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SciCrunch Registry is a curated repository of scientific resources, with a focus on biomedical resources, including tools, databases, and core facilities - visit SciCrunch to register your resource.

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Resource Name Proper Citation Abbreviations Resource Type Description Keywords Resource Relationships Related Condition Funding Defining Citation Availability Website Status Alternate IDs Alternate URLs Old URLs Parent Organization Resource ID Synonyms Record Last Update Mentions Count
Planet Microbe
 
Resource Report
Resource Website
1+ mentions
Planet Microbe (RRID:SCR_024478) web application, software resource Web based platform that enables data discovery from curated historical and on going oceanographic sequencing efforts. Enables discovery and integration of oceanographic ‘omics, environmental and physiochemical data layers. Used to centralize and standardize contextual data associated with major marine 'omic datasets. Used for marine microbiology to discover and analyze interconnected 'omics and environmental data. data discovery, curated oceanographic sequencing, biological and physiochemical measurements, water samples, marine microbiology, discover and analyze interconnected 'omics and environmental data, has parent organization: University of Arizona; Arizona; USA NSF PMID:32735679 Free, Freely available https://github.com/hurwitzlab/planet-microbe-app SCR_024478 2026-02-15 09:22:43 2
ORION Software
 
Resource Report
Resource Website
1+ mentions
ORION Software (RRID:SCR_004389) service resource, software resource ORION is our neuron reconstruction software package developed for the morphological reconstruction of neurons from confocal and multiphoton microscopy data. It accepts raw neuron stack data as input and it is capable of reconstructing the neuron structure, visualizing the output, and exporting the reconstruction in a variety of formats. We are developing tools that will enable Neuroscientists to explore single neuron function via sophisticated image analysis. Advanced optical imaging can produce both structural and functional data and is at the forefront of experimentally exploring the fast, small-scale dynamics of living neurons. Further, compartmental modeling of neuronal function enables rapid testing of hypotheses and estimating experimentally inaccessible parameters. Combining these two techniques will afford unprecedented capabilities in the study of single neuron function. Our software utility bridges the two Neuroscience techniques by rapidly, accurately, and robustly generating, from structural image data, a cylindrical morphology model suitable for simulating neuronal function. has parent organization: University of Houston; Texas; USA University of Houston; Texas; USA ;
NIA RO1-AG027577;
NSF IIS-0431144;
NSF IIS-0638875;
NSF DMS-0915242
nlx_40212 SCR_004389 2026-02-15 09:18:42 1
BioSimulations
 
Resource Report
Resource Website
BioSimulations (RRID:SCR_018733) web application, software resource Web tool for sharing and re-using biomodels, simulations, and visualizations of simulations results. Supports variety of modeling frameworks including kinetic, constraint based, and logical modeling, model formats including BNGL, CellML, SBML, and simulation tools including COPASI, libRoadRunner/tellurium, NFSim, VCell. Sharing, reusing, biomodel, simulation, visualization, simulation result, modeling framework support, simulation tool support, model format support, bio.tools is listed by: bio.tools
is listed by: Debian
has parent organization: Icahn School of Medicine at Mount Sinai; New York; USA
has parent organization: University of Connecticut; Connecticut; USA
NIBIB P41 EB023912;
NSF ;
NIGMS
Restricted biotools:biosimulations https://bio.tools/biosimulations SCR_018733 2026-02-15 09:22:23 0
runBioSimulations
 
Resource Report
Resource Website
1+ mentions
runBioSimulations (RRID:SCR_019110) web application, software resource Web tool for executing broad range of modeling studies and visualizing their results. Provides web interface for reusing any model. Models, simulations, and visualizations are available under licenses specified for each resource. Executing modeling studies, visualization, model reusing, simulation, bio.tools uses: BioSimulators
is listed by: bio.tools
is listed by: Debian
Center for Reproducible Biomodeling Modeling ;
National Institute of Bioimaging and Bioengineering ;
National Institute of General Medical Sciences ;
NSF ;
NIH
Free, Freely available biotools:runbiosimulations https://bio.tools/runbiosimulations SCR_019110 2026-02-15 09:22:22 3
PyNWB
 
