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SciCrunch Registry is a curated repository of scientific resources, with a focus on biomedical resources, including tools, databases, and core facilities - visit SciCrunch to register your resource.
| Resource Name | Proper Citation | Abbreviations | Resource Type |
Description |
Keywords | Resource Relationships | |||||||||||||
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Post-DVM Training Program on Animal Model Research for Veterinarians Resource Report Resource Website |
Post-DVM Training Program on Animal Model Research for Veterinarians (RRID:SCR_008303) | training resource | An institutional training program to train veterinarians in conducting research. The program trains veterinarians in acquiring the skills of a researcher as they undergo a specific M.S. or Ph.D program. The program urges graduates to take part in research concerning animal models of infectious diseases, immunology, and nutrition, among other health topics. | animal, biology, biomedical, comparative, disease, human, immunology, infectious, medicine, model, molecular, nutrition, physiology, research, toxicology, veterinarian | NIH | Must enroll in program | nif-0000-24382 | http://www.vetmed.vt.edu | SCR_008303 | Post-DVM Program on AMRV, Virginia-Maryland College of Veterinary Medicine | 2026-02-07 02:07:44 | 0 | |||||||
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DNAWorks at Helix Systems Resource Report Resource Website 10+ mentions |
DNAWorks at Helix Systems (RRID:SCR_008470) | service resource | DNAWorks automates the design of oligonucleotides for gene synthesis by PCR-based methods. The availability of sequences of entire genomes has dramatically increased the number of protein targets, many of which will need to be overexpressed in cells other than the original source of DNA. Gene synthesis often provides a fast and economically efficient approach. The synthetic gene can be optimized for expression and constructed for easy mutational manipulation without regard to the parent genome. DNAWorks accesses a computer program that automates the design of oligonucleotides for gene synthesis. The website provides forms for simple input information, i.e. amino acid sequence of the target protein and melting temperature (needed for the gene assembly) of synthetic oligonucleotides. The program outputs a series of oligonucleotide sequences with codons optimized for expression in an organism of choice. Those oligonucleotides are characterized by highly homogeneous melting temperatures and a minimized tendency for hairpin formation. The approach presented here simplifies the production of proteins from a wide variety of organisms for genomics-based studies. | oligonucleotide, pcr, oligo primer |
is listed by: 3DVC has parent organization: National Cancer Institute has parent organization: National Cancer Institute |
Intramural AIDS Targeted Antiviral Program of the Office of the Director ; NIH |
PMID:12000848 | nif-0000-30422 | SCR_008470 | DNAWorks | 2026-02-07 02:07:50 | 37 | |||||||
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LexGrid Resource Report Resource Website 1+ mentions |
LexGrid (RRID:SCR_006627) | LexGrid | software resource | LexGrid (Lexical Grid) provides support for a distributed network of lexical resources such as terminologies and ontologies via standards-based tools, storage formats, and access/update mechanisms. The Lexical Grid Vision is for a distributed network of terminological resources. It is the foundation of the National Center for Biomedical Ontology BioPortal interface and web-services, and can parse OBO format, as well as other formats such as OWL. Currently, there are many terminologies and ontologies in existence. Just about every terminology has its own format, its own set of tools, and its own update mechanisms. The only thing that most of these pieces have in common with each other is their incompatibility. This makes it very hard to use these resources to their full potential. We have designed the Lexical Grid as a way to bridge terminologies and ontologies with a common set of tools, formats and update mechanisms. The Lexical Grid is: * accessible through a set of common APIs * joined through shared indices * online accessible * downloadable * loosely coupled * locally extendable * globally revised * available in web-space on web-time * cross-linked The realization of this vision requires three interlocking components, which are: * Standards - access methods and formats need to be published and openly available * Tools - standards based tools must be readily available * Content - commonly used terminologies have to be available for access and download Platform: Windows compatible, Mac OS X compatible, Linux compatible, Unix compatible | software library, parse, ontology |
