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SciCrunch Registry is a curated repository of scientific resources, with a focus on biomedical resources, including tools, databases, and core facilities - visit SciCrunch to register your resource.

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Resource Name Proper Citation Abbreviations Resource Type Description Keywords Resource Relationships Related Condition Funding Defining Citation Availability Website Status Alternate IDs Alternate URLs Old URLs Parent Organization Resource ID Synonyms Record Last Update Mentions Count
TileQC
 
Resource Report
Resource Website
TileQC (RRID:SCR_001229) TileQC software resource THIS RESOURCE IS NO LONGER IN SERVICE. Documented on May,10, 2021.Software providing a visually oriented tile based approach to error detection for Solexa next-gen sequencing data. It is written in R and has both qualitative and quantitative error detection features. This software was written with the idea that the researcher's visual pattern recognition is the best way to detect novel errors and contains variety of ways to visualize that data. Once a new type of error is identified the data extraction features of the program may then be used as a starting point for the programmatic detection and/or filtration of similar errors. A supplementary role of tileQC is to convert the Eland and Q-score data contained within the Solexa "*_prb.txt" and "*_eland_results.txt" text files to a more flexible database form. Once in database form, tileQC simplifies the mechanics of interacting with that data and supplements standard SQL with an expression subsitution mechanism that allows R to be easily comingled with SQL. This system requires access to a mySQL server and the R package RMySQL as well as a few standard UNIX tools (also available on Windows and Macintosh). next-generation sequencing, quality control, solexa, r, tile, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
has parent organization: Oregon State University; Oregon; USA
PMID:18507856 THIS RESOURCE IS NO LONGER IN SERVICE biotools:tileqc, OMICS_02114 https://bio.tools/tileqc SCR_001229 TileQC: A tile based approached to quality control 2026-02-07 02:05:29 0
VAAL
 
Resource Report
Resource Website
VAAL (RRID:SCR_001184) VAAL software resource A polymorphism discovery algorithm for short reads. To run it, you provide reads (and quality scores) from a "sample genome" as input, along with a vector sequence to trim from the reads, and a reference sequence for a related genome to compare to. VAAL produces as output a an assembly for the sample genome, together with a mask showing which bases are "trusted". It then deduces from that a list of differences between the sample and related genomes. Alternatively, it can be provided as input read data for two sample genomes, together with a reference sequence for a related genome. In this case, VAAL produces assemblies for each of the sample genomes, and compares them to each other, thereby deducing a list of differences between them. VAAL has been tested on bacteria, using single lanes of 36 bp unpaired reads from the Illumina platform. Note: This software package is no longer supported and information on this page is provided for archival purposes only. dna sequence, polymorphism, parallel sequencing, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
has parent organization: Broad Institute
PMID:19079253 biotools:vaal, OMICS_02170 https://bio.tools/vaal SCR_001184 2026-02-07 02:05:28 0
Bionimbus
 
Resource Report
Resource Website
1+ mentions
Bionimbus (RRID:SCR_001189) Bionimbus service resource A cloud-based infrastructure for managing, analyzing and sharing genomics datasets. data sharing, cloud, genomics, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
has parent organization: Open Science Data Cloud
THIS RESOURCE IS NO LONGER IN SERVICE biotools:bionimbus, OMICS_02160 https://bio.tools/bionimbus SCR_001189 2026-02-07 02:05:32 2
SABER
 
Resource Report
Resource Website
50+ mentions
SABER (RRID:SCR_001257) SABER software resource Software program suitable for genome-scale data which uses a Markov-hidden Markov model (MHMM) to estimate local ancestry. The MHMM makes it possible to identify genomic blocks of a particular ancestry by use of any high-density single-nucleotide-polymorphism panel. One application is to perform admixture mapping without genotyping special ancestry-informative-marker panels. r, linux, ancestry, admixed, genetic, population, linkage disequilibrium, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
has parent organization: Stanford University School of Medicine; California; USA
PMID:16773560 Free, Available for download, Freely available biotools:saber, OMICS_02081 https://bio.tools/saber SCR_001257 2026-02-07 02:05:28 71
multtest
 