Resource Report
Resource Website
1+ mentions
PyNWB (RRID:SCR_017452) software application, software resource Software Python package for working with Neurodata stored in Neurodata Without Borders files. Software providing API allowing users to read and create NWB formatted HDF5 files. Developed in support to NWB project with aim of spreading standardized data format for cellular based neurophysiology information. Neurodata, stored, NWB, file, share, standardized, data, format, neurophysiology, BRAIN Initiative uses: Hierarchical Data Modeling Framework
is used by: NWB Explorer
is recommended by: BRAIN Initiative
is listed by: OMICtools
is related to: Neurodata Extensions Catalog
is related to: HDMF Common Schema
is related to: NWB Inspector
Kavli Foundation ;
General Electric ;
Howard Hughes Medical Institute ;
Allen Institute for Brain Science ;
NSF 0855272;
International Neuroinformatics Coordinating Facility ;
NIH BRAIN Initiative R24 MH116922
PMID:26590340 Free, Available for downloading, Freely available https://github.com/NeurodataWithoutBorders/pynwb https://github.com/AllenInstitute/nwb-api SCR_017452 2026-02-15 09:22:02 4
OmicsGAN
 
Resource Report
Resource Website
1+ mentions
OmicsGAN (RRID:SCR_022976) software application, software resource Software generative adversarial network to integrate two omics data and their interaction network to generate one synthetic data corresponding to each omics profile that can result in better phenotype prediction. Used to capture information from interaction network as well as two omics datasets and fuse them to generate synthetic data with better predictive signals. integrate two omics data, interaction network, generate one synthetic data corresponding to each omics profile, phenotype prediction NSF III1755761;
NIGMS R01GM113952;
NIDA DK097771
PMID:34415323 Free, Available for download, Freely available SCR_022976 Omics Generative Adversarial Network 2026-02-15 09:23:07 1
PRECISE
 
Resource Report
Resource Website
50+ mentions
PRECISE (RRID:SCR_007874) PRECISE data or information resource, database THIS RESOURCE IS NO LONGER IN SERVICE. Documented on May 12,2023. Database of interactions between amino acid residues of enzyme and its ligands. Provides summary of interactions between amino acid residues of enzyme and its various ligands including substrate and transition state analogues, cofactors, inhibitors, and products., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025. enzyme, enzyme and enzyme nomenclature databases, function, align, amino acid, analogue, atom, chain, cofactor, complex, hydrogen bond, inhibitor, interaction, ligand, product, residue, sequence, structure, substrate, transition state has parent organization: Boston University; Massachusetts; USA NSF THIS RESOURCE IS NO LONGER IN SERVICE nif-0000-21331, SCR_008230 http://precise.bu.edu/precisedb/ SCR_007874 Predicted and Consensus Interaction Sites in Enzymes 2026-02-16 09:47:03 53
iDEP: Integrated Differential Expression and Pathway analysis
 
Resource Report
Resource Website
1+ mentions
iDEP: Integrated Differential Expression and Pathway analysis (RRID:SCR_027373) iDEP web application, software resource Integrated web application for differential expression and pathway analysis of RNA-Seq data. differential expression, pathway analysis, RNA-Seq data, NIGMS GM083226;
NSF ;
State of South Dakota
PMID:30567491 Free, Freely available SCR_027373 2026-02-15 09:24:17 8
Genes to Cognition: Neuroscience Research Programme
 
Resource Report
Resource Website
10+ mentions
Genes to Cognition: Neuroscience Research Programme (RRID:SCR_007121) data or information resource, topical portal, portal A neuroscience research program that studies genes, the brain and behavior in an integrated manner, established to elucidate the molecular mechanisms of learning and memory, and shed light on the pathogenesis of disorders of cognition. Central to G2C investigations is the NMDA receptor complex (NRC/MASC), that is found at the synapses in the central nervous system which constitute the functional connections between neurons. Changes in the receptor and associated components are thought to be in a large part responsible for the phenomenon of synaptic plasticity, that may underlie learning and memory. G2C is addressing the function of synapse proteins using large scale approaches combining genomics, proteomics and genetic methods with electrophysiological and behavioral studies. This is incorporated with computational models of the organization of molecular networks at the synapse. These combined approaches provide a powerful and unique opportunity to understand the mechanisms of disease genes in behavior and brain pathology as well as provide fundamental insights into the complexity of the human brain. Additionally, Genes to Cognition makes available its biological resources, including gene-targeting vectors, ES cell lines, antibodies, and transgenic mice, generated for its phenotyping pipeline. The resources are freely-available to interested researchers. cognition, gene, neuroscience is listed by: 3DVC
has parent organization: Wellcome Trust Sanger Institute; Hinxton; United Kingdom
Wellcome Trust ;
MRC ;
BBSRC ;
Gatsby Charitable Foundation ;
Human Frontiers Science Programme ;
European Union ;
Framework Programme ;
EPSRC ;
NSF
nif-0000-10235 SCR_007121 G2C Neuroscience Research Program, G2C Research Programme, Genes to Cognition: Neuroscience Research Program, Genes to Cognition, G2C, Genes to Cognition - Neuroscience Research Programme, Genes to Cognition-Neuroscience Research Programme, G2C Research Program 2026-02-16 09:46:53 19
DelPhi
 
