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https://www.biotech.cornell.edu/core-facilities-brc/facilities/biomolecular-interactions-properties

Provides investigators with access to advanced tools for measuring biomolecular interactions and properties through variety of techniques from high throughput screening via automation to single reaction cuvette based methods.Facility complements technologies and techniques available through our Imaging facility and Proteomics and Metabolomics facility.

Proper citation: Cornell University Biotechnology Resource Center Biomolecular Interactions and Properties Core Facility (RRID:SCR_023117) Copy   

•   Source: SciCrunch Registry

https://chemh.stanford.edu/research/knowledge-centers

Shared resource to provide instrumentation and scientific expertise to Stanford researchers.Each Knowledge Center is organized around specific scientific area and offers services to the research community. Services, advice, training and instrument access, include area in High-Throughput Screening, Medicinal Chemistry, Crystallography, Cryo-EM, Metabolomics, Protein engineering, Protein expression.

Proper citation: Stanford Sarafan Chemistry, Engineering and Medicine for Human Health Knowledge Centers Core Facility (RRID:SCR_023238) Copy   

•   Source: SciCrunch Registry

http://www.nextgen.pitt.edu

Sequencing Core offers Illumina next generation sequencing services to University of Pittsburgh research community. Offers expertise in next generation sequencing technologies. Encourages to contact Assistant Director to arrange for consultation.Staff is available to share their experience and expertise to assist with development of projects of all sizes, standard or custom assay design, and other specialized application needs.

Proper citation: University of Pittsburgh Medical Center Children Hospital of Pittsburgh Health Sciences Sequencing Core Facility (RRID:SCR_023116) Copy   

•   Source: SciCrunch Registry

https://chemh.stanford.edu/research/knowledge-centers/protein-engineering

MSKC is main gateway for Stanford faculty and students interested to study biological molecules using SLAC X-ray facilities and other major bioimaging facilities.

Proper citation: Stanford Sarafan Protein Engineering Knowledge Center Core Facility (RRID:SCR_023237) Copy   

•   Source: SciCrunch Registry

https://chemh.stanford.edu/research/knowledge-centers/metabolomics

Provides scientific expertise and instrumentation for measurement of small molecules such as metabolites and lipids to ChEM-H and Stanford communities. Leverages expertise in mass spectrometry and allied techniques to understand biology of small molecules both metabolites and xenobiotics and to apply that understanding to advances in human health.

Proper citation: Stanford Sarafan Metabolomics Knowledge Center Core Facility (RRID:SCR_023236) Copy   

•   Source: SciCrunch Registry

http://www.arpege.cnrs.frCore FacilityArpege

Offers functional and structural analysis of protein complexes.Offers possibility to characterize all types of molecular interactions: ligand-target binding, protein-protein interactions, signal transduction, and signalling complexes. Staff members are skilled specialists in luminescence-based techniques and in receptor biology.Application portfolio includes Analysis of cell signalling, by measuring signal transduction;Ligand-target binding (pharmacological analysis, affinity, selectivity); Protein-protein interactions (oligomerization, effectors...); Activation of signalling pathways (G proteins, GRK, arrestins & internalization); Intracellular production of second messengers (cAMP, IP1, Ca2+); Phosphorylation of signalling proteins (ERK, AKT...); Measurement of global cell functions and of different cell parameters (proliferation, migration, invasion...).

Proper citation: Arpege Core Facility (RRID:SCR_023092) Copy   

•   Source: SciCrunch Registry

http://www.mgx.cnrs.fr

Offers genomic technologies to academic laboratories and biotechnology companies.Application portfolio includes Whole genome (re)sequencing, including the identification of variants (SNVs, mutations, indels, CNVs);Targeted sequencing, for instance exomes; Transcriptome analyses (RNA-Seq, small RNA-Seq, microarrays), including in single cells (single-cell 3 RNA-seq); Determination of chromatin structure and dynamics (ChIP-Seq, FAIRE-Seq, Hi-C); Epigenetic analyses (ChIP-Seq, RRBS, Bisulphite-Seq);Genotyping (RAD-Seq, GBS, microarrays).