is listed by: BioPortal is listed by: Gene Ontology Tools is related to: Gene Ontology is related to: OBO has parent organization: European Bioinformatics Institute has parent organization: National Cancer Institute |
NIH ; Cancer Biomedical Informatics Grid ; NLM LM07319 |
PMID:19261933 | Free for academic use | nlx_149194 | http://www.lexgrid.org/ | SCR_006627 | Lexical Grid | 2026-02-07 02:07:13 | 1 | ||||
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GOEx - Gene Ontology Explorer Resource Report Resource Website 10+ mentions |
GOEx - Gene Ontology Explorer (RRID:SCR_005779) | GOEx | software resource | THIS RESOURCE IS NO LONGER IN SERVICE. Documented July 5, 2018. Gene Ontology Explorer (GOEx) combines data from protein fold changes with GO over-representation statistics to help draw conclusions in proteomic experiments. It is tightly integrated within the PatternLab for Proteomics project and, thus, lies within a complete computational environment that provides parsers and pattern recognition tools designed for spectral counting. GOEx offers three independent methods to query data: an interactive directed acyclic graph, a specialist mode where key words can be searched, and an automatic search. A recent hack included in GOEx is to load the sparse matrix index file directly into GOEx, instead of going through the report generation using the AC/T-fold methods. This makes it easy for GOEx to analyze any list of proteins as long as the list follows the index file format (described in manuscript) . Please note that if using this alternative strategy, there will be no protein fold information. Platform: Windows compatible | proteomics, visualization, statistical analysis, gene ontology, parse, pattern recognition, spectral counting, analysis, protein fold |
is listed by: Gene Ontology Tools is related to: Gene Ontology has parent organization: Scripps Research Institute |
CNPq ; CAPES ; FAPERJ BBP grant ; PAPES ; PDTIS ; Ary Frauzino Foundation ; NIAID ; NIH ; genesis molecular biology laboratory ; Fiocruz-INCA collaboration ; NIAID UCSD/MCB0237059; NCRR P41RR011823; NIMH 5R01 MH067880 |
PMID:19239707 | THIS RESOURCE IS NO LONGER IN SERVICE | nlx_149249 | http://pcarvalho.com/patternlab/goex.shtml | SCR_005779 | Gene Ontology Explorer, GO Explorer | 2026-02-07 02:06:51 | 26 | ||||
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National Database for Clinical Trials related to Mental Illness Resource Report Resource Website 1+ mentions |
National Database for Clinical Trials related to Mental Illness (RRID:SCR_013795) | NDCT | data resource | A database which houses human subjects clinical trial data. NDCT currently contains data on 13,409 subjects and has access to data on 100,500 subjects from the NIMH Data Archive. Users can also sign up for news updates and watch video tutorials. | database, human, clinical trial, mental health, mental illness |
uses: NIMH Data Archive uses: RDoCdb is listed by: NIH Data Sharing Repositories is related to: NIMH Data Archive is related to: RDoCdb is related to: RDoCdb |
NIH | Public, Only for research | SCR_013795 | 2026-02-07 02:08:47 | 1 | ||||||||
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BICCN Cell Registry Resource Report Resource Website 10+ mentions |
BICCN Cell Registry (RRID:SCR_017267) | data or information resource | Searchable table of datasets. Data generated from projects through BRAIN Initiative Cell Census Network. Datasets can be filtered by species, research investigator, grant number or experimental technique. Includes links to data directories at data archives and links to protocols. | data, dataset, brain, initiative, cell, registry |
is related to: BRAIN Cell Data Center is related to: BRAIN Cell Data Center has parent organization: Allen Institute for Brain Science is provided by: BICCN |
NIH | Free, Freely available, Available for download | http://www.brainimagelibrary.org/download.html https://nemoarchive.org/resources/data-download.php |
SCR_017267 | BRAIN Initiative Cell Census Network Cell Registry, BICCN Cell Registry | 2026-02-07 02:10:02 | 11 | |||||||
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Xevo TQ-XS mass spectrometer Resource Report Resource Website 1+ mentions |
