research. transgenic mice, transgenic mouse, diabetes mouse is listed by: Eagle I
is listed by: NIDDK Information Network (dkNET)
has parent organization: University of Pennsylvania; Philadelphia; USA
has parent organization: Penn Diabetes Research Center
is organization facet of: Penn Diabetes Research Center
Diabetes Available to the research community, Fee for service nlx_156507 SCR_010036 Penn Diabetes Research Center Transgenic and Chimeric Mouse Core 2026-02-14 02:08:13 0
Vanderbilt Diabetes Research and Training Center Vanderbilt Diet Body Composition and Metabolism Core Facility
 
Resource Report
Resource Website
Vanderbilt Diabetes Research and Training Center Vanderbilt Diet Body Composition and Metabolism Core Facility (RRID:SCR_010191) core facility, access service resource, service resource THIS RESOURCE IS NO LONGER IN SERVICE. Documented on October 30,2023. Core facility that provides training and expertise in nutrition/diet methodology to obtain valid and reliable assessment and analyses of dietary intakes, nutritional status, body composition and metabolism. diabetes, nutrition methodology, body composition, metabolism is listed by: Eagle I
is listed by: NIDDK Information Network (dkNET)
has parent organization: Vanderbilt University; Tennessee; USA
has parent organization: Vanderbilt Diabetes Research and Training Center
is organization facet of: Vanderbilt Diabetes Research and Training Center
Diabetes NIDDK DK020593 THIS RESOURCE IS NO LONGER IN SERVICE nlx_156670 SCR_010191 Vanderbilt Diabetes Research and Training Center Vanderbilt Diet Body Composition and Metabolism Core 2026-02-14 02:08:14 0
Type 1 Diabetes - Rapid Access to Intervention Development
 
Resource Report
Resource Website
Type 1 Diabetes - Rapid Access to Intervention Development (RRID:SCR_000203) T1D-RAID service resource, resource NOTE: The T1D-RAID program is not currently accepting applications. Cooperative program that makes available, on a competitive basis, NCI resources for the pre-clinical development of drugs, natural products, and biologics to facilitate translation to the clinic of novel, scientifically meritorious therapeutic interventions for type 1 diabetes and its complications. A partial listing of those services includes: high-throughput screening, studies in animal models, formulation, pharmacology and toxicology studies, and bulk substances acquisition. Requests to T1D-RAID are brief (20 pages or less), and should clearly outline the resources required to ready the proposed therapeutic agent for clinical trials. T1D-RAID should enable entry into the clinic of promising molecules that are not otherwise likely to receive an adequate and timely clinical test. T1D-RAID is designed to accomplish the tasks that are rate-limiting in bringing discoveries from the laboratory to the clinic. Once a project has been approved, NIDDKstaff interact directly with the Principal Investigator (PI). NCI contractors perform the T1D-RAID-approved tasks under the direction of NIDDKand NCI staff. The required tasks will vary from project to project. In some cases T1D-RAID will support only one or two key missing steps necessary to bring a compound to the clinic; in other cases it may be necessary to supply the entire portfolio of development requirements needed to file an IND. Examples of tasks that can be supported by T1D-RAID include, but are not limited to: * Definition or optimization of dose and schedule for in vivo activity * Development of pharmacology assays * Conduct of pharmacology studies with a pre-determined assay * Acquisition of bulk substance (GMP and non-GMP) * Scale-up production from lab-scale to clinical-trials lot scale * Development of suitable formulations * Development of analytical methods for bulk substances * Production of dosage forms * Stability assurance of dosage forms * Range-finding initial toxicology * IND-directed toxicology, with correlative pharmacology and histopathology * Planning of clinical trials * Regulatory affairs, so that FDA requirements are likely to be satisfied by participating investigators seeking to test new molecular entities in the clinic * IND filing advice The output of T1D-RAID activities will be both products and information that will be made fully available to the originating investigator for support of an IND application and clinical trials. T1D-RAID does not sponsor clinical trials. therapeutic, drug, drug development, pharmacogenomics is listed by: NIDDK Information Network (dkNET)
is related to: Type 1 Diabetes Preclinical Testing Program
has parent organization: NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases
Type 1 diabetes, Diabetes NCI ;
NIDDK
nlx_152742 SCR_000203 Type 1 Diabetes - Rapid Access to Intervention Development (T1D-RAID) 2026-02-14 02:07:45 0
Resource for Genetic Epidemiology Research on Adult Health and Aging
 