Resource Report
Resource Website
1000+ mentions
DelPhi (RRID:SCR_008669) software application, software resource, simulation software DelPhi provides numerical solutions to the Poisson-Boltzmann equation (both linear and nonlinear form) for molecules of arbitrary shape and charge distribution. The current version is fast, accurate, and can handle extremely high lattice dimensions. It also includes flexible features for assigning different dielectric constants to different regions of space and treating systems containing mixed salt solutions. DelPhi takes as input a coordinate file format of a molecule or equivalent data for geometrical objects and/or charge distributions and calculates the electrostatic potential in and around the system, using a finite difference solution to the Poisson-Boltzmann equation. DelPhi is a versatile electrostatics simulation program that can be used to investigate electrostatic fields in a variety of molecular systems. Features of DelPhi include solutions to mixtures of salts of different valence; solutions to different dielectric constants to different regions of space; and estimation of the best relaxation parameter at run time. Poisson-Boltzmann equation, electrostatics, simulation software, mixed salt soluton has parent organization: Columbia University; New York; USA
has parent organization: Howard Hughes Medical Institute
NSF DBI-9904841 nif-0000-33392 SCR_008669 2026-02-16 09:47:14 1420
Human Brain Atlas
 
Resource Report
Resource Website
1+ mentions
Human Brain Atlas (RRID:SCR_006131) Human Brain Atlas data or information resource, video resource, atlas A labeled three-dimensional atlas of the human brain created from MRI images. In conjunction are presented anatomically labeled stained sections that correspond to the three-dimensional MRI images. The stained sections are from a different brain than the one which was scanned for the MRI images. Also available the major anatomical features of the human hypothalamus, axial sections stained for cell bodies or for nerve fibers, at six rostro-caudal levels of the human brain stem; images and Quicktime movies. The MRI subject was a 22-year-old adult male. Differing techniques used to study the anatomy of the human brain all have their advantages and disadvantages. Magnetic resonance imaging (MRI) allows for the three-dimensional viewing of the brain and structures, precise spatial relationships and some differentiation between types of tissue, however, the image resolution is somewhat limited. Stained sections, on the other hand, offer excellent resolution and the ability to see individual nuclei (cell stain) or fiber tracts (myelin stain), however, there are often spatial distortions inherent in the staining process. The nomenclature used is from Paxinos G, and Watson C. 1998. The Rat Brain in Stereotaxic Coordinates, 4th ed. Academic Press. San Diego, CA. 256 pp human, adult, mri, fiber stain, anatomy, normal, neuroanatomy, nissl stain, image, brainstem, cell body, nerve fiber, brain, coronal, sagittal, horizontal, 3d model, montage, weil, hypothalamus is used by: NIF Data Federation
has parent organization: Michigan State University; Michigan; USA
NSF IBN 0131267;
NSF 0131826;
NSF 0131028
Copyrighted, Public, Request that you secure their permission, Acknowledgement required nif-0000-00088 SCR_006131 MSU Brain Biodiversity Bank - Human Brain Atlas, Michigan State University Brain Biodiversity Bank - Human Brain Atlas 2026-02-16 09:46:37 3
PDB-Dev
 
Resource Report
Resource Website
10+ mentions
PDB-Dev (RRID:SCR_016185) service resource, data repository, storage service resource Data repository for integrative/hybrid structural models of macromolecules and their assemblies. This includes atomistic models as well as multi-scale models consisting of different coarse-grained representations. protein, prototype, deposition, integration, hybrid, model, macromolecule, assembly, crystallography, spectroscopy, microscopy, is related to: IHM-dictionary
has parent organization: Worldwide Protein Data Bank (wwPDB)
has parent organization: Rutgers University; New Jersey; USA
NSF DBI-1519158 Account required, Freely available, The research community can contribute to this resource SCR_016185 2026-02-16 09:48:58 35
CalC
 