Resource Report
Resource Website
10+ mentions
multtest (RRID:SCR_001255) multtest software resource Software package for non-parametric bootstrap and permutation resampling-based multiple testing procedures (including empirical Bayes methods) for controlling the family-wise error rate (FWER), generalized family-wise error rate (gFWER), tail probability of the proportion of false positives (TPPFP), and false discovery rate (FDR). Several choices of bootstrap-based null distribution are implemented (centered, centered and scaled, quantile-transformed). Single-step and step-wise methods are available. Tests based on a variety of t- and F-statistics (including t-statistics based on regression parameters from linear and survival models as well as those based on correlation parameters) are included. When probing hypotheses with t-statistics, users may also select a potentially faster null distribution which is multivariate normal with mean zero and variance covariance matrix derived from the vector influence function. Results are reported in terms of adjusted p-values, confidence regions and test statistic cutoffs. The procedures are directly applicable to identifying differentially expressed genes in DNA microarray experiments. differential expression, microarray, multiple comparison, bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
has parent organization: Bioconductor
Free, Available for download, Freely available biotools:multtest, OMICS_02085 https://bio.tools/multtest SCR_001255 multtest - Resampling-based multiple hypothesis testing 2026-02-07 02:05:29 33
BFCounter
 
Resource Report
Resource Website
1+ mentions
BFCounter (RRID:SCR_001248) BFCounter software resource Software program for counting k-mers in DNA sequence data. It identifies all the k-mers that occur more than once in a DNA sequence data set using a Bloom filter, a probabilistic data structure that stores all the observed k-mers implicitly in memory with greatly reduced memory requirements. c++, k-mer, dna sequence, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
has parent organization: Stanford University; Stanford; California
PMID:21831268 Free, Available for download, Freely available biotools:bfcounter, OMICS_02093 https://bio.tools/bfcounter http://pritch.bsd.uchicago.edu/bfcounter.html, http://pritchardlab.stanford.edu/bfcounter.html SCR_001248 BF Counter: Memory efficient K-mer counting Software 2026-02-07 02:05:28 5
TALLYMER
 
Resource Report
Resource Website
1+ mentions
TALLYMER (RRID:SCR_001244) Tallymer software resource A collection of flexible and memory-efficient software programs for k-mer counting and indexing of large sequence sets. It is based on enhanced suffix arrays which gives a much larger flexibility concerning the choice of the k-mer size. It can process large data sizes of several billion bases. k-mer, counting, sequence, genome annotation, genome, annotation, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
has parent organization: University of Hamburg; Hamburg; Germany
PMID:18976482 Free, Freely available biotools:tallymer, OMICS_02096 https://bio.tools/tallymer SCR_001244 2026-02-07 02:05:33 7
quantsmooth
 
Resource Report
Resource Website
1+ mentions
quantsmooth (RRID:SCR_001271) quantsmooth software resource Software package for quantile smoothing and genomic visualization of array data. copy number variation, visualization, bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
has parent organization: Bioconductor
PMID:15572474 Free, Available for download, Freely available OMICS_02067, BioTools:quantsmooth, biotools:quantsmooth https://bio.tools/quantsmooth
https://bio.tools/quantsmooth
https://bio.tools/quantsmooth
SCR_001271 2026-02-07 02:05:30 1
SNPchip
 
Resource Report
Resource Website
10+ mentions
SNPchip (RRID:SCR_001269) SNPchip software resource Software package that contains classes and methods useful for storing, visualizing and analyzing high density SNP data. Originally developed from the SNPscan web-tool, SNPchip utilizes S4 classes and extends other open source R tools available at Bioconductor, including the R packages Biobase and oligo. This has numerous advantages, including the ability to build statistical models for SNP-level data that operate on instances of the class, and to communicate with other R packages that add additional functionality. dna copy number, snp, genetic variability, visualization, high throughput, snp chip, microarray, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
has parent organization: Bioconductor
has parent organization: Johns Hopkins Bloomberg School of Public Health; Maryland; USA
PMID:17204461 Free, Available for download, Freely available OMICS_02069, biotools:snpchip https://bio.tools/snpchip SCR_001269 2026-02-07 02:05:34 13
ADMIXTURE
 