Resource Report
Resource Website
1+ mentions
Resource for Genetic Epidemiology Research on Adult Health and Aging (RRID:SCR_010472) GERA data or information resource, database Human genetics data from an immense (78,000) and ethnically diverse population available for secondary analysis to qualified researchers through the database of Genotypes and Phenotypes (dbGaP). It offers the opportunity to identify potential genetic risks and influences on a broad range of health conditions, particularly those related to aging. The GERA cohort is part of the Research Program on Genes, Environment, and Health (RPGEH), which includes more than 430,000 adult members of the Kaiser Permanente Northern California system. Data from this larger cohort include electronic medical records, behavioral and demographic information from surveys, and saliva samples from 200,000 participants obtained with informed consent for genomic and other analyses. The RPGEH database was made possible largely through early support from the Robert Wood Johnson Foundation to accelerate such health research. The genetic information in the GERA cohort translates into more than 55 billion bits of genetic data. Using newly developed techniques, the researchers conducted genome-wide scans to rapidly identify single nucleotide polymorphisms (SNPs) in the genomes of the people in the GERA cohort. These data will form the basis of genome-wide association studies (GWAS) that can look at hundreds of thousands to millions of SNPs at the same time. The RPGEH then combined the genetic data with information derived from Kaiser Permanente''s comprehensive longitudinal electronic medical records, as well as extensive survey data on participants'' health habits and backgrounds, providing researchers with an unparalleled research resource. As information is added to the Kaiser-UCSF database, the dbGaP database will also be updated. genotype, phenotype, genome-wide association study, saliva, dna, male, female, health condition, electronic medical record, single nucleotide polymorphism, adult human, late adult human, gene, genome has parent organization: NCBI database of Genotypes and Phenotypes (dbGap)
has parent organization: University of California at San Francisco; California; USA
Aging, Cardiovascular disease, Osteoarthritis, Depressive Disorder, Insomnia, Eye disease, Cancer, Diabetes NIMH ;
NIH Office of the Director ;
NIA AG036607
Application required, Non-commercial, Data Use Certification Agreement nlx_157735 SCR_010472 Genetic Epidemiology Research on Aging 2026-02-14 02:06:11 9
Diabetes Prevention Type 1
 
Resource Report
Resource Website
Diabetes Prevention Type 1 (RRID:SCR_001467) DPT-1 biomaterial supply resource, material resource Data set and biosepecimens of a multi-center clinical trial to determine if treatment with beta-cell antigens can delay the onset of Type 1 Diabetes Mellitus (Type 1 DM) in non-diabetic relatives of persons with Type 1 DM. Insulin is a well characterized antigen specifically produced by beta-cells, and it was used for this purpose in the initial DPT-1 studies. The protocol for high risk subjects uses daily subcutaneous insulin injections and an annual course of intravenous insulin treatment, while the protocol for intermediate risk subjects uses daily doses of insulin administered orally. Neither injected nor oral insulin at the doses used were observed to delay or prevent diabetes, although further studies are needed to test whether oral insulin can delay diabetes in people in the intermediate risk group with high titers of insulin autoantibodies. beta cell antigen, insulin, prevention, onset, subcutaneous injection, oral, intravenous, treatment, randomized, controlled trial, drug therapy, delay is listed by: One Mind Biospecimen Bank Listing
is listed by: ClinicalTrials.gov
is listed by: NIDDK Information Network (dkNET)
is listed by: Diabetes Research Centers
Type 1 diabetes, Diabetes NIDDK UC4 DK097835 Free, Freely Available nlx_152696 https://www.niddkrepository.org/niddk/jsp/public/dataset.jsp#DPT-1 SCR_001467 Diabetes Prevention Trial--Type 1 (DPT-1) dataset, DPT-1 (The Diabetes Prevention Type 1) 2026-02-14 02:06:31 0
HIRN Human Pancreas Analysis Program
 
Resource Report
Resource Website
100+ mentions
HIRN Human Pancreas Analysis Program (RRID:SCR_016202) HIRN-HPAP, HPAP data or information resource, database Program is performing deep phenotyping of human endocrine pancreas and its interaction with immune system to better understand cellular and molecular events that precede and lead to beta cell loss in Type-1 Diabetes (T1D) and islet dysfunction in Type-2 Diabetes (T2D). pancreas, endocrinology, immunology, molecular, biology, human, t1d, beta, cell has parent organization: HIRN Human Pancreas Analysis Consortium
is organization facet of: Human Islet Research Network (HIRN)
Type 1 diabetes, Diabetes NIDDK ;
NIDDK U01 DK104162;
NIDDK UC4 DK112217;
NIDDK UC4 DK112232
PMID:31127054 https://hirnetwork.org/consortium/hpap SCR_016202 Human Pancreas Analysis Program (HIRN-HPAP), PANC-DB 2026-02-14 02:06:53 120
Network for Pancreatic Organ Donors with Diabetes
 
