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URL: http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=155641251
Proper Citation: RRID:RRRC_00946
Description: Rattus norvegicus with name F344-Tg(CAG-ACE2)057BrydRrrc from RGD.
Species: Rattus norvegicus
Notes: The human ACE2 gene was placed under control of the synthetic CAG promoter which allows ubiquitous expression of the gene. Based on droplet digital PCR analysis, the strain carries only 1 copy of the transgene. The integration site is unknown. These rats express the human ACE2 gene. The encoded protein is a functional receptor for the spike glycoprotein of several human coronaviruses including SARS-CoV-2, the causative agent of coronavirus disease-2019 (COVID-19). Rat Resource and Research Center
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Source: Integrated Animals
Source Database: Rat Resource and Research Center (RRRC)