Xevo TQ-XS mass spectrometer (RRID:SCR_018510) | instrument resource | Advanced benchtop tandem quadrupole mass spectrometer which expands scope of ultimate sensitivity analysis. Fatures probe design which allows users much easier maintenance, optimization and improved reproducibility between operators. Method transfer onto Xevo TQ-XS is made simple by Xtended Dynamic Range detector which allows six orders of linear dynamic range. Wider compound coverage without changing ionization technique is delivered by the revolutionary UniSpray source option. | Benchtop mass spectrometer, instrument, equipment, USEDit |
is listed by: USEDit is related to: Stanford University Vincent Coates Foundation Mass Spectrometry Laboratory Core Facility |
NIH S10 OD026962 | https://www.waters.com/waters/library.htm?cid=134889751&lid=134891088&locale=en_US https://www.waters.com/webassets/cms/support/docs/715004990ra.pdf |
SCR_018510 | TQ-XS Triple Quad Mass Spectrometer, Xevo TQ-XS, SUMS Xevo | 2026-02-07 02:09:51 | 7 | ||||||||
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European Bioinformatics Institute Resource Report Resource Website 1000+ mentions |
European Bioinformatics Institute (RRID:SCR_004727) | EMBL-EBI | institution | Non-profit academic organization for research and services in bioinformatics. Provides freely available data from life science experiments, performs basic research in computational biology, and offers user training programme, manages databases of biological data including nucleic acid, protein sequences, and macromolecular structures. Part of EMBL. | organization, academic, bioinformatics, research, service, data, computational, biology, training, database, DNA, protein |
is used by: Blueprint Epigenome is listed by: re3data.org is related to: AgedBrainSYSBIO is related to: ProteomeXchange is related to: Open PHACTS is related to: RHEA is related to: TraCeR is related to: 3D-Beacons is related to: RNAcentral has parent organization: European Molecular Biology Laboratory is parent organization of: CoGenT++ is parent organization of: ENA Sequence Version Archive is parent organization of: Reaper - Demultiplexing trimming and filtering sequencing data is parent organization of: PeakAnalyzer is parent organization of: Tally is parent organization of: Clustal Omega is parent organization of: Biocatalogue - The Life Science Web Services Registry is parent organization of: Experimental Network for Functional Integration: A European Network of Excellence for Data Integration and Systems Biology is parent organization of: The Alternatve Splicing Database is parent organization of: BioModels is parent organization of: CHEBI is parent organization of: MAGE is parent organization of: Ensembl is parent organization of: MIAME is parent organization of: UniProt is parent organization of: Ligand-Gated Ion Channel Database is parent organization of: EBI Genomes is parent organization of: IMEx - The International Molecular Exchange Consortium is parent organization of: Toolbox at the European Bioinformatics Institute is parent organization of: Clustal W2 is parent organization of: ArrayExpress is parent organization of: IMGT/HLA is parent organization of: IntEnz- Integrated relational Enzyme database is parent organization of: IPD - Immuno Polymorphism Database is parent organization of: IPI is parent organization of: MicroArray and Gene Expression Markup Language is parent organization of: DaliLite Pairwise comparison of protein structures is parent organization of: Chemical Information Ontology is parent organization of: PANDIT : Protein and Associated Nucleotide Domains with Inferred Trees is parent organization of: Proteomics Identifications (PRIDE) is parent organization of: Software Ontology is parent organization of: FSSP - Families of Structurally Similar Proteins is parent organization of: Experimental Factor Ontology is parent organization of: Identifiers.org is parent organization of: HipSci is parent organization of: ProteomeXchange is parent organization of: Taxonomy is parent organization of: PDBe - Protein Data Bank in Europe is parent organization of: EBI Dbfetch is parent organization of: ProFunc is parent organization of: WSDbfetch (SOAP) is parent organization of: QuickGO is parent organization of: SAS - Sequence Annotated by Structure is parent organization of: UniProt DAS is parent organization of: UniParc at the EBI is parent organization of: Patent Abstracts is parent organization of: BioSample Database at EBI is parent organization of: Database of Genomic Variants Archive (DGVa) is parent organization of: European Genome phenome Archive is parent organization of: UniSave is parent organization of: ArchSchema is parent organization of: UniRef at the EBI is parent organization of: EBIMed is parent organization of: Kraken is parent organization of: SIMBioMS is parent organization of: Expression Profiler is parent organization of: Whatizit is parent organization of: InterProScan is parent organization of: VectorBase is parent organization of: DRCAT Resource Catalogue is parent organization of: FunTree is parent organization of: CREATE is parent organization of: BioMedBridges is parent organization of: PSICQUIC Registry is parent organization of: PDBsum is parent organization of: European Nucleotide Archive (ENA) is parent organization of: DrugPort is parent organization of: Ontology Lookup Service is parent organization of: EDAM Ontology is parent organization of: InterPro is parent organization of: MIRIAM Resources is parent organization of: EB-eye Search is parent organization of: SBO is parent organization of: Ensembl Genomes is parent organization of: NeuronVisio is parent organization of: IntAct is parent organization of: WSsas - Web Service for the SAS tool is parent organization of: Enzyme Structures Database is parent organization of: EMBOSS CpGPlot/CpGReport/Isochore is parent organization of: PaperMaker is parent organization of: CluSTr is parent organization of: Genome Reviews is parent organization of: GOA is parent organization of: Integr8 : Access to complete genomes and proteomes is parent organization of: IPD-ESTDAB- The European Searchable Tumour Line Database is parent organization of: IPD-HPA - Human Platelet Antigens is parent organization of: IPD-KIR - Killer-cell Immunoglobulin-like Receptors is parent organization of: IPD-MHC- Major Histocompatibility Complex is parent organization of: HilbertVis is parent organization of: Gene Expression Atlas is parent organization of: Parasite genome databases and genome research resources is parent organization of: Alternative Exon Database is parent organization of: AltExtron Database is parent organization of: Patent Data Resources is parent organization of: Pompep is parent organization of: Mouse finder is parent organization of: Gene Regulation Ontology is parent organization of: CiteXplore literature searching is parent organization of: MaxSprout is parent organization of: SRS is parent organization of: MicroCosm Targets is parent organization of: Kalign is parent organization of: MUSCLE is parent organization of: FASTA is parent organization of: WU-BLAST is parent organization of: Oases is parent organization of: HTS Mappers is parent organization of: CRAM is parent organization of: CSA - Catalytic Site Atlas is parent organization of: ArrayExpress (R) is parent organization of: WiggleTools is parent organization of: vsn is parent organization of: rlsim is parent organization of: ISA Infrastructure for Managing Experimental Metadata is parent organization of: BioMart Project is parent organization of: BioPerl is parent organization of: BioJS is parent organization of: EMDataResource.org is parent organization of: HTqPCR is parent organization of: Reactome is parent organization of: Europe PubMed Central is parent organization of: h5vc is parent organization of: LexGrid is parent organization of: Consensus CDS is parent organization of: 1000 Genomes: A Deep Catalog of Human Genetic Variation is parent organization of: OrChem is parent organization of: Orphanet Rare Disease Ontology is parent organization of: Reflect is parent organization of: BioLayout Express 3D is parent organization of: Virtual Fly Brain is parent organization of: GeneWise is parent organization of: PhenoMeNal is parent organization of: Ensembl Metazoa is parent organization of: Velvet |
EMBL member states ; European Union ; NIH ; Wellcome Trust ; UK Research Councils ; Industry Programme partners ; BBSRC |
grid.225360.0, Wikidata: Q1341845, ISNI: 0000 0000 9709 7726, nlx_72386 | https://ror.org/02catss52 | SCR_004727 | EBI, European Molecular Biology Laboratory - European Bioinformatics Institute | 2026-02-07 02:06:30 | 3689 | ||||||
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SLIDE Resource Report Resource Website 10+ mentions |