Resource Report
Resource Website
100+ mentions
Rating or validation data
Network for Pancreatic Organ Donors with Diabetes (RRID:SCR_014641) nPOD biomaterial supply resource, tissue bank, material resource A collaborative research project that supports nPOD approved diabetes investigators by freely providing rare and difficult-to-obtain tissues from type 1 and type 2 diabetes donors. Interested researchers are encouraged to apply to obtain nPOD tissues, or to request access to analyze cases in the nPOD Online Pathology site. Interested donors can contact nPOD directly for more information. biosample, diabetes, type 1 diabetes, type 2 diabetes, donor, human, tissue, tissue supplier, pancreas, biomaterial supply resource, organization is listed by: NIDDK Information Network (dkNET) Type 1 diabetes, Diabetes Public, Available to the research community, Must be an approved nPOD investigator to receive samples SCR_014641 Network for Pancreatic Organ Donors with Diabetes (nPOD), The Network for Pancreatic Organ Donors with Diabetes 2026-02-14 02:06:45 177
Attie Lab Diabetes Database
 
Resource Report
Resource Website
1+ mentions
Attie Lab Diabetes Database (RRID:SCR_016639) data or information resource, database Interactive database of gene expression and diabetes related clinical phenotypes. Allows to search gene expression in tissues as a function of obesity, strain, and age, in a mouse. interactive, database, gene, expression, diabetes, related, clinical, phenotype, mouse is listed by: OMICtools
has parent organization: University of Wisconsin-Madison; Wisconsin; USA
diabetes Free, Freely available SCR_016639 2026-02-14 02:06:54 3
Cooperative Study Group for Autoimmune Disease Prevention
 
Resource Report
Resource Website
Cooperative Study Group for Autoimmune Disease Prevention (RRID:SCR_006803) CSGADP knowledge environment, resource Collaborative network of investigators with a focus on prevention of autoimmune disease, defined as halting the development of autoimmune disease prior to clinical onset by means other than global immunosuppression, and an emphasis on Type 1 diabetes. Its mission is to engage in scientific discovery that significantly advances knowledge for the prevention and regulation of autoimmune disease. The specific goals enunciated in pursuit of this mission are: * To create improved models of disease pathogenesis and therapy to better understand immune mechanisms that will provide opportunities for prevention strategies * To use these models as validation platforms with which to test new tools applicable to human studies * To encourage core expertise and collaborative projects designed for rapid translation from animal to human studies, emphasizing the development of surrogate markers for disease progression and/or regulation which can be utilized in the context of clinical trials prevention, clinical, immune, model, disease pathogenesis, therapy is listed by: NIDDK Information Network (dkNET)
is listed by: NIDDK Research Resources
Type 1 diabetes, Diabetes, Autoimmune disease NIAID ;
NIDDK ;
NICHD ;
NIH Office of Research on Womens Health ;
Juvenile Diabetes Research Foundation International
nlx_152797 SCR_006803 2026-02-14 02:07:08 0
Renin Angiotensin System Study
 
