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Organism Information

URL: https://www.infrafrontier.eu/emma/strain-details/?q=5777

Proper Citation: RRID:IMSR_EM:05777

Description: Mus musculus with name B6.Cg-B2mtm1Unc H2-Ab1 Tg(HLA-A/H2-D/B2M)1Bpe Tg(HLA-DRA*0101.HLA-DRB1*0101)1Dma Tg(MMTV-neu/OT-I/OT-II)CBnel/Orl from IMSR.

Species: Mus musculus

Synonyms: SURE-L1/Her2-neu. B6.Cg-B2m H2-Ab1 Tg(HLA-A/H2-D/B2M)1Bpe Tg(HLA-DRA*0101.HLA-DRB1*0101)1Dma Tg(MMTV-neu/OT-I/OT-II)CBnel/Orl

Notes: gene symbol note: transgene insertion 1; Daniel M Altmann|transgene insertion 1; Beatrice Perarnau|histocompatibility 2; class II antigen A; beta 1|transgene insertion C; Brad Nelson|beta-2 microglobulin; mutant strain: Tg(HLA-DRA*0101;HLA-DRB1*0101)1Dma|Tg(HLA-A/H2-D/B2M)1Bpe|H2-Ab1|Tg(MMTV-neu/OT-I/OT-II)CBnel|B2m

Affected Gene: transgene insertion 1; Daniel M Altmann|transgene insertion 1; Beatrice Perarnau|histocompatibility 2; class II antigen A; beta 1|transgene insertion C; Brad Nelson|beta-2 microglobulin

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Ratings and Alerts

No rating or validation information has been found for B6.Cg-B2mtm1Unc H2-Ab1 Tg(HLA-A/H2-D/B2M)1Bpe Tg(HLA-DRA*0101.HLA-DRB1*0101)1Dma Tg(MMTV-neu/OT-I/OT-II)CBnel/Orl.

Issue
Warning. Researchers have noted that this genotype does not sufficiently model human type 1 diabetes mellitus.

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Data and Source Information

Source: Integrated Animals

Source Database: European Mouse Mutant Archive