Proper citation: Montpellier GenomiX Core Facility (RRID:SCR_023091) Copy   

•   Source: SciCrunch Registry

https://www.rockefeller.edu/crispr/

Provides gene targeting and mouse embryonic stem cell technology for members of Rockefeller University, Memorial Sloan-Kettering Cancer Center and their collaborators.CRISPR and Genome Editing services include mouse genomic knock-out and knock-in, mouse conditional knock-out, establishing new ES lines for gene targeting services, establishing ES lines from mutant mouse embryos, preparing ES cells introduced from off campus resources for injection or other application, assisting in embryoid body culture and in vitro differentiation of ES cells, and purification and evaluation of DNA for pronuclear injection.

Proper citation: Rockefeller University CRISPR and Genome Editing Resource Center Core Facility (RRID:SCR_023097) Copy   

•   Source: SciCrunch Registry

https://pnf.uchicago.edu

Facility is ISO Class 5 cleanroom that specializes in advanced lithographic processing of hard and soft materials. Facility is focused on supporting basic science, applied research, research and development, and prototype production using micro and nanofabrication.

Proper citation: University of Chicago Pritzker Nanofabrication Core Facility (RRID:SCR_022955) Copy   

•   Source: SciCrunch Registry

https://research.med.psu.edu/core-facilities/hpc/

Provides computational and storage tools needed to efficiently and effectively process data. High performance computing cluster housing compute cores, graphical processing unit cores, and directly attached high speed storage.

Proper citation: Penn State College of Medicine High Performance Computing Core Facility (RRID:SCR_022953) Copy   

•   Source: SciCrunch Registry

https://research.utexas.edu/cbrs/cores/cem/

Offers training, assisted and unassisted use of microscopes and equipment, as well as consultations and collaborations. Support includes single particle cryo-EM, Cryo-ET, Micro-ED,simple characterization of samples in vitrified aqueous mixtures (e.g. nanoparticle size, etc.).

Proper citation: University of Texas at Austin Cryo Electron Microscopy Core Facility (RRID:SCR_022951) Copy   

•   Source: SciCrunch Registry

http://www.sylvester.org/bcsr

Provides services and expertise that facilitate behavioral, psychosocial, community, translational, and population based oncology research. Services include coordinating recruitment and retention of diverse study participants representative of Sylvester South Florida catchment area;supporting development of culturally and linguistically tailored study materials; facilitating data collection and management, including for biospecimens, in clinical and community setting; assisting with development and delivery of evidence based interventions across cancer continuum from prevention to survivorship; offering, seminars, workshops and training.Offers consultation on culturally appropriate approaches for study implementation and provides translation of study materials into Spanish and/or Haitian Creole. Engages diverse stakeholders throughout South Florida in dialogue about cancer prevention and collaborative research opportunities.

Proper citation: University of Miami Sylvester Comprehensive Cancer Center Behavioral and Community Based Research Shared Resource Core Facility (RRID:SCR_022893) Copy   

•   Source: SciCrunch Registry

http://www.sylvester.org/MTSR

Provides preclinical drug discovery and development services to facilitate discovery of small molecules that have potential to become cancer therapeutics.Offers expertise in drug discovery and facilitates process of uncovering novel treatments for cancer. Services include target evaluation and assay development; small molecule library preparation, screening, and curation; high throughput screening enablement; plate imaging and transfers; assay identification, development and implementation; standard and customized assays (including live cell metabolic assays, cell death assays, clonogenic assays, and alphascreen); support for hit-to-lead pharmacology (including pharmacokinetics and ADME/T); data analytics for hit-picking; investigational new drug (IND) enablement; and full pipeline project management.Offers consultation, training, educational workshops and seminars.

