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URL: https://github.com/raphael-group/chisel
Proper Citation: CHISEL (RRID:SCR_023220)
Description: Software tool to infer allele and haplotype specific copy numbers in individual cells from low coverage single cell DNA sequencing data. Integrates weak allelic signals across individual cells, powering strength of single cell sequencing technologies to overcome weakness. Includes global clustering of RDRs and BAFs, and rigorous model selection procedure for inferring genome ploidy that improves both inference of allele specific and total copy numbers.
Abbreviations: CHISEL
Synonyms: Copy-number Haplotype Inference in Single-cell by Evolutionary Links
Resource Type: software resource, software application
Defining Citation: DOI:10.1038/s41587-020-0661-6
Keywords: infer allele and haplotype specific copy numbers, individual cells, low coverage single cell DNA sequencing data, weak allelic signals, weak signals integration,
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