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http://www.scienceexchange.com/facilities/high-throughput-clinical-proteomics-core-ucla

THIS RESOURCE IS NO LONGER IN SERVCE, documented September 6, 2016. The High-Throughput Clinical Proteomics (HTCP) core laboratory is a mass spectrometry core facility designed to profile large numbers of clinical samples for changes in protein content. We use small amounts (micrograms) of protein from samples such as urine, plasma, CSF, and cell lysates and incubate them with magnetic beads that bind different subsets of the total proteome. We then examine the different subsets of small proteins and peptides by high-resolution MALDI-TOF mass spectrometry. We measure the amounts and intact masses of the proteins in the samples and determine which have the greatest statistical relevance in defining clinical groupings before moving to physically isolate those peptides/proteins and identify them. The method works best for peptides and small proteins below 25 kDa and is an excellent complement to gel-based methods such as DIGE.

Proper citation: UCLA High-Throughput Clinical Proteomics Core (RRID:SCR_012205) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/applied-bioinformatics-core

THIS RESOURCE IS NO LONGER IN SERVICE, documented January 23, 2019. Core supports SBMRI investigators in exploring, understanding and analyzing complex biological data. Core is equipped with cutting-edge computational infrastructure and a selective collection of bioinformatics software. Core's services include consultation, data analysis and management, software development, and accessing to large computing resources. To meet various demands from the investigators, we provide services at multiple levels, from full service to cost-effective limited service as well as collaborative projects requiring longer-term commitment of time and effort.

Proper citation: Sanford-Burnham Applied Bioinformatics Core Facility (RRID:SCR_012208) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/center-for-drug-discovery-and-innovation

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on October 30,2023. The Center for Drug Discovery and Innovation (CDDI) is a Florida Center of Excellence serving the research community at USF and south Florida. From concept to clinical trials there are significant challenges in the successful development of new pharmaceuticals. It is the mission of CDDI to assist research groups at USF in overcoming some of the critical bottlenecks in early phase drug discovery.

Proper citation: USF Center for Drug Discovery and Innovation Labs and Facilities (RRID:SCR_012209) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/chemical-gmp-synthesis-facility

The Chemical GMP Synthesis Facility is a state-of-the-art manufacturing facility for small and large molecule therapeutics for clinical trials. The CGSF provides services for drug discovery, process research, development and early clinical manufacturing of pharmaceutical drug substances (APIs) that meet FDA requirements. www.cityofhope.org/chemicalgmp

Proper citation: Beckman Research Institute Chemical GMP Synthesis Facility (RRID:SCR_012174) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/analytical-instrumentation-facility-ncsu

The NCSU Analytical Instrumentation Facility (AIF) is a North Carolina State University resource for materials characterization. AIF operates a number of major analytical instruments providing quality analyses for all who require it. These instruments are operated and maintained by a professional staff who are experienced in the design and implementation of materials characterization experiments. For those who desire hands on involvement in their analyses, AIF staff trains users to operate analytical instrumentation, design efficient analytical experiments, and properly interpret the resulting data. In addition, AIF staff is involved in the development and/or enhancement of analytical techniques in a continuing effort to provide the level of capabilities required by the ever evolving needs of the NCSU research community. AIF provides short courses as well as formal classroom instruction to insure that NCSU''''s future engineers and scientists can, upon graduation, take with them an understanding of modern analytical techniques and an understanding of the instrumentation required to implement them.

Proper citation: NCSU Analytical Instrumentation Facility (RRID:SCR_012173) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/bioinformatics-support-unit

Core provides support to life science researchers with data analysis and experimental design from sequence analysis, microarrays, proteomics and beyond.

Proper citation: Newcastle University Bioinformatics Support Unit (RRID:SCR_012297) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/university-of-chicago

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on October 30,2023. Portal, Core facility

Proper citation: University of Chicago Labs and Facilities (RRID:SCR_012178) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/therapeutic-validation-core-iu

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on April 22,2024. Therapeutic Validation core (TVC) assists clinical investigators to develop and perform correlative biological assays needed to validate mechanism(s) of action of candidate drugs/therapies and to develop and test new hypotheses. The TVC also provides technical and intellectual support in the development, implementation, and validation of predictive and pharmacodynamic biomarkers for novel, molecularly-targeted anticancer agents.