Proper citation: University of Miami Sylvester Comprehensive Cancer Center Molecular Therapeutics Shared Resource Core Facility (RRID:SCR_022892) Copy   

•   Source: SciCrunch Registry

http://www.sylvester.org/BBSR

Provides expertise and analysis support for basic and translational research, clinical trials, and both interventional and non-interventional population-based studies. Offers support for data and large scale data analysis projects. Services include support for data analysis and interpretation; software access; algorithm and database development; support of scientific review, monitoring, and oversight of clinical and population science research protocols; consultation, training, educational workshops, lectures and seminars.Biostatistics services include support for statistical design of clinical trials, population studies, and laboratory experiments; sample size determination and justification; statistical analysis plans; statistical support for data and safety monitoring of clinical trials; data analysis and interpretation; prediction model development using machine learning techniques; and database design and data management. Bioinformatics services include project design for high-throughput genomics studies; support for next generation sequencing data analysis (including whole transcriptome profiling; targeted region gene expression and single-cell RNA-seq; epigenomics profiling such as ChIP-seq and ATAC-seq; and exome or whole genome sequencing analysis); pathway analysis; microbiome data analysis; functional metagenomics analysis; drug sensitivity and genomic association analysis; genomic data integration using public databases; integration analysis of genomic data across multiple platforms; genomic data visualization; and bioinformatics methods, analysis pipeline, software and algorithm development. BBSR services can be utilized for QA/QC, including quality assessment of sequencing data, sample outlier detection, batch effect determination, evaluation of spike-in control methods, randomized block design, and other strategies for data normalization. T

Proper citation: University of Miami Sylvester Comprehensive Cancer Center Biostatistics and Bioinformatics Shared Resource Core Facility (RRID:SCR_022890) Copy   

•   Source: SciCrunch Registry

https://npc.cnsi.ucla.edu/

Offers curated collection of high end scientific instrumentation to enable physicochemical characterization of nanoscale materials, devices, and systems under wide range of experimental conditions.Technical capabilities and expertise include surface analysis by Scanning Probe Microscopy (SPM); hydrodynamic size and surface charge analysis by Dynamic Light Scattering (DLS) and Zeta Potential (ZP) measurements; elemental and chemical analysis by Inductively Coupled Plasma Mass Spectrometry (ICP-MS).

Proper citation: University of California at Los Angeles California NanoSystems Institute Nano and Pico Characterization Laboratory Core Facility (RRID:SCR_022924) Copy   

•   Source: SciCrunch Registry

https://cbc.arizona.edu/research/support-services/facilities/molecular-structures-core

Core enables researchers to determine structures and dynamics, or motions, of large biomolecules such as proteins and DNA to understand how they interact with each other and with small molecules such as drugs.

Proper citation: University of Arizona Molecular Structures Core Facility (RRID:SCR_022888) Copy   

•   Source: SciCrunch Registry

https://sites.google.com/view/epsilon-uarizona/home?authuser=0

Facility offers imaging spectroscopy. Equipped with Xray Photoemission Spectroscopy, Ultraviolet Photoemission Spectroscopy, Inverse Photoemission Spectroscopy, energy filtered Photoelectron Emission Microscopy, and spatially resolved Angle Resolved Photoemission Spectroscopy and spatially resolved Xray Photoemission Spectroscopy.

Proper citation: University of Arizona Electron Photoemission Spectroscopy and Imaging Laboratory for Observation at the Nanoscale Core Facility (RRID:SCR_022887) Copy   

•   Source: SciCrunch Registry

https://cbc.arizona.edu/research/support-services/facilities/x-ray-diffraction-facility

Facility for investigation of single crystal and powder/thin film samples by X-Ray diffraction techniques.

Proper citation: University of Arizona Xray Diffraction Core Facility (RRID:SCR_022886) Copy   

•   Source: SciCrunch Registry

https://cbc.arizona.edu/research/support-services/facilities/surface-science-and-photoelectron-spectroscopy/about-lessa

Core for surface science, thin films studies, and nano scale characterization. Provides analytical and educational services to department and university on preparation, modification, and study of solid surfaces.

Proper citation: University of Arizona Laboratory for Electron Spectroscopy and Surface Analysis Core Facility (RRID:SCR_022885) Copy   

•   Source: SciCrunch Registry

https://www.ou.edu/microscopy

Offers access to instrumentation, training, and service using advanced light microscopy, scanning electron microscopy, and transmission electron microscopy. Provides access to core imaging and analytical characterization technologies. In addition to instrument access, SRNML personnel offer advice, hands-on training, education, and research collaboration. Provides range of sample preparation equipment.

Proper citation: University of Oklahoma Samuel Roberts Nobel Microscopy Laboratory Core Facility (RRID:SCR_022929) Copy   

•   Source: SciCrunch Registry