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SciCrunch Registry is a curated repository of scientific resources, with a focus on biomedical resources, including tools, databases, and core facilities - visit SciCrunch to register your resource.
http://www.bioconductor.org/packages/release/bioc/html/genoset.html
Software package to load, manipulate, and plot copynumber and BAF data by providing classes similar to ExpressionSet for copy number analysis. The class extends ExpressionSet by adding a locData slot for a RangedData or GRanegs object. This object contains feature genome location data and provides for efficient subsetting on genome location. CNSet and BAFSet extend GenoSet and require assayData matrices for Copy Number (cn) or Log-R Ratio (lrr) and B-Allele Frequency (baf) data. Implements and provides convenience functions for processing of copy number and B-Allele Frequency data.
Proper citation: GenoSet (RRID:SCR_001275) Copy
http://www.bioconductor.org/packages/2.14/bioc/html/CGHbase.html
Software package that contains functions and classes that are needed by arrayCGH packages.
Proper citation: CGHbase (RRID:SCR_001279) Copy
http://www.bioconductor.org/packages/release/bioc/html/simpleaffy.html
Software package that provides high level functions for reading Affy .CEL files, phenotypic data, and then computing simple things with it, such as t-tests, fold changes and the like. It makes heavy use of the affy library. It also has some basic scatter plot functions and mechanisms for generating high resolution journal figures.
Proper citation: Simpleaffy (RRID:SCR_001302) Copy
http://www.bioconductor.org/packages/2.4/bioc/html/rMAT.html
Software package for normalizing and analyzing tiling arrays and ChIP-chip data. It is the R-version of a MAT program.
Proper citation: rMAT (RRID:SCR_001583) Copy
http://www.bioconductor.org/packages/2.12/bioc/html/CGHcall.html
Software that calls aberrations for array CGH data using a six state mixture model and several biological concepts. It is written in R.
Proper citation: CGHcall (RRID:SCR_001578) Copy
https://www.bioconductor.org/packages//2.10/bioc/html/spade.html
An analysis and visualization software tool for high dimensional flow cytometry data that organizes cells into hierarchies of related phenotypes.
Proper citation: SPADE (RRID:SCR_001810) Copy
http://bioconductor.org/packages/release/bioc/html/MetaCyto.html
Software tool for automated meta-analysis of mass and flow cytometry data. Provides functions for preprocessing, automated gating and meta-analysis of cytometry data and collection of cytometry data from the ImmPort database.
Proper citation: MetaCyto (RRID:SCR_016415) Copy
https://www.bioconductor.org/packages/release/workflows/html/RnaSeqGeneEdgeRQL.html
Software to study analysis of an RNA-Seq experiment using the Rsubread and edgeR packages. The workflow starts from read alignment and continues on to data exploration, to differential expression and, finally, to pathway analysis. The analysis includes plots, GO and KEGG analyses, and the analysis of a expression signature as generated by a prior experiment.
Proper citation: RnaSeqGeneEdgeRQL (RRID:SCR_016699) Copy
http://bioconductor.org/packages/release/bioc/html/clusterProfiler.html
Software R package for statistical analysis and visualization of functional profiles for genes and gene clusters.
Proper citation: clusterProfiler (RRID:SCR_016884) Copy
http://bioconductor.org/packages/release/data/experiment/html/affydata.html
Software R package for analysis of Affymetrix Data. Contains samples data files of a large size.
Proper citation: affydata (RRID:SCR_016976) Copy
http://bioconductor.org/packages/CATALYST/
Software R package to provide pipeline for preprocessing of cytometry data, including normalization using bead standards, single cell deconvolution, and bead based compensation.
Proper citation: CATALYST (RRID:SCR_017127) Copy
http://bioconductor.org/packages/gage/
Software R package for gene set enrichment or pathway analysis. Applicable independent of microarray or RNAseq data attributes including sample sizes, experimental designs, assay platforms, and other types of heterogeneity. Pipeline routines of multiple GAGE analyses in batch, comparison between parallel analyses, and combined analysis of heterogeneous data from different sources and studies.
