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URL: http://igdb.nsclc.ibms.sinica.edu.tw/
Proper Citation: IGDB.NSCLC (RRID:SCR_006048)
Description: IGDB.NSCLC database is aiming to facilitate and prioritize identified lung cancer genes and microRNAs for pathological and mechanistic studies of lung tumorigenesis and for developing new strategies for clinical interventions. We integrated and curated various lung cancer genomic datasets to present # lung cancer genes with somatic mutations, experimental supports and statistic significance in association with clinicopathological features; # genomic alterations with copy number alterations (CNA) detected by high density SNP arrays, gain or loss regions detected by arrayed comparative genome hybridization (aCGH), and loss of heterozygosity (LOH) detected by microsatellite markers; # aberrant expression of genes and microRNAs detected by various microarrays. IGDB.NSCLC database provides user friendly interfaces and searching functions to display multiple layers of evidence for detecting lung cancer target genes and microRNAs, especially emphasizing on concordant alterations: # genes with altered expression located in the CNA regions; # microRNAs with altered expression located in the CNA regions; # somatic mutation genes located in the CNA regions; and # genes associated with clinicopathological features located in the CNA regions. These concordant altered genes and miRNAs should be prioritized for further basic and clinical studies.
Abbreviations: IGDB.NSCLC
Synonyms: Integrated Genomic Database of Non-Small Cell Lung Cancer
Resource Type: data or information resource, database
Defining Citation: PMID:22139933
Keywords: genomic database, non-small cell lung cancer, lung, pulmonary, cancer, genome, lung adenocarcinoma, squamous cell carcinoma, genomic alteration, lung tumorigenesis, copy number alteration, heterozygosity, gene, microrna, somatic mutation, clinical information, alteration, gene expression, microrna expression, somatic mutation, chromosome, lung cancer gene, aberrant expression, microarray, clinicopathology
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