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https://ipsc.bsd.uchicago.edu/

Core provides training to use latest episomal techniques to reprogram, expand and characterize human and mice iPS cells from skin or blood tissues of healthy subjects and diseased patients. Develops capability to differentiate iPS cells into specific somatic cells, such as neutrons, cardiomyocytes, and hepatocytes.

Proper citation: Chicago University iPSC Core Facility (RRID:SCR_017918) Copy   

•   Source: SciCrunch Registry

http://case.edu/medicine/ccir/imaging-research-core/

Core provides preclinical and clinical imaging instrumentation and techniques.Preclinical services include Bioluminescence,Fluorescence,In situ cryoimaging,Magnetic Resonance Imaging (MRI),Positron Emission Tomography (PET),Radiochemistry Synthesis, Scintigraphy,Ultrasound,X-ray / Computed Tomography (CT) / micro CT,Image Processing / Quantification clinical research imaging systems. Clinical services include Comprehensive MR imaging research services, Dedicated Siemens Skyra 3T MRI scanner, Large animal preclinical studies, or clinical human research may be conducted,Structural and functional brain scanning can be performed with Avotec LCD Projection System, Coodination of access to PET and CT scanners for additional preclinical and human imaging studies. Core includes PET radiopharmaceutical core facility. Core staff provide radiochemistry synthesis.

Proper citation: Case Western Reserve University Imaging Research Core Facility (RRID:SCR_017917) Copy   

•   Source: SciCrunch Registry

http://www.uwgnotobiotics.org/

Core at University of Washington (UW) is managed by Department of Comparative Medicine and open to investigators with research needs to maintain mice free of any microorganisms (germ-free), or with known population of microorganisms (gnotobiotic).Services provided include Rederivation, Germ-Free (GF) Mice, Isolator Maintenance of GF Mice, Experimental Study Support, Diet Sterility Testing, Technical Procedures.

Proper citation: Washington University Gnotobiotic Animal Core Facility (RRID:SCR_017887) Copy   

•   Source: SciCrunch Registry

http://www.kumc.edu/school-of-medicine/hoglund-brain-imaging-center/facilities-and-resources.html

Core provides imaging capabilities, including magnetic resonance imaging, magnetoencephalolgraphy, electroencephalography, magnetocardiography, and ultrasound,expertise in cognitive neuroscience, neurobiology, biomedical physics, and computing, together with support team of technologists, nurses, research associates, and research assistants. Through strong collaborations, these individuals assist with study design, collection of data, analysis, and interpretation of results. HBIC supports investigators with new technique development, feasibility studies, pilot funding, preparing grant applications and manuscripts, and compliance. Carries out investigator-initiated research and research/clinical trials sponsored by public and private agencies. Offers education and training.

Proper citation: Kansas University Medical Center Hoglund Brain Imaging Center Core Facility (RRID:SCR_017920) Copy   

•   Source: SciCrunch Registry

https://bds.berkeley.edu/facilities/cell-culture

Core provides cell cultures (mammalian and insect), media, supplies and expertise and consultation regarding cell culture needs, media, and experimental design.Provides tested media, serum, and cell lines at exceptionally low prices, large scale production of cells, expansion and harvesting of hybridoma lines,cryopreservation of cell lines, Cell Authentication by STR analysis provided in conjunction with DNA Sequencing Facility, Mycoplasma screeening,Use of 2 laminar flow hoods for mammalian or insect cell manipulation.