SLIDE (RRID:SCR_005137) | SLIDE | software resource | Software package that takes exon boundaries and RNA-Seq data as input to discern the set of mRNA isoforms that are most likely to present in an RNA-Seq sample. It is based on a linear model with a design matrix that models the sampling probability of RNA-Seq reads from different mRNA isoforms. To tackle the model unidentifiability issue, SLIDE uses a modified Lasso procedure for parameter estimation. Compared with deterministic isoform assembly algorithms (e.g., Cufflinks), SLIDE considers the stochastic aspects of RNA-Seq reads in exons from different isoforms and thus has increased power in detecting more novel isoforms. Another advantage of SLIDE is its flexibility of incorporating other transcriptomic data such as RACE, CAGE, and EST into its model to further increase isoform discovery accuracy. SLIDE can also work downstream of other RNA-Seq assembly algorithms to integrate newly discovered genes and exons. Besides isoform discovery, SLIDE sequentially uses the same linear model to estimate the abundance of discovered isoforms. |
is listed by: OMICtools has parent organization: University of California at Berkeley; Berkeley; USA |
NIH ; NHGRI HG004695; NHGRI HG005639; NEI EY019094 |
PMID:22135461 | OMICS_01291 | SCR_005137 | sparse linear modeling of RNA-Seq data for isoform discovery and abundance estimation | 2026-02-07 02:07:04 | 31 | |||||||
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NeuralAct Resource Report Resource Website 10+ mentions |
NeuralAct (RRID:SCR_002066) | NeuralAct | software resource | Software to visualize electrocorticographic (ECoG) and possibly also other kinds of neural activity (EEG / EMG/ DOT) on a 3D model of the cortical surface. The tool has been used to produce cortical activation images and image sequences in several recent studies using ECoG. The tool is written in matlab. The package is thoroughly documented and includes a demo. | brain, imaging, electrocorticographic, eeg, meg, dot, matlab, cortex, visualization, neural activity | NIH ; NIBIB EB006356; NIBIB EB000856; United States army research office W911NF-08-1-0216; United States army research office W911NF-07-1-0415 |
PMID:25381641 | Free, Available for download, Freely available | SciRes_000162 | http://www.neuralgate.org/software | SCR_002066 | NeuralAct: A tool to visualize cortical activity on a 3D model of the cortex | 2026-02-07 02:05:49 | 13 | |||||
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Thermo Orbitrap Eclipse nanoLC/MS system Resource Report Resource Website 10+ mentions |
Thermo Orbitrap Eclipse nanoLC/MS system (RRID:SCR_022212) | instrument resource | System includes Thermo Orbitrap Eclipse Tribid mass spectrometer and Waters M-Class Acquity nanoUPLC. This platform features sequential acquisition capabilities and multiple fragmentation types, enabling complex, in depth proteomic experiments. | Thermo Orbitrap Eclipse Tribrid mass spectrometer, Waters M-Class Acquity nanoUPLC, instrument, equipment, USEDit |
is listed by: USEDit is related to: Stanford University Vincent Coates Foundation Mass Spectrometry Laboratory Core Facility |
NIH S10 OD030473 | SCR_022212 | Thermo Orbitrap Eclipse nanoLC/MS, Orbitrap Eclipse nanoLC/MS | 2026-02-07 02:11:15 | 11 | |||||||||
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Cellarium Resource Report Resource Website |
Cellarium (RRID:SCR_025438) | software resource | Software platform to annotate cell types. | machine learning open source software, infrastructure, annotate cell types, |
is used by: BRAIN Initiative Cell Atlas Network has parent organization: Broad Institute |
NIH | Free, Freely available | https://github.com/10XGenomics/cell-annotation-service-client | SCR_025438 | 2026-02-07 02:17:01 | 0 | ||||||||
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National Institutes of Health Stem Cell Tables Resource Report Resource Website |
National Institutes of Health Stem Cell Tables (RRID:SCR_008359) | NIH Stem Cells | data or information resource, data set | Data tables providing an overview of information about stem cells that have been derived from mice and humans. The tables summarize published research that characterizes cells that are capable of developing into cells of multiple germ layers (i.e., multipotent or pluripotent) or that can generate the differentiated cell types of another tissue (i.e., plasticity) such as a bone marrow cell becoming a neuronal cell. The tables do not include information about cells considered progenitor or precursor cells or those that can proliferate without the demonstrated ability to generate cell types of other tissues. The tables list the tissue from which the cells were derived, the types of cells that developed, the