Resource Report
Resource Website
10+ mentions
CalC (RRID:SCR_014259) software application, software resource, simulation software A modeling tool for simulating intracellular calcium diffusion and buffering. CalC solves continuous reaction-diffusion PDEs describing the entry of calcium into a volume through point-like channels, and its diffusion, buffering and binding to calcium receptors. Its features include: being platform-independent; being operated by simple script; combinable with MATLAB; and providing real-time views. Demos and manuals are provided on the website. simulation software, modeling tool, intracellular calcium diffusion, intracellular calcium buffering, pde NSF 0417416;
NSF 0817703;
NSF 1517085
Free, Acknowledgement requested SCR_014259 Calcium Calculator 2026-02-16 09:48:33 30
NeuroRD
 
Resource Report
Resource Website
10+ mentions
NeuroRD (RRID:SCR_014769) software application, software resource, simulation software Stochastic reaction-diffusion simulator in Java which is used for simulating neuronal signaling pathways. simulation software, simulator, java, neuronal signaling pathway, neuron HFSP ;
NIMH K21-MH01141;
NSF IBN 0077509;
CRCNS program R01 AA16022;
CRCNS program AA18066
Available for download https://github.com/neurord/stochdiff/releases SCR_014769 2026-02-16 09:48:37 13
PICRUSt
 
Resource Report
Resource Website
10+ mentions
PICRUSt (RRID:SCR_016855) PICRUSt software application, software resource, simulation software Software package to predict metagenome functional content from marker gene (e.g., 16S rRNA) surveys and full genomes. Used to predict which gene families are present and then combines gene families to estimate the composite metagenome. predict, metagenome, functional, content, DNA, sample, marker, gene, sequence, data, microbiome, 16S, RNA is related to: PICRUSt2 Canadian Institutes of Health Research ;
Canada Research Chairs program ;
Howard Hughes Medical Institute ;
NIDDK P01 DK078669;
NHGRI U01 HG004866;
NHGRI R01 HG004872;
Crohn’s and Colitis Foundation of America ;
Sloan Foundation ;
NHGRI R01 HG005969;
NSF CAREER DBI1053486;
ARO W911NF1110473
PMID:23975157 Free, Available for download, Freely available SCR_016856 SCR_016855 Phylogenetic Investigation of Communities by Reconstruction of Unobserved States, PICRUSt 2026-02-16 09:49:06 36
abSENSE
 
Resource Report
Resource Website
1+ mentions
abSENSE (RRID:SCR_023223) source code, software resource Software to interpret undetected homolog.Method that calculates probability that homolog of given gene would fail to be detected by homology search in given species, even if homolog were present and evolving normally. undetected homolog, gene homolog detection failure, homology search, lineage-specific genes, homology detection failure Howard Hughes Medical Institute ;
NHGRI R01-HG009116;
NIGMS RO1-GM43987;
NSF 1764269;
Simons Center for the Mathematical and Statistical Analysis of Biology 594596;
Harvard University
PMID:33137085 Free, Available for download, Freely available http://www.eddylab.org/abSENSE/ SCR_023223 2026-02-15 09:23:06 1
PTNet
 
Resource Report
Resource Website
PTNet (RRID:SCR_022975) source code, software resource Graph based learning model for protein expression estimation by considering miRNA-mRNA interactions. Estimates protein levels by considering miRNA-mRNA interaction network, mRNA expression and miRNA expression. protein level, protein expression estimation, miRNA-mRNA interactions, mRNA expression, miRNA expression, NSF III1755761;
NIGMS R01GM113952;
NIDDK DK097771
DOI:10.1093/bib/bbab264 Free, Available for download, Freely available SCR_022975 2026-02-15 09:22:56 0
BehaviorDEPOT
 