Resource Report
Resource Website
1000+ mentions
ADMIXTURE (RRID:SCR_001263) ADMIXTURE software resource A software tool for maximum likelihood estimation of individual ancestries from multilocus SNP genotype datasets. It uses the same statistical model as STRUCTURE but calculates estimates much more rapidly using a fast numerical optimization algorithm. It uses a block relaxation approach to alternately update allele frequency and ancestry fraction parameters. Each block update is handled by solving a large number of independent convex optimization problems, which are tackled using a fast sequential quadratic programming algorithm. Convergence of the algorithm is accelerated using a novel quasi-Newton acceleration method., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025. ancestry, macos x, linux, admixture, allele, genome, single nucleotide polymorphism, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
has parent organization: University of California at Los Angeles; California; USA
PMID:19648217 THIS RESOURCE IS NO LONGER IN SERVICE biotools:admixture, OMICS_02077 http://www.genetics.ucla.edu/software/admixture/ SCR_001263 ADMIXTURE: fast ancestry estimation 2026-02-07 02:05:28 2675
gprege
 
Resource Report
Resource Website
1+ mentions
gprege (RRID:SCR_001324) gprege software resource Software R package for Gaussian Process Ranking and Estimation of Gene Expression time-series. The software fits two Gaussian processes (GPs) with an radial basis function (RBF) (+ noise diagonal) kernel on each profile. One GP kernel is initialized wih a short lengthscale hyperparameter, signal variance as the observed variance and a zero noise variance. It is optimized via scaled conjugate gradients (netlab). A second GP has fixed hyperparameters: zero inverse-width, zero signal variance and noise variance as the observed variance. The log-ratio of marginal likelihoods of the two hypotheses acts as a score of differential expression for the profile. Comparison via receiver operating characteristic curves (ROC curves) is performed against Bayesian hierarchical model for the analysis of time-series (BATS) (Angelini et.al, 2007). differential expression, microarray, preprocessing, time course, bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
has parent organization: Bioconductor
PMID:21599902 Free, Available for download, Freely available OMICS_02011, biotools:gprege http://www.bioconductor.org/packages/release/bioc/html/gprege.html SCR_001324 Gaussian Process Ranking and Estimation of Gene Expression time-series 2026-02-07 02:05:35 1
KAnalyze
 
Resource Report
Resource Website
1+ mentions
KAnalyze (RRID:SCR_001323) software resource A Java toolkit designed to convert DNA and RNA sequences into k-mers. standalone software, java, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
has parent organization: SourceForge
PMID:24642064 Free, Available for download, Freely available biotools:kanalyze, OMICS_03565 https://bio.tools/kanalyze SCR_001323 2026-02-07 02:05:30 2
beadarray
 
Resource Report
Resource Website
100+ mentions
beadarray (RRID:SCR_001314) beadarray software resource Software package to read bead-level data (raw TIFFs and text files) output by BeadScan as well as bead-summary data from BeadStudio. Methods for quality assessment and low-level analysis are provided. microarray, quality control, one channel, preprocessing, bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
is listed by: SoftCite
has parent organization: Bioconductor
PMID:17586828 GNU General Public License, v2 OMICS_02021, biotools:beadarray https://bio.tools/beadarray SCR_001314 beadarray - Quality assessment and low-level analysis for Illumina BeadArray data 2026-02-07 02:05:35 119
MACAT
 
Resource Report
Resource Website
MACAT (RRID:SCR_001350) MACAT software resource Software library that contains functions to investigate links between differential gene expression and the chromosomal localization of the genes. It is motivated by the common observation of phenomena involving large chromosomal regions in tumor cells. MACAT is the implementation of a statistical approach for identifying significantly differentially expressed chromosome regions. differential expression, microarray, visualization, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
has parent organization: Bioconductor
PMID:15572464 THIS RESOURCE IS NO LONGER IN SERVICE OMICS_01989, biotools:macat https://bio.tools/macat SCR_001350 MicroArray Chromosome Analysis Tool 2026-02-07 02:05:36 0
lapmix
 