Proper citation: University of California, Berkeley Biosciences Divisional Services Cell Culture Core Facility (RRID:SCR_017924) Copy   

•   Source: SciCrunch Registry

https://nyumc.ilab.agilent.com/service_center/show_external/4296?name=experimental-pathology-research-laboratory

Core provides services, access to instruments, and training to facilitate production of animal tissue samples for morphological and molecular analyses. Supports multiplex immunofluorescence staining, RNA in situ hybridization (ISH), and imaging analysis. Services include tissue preparation, processing, and sectioning, as well as histochemistry and immunohistochemistry of fresh, frozen, and fixed animal tissues, can optimize and validate commercial or proprietary antibodies for chromogenic or fluorescence-based immunohistochemistry including seven-color multiplexing.Provides access to database listing antibodies that have been tested in lab to date and are currently in stock.Offers basic imaging resources and digital whole-slide scanning of stained tissue sections, which allows researchers to view their slides online at their convenience.Researchers can also rent our self-service instruments. These include embedding station, microtome, cryostat, and vibratome. Provides access to brightfield and fluorescence upright and dissecting microscopes,laser capture microdissection scope, and high-throughput multispectral imaging system.To reserve time on instrument, faculty, staff, and investigators must be registered in iLab.

Proper citation: New York University School of Medicine Langone Health Experimental Pathology Research Laboratory Core Facility (RRID:SCR_017928) Copy   

•   Source: SciCrunch Registry

http://www.chori.org/Services/Elemental_Analysis_Facility/elemental_analysis.html

Core provides sample preparation, metal extraction, dissolved solids measurement, analytic consultation, and technical writing assistance) in support of wide range of clinical and biomedical research projects.Instruments include Agilent 5100 SVDV Inductively-Coupled Plasma-Optical Emission Spectrometer, SPS3 Robotic Autosampler,MARS5 Microwave Sample Digestion Oven,ICPExpert Advanced Workstation.Analytic Capabilities:Simultaneous, multi-element quantitation over wide dynamic range;Broad elemental detection capability with high precision and sensitivity;Compatible with range of clinical, nutritional, basic research, and pharmaceutical samples;Tolerant of high total dissolved solids and complex matrix components;NIST-traceable calibrants, standards, and other QA/QC controls included in analyses.

Proper citation: Children's Hospital Oakland Research Institute Elemental Analysis Core Facility (RRID:SCR_017927) Copy   

•   Source: SciCrunch Registry

https://www.purdue.edu/discoverypark/bioinformatics/

Core to facilitate, amplify, and accelerate biological research and discovery through application of bioinformatics. Provides bioinformatic analysis services for Next Generation Sequencing (NGS) data.

Proper citation: Purdue University Bioinformatics Core Facility (RRID:SCR_017896) Copy   

•   Source: SciCrunch Registry

https://ki.mit.edu/sbc/bioinformatics

Core provides support, assistance and training in wide range of bioinformatics topics. Maintains high-performance computing resource offering many bioinformatics applications, substantial processing power and secure storage. Provides support for desktop computing and poster printing. Services include Data Analysis, Software Support (access to proprietary bioinformatics resources Ingenuity Pathway Analysis and GeneGO MetaCore, Training sessions covering various bioinformatics topics, Linux compute cluster, data storage.

Proper citation: Massachusetts Institute of Technology Koch Institute Bioinformatics and Computing Core Facility (RRID:SCR_017894) Copy   

•   Source: SciCrunch Registry

https://www.med.unc.edu/cellbiophysio/research-facilities/histology-facility

Facility offers histological services including Tissue Sectioning:Paraffin embedding and frozen embedding in OCT;Paraffin section serial, random, serial interrupted;Frozen section thaw mount cold/warm, serial, free floating,thick slice, random and serial interrupted, CryoJane tape transfer;Vibratome section;Routine staining, i.e., H+E, Nuclear Fast Red Special staining, Alcian Blue, Cresyl Violet, PAS, Oil Red , Toluidine Blue, Von Kossa, Combined Massons Elastin, Picrosirius Red, Sudan IV, Thionin, Prussian Blue, Movats Pentachrome, Masson Trichrome, Alcian Blue/Phloxine/Tartrazine, others available upon request. Immunohistochemistry/Enzyme:ABC method (direct/indirect);Fluorescence;Biocytin detection;HRP;Single and multiple-labeling;Edu/Brdu,in situ Hybridization,RNAScope,BaseScope.