Resource Report
Resource Website
1+ mentions
Renin Angiotensin System Study (RRID:SCR_013385) RASS/B-RASS, RASS clinical trial, resource Randomized, multicenter, double-blind study to determine if renin angiotensin medications, either losartan (angiotensin II blocker) or enalapril (converting enzyme inhibitor), can prevent or delay the onset of diabetic kidney disease in patients with type 1 diabetic patients who do not have hypertension, diabetic nephropathy, or predictive levels of microalbuminuria. Two hundred eight five patients ages 16-61 with 2-20 yrs of Type 1 Diabetes Mellitus and no renal functional abnormalities were randomized into a parallel, double-blind, placebo-controlled study involving 3 groups (95 patients/group). Each group received an angiotensin-converting enzyme inhibitor (ACEI) (enalapril), or an angiotensin II receptor blocker (Losartan), or placebo. All patients had their usual Diabetes Mellitus (DM) management. Baseline studies included measures of glomerular filtration rate (GFR), urinary albumin excretion rate (UAE), blood pressure (BP), and a percutaneous renal biopsy. Patients were followed by quarterly measures of BP, HbA1C, UAE, and drug compliance. There were annual measures of GFR and a repeat renal biopsy after 5 yrs in the study. The main endpoint is kidney structural changes over time, especially mesangial fractional volume (v(Mes/glom)). Secondary endpoints will be other DN structural measures and measures of kidney function (UAE, GFR). These studies will determine whether rennin angiotensin system blockage in the early stages of DN can prevent the early kidney structural changes in this important disorder. Ancillary studies will evaluate the effects of treatment group on the development and progression of diabetic retinopathy and will develop predictors of study participants'''' compliance. Baseline, 2.5 and 5 year retinal fundus photographs in the RASS patients were obtained. enalapril, drug, losartan, angiotensin, medication, kidney, intervention, clinical, adolescent, adult human, renal biopsy, renin-angiotensin system, diabetic nephropathy, kidney, placebo, glomerular filtration rate, urinary albumin excretion rate, blood pressure is related to: NIDDK Information Network (dkNET)
has parent organization: ClinicalTrials.gov
has parent organization: University of Minnesota Twin Cities; Minnesota; USA
Type 1 diabetes, Diabetic kidney disease, Retinopathy, Nephropathy, Diabetes NIDDK PMID:19571282 nlx_152849 SCR_013385 Renin Angiotensin System Blockage-DN (RASS), Renin Angiotensin System Study (RASS/B-RASS) 2026-02-14 02:07:56 1
UK Biobank
 
Resource Report
Resource Website
1000+ mentions
UK Biobank (RRID:SCR_012815) material storage repository, storage service resource, service resource, biobank Biobank provides data collected at Assessment Center and via online questionnaires on participants aged 40-69 years recruited throughout United Kingdom and provides summary information to improve prevention, diagnosis and treatment of serious and life threatening illnesses. Data, collected, United Kingdom, prevention, diagnosis, treatment, illness, questionnaire, blood, urine, saliva, cognitive function, psychological status, hearing test, interview, operation, medication, blood pressure, body measurementdie is listed by: One Mind Biospecimen Bank Listing
is related to: AstraZeneca PheWAS Portal
cancer, heart diseases, stroke, diabetes, arthritis, osteoporosis, eye disorders, depression, dementia. UK Department of Health ;
MRC ;
Scottish Government ;
Welsh Assembly Government ;
Wellcome Trust
grid.421945.f, nlx_95741, ISNI: 0000 0004 0396 0496, Wikidata: Q7864819 https://ror.org/02frzq211 SCR_012815 2026-02-14 02:08:32 2914
Einstein-Mount Sinai Diabetes Research Center Biomarker Analytic Research Core Facility
 
Resource Report
Resource Website
10+ mentions
Einstein-Mount Sinai Diabetes Research Center Biomarker Analytic Research Core Facility (RRID:SCR_015067) BARC core facility, access service resource, service resource Core provides information and tools for Einstein and Montefiore investigators from initial study planning stage through analysis and data output. Facility services include: mass spectrometry analysis, including stable isotopes, as well as research-grade determination of lipids, and metabolic markers for human subjects and animal model projects; High-throughput robotics for semi-automated high-quality sample preparation and analysis by immunoassay and liquid chromatography–mass spectrometry (LC/MS); Support for novel developmental projects featuring applications of LC/MS and two-site bead-based assays; Research quality analysis of metabolites for human and animal samples using Olympus AU400 autoanalyzer; Advanced training in analytical chemistry. analytical research tools, biomarker core, mass spectrometry analysis, stable isotopes, lipids, metabolic markers, analytical chemistry, is listed by: NIDDK Information Network (dkNET)
is listed by: ABRF CoreMarketplace
has parent organization: Einstein-Mount Sinai Diabetes Research Center
is organization facet of: Einstein-Mount Sinai Diabetes Research Center
Diabetes New York Obesity Research Center ;
Center for the Study of Diabetic Complications ;
Montefiore Clinical Diabetes Center ;
NIDDK P30DK020541
Restricted ABRF_2862 https://coremarketplace.org/?FacilityID=2862&citation=1 http://www.einstein.yu.edu/centers/diabetes-research/wrap.aspx?id=45634 SCR_015067 Einstein-Mount Sinai Diabetes Research Center Biomarker and Analytical Research Core, Einstein-Mount Sinai Diabetes Research Center Biomarker Analytic Research Core 2026-02-14 02:08:24 29

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