Resource Report
Resource Website
lapmix (RRID:SCR_001347) lapmix software resource Software to identify differentially expressed genes. A hierarchical Bayesian approach is used, and the hyperparameters are estimated using empirical Bayes. differential expression, microarray, bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
has parent organization: Bioconductor
Free, Available for download, Freely available biotools:lapmix, OMICS_01992 https://bio.tools/lapmix SCR_001347 Laplace Mixture Model in Microarray Experiments 2026-02-07 02:05:36 0
FARMS
 
Resource Report
Resource Website
10+ mentions
FARMS (RRID:SCR_001344) FARMS software resource Software using a model-based technique for summarizing high-density oligonucleotide array data at probe level for Affymetrix GeneChips. It is based on a factor analysis model for which a Bayesian maximum a posteriori method optimizes the model parameters under the assumption of Gaussian measurement noise. oligonucleotide array, probe, affymetrix genechip, r, unix, windows, microarray, summarization, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
has parent organization: Johannes Kepler University of Linz; Linz; Austria
PMID:16473874 Free, Freely Available OMICS_01995, biotools:farms https://bio.tools/farms SCR_001344 Factor Analysis for Robust Microarray Summarization 2026-02-07 02:05:36 28
bridge
 
Resource Report
Resource Website
100+ mentions
bridge (RRID:SCR_001343) bridge software resource Software package to test for differentially expressed genes with microarray data. It can be used with both cDNA microarrays or Affymetrix chip. The packge fits a robust Bayesian hierarchical model for testing for differential expression. Outliers are modeled explicitly using a $t$-distribution. The model includes an exchangeable prior for the variances which allow different variances for the genes but still shrink extreme empirical variances. The model can be used for testing for differentially expressed genes among multiple samples, and can distinguish between the different possible patterns of differential expression when there are three or more samples. Parameter estimation is carried out using a novel version of Markov Chain Monte Carlo that is appropriate when the model puts mass on subspaces of the full parameter space. cdna microarray, affymetrix chip, differential expression, microarray, bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
has parent organization: Bioconductor
PMID:16542223 Free, Available for download, Freely available OMICS_01996, biotools:bridge http://www.bioconductor.org/packages/release/bioc/html/bridge.html SCR_001343 Bayesian Robust Inference for Differential Gene Expression 2026-02-07 02:05:31 154
aroma.light
 
Resource Report
Resource Website
1+ mentions
aroma.light (RRID:SCR_001312) aroma.light software resource Light-weight software package for normalization and visualization of microarray data using only basic R data types. Software can be used standalone, be utilized in other packages, or be wrapped up in higher-level classes. infrastructure, microarray, preprocessing, visualization, bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
has parent organization: Bioconductor
DOI:10.1186/1471-2105-11-245 Free, Available for download, Freely available OMICS_01998, biotools:aroma.light https://bio.tools/aroma.light
https://sources.debian.org/src/r-bioc-aroma.light/
SCR_001312 2026-02-07 02:05:29 1
BeadDataPackR
 
Resource Report
Resource Website
BeadDataPackR (RRID:SCR_001310) BeadDataPackR software resource Software that provides functionality for the compression and decompression of raw bead-level data from the Illumina BeadArray platform. microarray, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
has parent organization: Bioconductor
PMID:20981138 Free, Available for download, Freely available biotools:beaddatapackr, OMICS_02023 https://bio.tools/beaddatapackr SCR_001310 BeadDataPackR - Compression of Illumina BeadArray data 2026-02-07 02:05:35 0
OLIN
 
Resource Report
Resource Website
10+ mentions
OLIN (RRID:SCR_001304) OLIN software resource Software functions for normalization of two-color microarrays by optimised local regression and for detection of artifacts in microarray data. r, normalization, visualization, quality control, two-channel, microarray, preprocessing, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
has parent organization: Humboldt University of Berlin; Berlin; Germany
has parent organization: Bioconductor
PMID:15585527 Free, Available for download, Freely available biotools:olin, OMICS_02029 http://itb.biologie.hu-berlin.de/~futschik/software/R/OLIN/index.html SCR_001304 Optimised Local Intensity-dependent Normalisation 2026-02-07 02:05:35 18

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