conditions under which differentiation occurred, the methods by which the cells were characterized, and the primary references for the information. | ectoderm, endoderm, adipocyte, astrocyte, bone marrow, brain, cardiac, chondrocyte, differentiation, germ layer, hematopoietic stem cell, human, liver, mesenchymal stem cell, mesoderm, mouse, muscle, neuron, neuronal, osteoblast, pancreas, plasticity, platelet, red blood cell, skeletal, skin, spinal cord, neural stem cell, tenocyte, tissue, white blood cell, stem cell, multipotent stem cell, pluripotent stem cell, embryonic stem cell, embryonic primordial germ cell, primordial germ cell, neural progenitor cell, mesenchymal progenitor cell | has parent organization: National Institutes of Health | NIH | nif-0000-25459 | http://stemcells.nih.gov/info/scireport/appendixD.asp | SCR_008359 | 2026-02-11 10:57:48 | 0 | |||||||
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Project Tycho Resource Report Resource Website 1+ mentions |
Project Tycho (RRID:SCR_010489) | data or information resource, database | Database to advance the availability and use of public health data for science and policy making that includes data from all weekly notifiable disease reports for the United States dating back to 1888. Additional U.S. and international data will be released twice yearly. | population, disease, metadata standard, vaccination, public health data, health, incidence rate, death, statistics | has parent organization: University of Pittsburgh; Pennsylvania; USA | Smallpox, Polio, Measles, Mumps, Rubella, Hepatitis A, Whooping cough, Diphtheria, Etc. | Bill and Melinda Gates Foundation ; NIH |
PMID:24283231 PMID:24611167 |
Account required, Creative Commons Attribution License | nlx_157982 | SCR_010489 | Project Tycho Data for Health | 2026-02-11 10:58:20 | 2 | |||||
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Nanomaterial Registry Resource Report Resource Website 100+ mentions |
Nanomaterial Registry (RRID:SCR_013700) | MIAN | data or information resource, database | THIS RESOURCE IS NO LONGER IN SERVICE. Documented on June 9,2023. Registry that archives curated nanomaterial research data and their biological and environmental implications. The Registry provides data management plans for researchers, and accepts users' public-ready data, archive them, integrate them into the registry, allowing for the data to be shared publicly. Users can request more information on specific nanomaterial records, compare multiple nanomaterials, and export data to their desktop. | registry, information resource, nanomaterial, data management | is listed by: NIH Data Sharing Repositories | NIH | DOI:10.1109/BIBMW.2012.6470258 | THIS RESOURCE IS NO LONGER IN SERVICE | SCR_013793, r3d100011129 | https://doi.org/10.17616/R38S53 | SCR_013700 | 2026-02-11 10:58:56 | 151 | |||||
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Astrocyte Reactivity RNA-Seq Browser Resource Report Resource Website 1+ mentions |
Astrocyte Reactivity RNA-Seq Browser (RRID:SCR_015033) | data or information resource, database | Database containing information about RNA-sequencing and astrocyte reactivity. Searching a gene through this engine provides differential expression data for various experimental conditions. | astrocyte, glia, reactivity, rna-seq, search engine | has parent organization: University of California Los Angeles Department of Neurobiology | NIH NS057624; NIH NS084030; NIH P30 NS062691; NIH NS060677; NIH MH099559A; NIH MH104069; Dr. Miriam and Sheldon G. Adelson Medical Foundation ; Wings for Life |
PMID:27027288 | Public | SCR_015033 | 2026-02-11 10:59:02 | 3 | ||||||||
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LAMHDI: The Initiative to Link Animal Models to Human DIsease Resource Report Resource Website 1+ mentions |
LAMHDI: The Initiative to Link Animal Models to Human DIsease (RRID:SCR_008643) | data or information resource, database | THIS RESOURCE IS NO LONGER IN SERVICE, it has been replaced by Monarch Initiative. LAMHDI, the initiative to Link Animal Models to Human DIsease, is designed to accelerate the research process by providing biomedical researchers with a simple, comprehensive Web-based resource to find the best animal model for their research. LAMDHI is a free, Web-based, resource to help researchers bridge the gap between bench testing and human trials. It provides a free, unbiased resource that enables scientists to quickly find the best animal models for their research studies. LAMHDI includes mouse