Proper citation: North Carolina University School of Medicine Histology Research Core Facility (RRID:SCR_017893) Copy   

•   Source: SciCrunch Registry

https://ki.mit.edu/sbc/escell

Core provides service support to all MIT investigators who utilize specialized in vitro cells such as stem cells, organoids, or primary cell lines and/or novel mouse models to study human diseases such as cancer. Projects involve generation of new model system, such as CRISPR-mediated gene editing in mouse to introduce mutation that mimics one found in patients. Helps with projects required optimization of finicky cell cultures and other challenges.Provides customizable set of service options to match specific needs of each project, including consultative advice and troubleshooting, complete tissue culture and microinjection services within our facilities or hands-on training to enable investigators to perfom these experiments either at their own laboratory or within our facilities.Services Include:Gene Targeting genomic modification through traditional or CRISPR/Cas9 locus targeting, assistance with targeting strategies and vector designs;Embryonic Stem Cells generation of new ES lines from mouse strains, importation and testing of lines from outside sources, differentiation of ES lines into specific cell lineages or cell types and more;Microinjection injection of mouse ES cells into blastocysts to generate chimeras and injection of DNA, RNA or CRISPR RNPs into the pronucleus of fertilized mouse eggs to generate transgenic and edited mice;Specialized Tissue Culture establishemnt of new primary cell cultures from a tumor, tissue or organ; Isolation of fibroblasts (MEFs) from mice for culture and analysis;Tissue Culture for Xenograft and Syngenic Modeling optimization, validation and testing of cell lines for orthotopic placement into mice, coordinated with Preclinical Testing Facility;Repository of Reagent Mice Commonly used wild type mice such as C57BL/6j as well as KrasG12D-based models of cancers are maintained on campus for efficient distrubution;Training and Troubleshooting for all aspects of embryonic stem cells, primary cultures, animal breeding etc.;Serum, DMEM, LIF and other media components that have been tested and verified for use with ES cells.

Proper citation: Massachusetts Institute of Technology Koch Institute Preclinical Modeling Core Facility (RRID:SCR_017899) Copy   

•   Source: SciCrunch Registry

https://www.brown.edu/research/projects/superfund/cores/core-d

Core provides equipment and technical expertise for evaluation of molecular and morphological changes in cells, tissues, and organs following exposure to complex environmental contaminants. Provides equipment, including automated tissue processor, paraffin embedding center, two automated microtomes, cryostat, vibratome for soft-tissue sectioning, multiheaded light microscope with projection capabilities, system for laser capture microdissection, and slide scanner with analysis software for identification and quantification of morphological structures.Offers expertise in histopathological and immunocytochemial methods, including fixation, dehydration, embedding, sectioning, histological staining, immunolabeling, high-resolution imaging, and quantitative image analysis. Services in sample preparation, offers assistance in imaging and image analysis and provides consultation for ongoing or future research projects, training program for students and investigators who use centrally available equipment.

Proper citation: Brown University Molecular Pathology Core Facility (RRID:SCR_017898) Copy   

•   Source: SciCrunch Registry

https://sites.google.com/a/une.edu/confocal-microscopy-facility/

Core Facility provides access to Atomic Force Microscope and Leica SP5 Scanning Laser Confocal Microscope, located in Room 122 of Pickus Center for Biomedical Research on Biddeford Campus.

Proper citation: New England University Microscopy Core Facility (RRID:SCR_017891) Copy   

•   Source: SciCrunch Registry

http://www.uwinvivo.org/

Core provides rodent colony management. IVS staff oversee maintenance, breeding, weaning, identification, and record keeping of mouse and rat colonies. Core offers sample collection, sample administration, and testing of drug compounds in rodents. Services include Colony Management,Technical Procedures,Drug Testing.