Proper citation: IUSM Therapeutic Validation Core (RRID:SCR_012211) Copy   

•   Source: SciCrunch Registry

https://www.joslin.org/islet-isolation-core.html

Core facility that provides the following services: Rodent and Porcine Islet Isolation Services, Training Services. The main objective of the Islet Isolation Core is to provide Islets of Langerhans to investigators in the Boston area and beyond. By receiving islets from the Core one is assured of consistent high quality and purity of islets for experiments. The Core can isolate rodent and neonatal porcine islets. This leaves the investigator to concentrate on experiments rather than the complexity of islet isolation. The Core can buy the animals or the investigator can provide their own, such as special transgenic mice. Over the last five years the Core has isolated more than 10 million islets. They also provide training and advice. The Core can provide training not only for the isolation procedure but islet viability, islet size measurement, GSIS (Glucose Stimulated Insulin Secretion), STZ-induced diabetes, transplantation under the kidney capsule, and islet graft retrieval.

Proper citation: Joslin Diabetes Center Islet Isolation Core (RRID:SCR_012299) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/flow-cytometry-core-facility-utah

Serving 120+ investigators with a 5 laser high speed sorter and 3 benchtop analyzers with 13+ color capabilities, the Utah Flow Cytometry Core Facility has developed a paradigm to balance productivity with quality to minimize the cost per research project, keep overall costs contained, and provide the necessary scientific support. Central to this paradigm is a close working relationship with investigators to define their projects in the early stages of development to make optimal and efficient use of flow cytometry. In addition to high quality and well maintained instrumentation, success of this approach requires focused efforts in three major areas: 1) education of ALL users (faculty and staff) in the science and technology of flow cytometry, 2) active involvement in the scientific development of the project, 3) continuing education for core staff.

Proper citation: University of Utah Flow Cytometry Core Facility (RRID:SCR_012210) Copy   

•   Source: SciCrunch Registry

https://www.dfhcc.harvard.edu/research/core-facilities/tumor-imaging-metrics

Core provides centralized, standardized, accurate, consistent, and timely longitudinal, multimodality anatomic, volumetric and functional tumor metrics including CT, MR, PET/CT and other nuclear medicine imaging studies to evaluate therapeutic response for patients enrolled in DF/HCC oncologic clinical trials. TIMC supports more than 30 tumor response assessment criteria including but not limited to RECIST 1.1, iRECIST, Lugano, LYRIC, IWCLL and RANO. Results of tumor metric analyses are offered on password-protected secure web-based report.

Proper citation: Harvard Tumor Imaging Metrics Core Facility (RRID:SCR_012298) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/fluorescence-microscopy-and-imaging-core-laboratory

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on October 22, 2024. The Fluorescence Microscopy and Imaging Core Laboratory is a multi-user facility located in the Department of Pathology and Laboratory Medicine at The University of Texas Medical School Houston, within the Texas Medical Center. Its purpose is to allow research scientists access to state of the art Fluorescence Microscopes and Imaging equipment, to foster experimentation for the further understanding of scientific phenomena in many diverse areas of clinical and basic research.

Proper citation: UTHealth Fluorescence Microscopy and Imaging Core Laboratory (RRID:SCR_012293) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/genomics-core-facility-brown

Provides genomics and proteomics equipment to researchers at Brown University and to entire Rhode Island research community, as well as assistance with experimental design, trouble shooting, and data analysis. Offers Affymetrix microarray and Illumina NextGeneration services to academic community and external customers.