Proper citation: GAGE (RRID:SCR_017067) Copy
A package for statistical relative quantification of proteins and peptides in global, targeted, and data-independent proteomics. It handles shotgun, label-free, and label-based Selected Reaction Monitoring, as well as SWATH/DIA (Data Independent Acquisition) experiments. MSStats provide functionality for data processing and visualization, model-based statistical analysis, and model-based sample size calculations.
Proper citation: MSstats (RRID:SCR_014353) Copy
Computable knowledge regarding functions of genes and gene products. GO resources include biomedical ontologies that cover molecular domains of all life forms as well as extensive compilations of gene product annotations to these ontologies that provide largely species-neutral, comprehensive statements about what gene products do. Used to standardize representation of gene and gene product attributes across species and databases.
Proper citation: Gene Ontology (RRID:SCR_002811) Copy
http://www.imexconsortium.org/
Interaction database from international collaboration between major public interaction data providers who share curation effort and develop set of curation rules when capturing data from both directly deposited interaction data or from publications in peer reviewed journals. Performs complete curation of all protein-protein interactions experimentally demonstrated within publication and makes them available in single search interface on common website. Provides data in standards compliant download formats. IMEx partners produce their own separate resources, which range from all encompassing molecular interaction databases, such as are maintained by IntAct, MINT and DIP, organism-centric resources such as BioGrid or MPIDB or biological domain centric, such as MatrixDB. They have committed to making records available, via PSICQUIC webservice, which have been curated to IMEx rules and are available to users as single, non-redundant set of curated publications which can be searched at the IMEx website. Data is made available in standards-compliant tab-deliminated and XML formats, enabling to visualize data using wide range of tools. Consortium is open to participation of additional partners and encourages deposition of data, prior to publication, and will supply unique accession numbers which may be referenced within final article. Submitters may send their data directly to any of member databases using variety of formats, but should conform to guidelines as to minimum information required to describe data.
Proper citation: IMEx - The International Molecular Exchange Consortium (RRID:SCR_002805) Copy
http://www.bioconductor.org/packages/release/bioc/html/DSS.html
Software R library performing differntial analysis for count-based sequencing data. It detectes differentially expressed genes (DEGs) from RNA-seq, and differentially methylated loci or regions (DML/DMRs) from bisulfite sequencing (BS-seq). The core of DSS is a new dispersion shrinkage method for estimating the dispersion parameter from Gamma-Poisson or Beta-Binomial distributions.
Proper citation: DSS (RRID:SCR_002754) Copy
Software R-package for running gene set analysis using various statistical methods, from different gene level statistics and a wide range of gene-set collections. The Piano package contains functions for combining the results of multiple runs of gene set analyses.
Proper citation: Piano (RRID:SCR_003200) Copy
https://bioconductor.org/packages/FilterFFPE/
Software R package to find and filter artificial chimeric reads specifically generated in next generation sequencing process of formalin fixed paraffin embedded tissues. These artificial chimeric reads can lead to large number of false positive structural variant calls. Artifact chimeric read filter to improve SV detection in FFPE samples.
Proper citation: FilterFFPE (RRID:SCR_021086) Copy
http://www.bioconductor.org/packages/2.13/bioc/html/epigenomix.html
Software package for the integrative analysis of microarray based gene expression and histone modification data obtained by ChIP-seq. The package provides methods for data preprocessing and matching as well as methods for fitting bayesian mixture models in order to detect genes with differences in both data types.
Proper citation: epigenomix (RRID:SCR_006407) Copy
https://github.com/hemberg-lab/scmap
Software tool for unsupervised projection of single cell RNA-seq data. Used for projecting cells from scRNA-seq data set onto cell types or individual cells from other experiments.
Proper citation: Scmap (RRID:SCR_017338) Copy
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