Resource Report
Resource Website
1+ mentions
BehaviorDEPOT (RRID:SCR_023602) source code, software resource Software tool for automated behavioral detection based on markerless pose tracking. Behavioral analysis tool to first compile and clean point-tracking output from DeepLabCut, and then classify behavioral epochs using custom behavior classifiers. Used to detect frame by frame behavior from video time series and can analyze results of common experimental assays, including fear conditioning, decision-making in T-maze, open field, elevated plus maze, and novel object exploration. Calculates kinematic and postural statistics from keypoint tracking data from pose estimation software outputs. OpenBehavior, automated behavioral detection, markerless pose tracking, detect frame by frame behavior, video time series, kinematic and postural statistics, is listed by: OpenBehavior
is related to: SLEAP, LEAP and MotionMapper project
works with: DeepLabCut
NIMH K01MH116264;
NIMH K08MH116125;
Whitehall Foundation ;
Simonsen Foundation ;
NSF ;
NIMH T32MH073526;
Brain Research Foundation ;
Brain and Behavior Research Foundation
PMID:35997072 Free, Available for download, Freely available https://edspace.american.edu/openbehavior/project/behaviordepot/ SCR_023602 2026-02-15 09:23:13 1
ezBIDS
 
Resource Report
Resource Website
ezBIDS (RRID:SCR_025563) web application, software resource Web-based BIDS conversion tool to convert neuroimaging data and associated metadata to BIDS standard. Guided standardization of neuroimaging data interoperable with major data archives and platforms. Guided standardization, neuroimaging data, Brain Imaging Data Structure, BIDS conversion tool, convert neuroimaging data, associated metadata, interoperable, BIDS standard, NINDS UM1NS132207;
BRAIN CONNECTS ;
NIBIB R01EB029272;
NIBIB R01EB030896;
NSF ;
Kavli Foundation ;
Wellcome Trust ;
NIMH R01MH133701;
Spanish Government
PMID:38332144 Free, Freely available https://brainlife.io/ezbids/
SCR_025563 ez Brain Imaging Data Structure 2026-02-15 09:23:56 0
ALCHEMY
 
Resource Report
Resource Website
1+ mentions
ALCHEMY (RRID:SCR_005761) ALCHEMY source code, software resource ALCHEMY is a genotype calling algorithm for Affymetrix and Illumina products which is not based on clustering methods. Features include explicit handling of reduced heterozygosity due to inbreeding and accurate results with small sample sizes. ALCHEMY is a method for automated calling of diploid genotypes from raw intensity data produced by various high-throughput multiplexed SNP genotyping methods. It has been developed for and tested on Affymetrix GeneChip Arrays, Illumina GoldenGate, and Illumina Infinium based assays. Primary motivations for ALCHEMY''s development was the lack of available genotype calling methods which can perform well in the absence of heterozygous samples (due to panels of inbred lines being genotyped) or provide accurate calls with small sample batches. ALCHEMY differs from other genotype calling methods in that genotype inference is based on a parametric Bayesian model of the raw intensity data rather than a generalized clustering approach and the model incorporates population genetic principles such as Hardy-Weinberg equilibrium adjusted for inbreeding levels. ALCHEMY can simultaneously estimate individual sample inbreeding coefficients from the data and use them to improve statistical inference of diploid genotypes at individual SNPs. The main documentation for ALCHEMY is maintained on the sourceforge-hosted MediaWiki system. Features * Population genetic model based SNP genotype calling * Simultaneous estimation of per-sample inbreeding coefficients, allele frequencies, and genotypes * Bayesian model provides posterior probabilities of genotype correctness as quality measures * Growing number of scripts and supporting programs for validation of genotypes against control data and output reformating needs * Multithreaded program for parallel execution on multi-CPU/core systems * Non-clustering based methods can handle small sample sets for empirical optimization of sample preparation techniques and accurate calling of SNPs missing genotype classes ALCHEMY is written in C and developed on the GNU/Linux platform. It should compile on any current GNU/Linux distribution with the development packages for the GNU Scientific Library (gsl) and other development packages for standard system libraries. It may also compile and run on Mac OS X if gsl is installed. diploid, genotype, snp, bio.tools is listed by: bio.tools
is listed by: Debian
has parent organization: SourceForge
has parent organization: Cornell University; New York; USA
NSF 0606461 PMID:20926420 GNU General Public License biotools:alchemy, nlx_149227 https://bio.tools/alchemy SCR_005761 ALCHEMY - An automated population genetic model driven SNP genotype calling method 2026-02-15 09:19:11 5

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