Proper citation: Brown University Genomics Core Facility (RRID:SCR_012217) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/magnetic-resonance-facility

The Department of Chemistry''s Magnetic Resonance Facility underwent a major upgrade in 2006 and in 2011 with the addition of three NSF funded spectrometers: Varian Direct Drive 500 MHz and 600 MHz NMR''s and a Bruker EMX PLUS EPR.

Proper citation: UM Magnetic Resonance Facility (RRID:SCR_012184) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/centre-for-cellular-and-molecular-platforms

Centre for Cellular and Molecular Platforms (C-CAMP), is a Dept. of Biotechnology (Govt. of India) initiative and a not for profit organisation, that also forms an important part of the Bangalore Bio-cluster. We are acting as an enabler of bioscience research and entrepreneurship by providing research, development, training and service in state of the art technology platforms.

Proper citation: Centre for Cellular and Molecular Platforms (RRID:SCR_012188) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/central-proteomics-facility

The Central Proteomics Facility (CPF) of Oxford University offers proteomics mass spectrometry services and expertise to academic and commercial organisations. The facility is quipped with state-of-the-art Orbitrap and Q Exactive Orbitrap mass spectrometers. The facility routinely perfroms idenitification, post-translational modification and protein quantitation work using SILAC.

Proper citation: Oxford Central Proteomics Facility (RRID:SCR_012181) Copy   

•   Source: SciCrunch Registry

https://www.hsph.harvard.edu/niehs/core-components/ihsfc/

Self use flow cytometry facility. All new users must be trained by the facility manager over two orientation sessions and be approved to use the equipment in the facility.

Proper citation: HSPH NIEHS Center for Environmental Health Flow Cytometry Core Facility (RRID:SCR_012303) Copy   

•   Source: SciCrunch Registry

http://www.schepens.harvard.edu/graphics

Core facility that provides the following services: Web and graphic services, Web design and content management service, Photography service. Peter Mallen is a designer and illustrator who manages a full-service web and graphics studio in a moderately sized scientific research facility, Schepens Eye Research Institute. He provides a full range of graphic design, scientific illustration, web design and development, content management, and general design and production services. His products are utilized by: faculty and scientific staff (books, scientific publications, slide shows, grant applications); professional staff (Administration, Development & Public Affairs; brochures, books, pamphlets); the general public (Institute websites) as well as clients of our 250-seat state-of-the-art conference center, Starr Center for Scientific Communications.

Proper citation: Harvard SERI Graphic Services Core (RRID:SCR_012309) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/csisp-next-generation-sequencing-csisp

The Center for Public Health Research (CSISP) provides next generation sequencing services via the GS FLX+ System. The Genome Sequencer FLX+ System, with long-read GS FLX Titanium chemistry, is the flagship 454 Sequencing platform. Offering more than 1 million high-quality reads per run and read lengths up to 700 bases, the system is ideally suited for de novo sequencing of whole genomes and transcriptomes of any size, metagenomic characterization of complex samples, resequencing studies and more. The GS FLX+ System is at the heart of breakthrough scientific discoveries and hundreds of peer-reviewed publications to date. Applications The Genome Sequencer FLX+ System provides the power to address a broad range of applications in diverse fields of biology. The tremendous versatility of the system is based on the unique combination of read length, throughput, and read accuracy. The technology platform has enabled groundbreaking research in various fields. Next we mention some of the most usual applications: _���� Eukaryote and prokaryote whole genome sequencing _���� Metagenomics & Microbial Diversity _���� Transcriptome sequencing _���� HIV sequencing

Proper citation: CSISP Next Generation Sequencing (RRID:SCR_012308) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/high-throughput-genomics-center-washington

Provides high-throughput genomics data for government, biotechnology, and pharmaceutical industry customers worldwide. Created next-gen sequencing data sets including DNA sequencing, RNA-seq, ChIP-seq, DNase-seq, and Bisulfite-seq spanning a variety of organisms ranging from humans to plants. On-site bioinformaticians and biologists are available.

Proper citation: UW Medicine High Throughput Genomics Center (RRID:SCR_012278) Copy   

•   Source: SciCrunch Registry