Proper citation: Washington University In Vivo Services (IVS) Core Facility (RRID:SCR_017859) Copy   

•   Source: SciCrunch Registry

http://ssom.luc.edu/genomics/

Core provides next-generation sequencing capabilities using Illumina MiSeq. Helps with experimental design, quality control analysis, library preparation, and data analysis. MiSeq desktop sequencer allows to access applications such as targeted gene sequencing, metagenomics, small genome sequencing, targeted gene expression, amplicon sequencing, and HLA typing.MiSeq is capable of delivering up to 15 Gb of output with 25 million sequencing reads and 2x300 basepair read lengths.

Proper citation: Loyola University Genomics Core Facility (RRID:SCR_017857) Copy   

•   Source: SciCrunch Registry

http://www.uwtransgenics.org/

Core facility that creates transgenic and gene-targeted mice using pronuclear microinjection, targeted ES cell microinjection, and CRISPR/Cas9 gene editing. Offers mouse rederivation services to create specific pathogen free mice or to rederive cryopreserved mouse lines. Additionally, embryo and sperm cryopreservation services are available to provide long-term storage of valuable mouse strains or stocks. Services include:Pronuclear Microinjection,ES Cell Microinjection,ES Cell Electroporation CRISPR/Cas9,In Vitro Fertilization,Sperm Cryopreservation,Embryo Cryo,Embryo Rederivation.

Proper citation: University of Washington Transgenic Resources Program Core Facility (RRID:SCR_017863) Copy   

•   Source: SciCrunch Registry

http://nic.ucsf.edu/

Core provides light microscopy instrumentation, microscopy training and education and can provide assistance with experiment design, data acquisition, and image analysis. Provides training for users.Services include:Fluorescence imaging (up to 5 colors) Brightfield, phase contrast, and DIC imaging;High speed imaging (over 100 frames per second);Automated imaging, including multiwell plates;Super-resolution imaging (SIM / STORM / PALM);Single molecule imaging;3D confocal imaging;Gigapixel image stitching;Live cell time lapse imaging;Photoactivation and photobleaching;Light sheet imaging of cleared tissues.

Proper citation: University of California at San Francisco, Nikon Imaging Center Core Facility (RRID:SCR_017862) Copy   

•   Source: SciCrunch Registry

http://dmpi.duke.edu/molecular-genomics-shared-resource

Core offers variety of experimental platforms to facilitate genomics research. Accredited as Duke Shared Resource facility offers experience with genetic, genomic and epigenomic study design and technology, working closely with researchers to customize experiments to meet their needs. Applications include 10x Genomics NGS library generation for both single cell and gDNA experiments, DNA methylation microarrays, SNP genotyping and copy number microarrays, and Taqman targeted SNP genotyping.

Proper citation: Duke University Molecular Genomics Core Facility (RRID:SCR_017860) Copy   

•   Source: SciCrunch Registry

https://www.unmc.edu/vcr/cores/vcr-cores/electron-microscopy/index.html

Core provides instrumentation and technical assistance to research programs utilizing Transmission Electron Microscopy (TEM) and Scanning Electron Microscopy (SEM). Available for consultation and service.

Proper citation: Nebraska University Medical Center Electron Microscopy Core Facility (RRID:SCR_017864) Copy   

•   Source: SciCrunch Registry

http://nmr.science.oregonstate.edu

Facility maintains instrumentation, provides hands-on training to new users, experimental design expertise, assistance with data analysis and support for incorporating NMR into grants and manuscripts. NMR spectrometers are available at 800 MHz, 700 MHz, 500 MHz and 400 MHz (2), corresponding to magnetic field strengths ranging from 18.8 T to 9.4 T. Data processing and analysis software is available on workstations in NMR Facility. The facility supports scientific inquiry in research areas such as structural biology, organic chemistry, natural products analysis and environmental studies.

Proper citation: Oregon State University Nuclear Magnetic Resonance Core Facility (RRID:SCR_017909) Copy   

•   Source: SciCrunch Registry