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Resource Name
RRID:SCR_017768 RRID Copied      
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Northwestern University Mary Beth Donnelley Clinical Pharmacology Core Facility (RRID:SCR_017768)
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Resource Information

URL: http://www.feinberg.northwestern.edu/research/cores/units/clin-pharm.html

Proper Citation: Northwestern University Mary Beth Donnelley Clinical Pharmacology Core Facility (RRID:SCR_017768)

Description: Core provides quantitative mass spectrometry based support for in vitro studies and both preclinical and clinical studies of variety of small molecules, including cancer chemotherapeutic agents, analgesics, and antidepressants. Expertise includes optimizing design, conduct, analysis, interpretation, and reportage of pharmacokinetic studies. Helps with biological sample preparation, quantitative mass spectrometric drug concentration measurement, and drug concentration versus time data modeling. Small molecule concentrations in plasma and other body fluids are measured using Sciex 6500 QTrap with UPLC and nano LC or an Agilent HPLC system linked to Applied Biosystems API 3000 triple quadrupole mass spectrometer after sample preparation by, for example, solid-phase extraction. Drug concentration versus time relationships are fitted to various compartmental pharmacokinetic models using commercially available and specialized software.

Synonyms: Mary Beth Donnelley Clinical Pharmacology Core Facility

Resource Type: service resource, access service resource, core facility

Keywords: Clinical, pre clinical, pharmacology, quantitative, mass, spectrometry, cancer, chemotherapeutic, agent, analgesic, antidepressant, design, analysis, pharmacokinetic, study, drug, concentratiion, measure, sample, preparation, service, core

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