data from MGI, the Mouse Genome Informatics website; zebrafish data from ZFIN, the Zebrafish Model Organism Database; rat data from RGD, the Rat Genome Database; yeast data from SGD, the Saccharomyces Genome Database; and fly data from FlyBase. LAMHDI.org is operational today, and data is added regularly. Enhancements are planned to let researchers contribute their knowledge of the animal models available through LAMHDI. The LAMHDI goal is to allow researchers to share information about and access to animal models so they can refine research and testing, and reduce or replace the use of animal models where possible. LAMHDI Database Search: LAMHDI brings together scientifically validated information from various sources to create a composite multi-species database of animal models of human disease. To do this, the LAMHDI database is prepared from a variety of sources. The LAMHDI team takes publicly available data from OMIM, NCBI''s Entrez Gene database, Homologene, and WikiPathways, and builds a mathematical graph (think of it as a map or a web) that links these data together. OMIM is used to link human diseases with specific human genes, and Entrez provides universal identifiers for each of those genes. Human genes are linked to their counterpart genes in other species with Homologene, and those genes are linked to other genes tentatively or authoritatively using the data in WikiPathways. This preparatory work gives LAMHDI a web of human diseases linked to specific human genes, orthologous human genes, homologous genes in other species, and both human and non-human genes involved in specific metabolic pathways associated with those diseases. LAMHDI includes model data that partners provide directly from their data structures. For instance, MGI provides information about mouse models, including a disease for each model, as well as some genetic information (the ID of the model, in fact, identifies one or more genes). ZFIN provides genetic information for each zebrafish model, but no diseases, so zebrafish models are integrated by using the genes as the glue. For instance, a zebrafish model built to feature the zebrafish PKD2 gene would plug into the larger disease-gene map at the node representing the zebrafish PKD2 gene, which is connected to the node representing the human PKD2 gene, which in turn is connected to the node representing the human disease known as polycystic kidney disease. (Some of the partner data LAMHDI receives can even extend the base map. MGI provides a disease for every model, and in some cases this allows the creation of a disease-to-gene relationship in the LAMHDI database that might not already be documented in the OMIM dataset.) With curatorial and model information in hand, LAMHDI runs a lengthy automated process that exhaustively searches for every possible path between each model and each disease in the data, up to a set number of hops, producing for each disease-to-model pair a set of links from the disease to the model. The algorithm avoids circular paths and paths that include more than one disease anywhere in the middle of the path. At the end of this phase, LAMHDI has a comprehensive set of paths representing all the disease-to-model relationships in the data, varying in length from one hop to many hops. Each disease-to-model path is essentially a string of nodes in the data, where each node represents a disease, a gene, a linkage between genes (an orthologue, a homologue, or a pathway connection, referred to as a gene cluster or association), or a model. Each node has a human-friendly label, a set of terms and keywords, and - in most cases - a URL linking the node to the data source where it originated. When a researcher submits a search on the LAMHDI website, LAMHDI searches for the user''s search terms in its precomputed list of all known disease-to-model paths. It looks for the terms not only in the disease and model nodes, but also in every node along each path. The complete set of hits may include multiple paths between any given disease-to-model pair of endpoints. Each of these disease-to-model pair sets is ordered by the number of hops it involves, and the one involving the fewest hops is chosen to represent its respective disease-to-model pair in the search results presented to the user. Results are sorted by scores that represent their matches. The number of hops is one barometer of the strength of the evidence linking the model and the disease; fewer hops indicates the relationship is stronger, more hops indicates it may