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URL: https://www.hgsc.bcm.edu/other-mammals/mouse-genome-project
Proper Citation: Mouse Genome Project (RRID:SCR_013645)
Description: The goal of the mouse genome project is to determine the function of genes on mouse Chromosome 11 by saturating the chromosome with recessive mutations. The distal 40 cM of mouse Chr 11 exhibits linkage conservation with human Chromosome 17. We are using the chemical N-ethyl-N-nitrosourea (ENU) to saturate wild type chromosomes with point mutations. By determining the function of genes on a mouse chromosome, we can extrapolate to predict function on a human chromosome. We expect many of the new mutants to represent models of human diseases such as birth defects, patterning defects, growth and endocrine defects, neurological anomalies, and blood defects. Because many of the mutations we expect to isolate may be lethal or detrimental to the mice, we are using a unique approach to isolate mutations. This approach uses a balancer chromosome that is homozygous lethal and carries a dominant coat color marker to suppress recombination over a reasonable interval. On this site one can obtain a list of mutations on chromosome 11.
Synonyms: Mouse Genome Project
Resource Type: portal, topical portal, data or information resource
Keywords: mutant, bac mapping, enu mutagenesis, mouse, development, defect
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