be weaker. This indicator works best for comparing models from a single partner dataset: MGI explicitly identifies a disease for each mouse model, so there can be disease-to-model hits for mice that involve just one hop. Because ZFIN does not explicitly identify a disease for each model, no zebrafish model will involve fewer than four hops to the nearest disease, from the zebrafish model to a zebrafish gene to a gene cluster to a human gene to a human disease. | fly, animal, biologic, community, database, disease, genome, human, informatics, international, internet, knockout, model, mouse, network, organism, pathway, primate, rat, research, saccharomyces, testing, treatment, trial, worm, zebrafish |
has parent organization: University of Washington; Seattle; USA has parent organization: University of Wisconsin-Madison; Wisconsin; USA has parent organization: University of California at San Diego; California; USA |
NIH OD011883; NIH NS058296 |
THIS RESOURCE IS NO LONGER IN SERVICE | nif-0000-32417 | SCR_008643 | LAMHDI | 2026-02-11 10:57:53 | 2 | |||||||
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Mouse Thalamic Projectome Dataset Resource Report Resource Website |
Mouse Thalamic Projectome Dataset (RRID:SCR_015702) | data or information resource, data set | Data set of thalamo-centric mesoscopic projection maps to the cortex and striatum. The maps are established through two-color, viral (rAAV)-based tracing images and high throughout imaging. | jpeg image data set, projection map, thalamocortical map, viral (rAAV)-based tracing, thalamo-centric mesoscopic projection map | NIH DP2 OD008425; NINDS R01 NS081071; NIDDK T32 DK007680; NINDS P30 NS069305; NIDA R01 DA008163; NINDS U01 NS094247 |
PMID:25086607 PMID:27892854 |
Free | https://github.com/BJHunnicutt/anatomy | SCR_015702 | 2026-02-11 10:59:17 | 0 | ||||||||
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Nucleic Acid Database Resource Report Resource Website 10+ mentions |
Nucleic Acid Database (RRID:SCR_003255) | NDB | data or information resource, database | A database of three-dimensional structural information about nucleic acids and their complexes. In addition to primary data, it contains derived geometric data, classifications of structures and motifs, standards for describing nucleic acid features, as well as tools and software for the analysis of nucleic acids. A variety of search capabilities are available, as are many different types of reports. NDB maintains the macromolecular Crystallographic Information File (mmCIF). | nucleic acid, dna, nucleopeptide, nucleoprotein, nucleotide, rna, transfection, sequence, structure, function, bio.tools, FASEB list |
is listed by: re3data.org is listed by: bio.tools is listed by: Debian is related to: MINAS - Metal Ions in Nucleic AcidS is related to: Biological Magnetic Resonance Data Bank (BMRB) is related to: Jenalib: Jena Library of Biological Macromolecules has parent organization: Rutgers University; New Jersey; USA |
NSF ; DOE ; NIH |
PMID:24185695 PMID:1384741 |
Free, Available for download, Freely available | nif-0000-03184, biotools:ndb, r3d100010415 | https://bio.tools/ndb https://doi.org/10.17616/R3531R |
SCR_003255 | 2026-02-11 10:56:42 | 36 | |||||
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IntegromeDB Resource Report Resource Website 1+ mentions |
IntegromeDB (RRID:SCR_004620) | data or information resource, database | THIS RESOURCE IS NO LONGER IN SERVICE, documented May 26, 2016. Search engine that integrates over 100 curated and publicly contributed data sources and provides integrated views on the genomic, proteomic, transcriptomic, genetic and functional information currently available. Information featured in the database includes gene function, orthologies, gene expression, pathways and protein-protein interactions, mutations and SNPs, disease relationships, related drugs and compounds. | catalog, search engine, gene, protein, gene regulation, gene expression, protein-protein interaction, pathway, metagenomics, mutation, disease, transcriptional regulation, genomics, transcriptomics, genetics, function, interaction, ortholog |
is related to: ABS: A Database of Annotated Regulatory Binding Sites From Orthologous Promoters has parent organization: University of California at San Diego; California; USA |
NIH ; NIGMS R01 GM084881 |
PMID:22260095 PMID:20427517 |
THIS RESOURCE IS NO LONGER IN SERVICE | nlx_63198 | SCR_004620 | Integrome DB | 2026-02-11 10:56:56 | 3 |
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